• Title/Summary/Keyword: Basic Factor

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The Effect of Interferon-${\alpha}$ and bFGF on the Proliferation of Cultured Leiomyoma and Myometrial Cells (자궁근종과 자궁평활근 세포분열에 있어 Interferon-${\alpha}$ 및 basic Fibroblast Growth Factor (bFGF)의 효과)

  • Lee, B.S.;Park, J.S.;Kim, J.Y.;Bae, S.W.;Park, K.H.;Cho, D.J.;Lee, K.d;Kim, J.W.;Song, C.H.
    • Clinical and Experimental Reproductive Medicine
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    • v.24 no.3
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    • pp.355-359
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    • 1997
  • Leiomyomas, which are the commonest pelvic tumors in women, are originated from myometrial cells. Although the exact initial pathophysiologic event of the leiomyoma is not known, recent evidences suggested that the effects of sex steroid hormones in the process of tumor growth are mediated by local production of growth factors including epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II). If we look at the effects of other cytokines, it was suggested that basic fibroblast growth factor (bFGF) may stimulate the proliferation of myometrial and leiomyomas cells. And it was reported that interferon-${\alpha}$ inhibit the action of bFGF. Therefore, we examined the effect of bFGF and interferon-${\alpha}$ on the proliferation of leiomyoma and myometrial cells. bFGF stimulated the myometrial and leiomyoma cells significantly at the concentration of 1ng/ml (p<0.05) and 5ng/ml (p<0.05). However, Interferon-${\alpha}$ inhibited the cell proliferation of myometrial and leiomyoma cells significantly at the concentration of 100U/ml (p<0.05) and 1000U/ml (p<0.05). And the stimulated effects of bFGF with the various concentration on the myometrial and leiomyoma cells ware inhibited by interferon-${\alpha}$ with 100U/ml. Therefore, we concluded that bFGF may stimulate the myometrial and leiomyoma cell proliferation and interferon-${\alpha}$ may inhibit the myometrial and leiomyoma cell proliferation through blocking the effect of basic fibroblast growth factor.

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An Experimental Study on the Characteristics of Compressive Strength in Cement Mortar under High Temperature conditions in an Early Age (초기 고온이력이 시멘트 모르터의 강도발현에 미치는 영향에 관한 연구)

  • Kim Young-Joo;Choi Maeng-Ki;Gong Min-Ho;Park Hee-Gon;Kim Kwang-Ki;Jung Sang-Jin
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2005.05a
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    • pp.45-48
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    • 2005
  • This study is basic experiment for estimating influence of strength by curing temperature of concrete's heat of hydration and estimate relationship of compressive strength development by initial curing temperature factor, and then asume temperature factor which influence compressive strength development and for showing basic document of qualify control. According to the result of cement mortar by the curing temperature factor high-curing temperature shows high strength on 3 day compare with low curing-temperature, shows higher strength than the piece of high curing temperature.

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An Experimental Study on the Effects of High temperature Hysteresis on Concrete Strength Development (고온이력이 콘크리트의 강도발현에 미치는 영향에 관한 실험적 연구)

  • Kim, Hak-Young;Min, Hong-Jun;Jang, Hyung-Jun;Gong, Min-Ho;An, Moo-Young;Jung, Sang-Jin
    • Proceedings of the Korea Concrete Institute Conference
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    • 2006.05b
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    • pp.433-436
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    • 2006
  • This study is basic experiment for estimating influence of strength by curing temperature of concrete's heat of hydration and estimate relationship of compressive strength development by initial curing temperature factor, and then asume temperature factor which influence compressive strength development and for showing basic document of quality control. According to the result of managerial test pieces by the curing temperature factor high-curing temperature shows high strength on 3 day compare with low curing-temperature, shows higher strength than the piece of high curing temperature.

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Prediction of Shear Strength in High-Strength Concrete Beams Considering Size Effect (크기효과를 고려한 고강도 콘크리트 보의 전단강도 예측식 제안)

  • 배영훈;윤영수
    • Proceedings of the Korea Concrete Institute Conference
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    • 2003.05a
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    • pp.878-883
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    • 2003
  • To modify some problems of ACI shear provisions, ultimate shear strength equation considering size effect and arch action to compute shear strength in high-strength concrete beams without stirrups is presented in this research. Three basic equations, namely size reduction factor, rho factor, and arch action factor, are derived from crack band model of fracture mechanics, analysis of previous some shear equations for longitudinal reinforcement ratio, and concrete strut described as linear function in deep beams. Constants of basic equations are determined using statistical analysis of previous shear testing data. To verify proposed shear equation for each variable, namely d, , ρ, f/sub c/' and aid, about 250 experimental data are used and proposed shear equation is compared with ACI 318-99 code, CEB-FIP Model code, Kim & Park's equation and Zsutty's equation. While proposed shear equation is simpler than other shear equations, it is shown to be economical predictions and reasonable safety margin. Hence proposed shear strength equation is expected to be applied to practice shear design.

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Trend of Basic Research for Vocal Fold Scar (성대 반흔에 대한 기초연구의 최신 경향)

  • Lee, Byung-Joo
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.23 no.1
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    • pp.28-32
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    • 2012
  • Vocal fold scar disrupts structure of lamina propria and causes significant change in vocal fold tissue biomechanics, resulting in a range of voice problems that often significantly compromise patient quality of life. Although several therapeutic management have been offered in an attempt to improve vocal fold scar, the ideal treatment has not yet been found. Recently, several tissue engineering technique for vocal fold scar using growth factors, several cells, and scaffolds have been described in tissue culture and animal models. Several growth factors such as hepatocyte growth factor, basic fibroblast growth factor, and transforming growth factor beta 3 for therapy and prevention of vocal fold scar have been studied. Cell types to regenerate vocal folds in scarring tissue have been introduced autologous or scarred vocal fold fibroblast and adult mesenchymal stem cells. Decellularized organ matrix and several hyaluronic acid materials have used as scaffolds for vocal fold scar.

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An Experimental Study on the Characteristics of Strength in Mortar under High Temperature conditions in an Early Age (초기 고온이력을 받은 시멘트 모르타르의 강도 특성에 관한 실험적 연구)

  • Kim Young Joo;Kim Han Sik;Gong Min Ho;Kim Je Sub;Lee Young Do;Jung Sang Jin
    • Proceedings of the Korea Concrete Institute Conference
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    • 2005.05b
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    • pp.517-520
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    • 2005
  • This study is basic experiment for estimating influence of strength by curing temperature of concrete's heat of hydration and estimate relationship of compressive strength development by initial curing temperature factor, and then asume temperature factor which influence compressive strength development and for showing basic document of quality control. According to the result of cement mortar by the curing temperature factor high-curing temperature shows high strength on 3 day compare with low curing-temperature, shows higher strength than the piece of high curing temperature.

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A Basic Study on the Evaluation Factor for Deteriorated Level of Rural House (농촌주택의 노후도 평가요소 도출을 위한 기초연구)

  • Park, Gil-Beom;Park, Jun-Mo;Kim, Ok-Kyue
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2014.11a
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    • pp.107-108
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    • 2014
  • The rural area has aged and depressed for urban area in Korea. Furthermore, the rural house has deteriorated and is vulnerable to disaster which collapse, fire, landslide, and so on. For this matter, it need to an evaluated system for deteriorated level of rural house. The evaluated system has a repairing method and an estimated cost for rural house to offer native in rural area. This study could draw evaluation factor for deteriorated level of rural house as a basic study for the evaluated system. The evaluation factors is compared the Korean housing performance grade indication system, the Korean green building certification criteria, and the Japanese housing performance indication system. As a result, they could eight types. There are a mothproof, an waterproof, a finishing material, an asbestos cement slate of roofing, a mobility right, an opening and closing of doors and windows, an indoor environment.

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An Experimental Study on the Characteristics of Strength in Mortar under High Temperature conditions in an Early Age (모르터 압축강도 특성에 영향을 미치는 고온이력에 관한 실험적 연구)

  • Kim Young Joo;Gong Min Ho;Song In Myung;Yang Dong Il;Paik Min Su;Jung Sang Jin
    • Proceedings of the Korea Concrete Institute Conference
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    • 2004.11a
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    • pp.703-706
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    • 2004
  • This study is basic experiment for estimating influence of strength by curing temperature of concrete's heat of hydration and estimate relationship of compressive strength development by initial curing temperature factor, and then asume temperature factor which influence compressive strength development and for showing basic document of quality control. According to the result of cement mortar by the curing temperature factor high-curing temperature shows high strength on 3 day compare with low curing-temperature, shows higher strength than the piece of high curing temperature.

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Anti-angiogenic activity of conjugated linoleic acid on the basic fibroblast growth factor-induced angiogenesis

  • Moon, Eun-Joung;Lee, You-Mie;Kim, Kyu-Won
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.337.2-337.2
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    • 2002
  • Conjugated linoleic acid (CLA) is a potent inhibitor of mammary carcinogenesis. Cancer cells produce various angiogenic factors which stimulate host vascular endothelial cell mitogenesis and chemotaxis for their growth and metastasis. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor that is expressed in many tumors. In this study. we found that CLA decreased bFGF-induced endothelial cell proliferation and DNA synthesis in a dose-dependent manner. However, CLA did not inhibit endothelial cell migration. Furthermore CLA showed a potent inhibitory effect on embryonic vasculogenesis and bF GF-induced angiogenesis in vivo. Collectively. these results suggest that CLA selectively inhibis the active proliferating endothelial edll induced by bFGF. which may explain its anti-carcinogenix properties in vivo.

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Advanced electricity electron information communication facility obstacle factor and countermeasure investigation in digital age (디지털시대의 첨단 전기 전자 정보 통신설비 장애요인과 대책 고찰)

  • Kang, Tae-Keun
    • Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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    • 2004.05a
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    • pp.110-115
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    • 2004
  • Examine merits and demerits and obstacle factor that exist to all direction of digital infratechnology that is supplied on industry whole according to development special quality of computer by development of computer and Information Technology and electricity electron information communication facility that basic impulse insulation level does not exist examined scorched earth or an interference problem factor and countermeasure of semiconductor degauss of factor and electricity electron information transmission system that is numbed or causes system down.

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