• 척추신경추나의학회지
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• 제7권2호
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• pp.139-149
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• 2012

Objectives : The aim of this study was to report Bell's palsy patients with postauricular pain treated by Calculus Bovis Fel Ursi Moschus(BUM) Pharmacopuncture. Methods : The 6 patients were treated by the Korean medica treatment including herbal medication, dry needle acupuncture and physical therapy. We performed BUM Pharmacopuncture in Yepung for the treatment of postauricular pain once or twice. We have evaluated the effect of BUM Pharmacopuncture by Visual Analog Scale(VAS). Results : After BUM Pharmacopuncture for the treatment of postauricular pain, VAS were decreased in all cases. Conclusions : It was suggested that BUM Pharmacopuncture might have effect on control of auricular pain in Bell's palsy. Further, systemic studies will be needed to evaluate obvious effect of BUM pharmacopuncture on postauricular pain of Bell's palsy.

• Journal of Acupuncture Research
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• 제29권5호
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• pp.31-37
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• 2012

Objectives : The purpose of this study is to evaluate the effect of BUM pharmacopuncture and Soyeom pharmacopuncture on postauricular pain accompanied peripheral facial paralysis. Methods : We observed 31 peripheral facial paralysis patients with postauricular pain at Oriental Hospital of Semyung University from Jan. 1st, 2010 to Feb. 29th, 2012. One group(group A) was treated BUM Pharmacopuncture in the posterior ear with general oriental medical treatment and the other(group B) was treated Soyeom pharmacopuncture in the posterior ear with general oriental medical treatment. Results : 1. Postauricular pain was significantly decreased in each group but no significant difference between two groups. 2. Facial paralysis was significantly improved in each group and significant difference in group B. Conclusions : In peripheral facial paralysis patients with postauricular pain, both BUM pharmacopuncture and Soyeom pharmacopuncture were effective on postauricular pain.

• Journal of Acupuncture Research
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• 제30권5호
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• pp.25-39
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• 2013

Objectives : This study was designed to find out the differences of the acupuncture sensation by type of pharmacopuncture. And furthermore we try to find out whether normal saline(NS) is able to be constituted as an appropriate control group for the Calculus Bovis Fel Ursi Moschus(BUM) pharmacopuncture, mountain ginseng pharmacopuncture and sciatica no. 5 pharmacopuncture. Methods : NS and three type of pharmacopunctures were inserted into $ST_{36}$, and $ST_{37}$ of the subjects. Before and after the treatment, subjects completed a questionnaire rating the intensity of 13 kinds of acupuncture sensation(acupuncture sensation scale, ASS). We compared the subjective acupuncture sensation between the NS and three type of pharmacopunctures. Results : BUM pharmacopuncture showed significantly intense acupuncture sensation comparing other two pharmacopunctures and NS. There was no statistically significant difference among mountain ginseng pharmacopuncture, sciatica no. 5 pharmacopuncture and NS. Conclusions : We found that NS may be able to be an placebo pharmacopuncture for mountain ginseng pharmacopuncture and sciatica no. 5 pharmacopuncture. Additional study is needed for placebo pharmacopuncture of BUM pharmacopuncture.

• 대한약침학회지
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• 제16권4호
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• pp.30-35
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• 2013

Objectives: This study was designed to investigate the effects of Calculus Bovis-Fel Uris-Moschus pharmacopuncture (BUM) on the regional cerebral blood flow (rCBF) and the mean arterial blood pressure (MABP) in normal and cerebral ischemic rats and to investigate a possible pathway involved in the effects of BUM. Methods: The changes in the rCBF and the MABP following BUM into Fengfu (GV16) were determined by using a laser-Doppler flow meter and a pressure transducer, respectively. Results: BUM significantly increased the rCBF and decreased the MABP in normal rats in a dose-dependent manner. The effect on the rCBF was significantly inhibited by pretreatment with methylene blue (0.01 mg/kg, intraperitoneal), an inhibitor of guanylate cyclase, but was not affected by pretreatment with indomethacin (1 mg/kg, intraperitoneal), an inhibitor of cyclooxygenase. The BUM-induced decrease of the MABP was changed neither by methylene blue nor by indomethacin pretreatment. In the cerebral ischemic rats, the rCBF was stably increased upon cerebral reperfusion in the BUM group in contrast to the rapid and marked increase in the control group. Conclusion: This study demonstrated that BUM into Fengbu (GV16) increased the rCBF in a dose-dependent manner in the normal state; furthermore, it improved the stability of the rCBF in the ischemic state upon reperfusion. Also, the effects of BUM on the rCBF were attenuated by inhibition of guanylate cyclase, suggesting that the effects involved the guanylate cyclase pathway.

• Journal of Acupuncture Research
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• 제28권4호
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• pp.105-110
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• 2011

Objectives : The purpose of this study was to evaluate the effectiveness of Calculus Bovis Fel Ursi Moschus(BUM) pharmacopuncture on the treatment of acute low back pain patients. Methods : The subjects in this study were 30 patients with acute low back pain who were treated in Dept. of Acupuncture and Moxibustion, Jein Oriental Medicine Hospital from November 1, 2010 to June 30, 2011. These patients were randomly divided into two groups. In one group(control group), patients were treated with acupuncture. And in the other group(experimental group), patients were treated with both acupuncture and BUM pharmacopuncture. For evaluating change of pain, visual analog scale(VAS) and Oswestry disability index(ODI) were checked before and after. Results : Each group had significant decrease in VAS and ODI after each treatment. Experimental group had more significant decrease in VAS after each treatment than control group. Conclusions : We suggest that cotreatment of acupuncture and BUM pharmacopuncture on acute low back pain patients can be recommended as a useful therapy.

• 대한약침학회지
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• 제15권4호
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• pp.25-31
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• 2012

Objectives: This study was designed to investigate the effect of four pharmacopuncture drugs (scolopendrid, Calculus Bovis-Fel Uris-Moschus (BUM), bee venom 25%, and sweet bee venom 10%) on the cerebral hemodynamics, including changes in the regional cerebral blood flow (rCBF) and in the mean arterial blood pressure (MABP). Methods: The changes in the rCBF and the MABP were determined by using a laser-Doppler flowmeter and a pressure transducer, respectively. Results: Scolopendrid (0.3 ml, 1 ml/kg) caused no significant changes in the rCBF and the MABP, whereas BUM (0.3 ml, 1 ml/kg) decreased the rCBF and the MABP, bee venom 25% (0.3 ml, 1 ml/kg) increased the rCBF and lowered the MABP, and sweet bee venom 10% (0.3 ml, 1 ml/kg) increased the rCBF and had no significant effect on the MABP. Conclusions: The rCBF and the MABP were influenced differently by the administration of various pharmacopunctures. Further studies are needed to elucidate the underlying mechanism.

• 대한약침학회지
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• 제5권2호
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• pp.6-24
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• 2002

This experiment was carried out to study on the safety assessment of Bos tures$^{\circ}{\S}Ursus thibetanus^{\circ}{\S}$Moschus extract solution(BUM) for Herbal-acupuncture. SD rats and ICR mice were used for acute toxicity test. the results were summerized as follows; 1. In rats and mice, LD50 value could not be measured. 2. There were no abnormal finding in acute toxicity test treated BUM for Herbal-acupuncture

• 대한한의학회지
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• 제36권2호
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• pp.8-20
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• 2015

Objectives: This study aims to evaluate the efficacy of pharmacopuncture in the treatment of acute peripheral facial paralysis (APFP) through a meta-analysis of randomized controlled trials to assess the clinical evidence for pharmacopuncture as a treatment for PFP. Methods: Literature was searched using databases. The search terms used were "pharmacopuncture," "sweet BV," "apipuncture," "apitoxin," "injection acupuncture," and "herbal acupuncture" in English and "bongchim," "bongyakchim," and "yakchim" in Korean. The RevMan 5.2 program was used for meta-analysis. Results: In all, 1902 studies were screened and the full texts of 219 articles were reviewed. Of these, nine studies were included in the systematic review and nine studies were included in the meta-analysis. Treatments utilizing bee venom, sweet bee venom (SBV), Soyeom, Calculus Bovis Fel Ursi Moschus (BUM), Hominis Placenta, and Suseunghwagang (SSHG) were observed in nine RCTs. In the forest plot, the diamond favors the PA treatment against the control treatment. (95% CI: 0.34 [0.08, 0.60], Z = 2.57, P = 0.01), which Our meta-analysis in RevMan 5.2 confirmed the significant efficacy of PA in treating APFP. Conclusion: Our systematic review and meta-analysis suggest that treatments using Soyeom, bee venom, and BUM are effective in APFP and they reduce the duration of postauricular pain occurring at the acute stage of APFP. However, due to small effect size, further investigation is needed.

• 대한약침학회지
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• 제10권3호
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• pp.149-155
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• 2007

Objectives The purpose of this study is aimed at diagnosing and suggesting treatment plans for commonly seen clinical manifestation of heat symptom in the upper body and coldness in the lower body, also known as hot above, cold below syndrome. Methods Various reasons attribute to the presence of hot above, cold below syndrome, but mainly contributed by blockage of normal Qi flow by abnormality of heart-kidney root, spleen-stomach axis, and liver-lung axis. Diagnosing these abnormalities and timely alleviation to the healthy state is presented in the study. Results 1For heat in the upper body, Huang Lian Jie Du Tang(黃連解毒湯), CF, or JsD pharmacopuctures are injected on GB21, GB20. Qi stagnation in the thoracic area is treated with BUM injection on CV17. For impairment of transportation and transformation in the middle energizer, BUM pharmacopuncture is injected on CV12. Coldness in the lower energizer was relieved by bee venom or Sweet BV(Bee Venom free from enzymes) on CV6. Conclusion Above proposed methods of regulating water-fire were effective in treating hot above, cold below syndrome in clinical manifestations. But once the symptom subsides, treatment focused on eliminating innate cause should be rendered to achieve more successful results.

• Journal of Acupuncture Research
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• 제31권2호
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• pp.11-19
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• 2014

Objectives : This study was aimed to determine which pharmacopuncture was effective in relieving pain in standard pain model, acute grade 3 ankle sprain rat model. Methods : Percentage changes of weight bearing ratio(WBR), as pain indicator, were measured after anti-inflammation, neutro Eohyul, Hwangryunhaedock-decoction pharmacopuncture were injected to Guheo ($GB_{40}$). Results : In three kinds of pharmacopuncture, neutro Eohyul and Hwangryunhaedock-decoction pharmacopuncture represented more effect in percentage changes of WBR than surgical(non treatment), needling group. Conclusions : Comparing of pharmacopuncture in grade 3 ankle sprain rat model, these results provide basis to select pharmacopuncture in sprain disease. Furthermore, mechanism of pharmacopuncture's analgesia, anti-inflammation should be progressed.