• Journal of The Korean Dental Society of Anesthesiology
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• v.14 no.1
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• pp.41-47
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• 2014

Background: Autophagy is a self-eating process that is important for balancing sources of energy at critical times in development and in response stress. Autophagy also plays a protective role in removing clearing damaged intracellular organelles and aggregated proteins as well as eliminating intracellular pathogens. The purpose of the present study was to examine the protective effect of propofol against hypoxic damage using keratinocytes. Methods: Human keratinocytes (HaCaT cells) were obtained from the American Type Culture Collection. Propofol which were made by dissolving them in DMSO were kept frozen at $-4^{\circ}C$ until use. The stock was diluted to their concentration with DMEM when needed. Prior to propofol treatment cells were grown to about 80% confluence and then exposed to propofol at different concentrations (0, 25, 50, 75, $100{\mu}M$) for 2 h pretreatment. Cell viability was measured using a quantitative colorimetric assay with thiazolyl blue tetrazolium bromide (MTT assay), and fluorescence microscopy and western blot analysis were used for evaluation of autophagy processes. Results: The viability of propofol-treated HaCaT cells was increased in a dose-dependent manner. Propofol did not show any significant toxic effect on the HaCaT cells. The autophagy inhibitor, 3-methyladenine, reduced cell viability of hypoxia-injured HaCat cells. Fluorescence microscopy and western blot analysis showed propofol induce autophagy pathway signals. Conclusions: Propofol enhanced viability of hypoxia-injured HaCaT cells and we suggest propofol has cellular protective effects by autophagy signal pathway activation.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.1
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• pp.107-116
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• 2009

Quantum-dot Cellular Automata (QCA) is one of the most promising next generation nanoelectronic devices which will inherit the throne of CMOS which is the domineering implementation technology for large scale low power digital systems. In late 1990s, the basic operations of the QCA cell were already demonstrated on a hardware implementation. Also, design tools and simulators were developed. Nevertheless, its design technology is not quite ready for ultra large scale designs. This paper proposes a new approach which enables the QCA designs to inherit the verification methodologies and tools of CMOS designs, as well. First, a set of disciplinary rules strictly restrict the cell arrangement not to deviate from the predefined structures but to guarantee the deterministic digital behaviors is proposed. After the gate and interconnect structures of. the QCA design are identified, the signal integrity requirements including the input path balancing of majority gates, and the prevention of the noise amplification are checked. And then the digital logic is extracted and stored in the OpenAccess common engineering database which provides a connection to a large pool of CMOS design verification tools. Towards validating the proposed approach, we designed a 2-bit adder, a bit-serial adder, and an ALU bit-slice. For each design, the digital logic is extracted, translated into the Verilog net list, and then simulated using a commercial software.

• International Journal of Highway Engineering
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• v.11 no.2
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• pp.55-66
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• 2009

This study examines the consequent impact which Cheonggyechoen restoration project of Seoul makes on pedestrian network structure around the inner city, especially in terms of sustainable developments and the city's balanced development. It identifies variation of Global Integration and Local Integration of the pedestrian networks which is compared by before and after conditions with east-west and south-north walking axis by using Space Syntax. The results show respectively different set of Global and Local Integration. First, Global Integration shows high performance along the east-west axis, while pedestrian spatial networking is balancing through Donhwamunno and Samillo. Second, Local Integration illustrates both performance along both the east-west axis and the south-north axis after restoration of network. It is primarily concentrated in Taepyeongno$\sim$Samillo section(business and commercial-centered) before the restoration. In addition, total integration is holistically improved while the networking in Samillo$\sim$Baeogaegil section(the instrument shopping streets) if almost same as one another Moreover, in Baeogaegil$\sim$Dongdaemun Stadium section(market-centered), the connectivity of Cheonggyechoenro is improved after the restoration. All in all, Cheonggyechoen restoration project of Seoul allows traffics to be equally accessible from the east-west axis and the south-north axis and contributes to the connectivity improvement of the east-west axis as well as the south-north axis.

• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.1
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• pp.108-113
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• 2009

The functional regulator(FR) appliances act to remove the restrictive forces that prevent the normal maturation of the maxilla and mandible. FR appliances are different from other functional jaw orthopedic appliances(e.g., the twin block, bionator, and activator). $Fr{\ddot{a}}nkel$ has based his treatment philosophy on the concept that the capacity to regulate growth residues in the soft tissue environment, and that adequate space must be available for the proper development of the hard tissue. In class II malocclusion with mandibular retrusion, FR-II treatment is not only the change in the postural position of mandible, but also expansion of the dental arches. By balancing the neuromuscular environment, not only can severe malocclusions be treated successfully, but also the tendency toward relapse is minimized because the neural and soft tissue factors associated with the skeletal malocclusion have been addressed as well. We report cases using by FR-II that is applicated in cases of Class II malocclusion without fixed appliance, only FR-II and space supervision.

• Geophysics and Geophysical Exploration
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• v.14 no.1
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• pp.7-17
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• 2011

We have developed an inversion code for three-dimensional (3D) resistivity tomography including the anisotropy effect. The algorithm is based on the finite element approximations for the forward modelling and Active Constraint Balancing method is adopted to enhance the resolving power of the smoothness constraint least-squares inversion. Using numerical experiments, we have shown that anisotropic inversion is viable to get an accurate image of the subsurface when the subsurface shows strong electrical anisotropy. Moreover, anisotropy can be used as additional information in the interpretation of subsurface. This algorithm was also applied to the field dataset acquired in the abandoned old mine area, where a high-rise apartment block has been built up over a mining tunnel. The main purpose of the investigation was to evaluate the safety analysis of the building due to old mining activities. Strong electrical anisotropy has been observed and it was proven to be caused by geological setting of the site. To handle the anisotropy problem, field data were inverted by a 3D anisotropic tomography algorithm and we could obtain 3D subsurface images, which matches well with geology mapping observations. The inversion results have been used to provide the subsurface model for the safety analysis in rock engineering and we could assure the residents that the apartment has no problem in its safety after the completion of investigation works.

• Journal of KIISE:Software and Applications
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• v.30 no.7_8
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• pp.672-680
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• 2003

A shopbot is a software agent whose goal is to maximize buyer´s satisfaction through automatically gathering the price and quality information of goods as well as the services from on-line sellers. In the response to shopbots´ activities, sellers on the Internet need the agents called pricebots that can help them maximize their own profits. In this paper we adopts Q-learning, one of the model-free reinforcement learning methods as a price-setting algorithm of pricebots. A Q-learned agent increases profitability and eliminates the cyclic price wars when compared with the agents using the myoptimal (myopically optimal) pricing strategy Q-teaming needs to select a sequence of state-action fairs for the convergence of Q-teaming. When the uniform random method in selecting state-action pairs is used, the number of accesses to the Q-tables to obtain the optimal Q-values is quite large. Therefore, it is not appropriate for universal on-line learning in a real world environment. This phenomenon occurs because the uniform random selection reflects the uncertainty of exploitation for the optimal policy. In this paper, we propose a Mixed Nonstationary Policy (MNP), which consists of both the auxiliary Markov process and the original Markov process. MNP tries to keep balance of exploration and exploitation in reinforcement learning. Our experiment results show that the Q-learning agent using MNP converges to the optimal Q-values about 2.6 time faster than the uniform random selection on the average.

• Journal of Distribution Science
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• v.16 no.1
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• pp.87-99
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• 2018

Purpose - The Export Infrastructure Strengthening Program(EISP) is a project to expand exports of agri-food products through providing customized export information to food distribution companies and supporting overseas information activities. A total of 39.6 billion won was provided by 2016. So, the purpose of this study is to analyze whether EISP is effective for expanding exports of agri-food products. Research design, data, and methodology - A simple average difference between the export performance of the policy beneficiaries and the non-policy beneficiaries can be biased if the export capacity or inherent characteristics of the enterprise are not taken into consideration. In order to solve the problem of such a bias, the propensity score matching(PSM) method has been employed in this study. PSM is a method of converting the characteristics of an export company into an index through logit analysis and then reducing the matching to one dimension to improve the accuracy of the performance measurement. Results - The balancing test was conducted to determine how the characteristics of the policy beneficiary group and the matched policy non-beneficiary group corresponded to each other. As a result of the test, we could not reject the null hypothesis that there was no difference between the two groups, so that after the matching, the two groups were similar and the explanatory variables were well controlled. Using the nearest neighbor matching with propensity score estimating through logit analysis, we estimated average treatment effect on the treated(ATT). The food companies participating the EISP had the effect of increasing the exports of $ 5.88 million. As a result, the number of export contracts increased by 11.77, the number of exporting countries by 7.52, the number of export items by 47.51, and the number of buyers' consultation by 3.50. And overseas marketing expenses increased by 35.92 million won. Except for the number of export contracts, other export performance results showed statistically significant results. Conclusions - As the EISP has a positive effect on the expansion of agro-food exports, efforts should be made to find out the limitations or problems of the policy in the future and to make a greater contribution to the increase of exports.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.1
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• pp.44-52
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• 2020

Objective: Minerals are one of the important nutrients for supporting the growth of sheep grazing in the highland, northwest of China. The experiment was conducted to investigate the relationship of both macro and micro minerals in sheep grazing in the highlands of six districts located in the Qilian Mountain of China. Methods: Samples of herbage (n = 240) and soil (n = 240) were collected at random in a "W" shape across the area designated for harvesting from 24 farms, where the sheep commonly graze in October (winter) for mineral analyses. In addition, serum samples were taken via jugular vein from 20 sheep per farm from 24 farms (n = 480 samples in total) for serum minerals analyses. Mean values of macro and micro minerals were statistically compared among districts and the correlations among soil-plant-animal were statistically analyzed and correlations were regressed, as well. Results: The results revealed that there were variations for both macro and micro minerals among districts. Statistical analysis of the correlation coefficients between herbage and sheep were significantly different for most of the minerals but not for P, Cu, and Se. Many correlation regression coefficients were found significantly different among minerals of herbage, soil, and sheep serum especially those of K, Na, Fe, Mn, and Zn (between herbage and sheep serum), and Fe and Mn (between herbage and soil), Na, Fe, Mn, and Zn (between soil and sheep serum), respectively. The regression coefficient equations derived under this experiment for prediction of Ca (R² = 0.618), K (R² = 0.803), Mg (R² = 0.767), Na (R² = 0.670), Fe (R² = 0.865),Zn (R² = 0.950), Mn (R² = 0.936), and Se (R² = 0.630), resulted in significant R² values. Conclusion: It is inferred that the winter herbage minerals in all the districts were below the recommended levels for macro minerals which indicated there would be some mineral deficiencies in sheep grazing the herbage in these regions. Supplemental minerals may therefore play an important role in balancing the minerals available from the herbage in winter and would lead to increased productivity in sheep on the highland areas of China. These findings could be potentially applied to the other regions for improving the livestock productivity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.1B
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• pp.15-30
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• 2000

The important considerations in the design of fiber-optic networks are reliability and survivability preparing against a failure. The SDH(Synchronous Digital Hierarchy), the international standard of optical transmission, offers several network reconfiguration methods that enable network to be automatically restored from failure. One of the methods is the SHR(Self Healing Ring), which is a ring topology system. Most network providers have constructed their backbone networks with SHR architecture since it can provide survivability economically. The network architecture has eventually evolved into a multi-ring network comprised of interconnected rings. This paper addresses multi-ring network design problems is to minimize ring-construction cost. This problem can be formulated with MIP(mixed integer programming) model. However, it is difficult to solve the model within reasonable computing time on a large scale network because the model is NP-complete. Furthermore, in practice we should consider the problem of routing demands on rings to minimize total cost. This routing problem involves multiplex bundling at the intermediate nodes. A family of heuristic algorithms is presented for this problem. These algorithms include gateway selection and routing of inter-ring demands as well as load balancing on single rings. The developed heuristic algorithms are applied to some network provider's regional and long-distance transmission networks. We show an example of ring design and compare it with another ring topology design. Finally, we analysis the effect bundling.

• Journal of Digital Convergence
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• v.9 no.6
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• pp.81-90
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• 2011

Companies using internet as a kind of marketing means are increasing rapidly according to the expansion trend of e-commerce through internet and consumers also use internet as the common means of purchasing necessary articles. E-commerce using internet has advantages without limitation to temporal and spatial accessibility and general consumers and unspecified individuals also use internet to purchase their goods as well as general transactions such as advertisement, contract, payment and claim settlement. 'In the age of information, invasion of personal information resulted from the development of information and communication technology is one of the greatest problems all the countries in the world face. Therefore, Personal information protection Act is one of basic laws to protect personal information and rights and it is also an essential law in the age of information. In that sense, new Personal information protection Act is the advanced act containing various items to minimize the national damages from the leaking of private information and protect right to informational self-determination in the information society. It is expected that this legislation contributes to reduce the leaking of private information, enhance the level of privacy protection and develop privacy related industries. However, active participation of all members of our society and improvement of their recognition should be preceded for the rational and legal use of private information and the settlement of its protection culture. While the purpose of Personal information protection Act can protect privacy from collection, leaking, misuse and abuse of private information and enhance national interests and protect personal dignity and value, it also must perform the roles of balancing privacy protection with liberal information flow.