• The Journal of Korean Medicine
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• v.38 no.2
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• pp.31-40
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• 2017

Objectives: We investigated the effect of acupuncture on memory function in relation with neurogenesis in old rats. Methods: In this study, a step-down avoidance task for short-term memory and Y-maze task for spatial memory capability were conducted. Western blot analysis for brain-derived neurotorphic factor (BDNF) and tyrosine kinase B (TrkB), and immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU) were performed. Results: Short-term memory and spatial memories were decreased in the old-aged rats. Expressions of BDNF and TrkB in the hippocampus were significantly decreased in the old-aged rats. Neurogenesis in the hippocampal dentate gyrus was also decreased in the old-aged rats. However, acupuncture treatment alleviated impairment of short-term and spatial memories induced by ageing. Acupuncture also increased the expressions of BDNF and TrkB and enhanced neurogenesis in the hippocampus. The present study showed that acupuncture alleviated ageing-induced short-term and spatial memory loss by increasing of BDNF and neurogenesis. Acupuncture at ST41-acupoint showed most potent effect than at ST36-acupoint or non-acupoint. Conclusions: Acupuncture might be used as the effective therapeutic modality to ameliorate the age-related decrease of brain functions.

• Journal of the Mineralogical Society of Korea
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• v.2 no.2
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• pp.100-106
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• 1989

Die Titan-Augite sind die dominierenden Einsprenglings- und Grundmassephasen in allen tephritischen Gesteinen im Kaiserstuhl. Mg-Werte ($Mg/Mg+Fe^{2+}+Mn$) der Pyroxene schwanken von 60-85. Der FATS- und TITS-Anteil nimmt von phonolithischem Basanit und -Tephrit zum fraktionierten phonolithischen Tephrit hin ab. Die Kpx der einzelnen Gesteinsgruppen zeigen auch einen Fraktionier-ungstrend, der durch Abnahme von Si und Zunahme von Al vom phonolithischen Basanit und -Tephrit zum fraktionierten phonolithischen Tephrit gekennzeichnet ist. Der in Alkaligesteinen gewohnlich auftretende $gr{\ddot{u}}ne$ Kern der Px ist Fe-reicher und $Ti-{\ddot{a}}rmer$ als der $hellbra{\ddot{u}}nliche$-farblose Rand. Die $gr{\ddot{u}}nen$ Kerne weisen $gegen{\ddot{u}}ber$ den $hellbr{\ddot{a}}unlichen$ Randern $h{\ddot{o}}here$ $Na/Fe^{+3}$-Verhaltnisse auf.

• 기술발표회
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• s.2006
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• pp.45-53
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• 2006

Top-Down Construction Method has been considered as the steadiest and the most reasonable method of construction since 1984 when it was applied to LG Da-Dong building and its usage in the field construction has since grown rapidly. With increased cases, engineers not only pursue their studies of R & D continuously but also develop various technical methods based on Top-Down Construction in an era of rapid technological change to adopt them to the field construction. Top-Down Construction meets the needs of these challenging points, such as reduction and eliminates of temporary equipment for supporting permanent structures on the ground, improved method of construction, shortening construction periods, cost reduction, and allows for minimal environmental impact.

• Microbiology and Biotechnology Letters
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• v.24 no.4
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• pp.472-477
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• 1996

Natural human epidermal growth factor (nhEGF) was purified from pregnant human urine by benzoic acid adsorption, DEAE-Sepharose ion exchange, and immunoaffinity chromatography. The purified nhEGF was further separated into four fractions using Bondapak C$_{18}$ HPLC system. Following characterization by Western blot analysis and double immu- nodiffusion, we found that each fraction corresponds to four derivatives of the nhEGF. For biological analysis of nhEGF, we optimized the labeling time and serum concentration for the incorporatioin of 5-bromo-2'-deoxy uridine (BrdU), a non-radioactive alternative for [$^{3}$H]-thymidine uptake, into NIH 3T3 cells. The DNA synthesis of NIH 3T3 cells was gradually increased at the nhEGF concentrations between 0.1 - 10 ng/ml in the Dulbecco's Modified Eagles Medium (DMEM) containing 0.2% Fetal calf serum (FCS). When we assayed the biological activity of four fractions, the activity of the second fraction was superior to that of the others. Based on the results from the HPLC analysis spiked with recombinant human epidermal growth factor (rhEGF) and amino acid sequencing, we concluded that the second fraction was nhEGF and the other three fractions were the derivatives of nhEGF. In addition, the proportion of nhEGF was approximately 46% is compared with that of the other three derivatives.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.7 no.1
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• pp.40-44
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• 2014

A bridge resistance deviation-to-period (BRD-to-P) converter is presented for interfacing resistive biosensors. It consists of a linear operational transconductance amplifier (OTA) and a current-controlled oscillator (CCO) formed by a current-tunable Schmitt trigger and an integrator. The free running period of the converter is 1.824 ms when the bridge offset resistance is $1k{\Omega}$. The conversion sensitivity of the converter amounts to $3.814ms/{\Omega}$ over the resistance deviation range of $0-1.2{\Omega}$. The linearity error of the conversion characteristic is less than ${\pm}0.004%$.

• Journal of the Korean Institute of Gas
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• v.8 no.4 s.25
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• pp.8-14
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• 2004

Accidental releases of toxic gases heavily affect to the risk of process facilities. In this research, consequence analysis for accidental releases of ammonia and chlorine gases was studied using the risk based inspection, based on API-581 BRD. It was found out that consequence areas (toxic areas) decrease as temperature increases and as the pipe diameter and pressure decrease. For the same release condition, the toxic area by the release of chlorine gas was larger than that by the release of ammonia gas.

• Journal of the Korean Society of Safety
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• v.22 no.6
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• pp.35-40
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• 2007

As a way of improving the safety of the chemical facilities, the risk based-inspection(RBI) was executed for the facilities of the applied petrochemical plant using KS-RBI Ver. 3.0 program developed based on the API-581 based resource document(BRD). From an evaluation result of KS-RBI program, we could find the evaluation of the process safety management(PSM) for the applied plant, risk of the applied process, risk of static facilities and pipes, and the demage mechanism of the facilities. Also, we could suggest a proper inspection plan(frequency and method of inspection) using the calculated risk and the status of the facilities. Therefore, the applied plant could be achieved a reduced inspection cost by an extension of inspection frequency, improved productivity, improved reliability of the facilities, and a computerized history management.

• The Journal of Internal Korean Medicine
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• v.24 no.2
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• pp.300-314
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• 2003

Objectives : This study was carried out to investigate the effects of Sasammaickmoondong-tang(SME) on duodenal mucosal lesions induced by indomethacin in mouse. Methods : The normal group is that no inflammation elicitated mouse. Control group is that gastro-inflammation elicitated mouse. Sample group is that SME administered mouseice after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, control group was observed various injury-mucous surface cell, micro-villi, paneth cell, surface epithelial cell, goblet cell-by hemorrhagic erosion, while sample group was as same as normal group. In the immunohistochemical change, the distributions of COX-1, Bcl-2, and BrdU treated with SME noticeably increased than control group(p<0.05). The distributions of TUNEL, $NF-{\kappa}B$, COX-2, $IL-2R-{\alpha}$, NK-1.1, ICAM-1, and CD11b/18 treated with SME noticeably decreased than control group(p<0.05). And the distribution of SBA was as same as normal group. Conclusion : According to the above results, it is supposed that Sasammaickmoondong-tang is applicable to duodenal mucosal lesions.

• Molecules and Cells
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• v.43 no.2
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• pp.182-187
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• 2020

When cells are stimulated by growth factors, they make a critical choice in early G₁ phase: proceed forward to S phase, remain in G₁, or revert to G₀ phase. Once the critical decision is made, cells execute a fixed program independently of extracellular signals. The specific stage at which the critical decision is made is called the restriction point or R-point. The existence of the R-point raises a major question: what is the nature of the molecular machinery that decides whether or not a cell in G₁ will continue to advance through the cell cycle or exit from the cell cycle? The R-point program is perturbed in nearly all cancer cells. Therefore, exploring the nature of the R-point decision-making machinery will provide insight into how cells consult extracellular signals and intracellular status to make an appropriate R-point decision, as well into the development of cancers. Recent studies have shown that expression of a number of immediate early genes is associated with the R-point decision, and that the decision-making program constitutes an oncogene surveillance mechanism. In this review, we briefly summarize recent findings regarding the mechanisms underlying the context-dependent R-point decision.

• Food Science and Biotechnology
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• v.15 no.4
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• pp.599-602
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• 2006

The effects of ethanol extract from radish seeds on gastrointestinal function in rats were investigated. Rats were divided into 2 groups of 8 rats each, the basal group and the radish seed ethanol extract group. The radish seed ethanol extract group had a significantly decreased gastrointestinal transit time, but a significantly increased fecal weight compared with the basal group. The radish seed ethanol extract group also had significantly higher duodenal villus height and greater colonic mucosal thickness than the basal group. The radish seed ethanol extract group had a greater proliferation of 5-bromo-2-deoxy-uridine (BrdU) immunoreactive cells in the gastric mucosa as well as in the mucosa and submucosa of the small and large intestine than did the basal group. Thus, radish seed ethanol extract may be useful in preventing constipation based on the observation of an increase in fecal weight, a decrease in gastrointestinal transit time, and positive changes in the intestinal mucosa.