• 제목/요약/키워드: Baek seok

검색결과 2,038건 처리시간 0.031초

Antispasmodic Effects of Junsibaekchul-San In Vivo and In vitro

  • Hur, Jin-Il;Byun, Joon-Seok;Kim, Dae-Jun
    • 동의생리병리학회지
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    • 제24권1호
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    • pp.143-151
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    • 2010
  • In Vivo and In vitro antispasmodic effects of Jun-Si-Baek-Chul-San, a Traditional Korean Polyherbal Medicineconsisted of 7 types of herbs were observed in the present study. To clarify the effects of Jun-Si-Baek-Chul-San, on accelerating small intestinal movement induced by the stimulation of cholinergic neurotransmission, we evaluated the effects of Jun-Si-Baek-Chul-San on In vivo carbachol (an acetylcholinergic agent)-accelerated mice small intestinal transit and on In vitro contractions induced by low-frequency electrostimulation, KCl, histamine or acetylcholine using isolated guinea pig ileum. To induce the acceleration of mice small intestinal transit, Carbachol 1 mg/kg was once subcutaneously dosed 15min before last administration of the test drugs. In the present study, Jun-Si-Baek-Chul-San 500, 250 and 125 mg/kg or domperidone 20 mg/kg were orally pretreated on the carbachol-accelerated mice small intestinal transit once a day for 7 days and the small intestinal transit rateof activated charcoal powder were monitored. In vitro assays, Jun-Si-Baek-Chul-San1, 0.1, 0.01 and 0.001 mg/ml or domperidone $2{\times}10^{-5}M$ were treated 10min before ileal contraction was induced by filed stimulation, acetylcholine, KCl and histamine, and the % changes of contractions were observed compared to the treatment of inducer alone. In spontaneous contraction, the % changes of contractions were observed compared to treatment of vehicle alone at 10min after Jun-Si-Baek-Chul-San or domperidone treatment. The efficacy of Jun-Si-Baek-Chul-San was compared to those of domperidone. High concentration, 1 mg/ml of Jun-Si-Baek-Chul-San was found to decrease the spontaneous contraction of the isolated guinea-pig ileum. In addition, Jun-Si-Baek-Chul-San decrease contractions induced by electrostimulation, acetylcholine, histamine and KCl in the isolated guinea-pig ileum. In addition, Jun-Si-Baek-Chul-San effectively inhibited the accelerated small intestinal movement induced by carbachol stimulation of cholinergic neurotransmission in In vivo. Based on the results, although the exact molecular or action mechanism and which herbs or compound in Jun-Si-Baek-Chul-San are responsible for actions, it was concluded that Jun-Si-Baek-Chul-San normalization in the accelerated intestinal motility might be interfere with a variety of muscarinic, adrenergic and histaminic receptor activities or with the mobilization of calcium ions required for smooth muscle contraction non-specificly. Therefore, it is expected that Jun-Si-Baek-Chul-San will be promising as a prescription of clinical treatment of digestive tract disorders such as accelerated the motility of intestine, diarrhea or intestinal painful contractions.

의인(醫人) 백광현(白光玹)의 행적 연구 (A Study on the achievements of Baek Kwang-hyeon, a Doctor in Chosun Dynasty)

  • 방성혜;김남일;김도훈;차웅석
    • 한국의사학회지
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    • 제26권2호
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    • pp.99-110
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    • 2013
  • The purpose of this study is to investigate the life and achievements of a doctor whose name is Baek Kwang-hyeon. He was at first a soldier and later became a doctor. After years of practicing, he was chosen as a acupuncture specialist doctor of Royal Office of Medicine. He was also chosen as a Royal doctor. The method to do this study was to read the book "Jisagongyousa Bukyunghumbang(知事公遺事 附經驗方)", which is writing about his life and medical achievements. Also "Seongjeongwon Ilgi(承政院日記)" was searched to find more about Dr. Baek's life. The results were as follows. More unknown records about his life and works could be found. His medical achievements and originality could also be clarified. Through above books and other records, the annual report of his life could be presented at the end of this stuy.