• Journal of Environmental Impact Assessment
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• v.19 no.4
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• pp.443-452
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• 2010

본 연구에서는 도시지역의 하나인 주거지역에서 배출되는 강우유출수 내에 중금속이 장치형 비점 오염저감시설 중에 하나인 와류형시설에서 제거되는 특성을 파악하고자, 대상 중금속을 Zn으로 삼고 2007년 4월부터 2008년 11월까지 모니터링을 수행하였다. 유출수 모니터링은 와류형 시설의 유입부와 유출부에서 유량과 수질을 각각 시간변화에 따라 측정하였으며, 시설유입부와 유출부, 그리고 시설하부에 쌓인 침전물을 채취하여 침전물 모니터링도 수행하였다. 그 결과, 높은 강우강도에서 발생된 강우유출수는 와류형 시설내에 HRT를 감소시켜 Zn의 제거효율이 낮게 관측되었으며, 특히 HRT가 20분이내의 조건이 될 경우에는 처리효과가 없는 것으로 확인되었다. Zn는 입자성물질과 밀접한 관계를 맺으며 제거되는 특성을 보였으며, 입자성물질이 스크린에 의한 여과 및 침전작용이 일어날 때 입자성물질에 부착되어 거동하는 특성을 보였다. 그 중에 0.075mm 이하의 미세한 입자에 부착된 고농도의 Zn는 제거되지 못하였고, 와류형 시설 후단에 후처리시설로서 저류시설을 두어 충분한 HRT를 제공한 결과, 와류형 시설만을 운전하였을 때와 비교하여 높은 제거특성을 보이게 되었다.

• Journal of Korean Society on Water Environment
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• v.30 no.2
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• pp.159-165
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• 2014

Vegetative Filter Strip (VFS) is one of effective Best Management Practices (BMPs) to prevent sediment-laden water problem, is installed at the edge of source area such agricultural area so that sediment occurred in source area is trapped by VFS before it flow into stream or river. Appropriate scale of it needs to be simulated before it is installed, considering various field conditions. In this study, a model using VFSMOD-w model and Genetic Algorithm to determine effective VFS length was developed, it is available to calibrate input parameter related to source area sediment yield through thousands of VFSMOD-w simulations. Useful DBs, moreover, are stored in the model so that very specific input parameters can be used with reasonable values. Compared simulated values to observed data values for calibration, R2 and Nash-Stucliffe model efficiency coefficient were 0.74 and 0.65 in flow comparison, and 0.89 and 0.79 in sediment comparison. The model determined 1.0 m of Filter Length, 0.18 of Filter Slope, and 0.2 cm of Filter Media Spacing to reduce 80% of sediment by VFS. The model has not only Auto-Calibration module also DBs for specific input parameters, thus, the model is expected to be used for effective VFS scale.

• Journal of The Korean Society of Agricultural Engineers
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• v.57 no.1
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• pp.89-97
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• 2015

This study is to assess the effect of non-point source pollution discharge loads between tillage and no-tillage applications for upland crop areas using SWAT (Soil and Water Assessment Tool) watershed modeling. For Byulmi-cheon small rural catchment ($1.17km^2$) located in upstream of Gyeongan-cheon watershed, the rainfall, discharge and stream water quality have been monitored in the catchment outlet since 2011. The SWAT model was calibrated and validated in hourly basis using 19 rainfall events during 2011-2013. The average Nash-Sutcliffe model efficiency and $R^2$ (determination coefficient) for streamflow were 0.67 and 0.79 respectively. Using the 10 % surface runoff reduction from experiment results for no-tillage condition in field plots of 3 % and 8 % slopes under sesami cultivation, the soil saturated hydraulic conductivity for upland crop areas was adjusted from 0.001 mm/hr to 0.0025 mm/hr in average. Under the condition, the catchment sediment, T-N (total nitrogen, TN), and T-P (total phosphorus, TP) discharge loads were reduced by 6.9 %, 7.4 %, and 7.7 % respectively.

• Journal of The Korean Society of Agricultural Engineers
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• v.53 no.4
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• pp.11-19
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• 2011

PADDIMOD2 was deloped to estimate nonpoint source pollution from paddy rice fields. The PADDIMOD2 was enhanced to estimate runoff and pollutant load during non-growing as well as growing season and to be easily used for public by development of Excel based system. Nutrient concentration and hydrology were based on Dirac delta function and continuous source function, and tank model for growing season and Event Mean Concentrations (EMCs) and SCS-Curve Number method for non-growing season. The PADDIMOD2 consists of three main component (input data, parameters data, and output data) by including eight Excel spread sheets. As a result of model application, total precipitation and irrigation were 1,051.7 mm and 439.2 mm, respectivley and surface runoff and water loss including infiltration and evapotranspiration were 463.0 mm and 947.9 mm, respectively. Annual nutrient loadings of T-N and T-P from study area were 6.7 kg/$km^2$/day and 0.5 kg/$km^2$/day, respectively. Development of PADDIMOD2 was focused on minimizing input data and maximizing user friendly system and is expected to be useful tool to evaluate various non-structure BMPs and estimate unit load from paddy rice fields for application at Korean TMDL.

• Journal of Environmental Health Sciences
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• v.34 no.3
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• pp.247-254
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• 2008

Non-point source pollution that originates from surface applied chemicals in either liquid or solid form is a part of urban activities and it appears in the surface runoff caused by rainfall. This study investigates the characteristics of non point source pollution in relation to storm events and the first washing effect in the Study area, which is comprised of different land use types. Then, a Best Management Practices (BMP) model, for urban areas, is applied with the Storm water Management Model (SWMM) Windows Interface which was developed by the EPA in the USA. During the storm event analysis of the hydrographic and pollutographic data showed that the peak of pollutants concentration was within the peak flow, 30 to 60 minute into the storm event in the Study area. The results of simulation using SWMM Windows Interface, Structure Techniques as applied in the study were highly efficient for removal of pollutants. Predicted removal efficiency was 26.0% for SS, 22.1 for BOD, 24.1% for COD, 20.6% for T-N, and 21.6% for T-P, respectively.

• BMB Reports
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• v.51 no.3
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• pp.126-133
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• 2018

Hippo signaling plays critical roles in regulation of tissue homeostasis, organ size, and tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ through MST1/2 and LATS1/2 pathway. It is also engaged in cross-talk with various other signaling pathways, including WNT, BMPs, Notch, GPCRs, and Hedgehog to further modulate activities of YAP/TAZ. Because YAP and TAZ are transcriptional coactivators that lack DNA-binding activity, both proteins must interact with DNA-binding transcription factors to regulate target gene's expression. To activate target genes involved in cell proliferation, TEAD family members are major DNA-binding partners of YAP/TAZ. Accordingly, YAP/TAZ were originally classified as oncogenes. However, YAP might also play tumor-suppressing role. For example, YAP can bind to DNA-binding tumor suppressors including RUNXs and p73. Thus, YAP might act either as an oncogene or tumor suppressor depending on its binding partners. Here, we summarize roles of YAP depending on its DNA-binding partners and discuss context-dependent functions of YAP/TAZ.

• Korean Journal of Soil Science and Fertilizer
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• v.49 no.5
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• pp.440-448
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• 2016

Nonpoint sources of pollution (NPS) is defined as diffuse discharges of pollutants (e.g., nutrient, pesticide, sediment, and enteric microorganism) throughout the natural environment and they are associated with a variety of farming practices. Previous studies found that water soluble anionic polyacrylamide (PAM) is one of the highly effective measures for enhancing infiltration, reducing runoff, preventing erosion, controlling nonpoint source of pollutants, and eventually protecting soil and water environment. Potential benefits of PAM treatment in agricultural soil and water environments have been revealed by many research and they include low cost, easy and quick application, and suitability for use with other Best Management Practices (BMPs) for NPS control. This study reviews the various applications of PAM and discusses its further potentials in agricultural environment.

• BMB Reports
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• v.49 no.2
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• pp.122-127
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• 2016

Engineered bone tissue is thought to be the ideal alternative for bone grafts in the treatment of related bone diseases. BMP9 has been demonstrated as one of the most osteogenic factors, and enhancement of BMP9-induced osteogenesis will greatly accelerate the development of bone tissue engineering. Here, we investigated the effect of insulin-like growth factor 1 (IGF1) on BMP9-induced osteogenic differentiation, and unveiled a possible molecular mechanism underling this process. We found that IGF1 and BMP9 are both detectable in mesenchymal stem cells (MSCs). Exogenous expression of IGF1 potentiates BMP9-induced alkaline phosphatase (ALP), matrix mineralization, and ectopic bone formation. Similarly, IGF1 enhances BMP9-induced endochondral ossification. Mechanistically, we found that IGF1 increases BMP9-induced activation of BMP/Smad signaling in MSCs. Our findings demonstrate that IGF1 can enhance BMP9-induced osteogenic differentiation in MSCs, and that this effect may be mediated by the enhancement of the BMP/Smad signaling transduction triggered by BMP9.

• Journal of The Korean Society of Agricultural Engineers
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• v.57 no.4
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• pp.51-59
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• 2015

Various Best Management Practices (BMPs) have been suggested to reduce soil erosion and non point source (NPS) pollutant loads from agricultural fields. However, very little research regarding water quality improvement with No-till (NT) has been performed in Korea. Thus, effects of NT were investigated in this study. The objective of the study was to investigate the effect of NT on the surface runoff and sediment discharge in a field. Eight experimental plots of $5{\times}30m$ in size and 3 % or 8 % in slope prepared on gravelly sandy loam soil were treated with Conventional-till (CT) and NT. Runoff and NPS pollution discharge were monitored and compared the treatments. The amounts of rainfall from 13 monitored events ranged from 28.7 mm to 503.5 mm. The runoff amount was reduced by 17.6~59.2 % in 3 % NT and 29.6~53.2 % in 8 % NT. The average NPS pollution loads of the 3 % NT plots and 8 % NT plot were reduced about 45.1~89.2 % and 47.7~98.0 % compared to those of the CT plots, respectively. This research revealed that NT can reduce the NPS pollution loads substantially as well as increase the crop yield. Runoff and NPS pollution loads reduction by NT method could be contribute to improve the water quality of streams in agricultural regions.

• International Journal of Oral Biology
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• v.32 no.3
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• pp.103-107
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• 2007

We hypothesized that plaque-associated bacteria may have a role in maintenance of alveolar bone. To test it, immortalized gingival epithelial HOK-16B cells were co-cultured with live or lysed eight plaque bacterial species and the expression levels of bone morphogenetic protein (BMP)-2 and -4 were examined by real time reverse transcription-polymerase chain reaction. Un-stimulated HOK-16B cells expressed both BMP-2 and -4. Co-culture with plaque bacterial lysates had significant effects on the level of BMP-2 but not on that of BMP-4. Five species including Streptococcus sanguinis, S. gordonii, Veillonella atypica, Porphyromonas gingivalis, and Treponema denticola substantially up-regulated the level of BMP-2. In contrary to the upregulatory effect of lysate, live T. denticola suppressed the expression of BMP-2. In addition, in vitro osteoblastic differentiation assay using C2C12 cells and the conditioned medium of HOK-16B cells confirmed the production of BMPs by gingival epithelial cells and the modulation of BMP expression by the lysates of S. sanguinis and T. denticola. In conclusion, we have shown that plaque bacteria can regulate the expression of BMP-2 by gingival epithelial cells, the physiologic meaning of which needs further investigation.