• 한국공간구조학회:학술대회논문집
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• 한국공간구조학회 2008년도 춘계 학술발표회 논문집
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• pp.19-24
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• 2008

본 논문은 풍동실험과 정적하중 실험을 실시하여 강풍 설계시 대공간 구조물의 막구조 동적응답을 확인하여 거스트 계수(gust factor)를 산출해 보고자한다. 이를 위해 섬유재료의 변형률에 따라 하중을 구할 수 있는 막재료 성능실험과 4가지(saddle형, wave형, arch형, point형) 막구조 모형에 따른 횡방향 동적하중과 동적변형응답을 측정할 수 있는 풍동실험, 동적변형응답에 따라 정적하중을 구할 수 있는 정적하중실험을 실시함으로써 거스트 계수(gust factor)를 산출하였다.

• KIEAE Journal
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• 제14권6호
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• pp.105-110
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• 2014

The basic factors determining the amount of energy used in hospital buildings are weather conditions and building factors. But the real energy consumer is central plant equipment such as boilers and chillers that produce thermal energy for heating and cooling. Inaccurate decision of the primary equipment's size can cause a high initial-cost, an excessive equipment space, a wasted energy by low operation-efficiency and shortening of the machine's life. In this reason, the decision of optimal size for central plant equipment is very important. There are several factors for the decision such as an operation factor, a factor (equipment factor), piping losses and a simultaneous usage factor applied in the sizing process except a basic cooling load. But there is no standard method for applying those factors. Usually, factors are applied individually by an experience or custom of each engineer. In this study, the authors emphasize the meaning and the problem of those factors, examine them by analyzing factors which were applied to actual practices, and propose the recommendation value of safety, load, operation factors and application methods.

• 한국항만학회지
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• 제11권2호
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• pp.281-294
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• 1997

Fatigue strength analysis is one of the most important themes of ship structure design, as fatigue damages are reported on ship structures even now. But these need basic research workes which will take time. The others are the problem to apply fatigue strength analysis in design and have to be investigated in parallel with basic researches. The one of major items in the latter is the critical damage factor to define with S-N curve for fatigue strength analysis of ship structure design.

• 대한후두음성언어의학회지
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• 제30권2호
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• pp.124-127
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• 2019

Vocal fold scarring is an intractable phonosurgical condition. The number of patients with vocal fold scars is increasing with the aging of society and with the increasing application of laryngeal microsurgery. Many methods are available to treat these, including voice therapy, stem cells, regenerative scaffolds, and growth factors. However, no standard treatment strategy has yet been established, and novel techniques are required. Basic fibroblast growth factor has been shown to be effective for the treatment of mild chronic vocal fold scarring. The combined use of basic fibroblast growth factor and regenerative scaffolds is currently under investigation. Here, we report a female patient in whom vocal fold scarring developed after two laryngeal microsurgeries. We performed laryngeal microsurgery to remove the scar tissue and used basic fibroblast growth factor and a collagen scaffold to promote healing. The patient's voice quality was greatly increased, and she was content with her voice after 2 years of follow-up. This is the first report of this methodology in Korea and is presented along with a review of the literature.

• Molecules and Cells
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• 제37권6호
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• pp.487-496
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• 2014

Angiotensinogen (AGT), the precursor of angiotensin I, is known to be involved in tumor angiogenesis and associated with the pathogenesis of coronary atherosclerosis. This study was undertaken to determine the role played by AGT in endothelial progenitor cells (EPCs) in tumor progression and metastasis. It was found that the number of EPC colonies formed by AGT heterozygous knockout ($AGT^{+/-}$) cells was less than that formed by wild-type (WT) cells, and that the migration and tube formation abilities of $AGT^{+/-}$ EPCs were significantly lower than those of WT EPCs. In addition, the gene expressions of vascular endothelial growth factor (VEGF), Flk1, angiopoietin (Ang)-1, Ang-2, Tie-2, stromal derived factor (SDF)-1, C-X-C chemokine receptor type 4 (CXCR4), and of endothelial nitric oxide synthase (eNOS) were suppressed in $AGT^{+/-}$ EPCs. Furthermore, the expressions of hypoxia-inducible factor (HIF)-$1{\alpha}$and $-2{\alpha}$ were downregulated in $AGT^{+/-}$ early EPCs under hypoxic conditions, suggesting a blunting of response to hypoxia. Moreover, the activation of Akt/eNOS signaling pathways induced by VEGF, epithelial growth factor (EGF), or SDF-$1{\alpha}$ were suppressed in $AGT^{+/-}$ EPCs. In $AGT^{+/-}$ mice, the incorporation of EPCs into the tumor vasculature was significantly reduced, and lung tumor growth and melanoma metastasis were attenuated. In conclusion, AGT is required for hypoxia-induced vasculogenesis.

• 한국조경학회지
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• 제29권1호
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• pp.80-91
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• 2001

The purpose of this research is to provide a basic knowledge to open up for undeveloped park in process of the park policy establishment by setting up the priority of park development and valuation factor, valuation index as well as building a basic material to undeveloped neighborhood park in Daegu Metropolitan City. Thirteen urban neighborhood parks(1,841,663$m^2$) in the Daegu Metropolitan City were selected for this study. Analyzing and reviewing the previous research and literature review were conducted, and the evaluation index and analysis criteria were constructed to decide the development priority of parks. The results of this research are as follows; 1) Following to the result of the expert questionnaire test in order to estimate weight of valuation factors. It had a high score in available population, and estimated amount of the gross compensation, unpurchased land rate. On the other hand park rate of autonomous district, altitude, rate of population increase in autonomous district and a low score. 2) Generally, most f the plain type parks had a high score in the Sea level, land using pattern, an estimated amount of the gross compensation, but hill type parks had a high score the rate of green covered, park area for one person of administration building. 3) Daebong, Soosung, Dosan, 2.28 youth, Kyungnam parks were selected high priority. Soochang, Donsibong, Janggi, Dongin parks were selected middle priority. Bokhyun, Galsan, Manchon, Gusoosan parks, which were selected low priority. This research for undeveloped park is a basic research step to open up. Three many difficult things in shortage of the basic material for building valuation factor and measuring of the method measurement. The application of weight which make a decision importance among the valuation factor should have ore reasonable study and more scientific research from now because there still remains a lot of shortage of positive materials in there.

• Archives of Plastic Surgery
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• 제38권5호
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• pp.567-575
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• 2011

Purpose: Acellular human dermis is very useful implant for use in plastic and reconstructive surgery. However, the volume of acellular human dermis graft is known to decrease for a long time. Basic fibroblast growth factor (bFGF) is a polypeptide that enhances the collagen synthesis and angiogenesis. In the current study we examined whether bFGF could improve the survival of acellular human dermis ($SureDerm^{(R)}$) by increasing angiogenesis of the graft. Methods: Forty rats were divided into two groups (control and bFGF). A 2-mm thick piece of $SureDerm^{(R)}$ was cut into smaller pieces that were $15{\times}5$ mm in size. Two subcutaneous pockets were made on the back of each rat. Grafts sprayed with bFGF were implanted in the bFGF group and injected with bFGF after transplantation every 3 days for 2 weeks. In the control group, the grafts were treated with phosphate-buffered saline (PBS) instead of bFGF. Four days, and 1, 4, and 12 weeks after the implantation, the grafts were harvested and gross and histologic examinations were performed. Inflammation grade, graft thickness, neocollagen density, and neocapillary count were measured. Results: The bFGF group displayed more rapid accumulation of inflammatory cells with a higher density of neocapillaries, and increased active collagen synthesis. After 12 weeks, the thickness of the grafts in the control and bFGF groups was $75.15{\pm}4.80%$ and $81.79{\pm}5.72%$, respectively, in comparison to the thickness before transplantation. There was a statistically significant difference between both groups ($p$ <0.05). Conclusion: bFGF was effective in reducing the absorption of acellular human dermal grafts by increasing angiogenesis and accelerating engraftment. In conclusion, bFGF may be a good tool for use in acellular human dermal graft transplantation for reconstructive surgery involving soft-tissue defects.

• Biotechnology and Bioprocess Engineering:BBE
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• 제9권6호
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• pp.423-427
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• 2004

A simple purification procedure of bioactive human granulocyte macrophage colony stimulating factor (hGM-CSF) secreted in rice cell suspension culture has previously been described. In this study the protein was purified to apparent homogeneity with an overall yield of $80.1\%$ by ammonium sulfate precipitation and a single chromatographic step involving FPLCanion exchange chromatography. The purified hGM-CSF revealed at least five glycosylated forms ranging from $21.5{\~}29$ kDa, and its biological activity was independent of the glycosylation pattern. This is the first purification report of recombinant hGM-CSF to apparent homogeneity from rice cell suspension cultures.

• 복식
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• 제58권2호
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• pp.162-180
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• 2008

The purpose of this study is to find the basic design factors that affect the changes in body surface lines caused by lower limb movements, thereby resulting in slacks that fit well regardless of whether the human form is static or in motion. Using unmarried female university students aged 18-24 as subjects, a total of 32 body surface lines (15 body surface total lines and 17 body surface segment lines) were measured in one static and 9 movement poses, The analysis first involved the calculation of the expansion and contraction rates per body part in body surface line in 9 lower limb movements, Second, a factor analysis was conducted using the expansion and contraction rates of these changes in body surface line. The results of this study are as follows, According to the factor analysis, basic design factors that affect changes in body surface lines comprised 8 types of factors as illustrated in fig, 2-fig, 9, which explained 79.2% of total variate for the variables studied, Factor 1, comprising the lower segment of center back leg line, center front leg line and inner leg line, and lower limb girth except midway thigh girth and ankle girth below hip girth, accounted for 30.3% of total variance, Factor 2, comprising waist girth, the total and upper segment of center back leg line and center tront leg line, and front and back segment of crotch length, explained 17.4% of total variance, Factor 3, the total and upper segment of lateral leg line at the center, accounted for 56.5% of total variance in accordance with Factors 1, 2, and 3, Factor 4 was the contracting upper part of lower leg between legscye girth and midway thigh girth, Factor 5 comprised the total and upper segment of inner leg line and posterior knee girth, Factor 6 was the total crotch length, Factor 7 was the ankle girth, Factor 8 was the abdomen girth.

• 아동학회지
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• 제37권4호
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• pp.83-99
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• 2016

Objective: The purpose of this study was to analyze correlation effect size between Basic Psychological Needs (BPN) and factors affecting BPN. Methods: This research was reviewed and synthesized systematically by meta-analyse. Fifty-eight published studies between 2008 and 2016 were sampled and the effect sizes were acquired. Results: The major findings were as follows. In general, medium correlation effect sizes were found. Competency among sub-factors of BPN showed highest effects. Parental factor was more related to BPN than school and individual factors. Parenting behavior and family psychological backgrounds were the most crucial factors in the parental factors. School adjustment was the most critical factor in the school factors. In school grade, the elementary school was more related to BPN than junior high school and high school. Conclusion: Based on these results, we suggest a number of components for parent-education programs, and information for future research.