• Carbon letters
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• v.11 no.2
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• pp.122-126
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• 2010

The alginate-based hydrogel was prepared as a pH-sensitive drug delivery system. To enhance the drug loading capacity, activated carbon was introduced as a drug absorbent. The iron oxide was incorporated into the alginate matrix for the magnetic transferring to the target organ. The activated carbon and iron-oxide were dispersed uniformly in the alginate hydrogel. The drug release from the alginate/activated carbon composite hydrogel was carried out in various pH conditions with vitamin B12 and Lactobacillus lamnosers as model drugs. The fast and sustainable release of drug was observed in the basic condition due to the pH-sensitive solubility of alginate. The novel drug delivery system having pH-sensitive release property and magnetic movement to target place was developed by using the alginate/activated carbon composite magnetic hydrogels.

• The Korean Journal of Emergency Medical Services
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• v.6 no.1
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• pp.199-207
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• 2002

This is a study to evaluate the effects of the safety of ambulance driving and the occurrence of ambulance traffic accidents and to provide basic information for the description of various factors to reduce the ambulance traffic accidents. The major instruments of this study were Korean Self-Analysis Driver Opinionnaire. Questionnaire contains 8 items which measure driver's opinions or attitudees: driving courtesy, emotion, traffic law, speed, vehicle condition, the use of drugs, high-risk behavior, human factor. To take the analysis of data, the total of 187 drivers were investigated ambulance drivers in Gwangju Metropolitan City from 2002. 1. September to 2002. 20. September. The data were analyzed by the path analysis SPSS program. The result are as follows : 1. There was desirable attitude group(58.4%) and undesirable attitude group(41.7%) on safety ambulance driving. 2. It have suggested that rist factors of ambulance traffic accident much affected with emotion and speed control on safety ambulance driving(Y(Accident) = -2.00 + 0.6 X1(Emotion Control) + 0.4 $X_2$(Speed control) + E). 3. Almost 92.1% of respondents have agreed to necessity of emergency medical technics for ambulance drivers.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.107-107
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• 2003

The purpose of this study is to examine that the efflux transport system for choline from brain to blood is present at the blood-brain barrier (BBB) using brain efflux index (BEI) method. ［$^3$H］Choline was microinjected into parietal cortex area 2 (Par2) region of rat brain, and was eliminated from the brain with an apparent elimination half life of 45 min. The BBB efflux clearance of ［$^3$H］choline was 0.12 $m\ell$/min/g brain, which was calculated from the efflux rate constant (1.5${\times}$10$\^$-2/ min$\^$-1/) and the distribution volume in the brain slice (8.1 $m\ell$/g brain). This process was saturable and significantly inhibited by various organic cationic compounds including hemicholinium-3, tetraethylammonium chloride (TEA) and verapamil, by antioxidant, ${\alpha}$-phenyl-n-tert-butyl nitrone (PBN), and by Alzheimer's disease therapeutics, such as acetyl $\ell$-carnitine and tacrine. In conclusion, this finding is the first direct in vivo evidence that choline is transported from brain to the blood across the BBB via a carrier-mediated efflux transport process.

• Korean Journal of Pharmacognosy
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• v.27 no.2
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• pp.91-95
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• 1996

In the course of searching for acetylcholinesterase inhibitors from crude drugs, it was found that total MeOH extract of Corydalis Tuber showed significant inhibitory effect on acetylcholinesterase. To isolate acetylcholinesterase inhibitors from Corydalis Tuber, total MeOH extract of the the crude drug was subjected to activity guided fractionation. The MeOH extract was suspended in water and fractionated with methylene chloride and subjected to acid-base fractionation. Silica gel column chromatography of the basic fraction which showed significant inhibitory effect on acetylcholinesterase was carried out and 5 subfractions (1-5) were obtained. From subtraction 4, compound I was isolated. The structure of isolated compound I was identified by spectroscopic parameters of $^1H-NMR$, $^{13}C-NMR$, EI-MS and FAB-MS. The compound I was identified as berberine. It was found from the Lineweaver-Burk plot that berberine was a reversible and specific inhibitor of acetylcholinesterase having 90% inhibitory effect at the concentration of $2.5{\mu}M$.

• Journal of Yeungnam Medical Science
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• v.21 no.2
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• pp.133-142
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• 2004

Chronic obstructive pulmonary disease(COPD) is characterized by a not entirely reversible limitation in the airflow. An airflow limitation is progressive and associated with an abnormal inflammatory response of the lung to gases and harmful particles. In COPD, the weight loss is commonly observed and there is a negative impact on the respiratory as well as skeletal muscle function. The pathophysiological mechanisms that result in weight loss in COPD are not fully understood. However, the mechanisms of weight loss in COPD may be the result of an increased energy expenditure unbalanced by an adequate dietary intake. The commonly occurring weight loss and muscle wasting in COPD patients adversely affect the respiratory and peripheral muscle function, the exercise capacity, the health status, and even the survival rates. Therefore, it is very valuable to include management strategies that the increase energy balance in order to increase the weight and fat free mass. A Better understanding of the molecular and cellular pathological mechanisms of COPD can improve the many new directions for both the basic and clinical investigations. The Nutritional supply is an important components of a multidisciplinary pulmonary rehabilitation program. Future studies combining an exercise program, the role of anabolic steroids, nutritional individualization, a more targeted nutritional therapy, and the development of new drugs including anti-cytokines is needed for the effective management of COPD.

• YAKHAK HOEJI
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• v.40 no.6
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• pp.670-678
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• 1996

The combinations of N-4-salicyloamido-2-amino-6-piperidinopyrimidine 3-oxide (Salmi) and two transitional metals were colored. Among metals, Fe(III) made a distinct colored comp lex with Salmi. The mole ratio of Salmi and Fe(III) in the complex was 1:1. This Salmi-Fe(III) complex was recrystallized in Hexane/Acetone(=10/1, v/v) and investigated its physicochemical properties. The color of this complex was changed by pH.; deep violet pink in acids, orange in neutral, and yellow in bases. The range of color change was approximately 0.7 pH unit. Acid-base titration of various acidic or basic drugs using Salmi-Fe(III) complex as an indicator showed good accuracy and reproducibility.

• Journal of Korean society of Dental Hygiene
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• v.17 no.1
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• pp.63-76
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• 2017

Objectives: The purpose of this study is to investigate the factors affecting medical knowledge and practice of dental treatment for systemic disease among dental health care workers. Methods: A self-reported questionnaire was filled out by 222 dental health care workers working in Seoul, Daejeon, Busan, Gyeonggi province, Chungcheong province, and Jeolla province within the period between May 1 - June 30, 2016. Knowledge and medical knowledge about the clinical treatment of patients suffering from systemic disease and their practice were composed of items that were corrected, supplemented, and developed by themselves based on previous research. Results: Factors affecting knowledge about clinical treatment of patients suffering from systemic disease were place of employment, treatment about systemic disease, and practice of dental treatment for systemic diseases. Predictive power was 38.5%. Factors affecting practice of clinical treatment of patients suffering from systemic disease were sex, place of employment, treatment about systemic disease, the basic equipment and drugs needed for emergency care, and knowledge of dental treatment for systemic diseases. Predictive power was 39.1%. Conclusions: Dental health care workers' knowledge and practice of dental treatment of patients suffering from systemic diseases were important factors influencing each other.

• Korean Journal of Adult Nursing
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• v.27 no.3
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• pp.314-324
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• 2015

Purpose: The purpose of this study was to measure health-related quality of life (HRQOL) and the related factors according to gender in baby boomers by using Korea Health Panel Data 2012. Methods: The Korea Health Panel Data 2012 were collected from February to August 2012 by Korea Institute for Health and Social Affairs and National Health Insurance Corporation and the data of 1,802 respondents categorized as baby boomers were analyzed for this study. The data were analyzed by t-test, ${\chi}^2$ and multiple regression using SPSS/WIN 20.0 program. Results: For male, the influencing factors on HRQOL were economic activity and smoking. For female, the influencing factors on HRQOL were education, psychological and physical stress, unmet basic needs, and psychiatric drugs. The types of insurance, unmet medical needs, anxiety about the future, depression, and self-rated health status showed statistically significant relationships with HRQOL both for male and female. Conclusion: Health care providers are suggested to consider the founded gender differences in this study when they develop interventions for HRQOL improvement for baby boomers in a community.

• BMB Reports
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• v.46 no.12
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• pp.567-574
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• 2013

Liver plays a major role in maintaining glucose homeostasis in mammals. Under fasting conditions, hepatic glucose production is critical as a source of fuel to maintain the basic functions in other tissues, including skeletal muscle, red blood cells, and the brain. Fasting hormones glucagon and cortisol play major roles during the process, in part by activating the transcription of key enzyme genes in the gluconeogenesis such as phosphoenol pyruvate carboxykinase (PEPCK) and glucose 6 phosphatase catalytic subunit (G6Pase). Conversely, gluconeogenic transcription is repressed by pancreatic insulin under feeding conditions, which effectively inhibits transcriptional activator complexes by either promoting post-translational modifications or activating transcriptional inhibitors in the liver, resulting in the reduction of hepatic glucose output. The transcriptional regulatory machineries have been highlighted as targets for type 2 diabetes drugs to control glycemia, so understanding of the complex regulatory mechanisms for transcription circuits for hepatic gluconeogenesis is critical in the potential development of therapeutic tools for the treatment of this disease. In this review, the current understanding regarding the roles of two key transcriptional activators, CREB and FoxO1, in the regulation of hepatic gluconeogenic program is discussed.

• Archives of Pharmacal Research
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• v.18 no.4
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• pp.224-230
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• 1995

Recently, many attempts have been made to use hydrogels of various polymers as delivery systems of various drugs and bioactive materials to prolong and control their phamacological activities. In this study, we have evaluated the physico-chemical properties of methacrylic acid-methyacrylic acid methyl ester copolymer 9Eudispert mv)m a acrylic resin hydorgel, and its application to transdermal delivery system. In the dissolution tests, the release rate of salicylic acid (SA) and sodium salicylate (SOd. SA) were faster than lidocain (LD) and lidocain-HCl(LD-HCl). As the concentration of Eudispert mv polymer increased, the extensibility of Eudispert mu hydrogel decreased, whereas the swelling ratio increased. The more NaOH and polymer concentration increased, the more osmotic pressure linearly increased. The skin permeation of Sod. SA, an acidic model drug, was remarkably enhanced by Eudispert mv hydrogel. All fatty acids, except for Sod. glycolate, dramatically increased the skin permeation flux in Eudispert mu hydrogel containing LD-Hcl, a basic model drug. Consequently, it is suggested that Eudispert mv hydrogel may be used as potential transdermal delivery vehicle.