• Title/Summary/Keyword: BOLD effect

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Detection of Neuronal Activity by Motion Encoding Gradients: A Snail Ganglia Study

  • Park, Tae-S.;Park, Ji-Ho;Cho, Min-H.;Lee, Soo-Y.
    • Journal of Biomedical Engineering Research
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    • v.28 no.1
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    • pp.24-28
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    • 2007
  • Presuming that firing neurons have motions inside the MRI magnet due to the interaction between the neuronal magnetic field and the main magnetic field, we applied motion encoding gradients to dissected snail ganglia to observe faster responding MRI signal than the BOLD signal. To activate the snail ganglia in synchronization with the MRI pulse sequence, we used electrical stimulation with the frequency of 30 Hz and the pulse width of 2s. To observe the fast responding signal, we used the volume selected MRI sequence. The magnetic resonance signal intensity, measured with 8 ms long motion encoding gradient with a 20mT/m gradient strength, decreased about $3.46{\pm}1.48%$ when the ganglia were activated by the electrical stimulation.

A Study on Vivienne Westwood Design (비비엔 웨스트우드(Vivienne Westwood)의 작품세계 연구)

  • 방수란
    • Korean Journal of Human Ecology
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    • v.2 no.1
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    • pp.129-141
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    • 1999
  • The purpose of this study is to investigate the effect of historical costume style and painting on Vivienne Westwood design. For this purpose, the costume style after 16C and the rococo painting of 18C are researched. And through Westwood's recent designs, the external form and internal symbol are compared. The results of this study were as follows : 1. From Renaissance, Rococo, Crinoline, Bustle, S style were showed on Westwood design. 2. In external method, historical costume styles were expressed by silhouette, detail, costume item, textile and various cuttings. 3. In the case of painting, it focused on Rococo painting of 18C. Costumes in painting were realized or painting itself were used for textile. 4. Most of her design was cut in the round rather than in the flat, bold cutting and slash were employed. 5. These works are symbolizing the harmony of tradition and future, at the same time through the transformation of orthodox style, containing ridicule to the authority and a challenge to society as well as sex. These results let us know that Westwood is versatile to transform the history and harmonize the tradition and 20C Fashion successfully. (Korean J Human Ecology 2(1):129∼141, 1999)

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Evaluation of the effect of testosterone supplementation on the brain activity associated with sexual arousal in hypogonadal patients: Functional MRI

  • 은성종;서정진;정광우;강형근;김형중;이진명
    • Proceedings of the KSMRM Conference
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    • 2002.11a
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    • pp.112-112
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    • 2002
  • Purpose: The Purpose of this study was to evaluate the quantitative variation of brain activity evoked by visual sexual stimulation before and after testosterone supplementation in hypogonadal patients by using BOLD functional MR imaging.

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Influence of Extracellular Products from Haematococcus pluvialis on Growth and Bacteriocin Production by Three Species of Lactobacillus

  • Kim Jeong-Dong;Lee Choul-Gyun
    • Journal of Microbiology and Biotechnology
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    • v.16 no.6
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    • pp.849-854
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    • 2006
  • The effects of Haematococcus pluvialis extracellular products on microbial growth and bacteriocin production were investigated to improve bacteriocin synthesis during the growth cycle of Lactobacilli. Lactobacillus pentosus KJ-108, L. plantarum KJ-10311, and L. sakei KJ-2008 were cultured in MRS and enriched medium (ERM) with or without supplement of the extracellular products obtained from a late exponential phase culture of Haematococcus pluvialis in modified Bold's basal medium (MBBM). In both MRS and ERM, the extracellular products strongly enhanced the growth as well as the bacteriocin production of all the lactic acid bacteria tested. The enhancing effect was observed in ERM with pH adjusted at 5 and 6. In addition, some difference in growth effects with the extracellular products of H. pluvialis was observed between pH 5 and 6 in ERM, but no effect was observed in the minimal medium. The final biomass and the final concentration of bacteriocin activity were associated with the cell growth that was promoted by the extracellular products of H. pluvialis, and the enhanced cell growth of the three lactic acid bacterial strains induced the increase of the specific bacteriocin production. Therefore, bacteriocin production and activity were influenced by the addition of the extracellular products of H. pluvialis in the culture medium.

The Effect of the CEO's Entrepreneurship on Corporate Performance in the Restaurant Industry

  • Jun-Young Lee;Sung-Ho Bang;Ki-Hwan Ryu
    • International journal of advanced smart convergence
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    • v.12 no.3
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    • pp.168-174
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    • 2023
  • The purpose of this paper is to analyze entrepreneurship and to find out the impact of CEOs in the restaurant industry on corporate performance when they have entrepreneurship. Entrepreneurs need entrepreneurship to take risks and jump into the market to generate profits. Entrepreneurship is not limited to the abilities or resources held, but it is not limited to the ability or resources held, and entrepreneurship to act means the spirit to take uncertainty and preempt opportunities through innovative activities [1]. In this study, the CEO's entrepreneurship was set as an independent variable and corporate performance as a dependent variable. By applying and analyzing how the CEO's entrepreneurship affects corporate performance in the restaurant industry, the importance of entrepreneurship in the restaurant industry and the impact relationship on corporate performance are analyzed. To this end, 100 CEOs working in the restaurant industry will be surveyed using the Likert 5-point scale[2]. And an empirical analysis will be conducted through the SPSS program[3]. Entrepreneurship is a spirit that can take risks and seize opportunities through bold challenges to generate profits. Therefore, it has been confirmed that it affects corporate performance as a key factor for improving corporate performance, and from related studies, the entrepreneurship of the CEO of the restaurant industry is expected to have a positive (+) effect on corporate performance.

Gastroprotective Effect of Artemisia frigida Willd in HCl/Ethanol-induced Acute Gastritis (HCl/에탄올로 유발된 급성 위염에서 Artemisia frigida Willd의 위장 보호 효과)

  • Oh, Min Hyuck;Lee, Se Hui;Park, Hae-jin;Shin, Mi-rae;Sharav, Bold;Roh, Seong-soo
    • Korean Journal of Pharmacognosy
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    • v.52 no.4
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    • pp.242-250
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    • 2021
  • Artemisia frigida Willd (AW, Fringed sagewort), which is widespread in Mongolia, is a well-known medicinal plant as a member of the Compositae family. This study aims to explore the gastroprotective effect of water extract of AW on 150 mM HCl/60% ethanol-induced acute gastritis in 5 week old male ICR mice. Total polyphenols, total flavonoid contents, and anti-oxidant activity in vitro in AW were evaluated. First, the gross area of gastric mucosal damage was measured. Then western blot analysis was conducted to determine the possible mechanisms of action underlying the effects of AW. AW administration decreased gastric mucosal damage. Moreover, the group with AW treatment effectively inhibited nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression associated with oxidative stress. AW treatment enhanced an anti-oxidant effect through the increase of anti-oxidant proteins. Besides, the increased expressions of inflammatory cytokines induced by nuclear factor-kappa B (NF-κB) activation are alleviated through AW treatment. Taken together, AW exerted a gastroprotective effect against gastric mucosal damage. These results indicate that AW could have the potential used as a natural therapeutic drug for the treatment of acute gastritis.

A Study of the Effect of Acoustic Noise Attenuator on Auditory Functional MRI (소음 감쇠기를 이용한 청각의 뇌기능 자기공명영상)

  • Kim, S.H.;Kim, I.S.;Lee, J.J.;Park, J.A.;Lee, Y.J.;Yeo, J.R.;Bae, S.J.;Lee, S.H.;Chang, Y.
    • Investigative Magnetic Resonance Imaging
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    • v.9 no.2
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    • pp.134-139
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    • 2005
  • Purpose : To evaluate the usefulness of acoustic noise attenuator on auditory fMRI examination. Materials and methods : The acoustic noise attenuator consists of mask, earmuff and silicon earplug. The soft polyurethane sheet and polyurethane form , which has a good soundproof characteristic were used for mask and earmuff. Auditory fMRI experiments of 500 Hz pure tone stimulation were performed in three different cases; first all of mask, earmuff and earplug, secondly earmuff and earplug only and finally without attenuator in 4 normal hearing volunteers. For data acquisition, BOLD MR imaging technique was employed at a 1.5T MR scanner equipped with high performance gradient system. The raw data were analyzed using a SPM-99 analysis software and the activation maps were obtained. Results : In case of all items of acoustic attenuator used, the results revealed that activation was focused on primary auditory area. When only earmuff and earplug were used, the results showed that the activation spread over primary auditory and secondary associative areas. Last, when no device used, only weak activation was observed on the right auditory cortex. Conclusion : It is expected that the acoustic noise attenuator, which consists of earplugs, earmuffs and mask, is a very useful device in auditory fMRI study.

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A fMRI study on the cerebral activity induced by Electro-acupuncture on Sp9(Yinlingquan) (음릉천(陰陵泉)(Sp9)의 전침자극(電鍼刺戟)이 functional MRI상 뇌활성(腦活性) 변화(變化)에 미치는 영향(影響))

  • Kim, Jeong-ho;Lee, Hyun;Lim, Yun-kyoung;Hong, Kwon-eui;Lee, Byung-ryul;Kim, Yeon-jin
    • Journal of Acupuncture Research
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    • v.20 no.4
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    • pp.114-133
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    • 2003
  • Objective : The meridian theory in oriental medicine explains that Sp9(Yinlingquan) has been considered very important for gynecological disorders, spleen and stomach disorders, and water metabolic disorders. Functional MRI is the best method of showing the evidences of the effect of the Electro-acupuncture treatment through scientific methods. On this supposition, Electro-acupuncture stimulation on Sp9(Yinlingquan) was carried out on six healthy volunteers, using the gradient echo sequence with the 3.0T whole-body MRI system(ISOL). Methods : Electro-acupuncture stimulation on Sp9(Yinlingquan), the experiment was carried out on six healthy volunteers, using the gradient echo sequence with the 3.0T whole-body MRI system(ISOL). After the needle insertion on right Sp9(Yinlingquan), 2Hz of electric stimulation was given for 30 seconds, repeated five times, with 30 seconds' intervals. The Image analysis including motion correction, talairach transformation, and smoothing was done using SPM99. Results : The electro-acupuncture stimulation on Sp9(Yinlingquan) activates Brodmann Area 13, 19, 22, 39, 40, 47 which may be the central pathways of the electro-acupuncture stimulation on Sp9(Yinlingquan). We also hypothesize that those brain areas may be directly or indirectly related with the mechanism of the effect of electro-acupuncture stimulation on Sp9(Yinlingquan).

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fMRI study on the cerebral activity induced by Electro-acupuncture on Fenglong(St40) (풍륭(豊隆)(St40) 전침(電鍼)이 뇌활성(腦活性) 변화(變化)에 미치는 영향(影響) (fMRI를 이용한 연구))

  • Bae, Eun-jeong;Hong, Kwon-eui;Lee, Hyun;Lee, Byung-ryul;Yim, Yun-kyoung;Kim, Yeon-jin
    • Journal of Acupuncture Research
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    • v.20 no.5
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    • pp.208-226
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    • 2003
  • Objective : Recently many studies have showed the evidence of the effect of the acupuncture treatment through scientific methods. One of these methods is functional MRI. We performed electro-acupuncture on St40 and observed the change of brain activation using fMRI. Methods : To see the effects of electro-acupuncture stimulation on Fenglong(St40), the experiment was carried out on six healthy volunteers, using the gradient echo sequence with 3.0T whole-body MRI system(ISOL). after the needle insertion on right Fenglong(St40), 2 Hz of electric stimulation was given for 30 seconds, repeated five times, with 30 seconds' intervals. Results & Conclussion : Electro-acupuncture stimulation on Fenglong(St40) activated Brodmann's Areas of 2, 3, 4, 6, 9, 10, 13, 18, 22, 30, 40, 42, 43 which may be the central pathways of electro-acupuncture stimulation on Fenglong(St40).

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Citizens' Expectations from Government and Policy Attitude with Regard to Reducing Overlap and Duplicating among Government Programs -Does an Income Class Difference Matter?- (유사중복사업 통폐합 정책에 대한 기대효과와 태도 -소득계층 간의 차이를 중심으로-)

  • Lee, Jae-Wan
    • The Journal of the Korea Contents Association
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    • v.17 no.7
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    • pp.133-143
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    • 2017
  • The objective of this study is to examine whether citizens' expectations of policy impacts of the government's efforts to reduce overlap and duplication among its programs have any influence on citizens' policy attitude. Furthermore, this study examines whether the influence is differential and dependent on income class differences. The results suggest that 'reducing budget waste' bas a positive impact on policy attitude whereas 'enhancing work performance' bad no significant impact. And the results reveal that middle class bold a more negative view than upper class on the government's efforts. Concerning the moderating effect. income class differences weaken the positive relationship between 'reducing budget waste' and policy attitude as well the negative relationship between 'enhancing work performance' and policy attitude. The policy implication of this study is, to gain support from citizens for its overlap and duplication reduction policies, it is critical that the government should publicize that there exists a more of citizens benefitting from such policies.