• 제어로봇시스템학회논문지
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• 제17권10호
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• pp.989-994
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• 2011

This study aims to demonstrate the feasibility of a visual servoing-based paired structured light (SL) robot for estimating structural displacement under various external loads. The former paired SL robot, which was proposed in the previous study, was composed of two screens facing with each other, each with one or two lasers and a camera. It was found that the paired SL robot could estimate the translational and rotational displacement each in 3-DOF with high accuracy and low cost. However, the measurable range is fairly limited due to the limited screen size. In this paper, therefore, a visual servoing-based 2-DOF manipulator which controls the pose of lasers is introduced. By controlling the positions of the projected laser points to be on the screen, the proposed robot can estimate the displacement regardless of the screen size. We performed various simulations and experimental tests to verify the performance of the newly proposed robot. The results show that the proposed system overcomes the range limitation of the former system and it can be utilized to accurately estimate the structural displacement.

• 대한안전경영과학회지
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• 제14권1호
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• pp.101-108
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• 2012

In this study was conducted numerical analysis to evaluate the stability of BTR(Built-in Timber Roof Tunneling Method), which is one of construction methods of underground structures in the non-opening state. The discretion method was applied to individually model reinforcing members of BTR, and the homogeneity analysis technic by area ratio was used to verify the feasibility comparing this result with that from conventional analysis method. The parameter study was performed to evaluate the effect varying ground depth, distance length of reinforcing supports and to verify the field applicability of new analysis method. The results showed the very precise value with allowable error, so this method can be applied in the field, The more length of supporting members caused the more vertical displacement and the top displacement increment of support members is larger than that of ground surace. The effect of ground depth was more impressive than that of distance length of reinforcing supports.

• 한국임상약학회지
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• 제23권1호
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• pp.77-80
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• 2013

메치실린 저항성 황색 포도상구균(MRSA)에 감염된 환자에게 단기간 연속적으로 반코마이신을 투여했을 때 비정상적으로 호중구의 수치가 감소한 약인성 부작용 사례를 보고하고자 한다. 해당 여성 환자는 61세로서 MRSA 감염증을 판정받고 반코마이신 투여와 더불어 점차 백혈구(WBC)와 절대호중구수치(ANC)가 감소하였고, 제10일째에 이르러 호중구 감소증이 발생하여 ANC가 최저 430 $cells/mm^3$까지 낮아졌으나, 반코마이신의 투여를 중단하자 곧 정상수준으로 회복되었다. 본 사례는 Naranjo Probability Scale과 Korean Algorithm Score(Ver. 2.0)로 각각 평가하였을 때 반코마이신의 투여와 호중구감소증의 발현 사이에 모두 '가능한(probable)' 정도의 인과관계를 가진 것으로 평가되었다. 이는 통상적으로 20일 이상 연속투여를 할 때 임상적으로 관측되던 반코마이신-유래 호중구감소증이 단지 10일 정도의 단기간 투여만으로도 발생할 수 있다는 임상적 약물부작용의 사례로서, 향후 MRSA환자에게 반코마이신을 선택할 때에는 이와 같은 부작용을 고려하여 환자의 WBC와 ANC를 면밀히 관찰하면서 투여할 필요성이 있음을 시사한다.

• Nuclear Engineering and Technology
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• 제31권5호
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• pp.465-475
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• 1999

The objective of the present work is to assess the analysis capability of two wall film condensation models, the default and the alternative models, of RELAP5/MOD3.2 on condensation experiments in the presence of noncondensable gas in a vertical tube of PCCS of CP-1300. In the calculation of a base case the default model of RELAP5/MOD3.2 under-predicts the heat transfer coefficients, and Its alternative model over-predicts them throughout the condensing tube, Also, both models over-predict the void fractions. The nodalization study shows that the variation of the node number does not change both modeling results of RELAP5/MOD3.2 Sensitivity study for varying input parameters shows that the inlet steam-air mixture flow rate, the inlet air mass fraction, and the inlet saturated steam temperature give significant changes of their heat transfer coefficients Run statistics show that the grind time of the default model is always higher than that of the alternative model by about 23%.

• Biomolecules & Therapeutics
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• 제31권2호
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• pp.193-199
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• 2023

In this investigation, we made a study of the efficacy of luteolin (a flavonoid found in plants such as vegetables, herbs and fruits) on vascular contractibility and to elucidate the mechanism underlying the relaxation. Isometric contractions of denuded muscles were stored and combined with western blot analysis which was conducted to assess the phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) and phosphorylation-dependent inhibitory protein for myosin phosphatase (CPI-17) and to examine the effect of luteolin on the RhoA/ROCK/CPI-17 pathway. Luteolin significantly alleviated phorbol ester-, fluoride- and thromboxane mimetic-elicited contractions regardless of endothelial nitric oxide synthesis, implying its direct effect on smooth muscle. It also significantly alleviated the fluoride-elicited elevation in pCPI-17 and pMYPT1 levels and phorbol 12,13-dibutyrate-elicited increase in pERK1/2 level, suggesting depression of ROCK and PKC/MEK activity and ensuing phosphorylation of MYPT1, CPI-17 and ERK1/2. Taken together, these results suggest that luteolin-elicited relaxation includes myosin phosphatase reactivation and calcium desensitization, which seems to be arbitrated by CPI-17 dephosphorylation via ROCK/PKC inhibition.

• Biomolecules & Therapeutics
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• 제30권2호
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• pp.145-150
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• 2022

In this study, we investigated the influence of galangin on vascular contractibility and to determine the mechanism underlying the relaxation. Isometric contractions of denuded aortic muscles were recorded and combined with western blot analysis which was performed to measure the phosphorylation of phosphorylation-dependent inhibitory protein of myosin phosphatase (CPI-17) and myosin phosphatase targeting subunit 1 (MYPT1) and to evaluate the effect of galangin on the RhoA/ROCK/CPI-17 pathway. Galangin significantly inhibited phorbol ester-, fluoride- and thromboxane mimetic-induced vasoconstrictions regardless of endothelial nitric oxide synthesis, suggesting its direct effect on vascular smooth muscle. Galangin significantly inhibited the fluoride-dependent increase in pMYPT1 and pCPI-17 levels and phorbol 12,13-dibutyrate-dependent increase in pERK1/2 level, suggesting repression of ROCK and MEK activity and subsequent phosphorylation of MYPT1, CPI-17 and ERK1/2. Taken together, these results suggest that galangin-induced relaxation involves myosin phosphatase reactivation and calcium desensitization, which appears to be mediated by CPI-17 dephosphorylation via not PKC but ROCK inactivation.

• Biomolecules & Therapeutics
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• 제32권3호
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• pp.361-367
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• 2024

In this study, we investigated the efficacy of kaempferol (a flavonoid found in plants and plant-derived foods such as kale, beans, tea, spinach and broccoli) on vascular contractibility and aimed to clarify the detailed mechanism underlying the relaxation. Isometric contractions of divested muscles were stored and linked with western blot analysis which was carried out to estimate the phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) and phosphorylation-dependent inhibitory protein for myosin phosphatase (CPI-17) and to estimate the effect of kaempferol on the RhoA/ROCK/CPI-17 pathway. Kaempferol conspicuously impeded phorbol ester-, fluoride- and a thromboxane mimetic-derived contractions regardless of endothelial nitric oxide synthesis, indicating its direct effect on smooth muscles. It also conspicuously impeded the fluoride-derived elevation in phospho-MYPT1 rather than phospho-CPI-17 levels and phorbol 12,13-dibutyrate-derived increase in phospho-CPI-17 and phospho-ERK1/2 levels, suggesting the depression of PKC and MEK activities and subsequent phosphorylation of CPI-17 and ERK1/2. Taken together, these outcomes suggest that kaempferol-derived relaxation incorporates myosin phosphatase retrieval and calcium desensitization, which appear to be modulated by CPI-17 dephosphorylation mainly through PKC inactivation.

• International Journal of Industrial Entomology and Biomaterials
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• 제12권2호
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• pp.57-61
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• 2006

Suppressor of cytokine signaling (SOCS) is known to be as a negative feedback regulator in Janus kinase signal transducer and activator of transcription signaling. Highly conserved SOCS box domain was cloned from a Korean malaria vector, Anopheles sinensis. Sequence analysis indicates that it has identity to Anopheles gambiae (96%), Aedes aegypti (94%), Drosophila melanogaster (78%), Mus musculus (72%) and Homo sapiens (72%), respectively. Tissue specificity RT-PCR demonstrated that the expression level of AsSOCS transcript was high at abdomen, midgut, and ovary, whereas developmental expression patterns showed that the level of AsSOCS was high at egg, early pupae, and adult female. On the other hand, RT-PCR analysis after bacterial challenge showed that SOCS mRNA was strongly induced in larvae. In addition, it was also induced by various immune elicitors such as lipoteicoic acid, CpG-DNA, and laminarin. It seems that AsSOCS, repressor of JAK-STAT pathway, is highly conserved in mosquito, and may play an important role in mosquito innate immune response.

• 마이크로전자및패키징학회지
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• 제11권3호
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• pp.77-82
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• 2004

본 연구에서는 고유전율(K100) 및 저유전율(K7.8) LTCC(Low Temperature Co-fired Ceramics) 그린 시트를 이종 LTCC 기판으로 동시 소성하는 경우, 고유전율 LTCC 내의 유리 분말 함유량에 따라 발생하는 수축 거동 변화가 이종 LTCC기판의 휨 특성에 미치는 영향에 대하여 평가하였다. 유리 분말 함유량의 증가에 따른 고유전율 LTCC 그린시트의 수축률 및 유전 특성을 측정하였으며, 고유전율/저유전율 비대칭형 적층체의 소결 거동을 고온 현미경을 이용하여 실시간으로 측정하였다. $50\%$ 유리가 첨가된 K100 조성의 경우 수축 개시 온도 및 수축 구간의 범위 , 최종 수축률이 K7.8 조성과 유사하였으며, 동시 소성 시 가장 우수한 휨 특성을 나타내었다.

• 반도체디스플레이기술학회지
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• 제9권1호
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• pp.35-40
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• 2010

We have investigated the effects of hydrogen injection via in-situ gas addition ($O_2$, $H_2$, or $O_2$ + $H_2$ gas) and plasma post-treatment (Ar or Ar + H plasma) on material properties of ZnO that is considered to be as a channel layer in transparent thin film transistors. The variations in the electrical resistivity, optical transmittance and bandgap energy, and crystal quality of ZnO thin films were characterized in terms of the methods and conditions used in hydrogen injection. The resistivity was significantly decreased by injection of hydrogen; approximately $10^6\;{\Omega}cm$ for as-grown, $1.2\;{\times}\;10^2\;{\Omega}cm$ for in-situ with $O_2/H_2\;=\;2/3$ addition, and $0.1\;{\Omega}cm$ after Ar + H plasma treatment of 90 min. The average transmittance of ZnO films measured at a wavelength of 400-700 nm was gradually increased by increasing the post-treatment time in Ar + H plasma. The optical bandgap energy of ZnO films was almost monotonically increased by decreasing the $O_2/H_2$ ratio in in-situ gas addition or by increasing the post-treatment time in Ar + H plasma, while the post-treatment using Ar plasma hardly affected the bandgap energy. The role of hydrogen in ZnO was discussed by considering the creation and annihilation of oxygen vacancies as well as the formation of shallow donors by hydrogen.