• 한국인공지능학회지
• /
• 제6권2호
• /
• pp.17-22
• /
• 2018

According to the World Health Organization, the top 10 causes of death worldwide include heart disease. Heart diseases include coronary disease, which induces acute myocardial infarction. Ticagrelor drugs are being used to treat acute alliances, but it has become difficult to breathe due to the drugs. In a related study, Tobias predicted that uric acid causes acute respiratory distress independently of other factors, including BNP. And in the Ahmad study, serum uric acid numbers were related to the left ventricle depending on the level of uric acid. Experimental data are data used after 155 patients who received coronary intervention took ticagrelor. The research methods were leveraged by gradient decent algorithm and linear regression. In order to avoid overfitting in the experiment, training data and test data were separated into 70 and 30 percent respectively. The experimental results lacked the predictability of other attributes except DT in the correlation coefficient and crystal coefficient. However, all attributes related to dyspnea other than DT are determined to be related to causing relaxation of the heart in the left ventricle. Therefore, the attribute causing dyspnea is determined to be an attribute causing relaxation of the heart of the DT and left ventricle.

• The Korean Journal of Physiology and Pharmacology
• /
• 제19권3호
• /
• pp.203-210
• /
• 2015

AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism. Previous studies have shown that activation of AMPK results in suppression of cardiac myocyte hypertrophy via inhibition of the p70S6 kinase (p70S6K) and eukaryotic elongation factor-2 (eEF2) signaling pathways. Epigallocatechin-3-gallate (EGCG), the major polyphenol found in green tea, possesses multiple protective effects on the cardiovascular system including cardiac hypertrophy. However, the molecular mechanisms has not been well investigated. In this study, we found that EGCG could significantly reduce natriuretic peptides type A (Nppa), brain natriuretic polypeptide (BNP) mRNA expression and decrease cell surface area in H9C2 cardiomyocytes stimulated with phenylephrine (PE). Moreover, we showed that AMPK is activated in H9C2 cardiomyocytes by EGCG, and AMPK-dependent pathway participates in the inhibitory effects of EGCG on cardiac hypertrophy. Taken together, our findings provide the first evidence that the effect of EGCG against cardiac hypertrophy may be attributed to its activation on AMPK-dependent signaling pathway, suggesting the therapeutic potential of EGCG on the prevention of cardiac remodeling in patients with pressure overload hypertrophy.

• 한국항해항만학회:학술대회논문집
• /
• 한국항해항만학회 2021년도 추계학술대회
• /
• pp.76-77
• /
• 2021

자율운항선박의 발전에 맞춰 선박의 안전관리체계 전환에 대비한 전문 선박관리감독 인력양성이 필요하다. 이에 본 연구에서 현업에 종사하는 선박관리감독을 대상으로 자율운항선박에 도입에 대비하여 선박관리감독에게 요구되는 역량이 무엇인지 조사하고 미래의 역량 개발 방안을 제시하고자 한다.

• Clinical and Experimental Pediatrics
• /
• 제53권7호
• /
• pp.745-752
• /
• 2010

Purpose: There is currently little evidence to support intravenous immune globulin (IVIG) therapy for pediatric myocarditis. The purpose of our retrospective study was to assess the effects of IVIG therapy in patients with presumed myocarditis on survival and recovery of ventricular function and to determine the factors associated with its poor outcome. Methods: We reviewed all consecutive cases of patients with myocarditis with left ventricular dysfunction verified by echocardiogram who had visited 3 university hospitals between January 2000 and September 2009. These patients were divided into 2 groups. Group 1 consisted of 23 patients (69.6%) who received IVIG alone or IVIG in combination with steroids, and group 2 consisted of 10 patients (30.3%) who received neither IVIG nor other immunosuppressive agents. Clinical manifestations, laboratory results, echocardiographic findings, and outcomes were compared between these 2 groups. Results: One year after the initial presentation, the difference in the probability of survival did not show statistical significance in IVIGtreated patients ($P$=0.607). Of the echocardiographic parameters on admission, a shortening fraction of less than 15% was associated with unremitting cardiac failure. Furthermore, anemic patients were more likely to have elevated N-terminal fragment levels of the B-type natriuretic peptide (NT-proBNP) in the progressed group ($P$=0.036). Conclusion: There was no difference between the IVIG-treated patients and the control patients in the degree of recovery of left ventricular function and survival. Prospective, randomized, clinical studies are needed to elucidate the effects of IVIG treatment during the acute stage of myocarditis on ultimate outcomes.

• 보건의료산업학회지
• /
• 제7권3호
• /
• pp.71-82
• /
• 2013

Arterial stiffness(AS) is an important pathologic state of vascular injury. This study was carried out to elucidate the effect of physiological variables on brachial-ankle pulse wave velocity(BAPWV), index of AS. Four hundred adults(volunteers) participated in this study. Body indices, biochemical, cardiac and inflammatory markers, and right(Rt)- and left(Lt)-BAPWV were measured. Body mass index(BMI), Rt- and Lt-BAPWV, glucose, triglyceride, alkaline phosphatase(ALP), gamma-glutamyl transferase(GGT), creatinine, uric acid, troponin-I(TNI), NT-proBNP and high sensitivity C-reactive protein(hs-CRP) levels were higher than the reference value of each variable. Rt- and Lt-BAPWV were directly correlated with age, body weight, BMI, glucose, ketone, aspartate aminotransferase, alanine aminotransferase, ALP, GGT, total cholesterol, low density lipoprotein, lipoprotein(a), apolipoprotein-B, blood urea nitrogen, heart rate, TNI, creatine kinase, CK-MB, lactic dehydrogenase, myoglobin, hs-CRP, lipase, reumatoid factor, fibrinogen and D-dimer (P<0.05, P<0.01, P<0.001 or P<0.000, respectively), but inversely associated with total bilirubin, uric acid, apolipoprotein-A1 and GFR (P<0.05). These observations suggest that a variety of physiological variables may influence BAPWV, resulting in increased risk or prevention of cardiovascular and/or cerebrovascular attacks. Therefore, physiological variables affecting BAPWV should be regularly controlled.

• Ocean and Polar Research
• /
• 제30권3호
• /
• pp.215-224
• /
• 2008

A piston core (MR06-04 PC23A) collected from the northern continental slope in the central Bering Sea has recorded the high-resolution millennial-scale variation of calcium carbonate ($CaCO3$) content during the last 65 kyr. An estimation of the age of the core sediments was carried out by using the lithologic correlation of the deglacial laminated layers with a neighboring core (HLY02023JPC), complementing the last appearance datum of both Lychnocanoma nipponica sakaii (54 kyr) and Amphimelissa setosa (85 kyr). The probable age of core MR06-04 PC23A was approximately younger than 65 kyr. Two distinct events of a significant increase of $CaCO3$ in the deglacial laminated sediments clearly correspond to MWP1A and MWP1B in the Bering Sea (Gorbarenko et al. 2005) and to T1ANP and T1BNP in the North Pacific (Gorbarenko 1996). These pronounced peaks of $CaCO3$ contents result from the elevated carbonate production in the surface water and the subsequent weakened dilution due to terrestrial input, along with an enhanced oxygen minimum zone. The $CaCO3$ contents are low (${\sim}2%$) during the last glacial period mainly because of a low carbonate production caused by an expanded sea-ice cover and an increased dilution by terrigenous particles due to their closer distance to the continent during the sea-level low stand. The occurrence of seven distinct $CaCO3$ peaks in core MR06-04 PC23A is remarkable during MIS 3 and MIS 4, and they most likely correlate to the short-term millennial Dansgaard-Oeschger events.

• Clinical and Experimental Pediatrics
• /
• 제58권10호
• /
• pp.374-379
• /
• 2015

Purpose: Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular signs of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and those without uveitis. Methods: We conducted a prospective study with 110 KD patients from January 2008 to June 2013. The study group (n=32, KD with uveitis) was compared with the control group (n=78, KD without uveitis). Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, and level of alanine aminotransferase, aspartate aminotransferase, serum total protein, albumin, C-reactive protein (CRP), and N-terminal probrain natriuretic peptide (NT-pro BNP). Echocardiographic measurements and intravenous immunoglobulin responses were compared between the two groups. Results: The incidence of uveitis was 29.0%. Neutrophil counts and patient age were higher in the uveitis group than in the control group. ESR and CRP level were slightly increased in the uveitis group compared with the control group, but the difference between the two groups was not significant. No significant differences in coronary arterial complication and treatment responses were observed between the two groups. Conclusion: Uveitis is an important ocular sign in the diagnosis of incomplete KD. It is significantly associated with patient age and neutrophil count.

• The Korean Journal of Physiology and Pharmacology
• /
• 제4권4호
• /
• pp.283-289
• /
• 2000

Natriuretic peptides comprise a family of three structurally related peptides; atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The present study was performed to investigate the effect of ANP on the proliferation and activity of ROS17/2.8 and HOS cells which are well-characterized osteoblastic cell lines. ANP dose-dependently decreased the number of ROS17/2.8 and HOS cells after 48-hour treatment. ANP generally increased the alkaline phosphatase activity of ROS17/2.8 and HOS cells after 48 hr treatment, regardless of the fact that basal activity of alkaline phosphatase was much lower in HOS cells compared to that of ROS17/1.8 cells. ANP increased the NBT reduction by ROS17/2.8 and HOS cells. ANP showed the variable but no significant effect on the nitric oxide production by ROS17/2.8 and HOS cells. ROS17/2.8 and HOS cells produced and secreted gelatinase into culture medium, and this enzyme was thought to be the gelatinase A type with the molecular weight determination. The gelatinase activity produced by ROS17/2.8 cells was increased by the treatment of ANP. However, the enzyme activity was not affected by ANP treatment in the HOS cell culture. In summary, ANP decreased the proliferation and increased the alkaline phosphatase activity and NBT reduction of osteoblasts. These results indicate that ANP is one of the important regulators of bone metabolism.

• 정보학연구
• /
• 제5권3호
• /
• pp.97-119
• /
• 2002

각 은행들은 인터넷 뱅킹을 통해 경쟁력 확보하기 위해 서비스 개발에 박차를 가하고 있을 뿐만 아니라, 새로운 뱅킹 비즈니스 모델을 구현하고 있다. 특히 인터넷 뱅킹 경쟁력 평가는 단순히 인터넷 뱅킹 사이트의 서비스 평가와는 다르다. 국내외 인터넷 뱅킹에서 제공하는 서비스 상품들은 성공적인 합병과 다양한 온라인 접점의 구축을 통해 금융서비스를 가장 효율적으로 제공하며, 또한 은행업무뿐만 아니라 증권서비스, 보험, 소비자금융, 리스, 부동산업무 등을 원스톱으로 제공하는 등 다양한 서비스를 제공하며, 사업의 영역을 넓혀가고 있다. 그리고 대부분의 국내외 은행 및 금융기관들이 인터넷 뱅킹 서비스 개발을 통하여 경영효율성을 증대시키고 경쟁력을 제고하고자 노력하고 있다. 특히 국내외 은행들이 일대일 맞춤 서비스, 개인 재무관리 그리고 인터넷뱅킹을 이용한 아파트관리비 납부서비스 상품을 개발하여 제공하고 있을 뿐만 아니라, 통합모바일서비스, 세금 전자납부 징수, 인터넷 무서류 대출 상품 서비스를 개발하여 시장에서 판매하고 있다. 따라서 현재의 고객 및 잠재고객들이 은행의 인터넷 뱅킹 서비스를 적극 이용하도록 유치함으로써 은행 및 금융기관들은 그들의 경쟁적위상을 제고시키고자 노력하고 있다.

• 한국콘텐츠학회논문지
• /
• 제10권4호
• /
• pp.386-396
• /
• 2010

본 연구의 목적은 최근 노사 간 이슈가 되고 있는 비정규직 이슈에 주목하여 비정규직 노사분규의 사례 중 대표적인 하이닉스 사내하청 노사분규사례의 발생원인 및 해결과정 등 전 과정을 살펴봄으로써 향후 유사한 노사분규에 대한 시사점을 주고자 함에 있다. 사례분석결과 하청노조는 교섭상대방인 하청회사가 존재 할 때까지는 하청회사들과 교섭하지만, 이후 하청회사는 폐업을 하게 되고 이에 따라 하청노조원들은 직장을 잃게 되고 교섭상대방은 원청회사로 바꾸어 직접교섭과 고용을 주장한다. 원청회사의 교섭거부와 하청노조의 불법을 포함한 전 방위적 공세 속에서 지역사회 등의 노력으로 중재가 시도되고 이후 사적 조정 그리고 최종 직접교섭으로 동 분규는 해결된다. 해결에 있어서는 고용을 배제되고 위로금 등으로 해결되어 불법과 무원칙이 난무하는 한국의 노사관계에서 나름대로 법과 원칙에 입각한 해결이라는 의미 있는 결과를 나타냈다. 마지막으로, 이상의 연구결과를 토대로 시사점을 제시하였다.