• Journal of Pharmacopuncture
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• v.19 no.2
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• pp.155-162
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• 2016

Objectives: Bufonis venonum (BV) is toad venom and is the dried, white secretions of the auricular and the skin glands of toads. This study was performed to evaluate the toxicity of intravenous injection of Bufonis venonum pharmacopuncture (BVP) through a single-dose test with sprague-dawley (SD) rats. Methods: Twenty male and 20 female 6-week-old SD rats were injected intravenously in the caudal vein with BVP or normal saline. The animals were divided into four groups with five female and five male rats per group: the control group injected with normal saline, the low-dosage group injected with 0.1 mL/animal of BVP, the medium-dosage group injected with 0.5 mL/animal of BVP and the high-dosage group injected with 1.0 mL/animal of BVP. We performed clinical observations every day and body weight measurements on days 3, 7 and 14 after the injection. We also conducted hematology, serum biochemistry, and histological observations immediately after the observation period. Results: No mortalities were observed in any experimental group. Paleness occurred in the medium- and the high-dosage groups, and congestion on tails was observed in females in the medium- and the high-dosage groups. No significant changes in weight, hematology, serum biochemistry, and histological observations that could be attributed to the intravenous injection of BVP were observed in any experimental group. Conclusion: The lethal dose of intravenously-administered BVP in SD rats is over 1.0 mL/animal.

• Journal of Pharmacopuncture
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• v.18 no.4
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• pp.51-58
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• 2015

Objectives: Bufonis venonum (BV) is the dried white secretions of the auricular and skin glands of the toads Bufo bufo gargarizans or Bufo melanosticus Schneider. This study was performed to evaluate the toxicity of intramuscularly-administered Bufonis venonum pharmacopuncture (BVP) and to calculate its approximate lethality through a single-dose test with Sprague-Dawley (SD) rats. Methods: Twenty male and 20 female 6-week-old SD rats were injected intramuscularly with BVP or normal saline. The animals were divided into four groups with five female and five male rats per group: the control group injected with normal saline at 0.5 mL/animal, the low-dosage group injected with 0.125 mL/animal of BVP, the medium-dosage group injected with 0.25 mL/animal of BVP and the high-dosage group injected with 0.5 mL/animal of BVP. All injections were in the left thighs of the rats. After administration, we conducted clinical observations everyday and body weight measurements on days 3, 7 and 14 after the injection. We also carried out hematology, serum biochemistry, and histological observations on day 15 after treatment. Results: No mortalities were observed in any experimental group. No significant changes in weight, hematology, serum biochemistry, and histological observations that could be attributed to the intramuscular injection of BVP were observed in any experimental group. Conclusion: Lethal dose of BVP administered via intramuscular injection in SD rats is over 0.5 mL/animal.

• International Journal of Computer Science & Network Security
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• v.21 no.12
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• pp.223-227
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• 2021

A treatment based on the algebraic operations on fuzzy numbers is used to replace the fuzzy problem into an equivalent crisp one. The finite difference technique is used to replace the continuous boundary value problem (BVP) of arbitrary order 1<α≤2, with fuzzy boundary parameters into an equivalent crisp (algebraic or differential) system. Three numerical examples with different behaviors are considered to illustrate the treatment of the singular perturbed case with different fractional orders of the BVP (α=1.8, α=1.9) as well as the classical second order (α=2). The calculated fuzzy solutions are compared with the crisp solutions of the singular perturbed BVP using triangular membership function (r-cut representation in parametric form) for different values of the singular perturbed parameter (ε=0.8, ε=0.9, ε=1.0). Results are illustrated graphically for the different values of the included parameters.

• Journal of Acupuncture Research
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• v.23 no.5
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• pp.39-54
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• 2006

Objectives : Herniation of Nucleus Pulpous (HNP) of Lumbar is one of the most common causes of low back pain. The aim of this study is to investigate the effectiveness of acupuncture, bee venom acupuncture (BVA), and bee venom Pharmacopuncture (BVP) therapy for HNP. Methods : We separated 35 patients with HNP of L-spine into three groups; Acupuncture treated group, BVA treated group, and BVP treated group, and monitored for 30 days. 4 grades of recovery degree, score of Visual Analog Scale (VAS), and Oswestry Disability Index (ODI) were examined for comparison. Results : 1. Visual Analogue Scale of low back pain and radiating pain showed significant decrease in BVA and BVP groups compared to the Acupuncture group at VAS0_2, VAS0_3 evaluations. 2. ODI of disability of daily activities showed significant decrease in BVA and BVP groups compared to the Acupuncture group at VAS0_1, VAS0_2, and VAS0_3 evaluations. 3. Compared to the Acupuncture group, BVA and BVP groups were improved in S.L.R.T and R.O.M of L-spine as confirmed by the physical examination. 4. Treatment efficacy was more apparent in acute cases as ODI was significantly lower than chronic cases. Conclusion : BVA and BVP therapies can be used in addition to the acupuncture therapy for highly effective treatment of HNP. Further clinical studies are required to verify these findings.

• Journal of Pharmacopuncture
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• v.10 no.2 s.23
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• pp.99-105
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• 2007

Objectives : It is the aim of this study to derive lurker studies evaluating the effectiveness of bee-venom phamacopuncture on malignant melanoma patients. We present a patient of malignant melanoma at right maxilla who survives over one year with stable disease (SD) by the treatment of Bee Venom Phamacopuncture (BVP). Methods : We followed the treatment and examination. We prescribed to the patient what to be taken 1.5cc BVP once a day. Picture series, Head series were followed-up and Neck computed tomography (CT) and positron emission tomography computed tomography (PET CT) were performed to evaluate the therapeutic efficacy. Results : The patient survives over one year and continued stable disease over 6 months. Picture series, Head series X-ray, neck CT and PET CT were shown no interval change. Conclusion : This case may give us the possibility that BVP offers potential benefits for patients with malignant melanoma.

• Journal of Pharmacopuncture
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• v.15 no.4
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• pp.7-14
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• 2012

Objectives: The purpose of this study is to compare the effects of bee venom pharmacopuncture (BVP) therapy according to the methods used to treat knee osteoarthritis (OA): intra-acupoint combined with intra-articular injection, intra-acupoint injection, and intra-articular injection. Methods: A total of 69 patients were recruited by the Department of Acupuncture & Moxibustion at Dong-Eui Oriental University Hospital from February 1 to July 23, 2012. The patients were assigned to 3 groups: the first group with intra-acupoint combined with intra-articular BVP Injection (the experimental group), the 2nd group with intra-acupoint BVP injection (control group II), and the 3rd group with intra-articular BVP injection (control group II). The participants were assigned in the order in which they were recruited. Treatments were done twice a week, for a total of 9 times. The effectiveness was assessed by using the visual analouge scale (VAS) and the Korea Western Ontario and McMaster Universities Osteoarthritis Index (KWOMAC). Results: All three groups exhibited significant VAS and KWOMAC effects. Moreover, the 4 week follow-up after the final treatment showed a persistence of BVP effects. However, when the groups were compared, no statistically significant differences in VAS and KWOMAC were noted, but when improvement was considered, the results showed that intra-articular injection was more effective than intra-acupoint injection. Especially, intra-acupoint combined with intra-articular injection was the most effective among the three treatments. Conclusions: Combining intra-acupoint with intra-articular injection, depending on the patient's symptoms, may produce better results when conservatively treating knee OA.

• Interaction and multiscale mechanics
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• v.6 no.4
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• pp.357-375
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• 2013

In this paper, the forced vibration problem of an Euler-Bernoulli beam that is joined with a semi-infinite field of a compressible fluid is considered as a boundary value problem (BVP). This BVP includes two partial differential equations (PDE) and some boundary conditions (BC), which are introduced comprehensively. After that, the closed-form solution of this fluid-structure interaction problem is obtained in the frequency domain. Some mathematical techniques are utilized, and two unknown functions of the BVP, including the beam displacement at each section and the fluid dynamic pressure at all points, are attained. These functions are expressed as an infinite series and evaluated quantitatively for a real example in the results section. In addition, finite element analysis is carried out for comparison.

• Proceedings of the KIEE Conference
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• 1995.11a
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• pp.154-156
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• 1995

The effect of a periodic and a chaotic' behaviour in the Bonhoeffer-Van der Pol(BVP) oscillation of the nerve membrane driven by a periodic stimulating current $A_1=cos\;{\omega}\;t$ are investigated by numeric analysis and hardware Implementation. To control the chaotic motion, we are suggested by temperature parameter c, $c=c(1+\eta\;cos\;{\Omega}\;t)$ which the values of $\eta,\;Omega$ varied respectively. The feasibilities of chaotic and periodic phenomena were analysed by phase plane and time series.

• Journal of applied mathematics & informatics
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• v.9 no.1
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• pp.101-124
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• 2002

The convergence rate of a numerical procedure barred on Schwarz Alternating Method (SAM) for solving elliptic boundary value problems (BVP's) depends on the selection of the interface conditions applied on the interior boundaries of the overlapping subdomains. It hee been observed that the Robin condition(mixed interface condition), controlled by a parameter, can optimize SAM's convergence rate. Since the convergence rate is very sensitive to the parameter, Tang[17] suggested another interface condition called over-determined interface condition. Based on the over-determined interface condition, we formulate the two-layer multi-parameterized SAM. For the SAM and the one-dimensional elliptic model BVP's, we determine analytically the optimal values of the parameters. For the two-dimensional elliptic BVP's , we also formulate the two-layer multi-parameterized SAM and suggest a choice of multi-parameter to produce good convergence rate .

• Journal of Acupuncture Research
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• v.25 no.5
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• pp.197-204
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• 2008

Objectives : This is a clinical report about the 47-year-old female patient with Trigeminal Neuralgia(TN) treated by oriental medicine treatment including Bee Venom Pharmacopuncture therapy(BVP), without any western medical treatment. Methods : The patient was treated by acupuncture, herb medication, and BVP. The improvement of the patient was judged by Visual Analog Scale(VAS). Results : The pain was gradually reduced and VAS became 0 after 8 days of treatment. Since then the pain didn't reappeared for 6 months. Conclusions : Oriental medicine treatment including BVP was very effective to improve the TN patient's symptoms. It is necessary to have more observation and many cases of patients with TN.