• Journal of Korean Neurosurgical Society
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• 제65권5호
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• pp.688-696
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• 2022

Objective : Transvenous embolization (TVE) via an occluded inferior petrosal sinus (IPS) in a cavernous sinus dural arteriovenous fistula (CSDAVF) is challenging, often requiring navigation of a microcatheter through resistive obstacles between the occluded IPS and shunted pouch (SP), although the reopening technique was successfully performed. We report five cases of successful access to the cavernous sinus (CS) or SP using the rigid-tipped microguidewire such as chronic total occlusion (CTO) wire aiming to share our initial experience with this wire. Methods : In this retrospective study, four patients with CSDAVF underwent five procedures using the CTO wire puncture during transfemoral transvenous coil embolization. Puncture success, shunt occlusion, and complications including any hemorrhage and cranial nerve palsy were evaluated. Results : Despite successful access through the occluded IPS, further entry into the target area using neurointerventional devices was impossible due to a short-segment stricture before the CS (three cases) and a membranous barrier within the CS (two cases). However, puncturing these structures using the rigid-tipped microguidewire was successful in all cases. We could advance the microcatheter over the rigid-tipped microguidewire for the navigation to the SP and achieved complete occlusion of the SP without complications. Conclusion : The use of the rigid-tipped microguidewire in the TVE via the occluded IPS of the CSDAVF would be feasible and safe.

• Journal of Korea Trade
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• 제25권6호
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• pp.105-125
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• 2021

Purpose - This study analyzes the effects that the response to the technical barriers to trade (TBT), which are used by various countries as means to restrict imports, exerts on exports at a time when protectionism is emerging in the face of a global economic downturn. TBT has been widely used in developed countries for the safety and protection of their people. Recently, the use of TBT as a tool of protectionism has increased considerably in developing countries as well. Therefore, this study analyzes the South Korean SMEs' response and export performance. Design/methodology - To analyze SMEs' response to TBT and their export performance, this study conducted empirical analysis through statistical analysis. To this end, the research established a theory based on previous research and designed its hypothesis and research model. To verify the hypothesis and research model, factor analysis addressing validity and reliability was performed using SPSS 25 and AMOS 26, and the structural equation model was analyzed. Findings - This study found the causal relationship between the independent variable, the mediating variable, and the dependent variable adopted against the theoretical background to have little or no effect, in contrast with previous studies. In a break from previous studies, all hypotheses were rejected for innovation strategic competencies, one of the sub-factors of the independent variable, which is believed to be a result of the lack of practical research related to TBT. Originality/value - Previous studies performed analysis using trade statistics or macro data. A number of such studies analyzed the relationship between technical regulation and trade volume. This study differs from previous studies in some respects, because it analyzed the export performance of companies by establishing a hypothesis and implementing a research model with the factors analyzed in previous studies. In addition, a new attempt has been made by classifying the TBT response factors into technology competencies, human resource competencies, and innovation strategic competencies, and utilizing technology innovation and the export support system as mediating effects.

• Journal of Ginseng Research
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• 제46권3호
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• pp.464-472
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• 2022

Background: Gut microbiota influence the central nervous system through gut-brain-axis. They also affect the neurological disorders. Gut microbiota differs in patients with Alzheimer's disease (AD), as a potential factor that leads to progression of AD. Oral intake of Korean Red Ginseng (KRG) improves the cognitive functions. Therefore, it can be proposed that KRG affect the microbiota on the gut-brain-axis to the brain. Methods: Tg2576 were used for the experimental model of AD. They were divided into four groups: wild type (n = 6), AD mice (n = 6), AD mice with 30 mg/kg/day (n = 6) or 100 mg/kg/day (n = 6) of KRG. Following two weeks, changes in gut microbiota were analyzed by Illumina HiSeq4000 platform 16S gene sequencing. Microglial activation were evaluated by quantitative Western blot analyses of Iba-1 protein. Claudin-5, occludin, laminin and CD13 assay were conducted for Blood-brain barrier (BBB) integrity. Amyloid beta (Aβ) accumulation demonstrated through Aβ 42/40 ratio was accessed by ELISA, and cognition were monitored by Novel object location test. Results: KRG improved the cognitive behavior of mice (30 mg/kg/day p < 0.05; 100 mg/kg/day p < 0.01), and decreased Aβ 42/40 ratio (p < 0.01) indicating reduced Aβ accumulation. Increased Iba-1 (p < 0.001) for reduced microglial activation, and upregulation of Claudin-5 (p < 0.05) for decreased BBB permeability were shown. In particular, diversity of gut microbiota was altered (30 mg/kg/day q-value<0.05), showing increased population of Lactobacillus species. (30 mg/kg/day 411%; 100 mg/kg/day 1040%). Conclusions: KRG administration showed the Lactobacillus dominance in the gut microbiota. Improvement of AD pathology by KRG can be medicated through gut-brain axis in mice model of AD.

• 한국정보통신학회논문지
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• 제26권9호
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• pp.1279-1292
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• 2022

신체적 불편함으로 인해 기존의 마우스와 같은 입력 장치의 사용이 힘든 사용자에게 도움이 될 수 있는 시스템으로 얼굴 인식과 Pyautogui 마우스 제어 기반의 비접촉식 입력 기법을 제안한다. 본 연구는 특히 화면 확대/축소나 스크롤 기능과 같이 웹 서핑을 보다 편리하게 돕는 기능이 포함되어 있으며, 개인의 신체적 차이 및 웹 사용 습관을 고려해 여러 설정값을 조정할 수 있도록 하였다. 또한, 기존의 시스템에서 한계점으로 제시되었던 눈 피로도에 대한 문제도 해결하였다. 추가로 고성능 CPU나 GPU 환경이 요구되지 않고 별도의 트래커 장치나 고성능 카메라 또한 필요하지 않다. 이러한 연구를 통해 손을 쓰기 어려운 장애인 및 노인들의 웹 접근성을 높여 배리어프리 실현에 기여하고자 한다.

• Animal Bioscience
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• 제35권6호
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• pp.791-803
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• 2022

Genome/gene-editing (GE) techniques, characterized by a low technological barrier, high efficiency, and broad application among organisms, are now being employed not only in medical science but also in agriculture/veterinary science. Different engineered CRISPR/Cas9s have been identified to expand the application of this technology. In pig production, GE is a precise new breeding technology (NBT), and promising outcomes in improving economic traits, such as growth, lean or healthy meat production, animal welfare, and disease resistance, have already been documented and reviewed. These promising achievements in porcine gene editing, including the Myostatin gene knockout (KO) in indigenous breeds to improve lean meat production, the uncoupling protein 1 (UCP1) gene knock-in to enhance piglet thermogenesis and survival under cold stress, the generation of GGTA1 and CMP-N-glycolylneuraminic acid hydroxylase (CMAH) gene double KO (dKO) pigs to produce healthy red meat, and the KO or deletion of exon 7 of the CD163 gene to confer resistance to porcine reproductive and respiratory syndrome virus infection, are described in the present article. Other related approaches for such purposes are also discussed. The current trend of global regulations or legislation for GE organisms is that they are exempted from classification as genetically modified organisms (GMOs) if no exogenes are integrated into the genome, according to product-based and not process-based methods. Moreover, an updated case study in the EU showed that current GMO legislation is not fit for purpose in term of NBTs, which contribute to the objectives of the EU's Green Deal and biodiversity strategies and even meet the United Nations' sustainable development goals for a more resilient and sustainable agri-food system. The GE pigs generated via NBT will be exempted from classification as GMOs, and their global valorization and commercialization can be foreseen.

• 대한의용생체공학회:의공학회지
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• 제43권4호
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• pp.193-198
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• 2022

Contrast enhanced magnetic resonance imaging using gadolinium-based contrast agent (GBCA) is a very useful in vivo technique to visualize the inner ear pathology including endolymphatic hydrops. Although systemic intravenous (IV) administration can visualize the perilymph space, the visualization was possible by indirect passage of contrast agent through blood-perilymph barrier. All animal experimental procedures were performed under anesthesia with 5% isoflurane. Lipopolysaccharide (LPS) was instilled into the left tympanic cavity through the tympanic membrane using a sterile 27gauge needle to induce hydrops model. Tucker-Davis Technologies system was used to measure Auditory Brainstem Responses (ABRs). For intracerebroven-tricular (ICV) administration, 25 µmol of GADOVIST (Bayer, Berlin, Germany) was used and diluted GADOVIST injection was 10 µl. MR imaging was acquired with a 9.4 Tesla MRI scanner. Transmit-receive volume coil with 40 mm inner diameter and 75 mm out diameter was used. ICV administration well demonstrated the strong enhancement along the cerebrospinal fluid (CSF) microcirculation pathway including CSF fluid in the subarachnoid space and CSF space of the inner ear structures. On the other hand, IV administration showed no contrast enhancement along the CSF microcirculation pathway and showed weak enhancement in the inner ear structures. In case of rat hydrops model, ICV administration showed that the reduced contrast enhancement in the perilymph space of the hydrops induced inner ear compared to the contrast enhancement in the perilymph space of the normal inner ear. New systemic ICV administration method provide contrast enhancement of GBCA in the inner ear through CSF microcirculation pathway.

• Animal Bioscience
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• 제36권5호
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• pp.810-817
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• 2023

Objective: The aim was to compare the behavioral response to full separation of cows and calves maintained together for 100 days or 24 h. Methods: Twelve Holstein-Friesian cow-calf pairs were enrolled into either treatment or industry groups (n = 6 cow-calf pairs/group). The treatment cows and calves were maintained on pasture together for 106±8.6 d and temporarily separated twice a day for milking. The Industry cows and their calves, were separated within 24 h postpartum. Triaxial accelerometer neck-mounted sensors were fitted to cows 3 weeks before separation to measure hourly rumination and activity. Before separation, cow and calf behavior was observed by scan sampling for 15 min. During the separation process, frequency of vocalizations and turn arounds were recorded. At separation, cows were moved to an observation pen where behavior was recorded for 3 d. A CCTV camera was used to record video footage of cows within the observation pens and behavior was documented from the videos in 15 min intervals across the 3 d. Results: Before separation, industry calves were more likely to be near their mother than Treatment calves. During the separation process, vocalization and turn around behavior was similar between groups. After full separation, treatment cows vocalized three times more than industry cows. However, the frequency of time spent close to barrier, standing, lying, walking, and eating were similar between industry and treatment cows. Treatment cows had greater rumination duration, and were more active, than industry cows. Conclusion: These findings suggest a similar behavioral response to full calf separation and greater occurrence of vocalizations, from cows maintained in a long-term, pasture-based, cow-calf rearing system when ompared to cows separated within 24 h. However, further work is required to assess the impact of full separation on calf behavior.

• 예술인문사회 융합 멀티미디어 논문지
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• 제6권1호
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• pp.39-48
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• 2016

암묵지는 전이를 통해 증식되며, 가치 또한 증대된다. 암묵지 전이는 조직의 경쟁력 향상을 위한 가장 중요한 역할을 담당하고 있다. 암묵지 전이가 매우 중요함에도 불구하고, 암묵지 전이는 활발히 이루어지지 못하고 있다. 암묵지 전이를 방해하는 장벽이 암묵지 전이를 저해하고 있기 때문이다. 암묵지 전이를 방해하는 장벽은 지식과 지식전문가에 대한 이해부족, 업무 가중 및 미흡한 보상, 신뢰부족과 지식 접착성(Knowledge Stickiness)이다. 암묵지 전이의 장벽을 극복하기 위해서는 암묵지 지식전이를 주도적으로 추진하는 대리인이 필요하다. 지식중개자는 암묵지 전이를 위한 근간이며, 효율적인 지식네트워크의 구축은 암묵지 전이를 위한 핵심성공요소이다. 그러나 지식네트워크 관련된 대부분의 연구는 네트워크의 근접성과 밀도, 중심성 등 기초지표를 활용하는 수준에 머무르고 있다. 암묵지 전이 활성화를 위한 새로운 지식중개인 진단 프레임워크가 필요하다. 따라서 사회연결망분석을 기반으로 조직관점 및 지식근로자관점의 암묵지 전이를 분석하고, 이를 기반으로 BSKT 구축안을 제시하고자 한다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.330-330
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• 2022

In recent studies, cold plasma has been used to induce exudation of polyphenols and flavonoids from food materials, leading to enhancement of functional properties. And it is known that polyphenols interact with inflammation related metabolism. The objectives of this study were to investigate the effects of cold plasma treatments on the increase of total phenolic content (TPC), total flavonoid content (TFC), and anti-inflammatory activities of 'Sinpalkwang' peanut (Arachis hypogaea L.) hull. Plasma treatments were carried out using a dielectric barrier discharge gas exchange system at different radicals and temperatures (O₃-25℃, O₃-150℃, NO_x-150℃). Significant differences in TPC, TFC, and inflammatory mediator such as nitric oxide (NO) and tumor necrosis factor a (TNF-α) in lipopolysaccharide stimulated Raw 264.7 macrophages were observed between treated and non-treated peanut hull samples (p < 0.001). Cold plasma treated samples showed higher content (TPC: 2.87-2.93 mg/g sample, TFC: 0.96-0.98 mg/g sample) than non-treated sample (TPC: 2.47 mg/g sample, TFC: 0.78 mg/g sample). Cold plasma treated samples showed lower content of NO (3.3-5.0 uM) and TNF-α (141.4-162.2 ng/mL) than non-treated sample (NO: 11.1 uM, TNF-α: 210.2 ng/mL). This study suggests that cold plasma has potential to improve functionalities of food materials and that cold plasma treated peanut hull can be used as immune enhancing materials.

• 문화기술의 융합
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• 제9권5호
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• pp.591-596
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• 2023

본 연구는 10대 1인 미디어 제작자를 중점으로 하여 쉽고 편리하게 영상을 제작할 수 있는 프로그램을 개발하였다. 사용자 조사를 통해 나타난 10대 제작자들의 요구사항과 문제점을 파악하여 사용자가 원하는 캐릭터 커스터마이징 기능과 GPT를 활용한 감정 및 행동 추천 시스템을 구현하였다. 렌더링 과정에서는 OpenCV와 FFmpeg를 사용하여 오디오와 영상을 결합하여 최종 영상을 생성하였다. 영상 제작에 전문성이 없는 10대 사용자들은 간단한 인터페이스를 통해 웹드라마 캐릭터를 커스터마이징하고, GPT의 도움을 받아 감정과 행동을 추천받을 수 있다. 본 연구의 프로그램은 편집 및 연출에 전문성이 없는 10대 사용자들을 대상으로 양질의 영상 제작을 돕고, 영상 제작에 대한 진입장벽을 낮춰주며, 1인 미디어 산업의 발전에 기여할 수 있는 도구가 될 것으로 기대된다. 향후 모바일이나 세로해상도 버전의 영상을 고려한 영상 제작 환경을 제공할 수 있도록 할 예정이다.