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http://dx.doi.org/10.12811/kshsm.2013.7.3.071

Correlation between Arterial Stiffness and Physiological Parameters  

Shin, Jae-Wook (Department of Clinical Laboratory Science, Catholic University of Pusan)
Seok, Seong-Ja (Department of Clinical Pathology, Sorabol College)
Lee, Gil-Hyun (Department of Clinical Laboratory Science, Catholic University of Pusan)
Choi, Seok-Cheol (Department of Clinical Laboratory Science, Catholic University of Pusan)
Hyun, Kyung-Yae (Department of Clinical Laboratory Sciense, Dong-Eui University)
Publication Information
The Korean Journal of Health Service Management / v.7, no.3, 2013 , pp. 71-82 More about this Journal
Abstract
Arterial stiffness(AS) is an important pathologic state of vascular injury. This study was carried out to elucidate the effect of physiological variables on brachial-ankle pulse wave velocity(BAPWV), index of AS. Four hundred adults(volunteers) participated in this study. Body indices, biochemical, cardiac and inflammatory markers, and right(Rt)- and left(Lt)-BAPWV were measured. Body mass index(BMI), Rt- and Lt-BAPWV, glucose, triglyceride, alkaline phosphatase(ALP), gamma-glutamyl transferase(GGT), creatinine, uric acid, troponin-I(TNI), NT-proBNP and high sensitivity C-reactive protein(hs-CRP) levels were higher than the reference value of each variable. Rt- and Lt-BAPWV were directly correlated with age, body weight, BMI, glucose, ketone, aspartate aminotransferase, alanine aminotransferase, ALP, GGT, total cholesterol, low density lipoprotein, lipoprotein(a), apolipoprotein-B, blood urea nitrogen, heart rate, TNI, creatine kinase, CK-MB, lactic dehydrogenase, myoglobin, hs-CRP, lipase, reumatoid factor, fibrinogen and D-dimer (P<0.05, P<0.01, P<0.001 or P<0.000, respectively), but inversely associated with total bilirubin, uric acid, apolipoprotein-A1 and GFR (P<0.05). These observations suggest that a variety of physiological variables may influence BAPWV, resulting in increased risk or prevention of cardiovascular and/or cerebrovascular attacks. Therefore, physiological variables affecting BAPWV should be regularly controlled.
Keywords
Arterial Stiffness; BAPWV; Body Index; Biochemical Marker; Cardiac Marker; Inflammatory Marker;
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