• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.1
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• pp.1-10
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• 2014

At present, there are few research papers on skin penetration of cosmeceutical ingredients. What is worse is that in vivo studies are hard to find. In this study, we measured skin epidermal penetration of cosmeceutical ingredients using in vivo Raman spectroscopy and compared with the results obtained from experiments using in vitro franz cell. Results showed that ascorbyl-2-glucoside, retinol, retinyl palmitate, and kojic acid were good for penetration ratio in measurement in vitro and retinol, vitamin C, and arbutin were good in measurement in vivo. Among them, retinol was best in skin penetration in vivo experiment using Raman spectroscopy and ascorbyl-2-glucoside was best in skin penetration in vitro experiment using Franz cell system. It is estimated that the differences were originated from the experimental procedures of two different methods; in vivo Raman experiment can be sensitive to the effect of epidermis and dermis as characteristics of matter by estimating the stratum corneum and in vitro measurement is evaluation of material to penetrate skin of hairless mouse. However, most penetration barrier is the stratum corneum, thus it is important to examine movement of material in the stratum corneum. We expect that these results provided useful information for many cosmetic related research.

• Tunnel and Underground Space
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• v.23 no.5
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• pp.372-382
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• 2013

Thermal-hydro-mechanical (THM) modeling is a critical R&D issue in the performance and safety assessment of a high-level waste repository. With an $\ddot{A}$sp$\ddot{o}$ prototype repository, its thermal behavior was analyzed and then compared with in-situ experimental data for its validation. A model simulation was used to calculate the temperature distributions in the deposition holes, deposition tunnel, and surrounding host rock. A comparison of the simulation results with the experimental data was made for deposition hole DH-6, which showed that there was a temperature difference of $2{\sim}5^{\circ}C$ depending on the location of the measuring points, but there was a similar trend in the evolution curves of temperature as a function of time. It was expected that the coupled modeling of the thermal behavior with the hydro-mechanical behavior in the buffer and backfill of the $\ddot{A}$sp$\ddot{o}$ prototype repository would give a better agreement between the experimental and model calculation results.

• Korean Journal of Veterinary Research
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• v.51 no.3
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• pp.217-225
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• 2011

Glatiramer acetate (GA; Copaxone) has been shown to be effective in preventing and suppressing experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). It has been recently shown that GA-reactive T cells migrate through the blood-brain barrier, accumulate in the central nervous system (CNS), secrete antiinflammatory cytokines and suppress production of proinflammatory cytokines of EAE and MS. Development of EAE requires coordinated expression of a number of genes involved in the activation and effector functions of inflammatory cells. Activation of inflammatory cells is regulated at the transcriptional level by several families of transcription factors. One of these is the nuclear factor kappa B ($NF{\kappa}B$) family which is present in a variety of cell types and involved in the activation of immune-relative genes during inflammatory process. Since it is highly activated at site of inflammation, $NF{\kappa}B$ activation is also implicated in the pathogenesis of EAE. In this study, we examined whether the inhibition of $NF{\kappa}B$ activation induced by GA can have suppressive therapeutic effects in EAE mice. We observed the expression of $NF{\kappa}B$ and phospho-$I{\kappa}B$ proteins increased in GA-treated EAE mice compared to EAE control groups. The immunoreactivity in inflammatory cells and glial cells of $NF{\kappa}B$ and phospho-$I{\kappa}B$ significantly decreased at the GA-treated EAE mice. These results suggest that treatment of GA in EAE inhibits the activation of $NF{\kappa}B$ and phophorylation of $I{\kappa}B$ in the CNS. Subsequently, the inhibition of $NF{\kappa}B$ activation and $I{\kappa}B$ phosphorylation leads to the anti-inflammatory effects thereby to reduce the progression and severity of EAE.

• Proceedings of the Korean Geotechical Society Conference
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• 2001.03a
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• pp.167-174
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• 2001

Reflection method using ultrasonic source has been attempted to obtain the information about tunnel lining structures composed of lining, shotcrete, water barrier and voids at the back of lining. In this work, two different types of sources, i.e. single-pulse source and sweep source, can be used. Single-pulse source with short time duration has the frequency content whose amplitudes tend to be concentrated around the dominant frequency, whereas sweep source with long time duration denotes a flat distribution of relatively larger amplitude over a broad frequency band, although the peak to peak amplitude of single-pulse source wavelet is equivalent to that of sweep source one. In traditional seismic application, a single-pulse source(weight drop, dynamite) is typically used. However, to investigate the fine structure, as it is the case in the tunnel lining structure, the sweep wavelet can be also a desirable source waveform primarily due to the higher energy over a broad frequency band. For the investigation purposes of sweep source, a physical modeling is a useful tool, especially to study problems of wave propagation in the fine layered media. The main purpose of this work was using a physical modeling technique to explore the applicability of sweep source to the delineation of inner layer boundaries. To this end, a two-dimensional physical model analogous to the lining structure was built and a special ultrasonic sweep source was devised. The measurements were carried out in the sweep frequency range 10 ∼ 60 KHz, as peformed in the regular reflection survey(e.g. roll-along technique). The measured data were further rearranged with a proper software (cross-correlation). The resulting seismograms(raw data) showed quitely similar features to those from a single-pulse source, in which high frequency content of reflection events could be considerably emphasized, as expected. The data were further processed by using a regular data processing system "FOCUS" and the results(stack section) were well associated with the known model structure. In this context, it is worthy to note that in view of measuring condition the sweep source would be applied to benefit the penetration of high frequency energy into the media and to enhance the resolution of reflection events.

• The Journal of Korean Medicine
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• v.17 no.2 s.32
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• pp.34-47
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• 1996

We have seen a sharp increase in the utilization rate of medical services since the launch of Nation Health Insurance system in 1989. However, the market share of oriental medicine in the Korean health sector has been gradually diminished mainly due to low insurance coverage and high price. Especially high price as an entry barrier to oriental medical services has played a major role in decreasing market share. This paper investigated the effects of price discount on the financial condition and market share of oriental medical institutions. Microeconomic theory and multiple regression analysis were used as a methodology in testing the alternative hypothesis: price discount of enveloped herb drug will result in increases in both the revenue and market share of oriental medical institutions. Data was collected from the statistical yearbook and sample survey. The price elasticity of demand for enveloped herb drug was estimated at 5.8 during 1987-1995 period, which means that a 1% decrease in price will bring about a 5.8% increase in the utilization of oriental medical services. The empirical result shows that a drastic price discount for the enveloped herb drug will eventually improve the financial status of the oriental medical institutions and enlarge the market share of oriental medicine in the Korean health care sector.

• Journal of the Korean institute of surface engineering
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• v.46 no.4
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• pp.145-152
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• 2013

The growth behavior of nanocrystalline diamond (NCD) film has been studied for three different substrates, i.e. bare Si wafer, 1 ${\mu}m$ thick W and Ti films deposited on Si wafer by DC sputter. The surface roughness values of the substrates measured by AFM were Si < W < Ti. After ultrasonic seeding treatment using nanometer sized diamond powder, surface roughness remained as Si < W < Ti. The contact angles of the substrates were Si ($56^{\circ}$) > W ($31^{\circ}$) > Ti ($0^{\circ}$). During deposition in the microwave plasma CVD system, NCD particles were formed and evolved to film. For the first 0.5h, the values of NCD particle density were measured as Si < W < Ti. Since the energy barrier for heterogeneous nucleation is proportional to the contact angle of the substrate, the initial nucleus or particle densities are believed to be Si < W < Ti. Meanwhile, the NCD growth rate up to 2 h was W > Si > Ti. In the case of W substrate, NCD particles were coalesced and evolved to the film in the short time of 0.5 h, which could be attributed to the fact that the diffusion of carbon species on W substrate was fast. The slower diffusion of carbon on Si substrate is believed to be the reason for slower film growth than on W substrate. The surface of Ti substrate was observed as a vertically aligned needle shape. The NCD particle formed on the top of a Ti needle should be coalesced with the particle on the nearby needle by carbon diffusion. In this case, the diffusion length is longer than that of Si or W substrate which shows a relatively flat surface. This results in a slow growth rate of NCD on Ti substrate. As deposition time is prolonged, NCD particles grow with carbon species attached from the plasma and coalesce with nearby particles, leaving many voids in NCD/Ti interface. The low adhesion of NCD films on Ti substrate is related to the void structure of NCD/Ti interface.

• The Korean Journal of Quaternary Research
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• v.9 no.1
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• pp.33-42
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• 1995

우리나라의 서해(West Sea)는 일명 황해(Yellow Sea)라고 일컬어지는 약 40여 m의 평균 수심을 갖는 대륙붕 해저지형 분지에 의하여 지배되는 전형적 육연해이다, 그런데 이 바다는 중심부(황해의 중심부)를 기준으로 하여 중국 대륙의 산동반도에서 양가강 하구에 이르는 서부 해안을 가지며 북부에는 발해만의 해안이 있고 동부에는 서해(황해) 특유의 넓 은 조수환경(tidal environment)과 조수해안이 발달한다. 그러나 남쪽으로는 북서태평양과 연결된다. 한국 서해안이 평균 4m 이상의 조차(tidal range)를 나타내는 조간대 조수환경이 며 조간대 해저지형(intertidal morphology)이 전형적인 퇴적층(체)에 의하여 지배되는 여러 가지 특징을 나타낸다. 서해안 조수환경은 네델란드, 독일 또는 지배되는 여러 가지 특징을 나타낸다. 서해안 조수환경은 네델란드 독일 또는 미국의 경우와 같이 연구가 잘되어 세계 적으로 널리 알려진 소위 barrier island system and tidal depositional environments와는 크 게 다른 퇴적과정과 환경이다. 경기도 남양만의 조수 환경의 경우, 조간대 해저지형 요소인 조류로(tidal channel)와 조간대 정규해저(intertidal zone proper)에 관한 동력적 퇴적과정 연 구결과 조간대 특유의 lateral sedimentation 과 vertical sedimentation 2가지 퇴적과정중 후 자의 퇴적과정이 우세한 것으로 밝혀졌고 이러한 퇴적과정의 진행이 매우 안정한 지속성을 가지는 것이 특징이다, 이러한 퇴적과정의 조간대 퇴적물의 쇄설 입자는 약 20% 미만의 모 래(sand) 입자 50~70%의 실트(silt) 와 점토(clay) 입자가 20~30%에 달하는 입자조직 (grain texture)의 퇴적상을 나타낸다. 결과적으로 조간대의 동력적인 조수수괴의 수위(level of tidal water)는 평균 만조선과 평균 저조선으로 한정되며 이것은 퇴적과정과 퇴적작용의 조정(control) 요인으로 조간대 퇴적상의 발달과 분포에 큰 영향을 미친다, 예를들면 남양만 등의 대부분의 서해안 조간대 표층 퇴적상(녁\ulcorner미 sedimentary faci-es)은 만조선에서 간조 선에 가까울수록 조립화현상(coarsening trend)을 나타낸다. 이러한 퇴적상 변화는 저조선에 서 만조선으로의 조간대 지형과 주조수로의 지형.수력학적 특성이 다음과 같기 때문이다. a) a general decrease in width b) a general decrease in depth c) a general decrease in maximum and average current velocities d) a general increase in contents of suspended mud e) a general decrease in grain size of the bottom sand and an increasing abundance of muddy deposits. 우리나라 서해안 조간대 퇴적층(체)의 수직 층서(vertical stratigraphy)는 지난 3여년동안의 수십개의 vibracoring(주상시추)에 의하여 매우 흥미롭고 중요하게 밝혀지고 있는바 이것은 현세(Holocene)와 선현세(preHolocene: 11000 years BP)의 오랜시간 경과에 따른 조수환경 변화의 수직퇴적 과정과 기후 해수면 변화의 현상에 원인이 있다고 해석된다.(박용안 외, 1992-1995)결과적으로 서해안 조수퇴적체(층)의 분지주변(basim margin)진화과정이 밝혀지 고 있다.

• Korean Journal of Community Nutrition
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• v.13 no.6
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• pp.818-828
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• 2008

This study was conducted to investigate actual conditions and needs on breastfeeding education for pregnant women in health centers for the development of a breastfeeding educational program. The questionnaires were mailed to 245 health centers and 148 (60.4%) questionnaires were returned. 91% of the health centers had breastfeeding education for pregnant women. 66% of them operated breastfeeding education as one part of other health programs. About 76% of supervisors and 64% of educators were the nurses. The teaching methods frequently used were lectures (30.5%), giving out booklets and leaflets (22.6%), demonstration and practice (21.5%), personal counseling (13.3%), and others. The teaching materials used were materials of outside speakers (39.7%), materials of development oneself (19.0%), materials of academic association or institute (14.8%), and others. The subjects which educators taught were the benefits of breastfeeding (16.7%), breastfeeding techniques (15.8%), caring for breasts before and after delivery (15.1%), nutritional management for lactating women (14.2%), coping strategies for the difficult situation of breastfeeding (13.3%), and others. Those were different from each other according to the educators' general characteristics. Success factors of education were increased motivation for breastfeeding (52.8%), practice (22.6%), professional's lecture (11.3%) and others. The failure factors of education were the ineffectiveness of the lecture method (69.2%), lack of education for supporters (15.4%) and lack of standardized education (15.4%). The most important barrier of education was the lack of a standardized breastfeeding educational programs (43.9%). The most effective teaching methods that educators thought were demonstration and practice (24.0%). The educators thought they need the tools and space for practice (28.2%), a standardized breastfeeding educational program (26.9%), and the human resources (24.4%) for effective education. Subjects that educators thought important for education were the breastfeeding techniques, benefits of breastfeeding, caring for breasts before and after delivery, nutritional management for lactating women, coping strategies for the difficult situation of breastfeeding, rooming system after delivery, ways to assess mother's milk quantity, introducing successful cases of breastfeeding in rank order. To promote the effectiveness of breastfeeding education, standardized breastfeeding educational programs, diverse teaching materials, space and tools, and human resources are needed.

• Journal of the Korean Geotechnical Society
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• v.33 no.10
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• pp.25-31
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• 2017

The buffer is one of the major components of an engineered barrier system (EBS) for the disposal of high-level radioactive waste (HLW). As the buffer is located between a disposal canister and host rock, it is indispensable to assure the disposal safety of high-level radioactive waste. It can restrain the release of radionuclide and protect the canister from the inflow of groundwater. Since high quantity of heat from a disposal canister is released to the surrounding buffer, thermal properties of the buffer are very important parameters for the analysis of the entire disposal safety. Especially, temperature criteria of the compacted bentonite buffer can affect the design of HLW repository facility. Therefore, this paper investigated thermal properties for the Kyungju compacted bentonite buffer which is the only bentonite produced in South Korea. Hot wire method and dual probe method were used to measure thermal conductivity and specific heat capacity of the compacted bentonite buffer according to the temperature variation. Thermal conductivity and specific heat capacity were decreased dramatically when temperature variation was between $22^{\circ}C{\sim}110^{\circ}C$ as degree of saturation decreased according to the temperature variation. However, there was little variation under the high temperature condition at $110^{\circ}C{\sim}150^{\circ}C$.

• Journal of Korean Society of Forest Science
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• v.102 no.1
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• pp.122-128
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• 2013

Genetic diversity and population genetic structure were estimated in nine natural populations of Exochorda serratifolia in South Korea using ISSR marker system. Average of polymorphic loci per primer was 5.8 (S.D.=2.32) and percentage of polymorphic loci per population was 78.7% with total 35 loci from 6 ISSR primers. In AMOVA, 27.8% of total genetic variation came from genetic difference among populations and 72.2% was resulted from difference among individual trees within populations. Genetic differentiations by Bayesian inference were 0.249 of ${\theta}^{11}$ and 0.227 of $G_{ST}$. Inbreeding coefficient for total populations was 0.412. There was significant correlation between genetic distance and geographic distance among populations. On the results of Bayesian cluster analysis, nine populations were assigned into three groups. The first group included 5 populations, and the second and the third had two populations per group, respectively. These three regions could explain 10.0% of total genetic variation from hierarchical AMOVA, and the levels of among-population and among-individual were explained 19.7% and 70.3%, respectively. The geographic distribution of populations following the three Bayesian clusters could be explained with mountain range as Baekdudaegan which is the main chain of mountains in Korea. The mountains as the physical barrier might hamper gene flow in the pearlbush. So when protected areas are designated for conservation of this species, we should consider those three regions into considerations and would better to choose at least one population per region.