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Effects of Radish Seed Ethanol Extracts on Gastrointestinal Function in Rats  

Lee, Chang-Hyun (Department of Anatomy, College of Oriental Medicine, Woosuk University)
Lee, Moon-Won (Department of Anatomy, College of Oriental Medicine, Woosuk University)
Song, Geun-Seoup (Department of Food Engineering, Iksan National College)
Kim, Young-Soo (Faculty of Biotechnology (Food Science and Technology Major), Chonbuk National University)
Publication Information
Food Science and Biotechnology / v.15, no.4, 2006 , pp. 599-602 More about this Journal
Abstract
The effects of ethanol extract from radish seeds on gastrointestinal function in rats were investigated. Rats were divided into 2 groups of 8 rats each, the basal group and the radish seed ethanol extract group. The radish seed ethanol extract group had a significantly decreased gastrointestinal transit time, but a significantly increased fecal weight compared with the basal group. The radish seed ethanol extract group also had significantly higher duodenal villus height and greater colonic mucosal thickness than the basal group. The radish seed ethanol extract group had a greater proliferation of 5-bromo-2-deoxy-uridine (BrdU) immunoreactive cells in the gastric mucosa as well as in the mucosa and submucosa of the small and large intestine than did the basal group. Thus, radish seed ethanol extract may be useful in preventing constipation based on the observation of an increase in fecal weight, a decrease in gastrointestinal transit time, and positive changes in the intestinal mucosa.
Keywords
radish seed; gastrointestinal function; villus height; mucosal thickness; immunoreactive cells;
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Times Cited By Web Of Science : 0  (Related Records In Web of Science)
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1 Choi YK, Lee CH, Lee MY, Kwon J, Song GS, Kim YS. Effect of alcohol insoluble residues from stem and root barks of elm (Ulmus davidiana) on intestinal characteristics in rats. Food Sci. Biotechnol. 15: 380-384 (2006)   과학기술학회마을
2 Lee C-H, Oh S-H, Yang E-J, Kim Y-S. Effects of raw, cooked, and germinated small black soybean powders on dietary fiber content and gastrointestinal functions. Food Sci. Biotechnol. 15: 635-638 (2006)   과학기술학회마을
3 Vargas R, Perez RM, Perez S, Zavala MA, Perez C. Antiurolithiatic activity of Raphanus sativus aqueous extract on rat. J. Ethnopharmcol. 68: 335-338 (1999)   DOI   ScienceOn
4 Hamilton SM, Teel RW. Effects of isothiocyanates on cytochrome P-450 1A1 and 1A2 activity and on the mutagenicity of heterocyclic amines. Anticancer Res. 16: 3597-3602 (1996)
5 Lugasi A, Dworschak E, Blazovics A, Kery A. Antioxidant and free radical scavenging peoperties of squeezed juice from black radish. Phytother. Res. 12: 502-506 (1998)   DOI   ScienceOn
6 Sigleo S, Jackson MJ, Vahouny GV. Effects of dietary fiber constituents on intestinal morphology and nutrient transport. Am. J. Physiol. 246: G34-G39 (1984)
7 Ghayur MN, Gilani AH. Gastrointestinal stimulatory and uterotonic activities of dietary radish leaves extract are mediated through multiple pathways. Phytother. Res. 19: 750-755 (2005)   DOI   ScienceOn
8 Curtis IS. The noble radish: past, present, and future. Trends Plant Sci. 8: 305-307 (2003)   DOI   ScienceOn
9 Bensky D, Gamble A. Chinese herbal medicine: materia medica, Revised ed. Eastland Press, Seattle, WA, USA. pp. 227-228 (1986)
10 Baik SO, Kim HK, Lee YH, Kim YS. Preparation of active fraction from radish water extracts for improving the intestinal functions and constipation activities. J. Korean Soc. Appl. Biol. Chem. 47: 315-320 (2004)   과학기술학회마을
11 Cassidy MM, Lightfoot FG, Grau LE, Story JA, Kritchevsky D, Vahouny GV. Effect of chronic fiber intake on the ultrastructural topography of rat jejunum and colon: a scanning microscopy study. Am. J. Crin. Nutr. 34: 218-228 (1981)   DOI
12 Potten CS. Extreme sensitivity of some intestinal crypt cells to x and y irradiation. Nature 269: 518-521 (1977)   DOI   ScienceOn
13 Bosaeus I. Fiber effects on intestinal functions (diarrhea, constipation, and irritable bowel syndrome). Clin. Nutr. Suppl. 1: 33-38 (2004)
14 Jung KY, Choo YK, Kim HM, Choi BK. Radish extract stimulates motility of the intestine via the muscarinic receptors. J. Pharm. Pharmacol. 52: 1031-1036 (2000)   DOI   ScienceOn
15 Loehry CA, Creame B. Three-dimensional structure of rat small intestine related to mucosal dynamics. Gut 10: 112-120 (1968)   DOI   ScienceOn
16 Ito M, Kizawa K, Hamada K, Cotsarelis G. Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen. Differentiation 72: 548-557 (2004)   DOI   ScienceOn
17 Hecht SS. Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. J. Nutr. 129: 768S-774S (1999)   DOI
18 Gilani AH, Ghayur MN. Pharmacological basis for the gut stimulatory activity of Raphanus sativus leaves. J. Ethnopharmacol. 95: 169-172 (2004)   DOI   ScienceOn
19 Wang L, Wei L, Wang L, Xu C. Effects of peroxidase on hyperlipidemia in mice. J. Agr. Food Chem. 50: 868-870 (2002)   DOI   ScienceOn
20 Jablonka-Shariff A, Grazul-Bilska AT, Redmer DA, Reynolds LP. Growth and cellular proliferation of ovine corpora lutea throughout thre estrus cycle. Endocrinology 133: 1871-1879 (1993)   DOI   ScienceOn