• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.18 no.5
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• pp.572-581
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• 2008

The performance of a barrel stave flextensional transducer is determined by the properties of its constituent materials and the effects of many structural parameters. In this study, with the finite element method, the structure of a barrel stave flextensional transducer was optimized to achieve the widest bandwidth while satisfying the requirements on pressure and center frequency. The optimization was carried out with the SQP-PD method for multi-variable minimization. The optimized barrel stave flextensional transducer satisfied all the required specifications.

• BMB Reports
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• v.38 no.5
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• pp.507-516
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• 2005

Antimicrobial peptides (AMPs) have been isolated and characterized from tissues and organisms representing virtually every kingdom and phylum. Their amino acid composition, amphipathicity, cationic charge, and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of AMP activity, their relevance to resolving how peptides damage and kill microorganisms still needs to be clarified. Moreover, many AMPs employ sophisticated and dynamic mechanisms of action to carry out their likely roles in antimicrobial host defense. Recently, it has been speculated that transmembrane pore formation is not the only mechanism of microbial killing by AMPs. In fact, several observations suggest that translocated AMPs can alter cytoplasmic membrane septum formation, reduce cell-wall, nucleic acid, and protein synthesis, and inhibit enzymatic activity. In this review, we present the structures of several AMPs as well as models of how AMPs induce pore formation. AMPs have received special attention as a possible alternative way to combat antibiotic-resistant bacterial strains. It may be possible to design synthetic AMPs with enhanced activity for microbial cells, especially those with antibiotic resistance, as well as synergistic effects with conventional antibiotic agents that lack cytotoxic or hemolytic activity.

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.173-173
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• 2006

We have explored a strategy to control the supramolecular nano-structures self-assembled from rigid segments through attachment of flexible chains through microphase separation and anisotropic arrangement. Supramolecular structures formed by self-assembly of rigid building blocks can be precisely controlled from 1-D layered, 3-D bicontinuous cubic to 2-D cylindrical structures by systematic variation of the type and relative length of the respective blocks. Furthermore, depending on the individual molecular architectures, rigid building blocks self-assemble into a wide range of supramolecular structures such as honeycomb, disk, cylinder, helix, tube, barrel stave, and nano-cage.

• Journal of Microbiology and Biotechnology
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• v.25 no.6
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• pp.759-764
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• 2015

Antimicrobial peptides (AMPs) are one of the critical components in host innate immune responses to imbalanced and invading microbial pathogens. Although the antimicrobial activity and mechanism of action have been thoroughly investigated for decades, the exact biological properties of AMPs are still elusive. Most AMPs generally exert the antimicrobial effect by targeting the microbial membrane, such as barrel stave, toroidal, and carpet mechanisms. Thus, the mode of action in model membranes and the discrimination of AMPs to discrepant lipid compositions between mammalian cells and microbial pathogens (cell selectivity) have been studied intensively. However, the latest reports suggest that not only AMPs recently isolated but also well-known membrane-disruptive AMPs play a role in intracellular killing, such as apoptosis induction. In this mini-review, we will review some representative AMPs and their antimicrobial mechanisms and provide new insights into the dual mechanism of AMPs.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 1999.05a
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• pp.307-312
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• 1999

A piezoelectric flextentional sonar transducer has been simulated using a coupled FE-BEM. The dynamics of the sonar transducer is modelled in three dimensions and is analyzed with external electrical excitation conditions. Different results are available such as steady-state displacement modes, underwater directivity patterns. It is shown that the present barrel-stave sonar transducer of the piezoelectric material produces flextentional displacements which could be related with higher output power, lower quality factor and more omnidirectional beam pattern than other types of sonar transducers.

• Journal of Yeungnam Medical Science
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• v.10 no.2
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• pp.493-505
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• 1993

The congenital cutis aplasia mainly occurs in head, sometimes involving the skull and dura mater. It's cause and the rate of falling ill are not known yet, it is the disease that rate of death is high by the infection, such as, the injured vascular hemorrhange of meningitis. Craniosynostosis is the disease the appears the skull as well as the facial deformity with growing, has from the developmental difficiency, visual distibance, motor disturbance, convulsion to the neurologic impairment of mental retardation, and accompanies the each characteristic deformity following the suture fused. Satisfactory results was achieved by local flap surgery and conservative treatment on the infant, diagnosed as the congenital cutis aplasia, case 1 Also successful treatment experiences of craniosynostosis(oxycephaly, brachycephaly, trigonocephaly, cloverleaf deformity) through the frontal bone advancement and the barrel stave asteotomy, were reviewed & pursues and investigates the intracranial volume of before and after of surgery, and then reports with the literature investigation.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.218-223
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• 1999

A piezoelectric flextentional deep-water sonar transducer has been simulated using a coupled FE-BEM. The dynamics of the sonar transducer is modelled in three dimensions and is analyzed with extern리 electrical excitation conditions as well as external acoustic pressure loading conditions. Different results are available such as steady-state frequency response for RX and TX, displacement modes, directivity patterns, back-scattering patterns, resonant frequencies, bandwidths, quality factors, transmitting voltage (TV) responses, input receiving sensitivity (RS) responses. White the present barrel-stave typed sonar transducer of the piezoelectric material is being simulated, the external surface of the transducer is modified in order to allow the same water pressure to be applied to the inner and the outer surfaces of the transducer. With this modification for deep-water application, the resonance frequency of the modified flextentional sonar transducer becomes much lower than that of the unmodified flextentional sonar transducer. The results of the present sonar transducer modelling are also compared with those of a commercial package such as ATILA.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.3 no.3
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• pp.559-567
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• 1999

A piezoelectric flextentional sonar transducer has been simulated using a coupled FE-BEM. The dynamics of the sonar transducer is modelled in three dimensions and is analyzed with external electrical excitation conditions. Different results are available such as steady-state displacement modes, underwater directivity patterns, resonant frequencies, bandwidths, quality factors, output acoustic powers and transmitting voltage responses. It is shown that the present barrel-stave sonar transducer of the piezoelectric material produces flextentional displacements which could be related with higher output power, lower quality factor and more omnidirectional beam pattern than other types of sonar transducers. The results of the present sonar transducer modelling are also compared with those of a commercial package such as ATILA.

• Journal of Sensor Science and Technology
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• v.8 no.5
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• pp.377-387
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• 1999

A piezoelectric flextentional deep-water sonar transducer has been designed using a coupled FE-HEM. The dynamics of the sonar transducer is modelled in three dimensions and is analyzed with external electrical excitation conditions. Different results are available such as steady-state frequency response for TX displacement modes, directivity patterns, resonance frequencies, TVRs. While the conventional barrel-stave typed sonar transducer of the piezoelectric material is designed, the external surface of the transducer is modified in order to allow the same hydrostatic pressure to be applied onto the inner and the outer surfaces of the transducer. With this modification for deep-water application, a new resonance mode is generated at lower frequency. This lower resonance mode can be adjusted according to the degree of the outer surface modification.

• Archives of Plastic Surgery
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• v.38 no.5
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• pp.683-686
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• 2011

Purpose: Craniosynostosis of three or more cranial sutures was not common. "Mercedes Benz pattern," named by Moore1 was a rare form of craniosynostosis and had an atypical pattern of premature closure of cranial suture. It was not reported in Republic of Korea. We report this case with literature review. Methods: A 13-months-old male patient visited our clinic due to exophthalmos. He showed normal developmental course. Other neurological tests were normal but he was Crouzon syndrome patient. CT scans showed bilateral lambdoid and posterior sagittal sutures were fused and the length of the skull was extended. Cranioplasty with pi craniotomy & Barrel-Stave osteotomy and recombination of the bone flap was performed. Results: The patient was discharged after post operative 10 days without any complications. In follow up visit after 2.7 years, he was in good state without recurrence and functional abnormality of skull. Conclusion: This was the first case of Mercedes Benz pattern craniosynostosis with Crouzon syndrome in Korea. This type of craniosynostosis has to be considered differently from single type of craniosynostosis or typical syndromic craniosynostosis clinically and surgically.