• 동의생리병리학회지
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• 제31권3호
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• pp.153-158
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• 2017

As social interest in acne treatment has grown, various external preparations have been developed and studied. So, we investigated the external prescription which can treat acne in medical classics, then reviewed and divided it by dynasty. The data for analysis of Herbal formula was taken from 'medicine Dictionary of traditional Chinese medicine prescriptions(中醫方劑大辭典)'. 31 external medicines were searched, 3 were before song(宋) dynasty, 11 were Song(宋) dynasty, 11 were Yuan(元) dynasty, 7 were Ming(明) dynasty and 7 were Qing(淸) dynasty. The recipe and usage were only making them pill(丸) and paste(膏) using grinded medicinal herbs, then rubbing to face. As the age developed, unique manufacturing process(i.e fermentation method), and usage(i.e time-based usage, herbal medicine extracts for wash) were proposed. The external application with oriental medicine for acne used with Angelicae Gahuricae Radix(n=12), Bletillae Rhizoma(n=8), Syzygii Flos, Saposhnikoviae Radix(n=7) and so on. In particular, Bletillae Rhizoma was searched with high frequency in this study, but it was not included or studied in patent composition. The results of this study will provide basic data for future experiments and clinical studies.

• 대한한의학원전학회지
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• 제33권3호
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• pp.49-61
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• 2020

Objectives : The purpose of this paper is to collect basic data about Seo, Byung-Hyo and lay the groundwork for future analysis of his medical ideas. Methods : The life of Seo in regards to family and relationships was reconstructed through his genealogy and newspaper articles. His medical ideas were analyzed through the treatment records in books and historical material. Results : 1. Seo was primarily a clinician rather than a social worker throughout the Korean Empire and Japanese colonial era. 2. 『Summary of Experienced Old Prescriptions (經驗古方要抄)』 was a concise book that mainly took after the 『New Edition on Universal Relief (濟衆新編)』, supplemented by contents from the 『DongUiBogam(Treasured Mirror of Eastern Medicine)』. 3. It is meaningful that Seo's book restored and developed the single-ingredient prescription tradition of the 『DongUiBogam(Treasured Mirror of Eastern Medicine)』. 4. Seo faithfully followed the tradition of royal court medicine and utilized new prescriptions that were proven effective. Analysis of the prescription contents of 『A royal palace's diary(內殿日記)』 displays such characteristic. Conclusions : Seo, Byung-Hyo could be regarded as a clinician who faithfully inherited and developed 『DongUiBogam(Treasured Mirror of Eastern Medicine)』 and 『New Edition on Universal Relief (濟衆新編)』.

• 동의생리병리학회지
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• 제20권1호
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• pp.15-19
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• 2006

The anti-angiogenic activity of ethanol extract of Bojungbangam-tang, a new herbal prescription composed of nine crude drugs, was evaluated in human umbilical vein endothelial cells (HUVECs). HPLC profile revealed that five major compunds such as apioliquiritin, narirutin, hesperidin, liquiritin and glycyrrhizin. Ethanol extract of Bojungbangam-tang (EBJT) did not showed any significant cytotoxicity against HUVECs up to 200 ug/ml. EBJT significantly inhibited basic fibroblast growth factor (bFGF)-induced HUVECs proliferation to 69% at 200 ${\mu}g/ml$. Migration using window scraping method and tube formation in bFGF stimulated HUVECs were also significantly suppressed by EBJT in a dose-dependent manner. Taken together, these results suggest that Bojungbangam-tang can be a potent prescription for angiogenesis related disease.

• 운동영양학회지
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• 제24권3호
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• pp.19-24
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• 2020

[Purpose] Although physical activity is required to prevent or ameliorate osteoporosis, medicine prescription should precede it, since it may be limited in severe osteoporosis patients. Furthermore, osteoporosis has a great effect on physical activity disorders that accompany fractures and pain, and therefore, research on treatment or prevention to decrease the number of patients is required. The purpose of this study was to discover candidate substances from natural products with an effective pharmacological action and to prepare basic data to help patients. [Methods] To prepare the osteoporosis model, ovariectomy (OVX) was performed using surgical methods. The prepared prescription [Shinkiwhan (SKH), a Korean medicine] was administered orally at a dose of 210 mg/kg/day for 8 weeks. After completion of the animal experiment, the bone mineral density (BMD) was analyzed using double-energy X-ray absorptiometry. The analysis of the effect of drugs on bones was performed using histological analysis and immunostaining. [Results] SKH increased the BMD in the OVX rats. Furthermore, SKH significantly increased the expression of osteoprotegerin and downregulated receptor activator of nuclear factor kappa B ligand and phosphorylation of c-jun N-terminal kinases in the bones of the OVX model. [Conclusion] Our findings suggest a protective effect of SKH against BMD loss in the OVX model.

• 대한한방소아과학회지
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• 제18권2호
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• pp.233-249
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• 2004

Objectives : Infectious mononucleosis is a clinical syndrome caused by Epstein-Barr virus that is particularly common in adolescents and children. This study was progressed for current oriental medical treatment of infectious mononucleosis in china. The purpose of this study is the opening oriental medical approach to infectious mononucleosis in Korea Methods : Authors conducted a literature search in data of Traditional Chinese Medical Journal. The data were extracted in a standardized, predefined manner and accessed critically. Results : The study for infectious mononucleosis consists of basic, clinical, experimental study. Basic study consists of etiology & pathogenesis and the rule of treatment. Clinical study consists of symptoms-based treatment and adequate prescription treatment. Experimental study consists of effective herbs and new traditional chinese medical injection. Conclusion : Traditional chinese medical approach using herbs works in children with infectious mononucleosis in Korea.

• 동의생리병리학회지
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• 제23권1호
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• pp.15-26
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• 2009

The purpose of this report was to provide the information about activity and safety of Yukmijihwang-tang by analyzing domestic/international papers and theses about Yukmijihwang-tang. Domestic/international papers and theses related to Yukmijihwang-tang were reviewed and analyzed. These papers were then classified by year, experimental method, and activity subject. The following results were obtained in this study. The study of Yukmijihwang-tang started from 1978 and was rapidly increased after 1990s. The study of Yukmijihwang-tang was continuously increased now and was mainly forcused on experimental model rather than clinical study. The paper of SCI journal or non-SCI journal was 27 volume and the other domestic paper was 64 volume. The total papers of Yukmijihwang-tang, 91 volume was analysed in this study. Allatoin, gallic acid, loganin, morroniside, paeoniflorin, paenol, urosolic acid were determined in Yukmijihwang-tang by using HPLC and HPLC-MS-MS. In classified Yukmijihwang-tang paper by experimental method and animal, more than a half study was in vivo experiment used rat. Furthermore clinical experiments were performed variously. As these studies were classified by subject, papers related to renal function were most abundant by 16 papers. Besides there were several papers related to cognitive vitality, anti-diabetic effect, immuno-regulation, reproductive activity, anti-oxidant effect, liver function, anti-cancer and blood pressure depress. According to basic research and clinic research data, it is supported that Yukmijihwang-tang was useful prescription in renal function, cognitive vitality, anti-diabetic effect and reproductive activity. Many study of basic and clinic research were performed and reported variously on Yukmijihwang-tang in domestic/international journal. According to basic research and clinic research data, it is supported that Yukmijihwang-tang was useful prescription in renal function, cognitive vitality, anti-diabetic effect and reproductive activity. However, studies on efficacy and mechanism of Yukmijihwang-tang should be conducted at the molecular biology level and studies on safety of Yukmijihwang-tang need to be completed at the clinical level.

• 대한한의학회지
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• 제17권2호
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• pp.58-72
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• 1996

I. PURPOSE AND SIGNIFICANCE OF RESEARCH The presentation of research direction for compositive study and application of oriental medicine is urgently demanded. Since there is few investigation for the interest in basic and clinical field of oriental medicine, and we hope that compositive study and concentrative research between instruction in college and local clinics is established by this research. II. RESEARCH CONTENT ${\cdot}$ Analysis of survey in basic field of oriental medicine as instruction curriculum. ${\cdot}$ Analysis of survey in clinical field of oriental medicine as the classification of disease. III. RESULT The result of investigation shows that the most interested field is acupuncture and moxibustion in clinical field and diagnostics in basic field of oriental medicine. And oriental medicinal clinic doctors are concerned about prescription and a newly-developed techniques such as new acupuncture therapy, new machines. They hope that a study of oriental medicine in clinical field be accomplished with the special clinics as leader. According to the previous results, we can work out the foundation of compositive study and concentrative research between instruction in college and local clinics, and on this ground it is considered that we can grope for the presentation of research direction of local clinics.

• Journal of Microbiology and Biotechnology
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• 제20권12호
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• pp.1764-1768
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• 2010

In this study, the prevalence of antibiotic resistance was examined among 74 Staphylococcus pseudintermedius strains recently isolated from clinical cases of canine pyoderma and otitis externa at the veterinary teaching hospital at Konkuk University, Korea. Bacterial resistance to the nine commonly used antibiotics was evaluated by a standard disk diffusion technique based on the guidelines of the Clinical and Laboratory Standards Institute. The results demonstrated that most S. pseudintermedius isolates were resistant to penicillin (95.9%) or tetracycline (91.9%), but highly susceptible to amoxicillin/clavulanic acid (90.5%). Among the 74 isolates, 13 mecA-positive and methicillin-resistant S. pseudintermedius (MRSP) strains were identified, displaying a high level of resistance (84.6-100%) to each of the individual antibiotics evaluated, with the exception of amoxicillin/clavulanic acid (46.2% resistance). Notably, all of the MRSP isolates exhibited simultaneous resistance to four or more different antibiotics, indicating that they are multiple drug resistant (MDR) strains. Taken together, these results imply that more careful selection or prescription of antibiotics for canine pyoderma and otitis externa should be required for reducing the emergence and/or spread of MDR strains, especially MDR-MRSP isolates, in veterinary pet clinics in Korea.

• 대한한의학방제학회지
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• 제26권2호
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• pp.147-170
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• 2018

Objectivs : This report describes the studies as follows through the research of 163prescribtions in low-chapter from Bangyakhappyun. Methods : Analysis the 163prescribtions of basic prescribtions, therapeutic area, symptoms and pathology. Result : Many prescriptions are contained in the diseases areas such as defecate diseases, women diseases, internal diseases, exogenous febrile diseases. And prescriptions in the low-chapter are used in the areas such as eye, aggregation, mouth and tongue, teeth, hand, back, neck, emergency. Eighty-five basic prescriptions are analyzed from the low-chapter and the ratio of nineteen prescriptions containing Ijintang, Pyeongwisan, Oryungsan, Samultang, Sunggitang, Jichultang are over 60%. The efficacy classifications containing basic prescriptions frequently used are researched in the following order: heat-clearing and fire-purging formulae, digestant formulae, phlegm-dispelling formulae, qi-regulating formulae and blood-activating formulae. And tonifying and replenishing formulae are rarely used. Most of the prescriptions in the low-chapter are used for the excess syndrome and few of them are used for the deficiency syndrome. And six excesses, food damage, phlegm are the major causes of excess syndrome. Conclusions : As s result of study on analysis all prescriptions in low-chapter from Bangyakhappyun. We can understand more about basic prescriptions, symptoms of prescriptions and pathology.

• 동의생리병리학회지
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• 제24권6호
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• pp.1111-1116
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• 2010

We in this paper design and implement a traditional korean medicine diagnosis system based on basic ontology. If doctors put the symptoms or tongues or pulses of a patient in the diagnosis system, they can be recommended for the diagnosis results. To support the doctors decision, the diagnosis system make the inference based on the basic ontology and compute the similarity between symptoms of patient and those of ontology. The diagnosis systems also provide the learning mechanism about diagnosis results which save the results in the ontology and reuse them in the next diagnosis. Thus, doctors can share their knowledge for the diagnosis by exchanging their ontology each other. In future, we will expand the knowledge of the basic ontology continuously so that doctors can get the more accurate diagnosis results. We also implement the prescription function and integrate it to the diagnosis system.