• Journal of Korean Academy of Fundamentals of Nursing
• /
• v.10 no.1
• /
• pp.30-36
• /
• 2003

Purpose: The strength of hand grip, low back muscles and knee joint muscles were measured and then compared to the bone mineral density (BMD) of each forearm bones (including ulna and radius), lumbar spine, and femur in young women in order to identify the relationship between muscle strength and bone mineral density. Method: The BMD was measured with a Dual Energy X-ray Absorptiometry and muscle strength was measured with a handgrip dynamometer and a Cybex Norm. Data were analyzed with frequencies, percentages, means, and Pearson correlation coefficients. Result: 1) Higher grip strength correlated positively with higher BMD in the forearm (r=.246, p=.007), higher low back extensor strength with higher BMD in the femur (neck, trochanter and Ward's triangle)($r=.323{\sim}.226$, $p=.003{\sim}.043$) and higher strength in the knee joint extensor with higher BMD in the lumbar spine (r=.227, p=.041), femur neck, and femur trochanter significantly ($r=.295{\sim}.226$, $p=.007{\sim}.043$). There was no significant correlation between the strength of low back extensors and BMD in the lumbar spine, now with strength of knee joint flexor and the BMD in the femur. 2) The muscle strength of each part of the body had significant positive correlations to each other part ($r=.255{\sim}.728$ $p=.021{\sim}.000$) Conclusion: The results of this study showed that with the development of a muscle there was an increased BMD of the corresponding part, and the BMD of each part was influenced by adjacent muscles. To promote the health of bones, it is important to strengthen the muscles of related bones, based on balanced development of all muscles.

• Journal of Korean Academy of Nursing
• /
• v.29 no.3
• /
• pp.530-540
• /
• 1999

The purpose of this study was to investigate the life style, self-efficacy, and Bone Marrow Density (BMD) in osteoporosis female patients. The subjects were recruited at the four Osteoporosis Clinics. A convenience sample of 190 women completed a survey instrument which included the Osteoporosis Self-Efficacy Questionnaire, Life Style Questionnaire and demographic items. BMD of L$_4$ was measured by Dual Photon Absor photiometry. The sample ranged in age from 40 to 82 years (Mean＝60.28). Eighty-one percent were married and 14.9% were widowed. Forty-four percent lived with their spouse and children. Excercise, diet, medication, alcohol consumption, and smoking were measured to investigate the life style. Fifty-seven percent of the subjects exercised regularly. Mountain climbing, brisk walking, and free gymnastics were frequently cited excercises by the subjects in this study. Sixty percent drank one cup of milk and 34.7% had 1.13 cups of coffee in a day. Thirty-nine percent used calcium supplements, 9.5% drank alcohol, and 3.2% smoked cigarettes. Economic status and education level were related to self-efficacy. Age, economic status, and education level were related to BMD. As a life style, exercise, diet(milk, ice cream, and coffee), and medication(calcium) were associated with self-efficacy. The subjects who exercised regularly and took calcium supplements for a longer time had a higher level of self-efficacy than those who did not. Smoking and alcohol consumption had no relationship with self-efficacy. Excercise, medication(calcium), and alcohol consumption were related to BMD. The subjects who took calcium supplements for a longer time had a higher level of BMD. Alcohol consumption was not related to self-efficacy but related to BMD. The subject who drank alcohol had a higher level of BMD than those who did not drink. The amount of alcohol consumption was positively related to BMD.

• Journal of Preventive Medicine and Public Health
• /
• v.53 no.5
• /
• pp.342-352
• /
• 2020

Objectives: The aim of this retrospective cohort study was to investigate whether non-alcoholic fatty liver disease (NAFLD) was associated with incident bone mineral density (BMD) decrease. Methods: This study included 4536 subjects with normal BMD at baseline. NAFLD was defined as the presence of fatty liver on abdominal ultrasonography without significant alcohol consumption or other causes. Decreased BMD was defined as a diagnosis of osteopenia, osteoporosis, or BMD below the expected range for the patient's age based on dual-energy X-ray absorptiometry. Cox proportional hazards models were used to estimate the hazard ratio of incident BMD decrease in subjects with or without NAFLD. Subgroup analyses were conducted according to the relevant factors. Results: Across 13 354 person-years of total follow-up, decreased BMD was observed in 606 subjects, corresponding to an incidence of 45.4 cases per 1000 person-years (median follow-up duration, 2.1 years). In the model adjusted for age and sex, the hazard ratio was 0.65 (95% confidence interval, 0.51 to 0.82), and statistical significance disappeared after adjustment for body mass index (BMI) and cardiometabolic factors. In the subgroup analyses, NAFLD was associated with a lower risk of incident BMD decrease in females even after adjustment for confounders. The direction of the effect of NAFLD on the risk of BMD decrease changed depending on BMI category and body fat percentage, although the impact was statistically insignificant. Conclusions: NAFLD had a significant protective effect on BMD in females. However, the effects may vary depending on BMI category or body fat percentage.

• Molecules and Cells
• /
• v.23 no.2
• /
• pp.246-251
• /
• 2007

Osteoporosis is a common metabolic bone disease characterized by low bone mineral density (BMD) with an increased risk of fracture. Low bone mass results from an imbalance between bone formation by osteoblasts and bone resorption by osteoclasts. Microphthalmia-associated transcription factor (MITF) plays a critical role in osteoclast development and thus is an important candidate gene affecting bone turnover and BMD. In order to investigate the genetic effects of MITF variations on osteoporosis, we directly sequenced the MITF gene in 24 Koreans, and identified fifteen sequence variants. Two polymorphisms (+227719C > T and +228953A > G) were selected based on their allele frequencies, and then genotyped in a larger number of postmenopausal women (n = 560). Areal BMD ($g/cm^2$) of the anterior-posterior lumbar spine and the non-dominant proximal femur was measured by dual-energy X-ray absorptiometry. We found that the MITF + 227719C > T polymorphism was significantly associated with low BMD of the trochanter (p = 0.005-0.006) and total femur (p = 0.02-0.03) (codominant and dominant models), while there was no association with BMD of the lumbar spine. The MITF+228953A > G polymorphism was also associated with low BMD of the femoral shaft (p = 0.05) in the recessive model. Haplotype analysis showed that haplotype 3 of the MITF gene (MITF-ht3) was associated with low BMD of the trochanter (p = 0.03-0.05) and total femur (p = 0.05) (dominant and codominant models). Our results suggest that MITF variants may play a role in the decreased BMD of the proximal femur in postmenopausal women.

• Journal of the East Asian Society of Dietary Life
• /
• v.24 no.6
• /
• pp.710-722
• /
• 2014

This study investigated factors affecting the bone mineral density (BMD) of Korean adult men. Data on BMD and anthropometric (height, weight, body mass index, BMI, waist circumference, body fat) and biochemical(total cholesterol, vitamin D, alkaline phosphatase, ALP) measurements were obtained from the Fourth and Fifth Korea National Health and Nutrition Examination Surveys (KNHANES, 2008~2011). Overall, BMD of the subjects was decreased from year to year (T-score of 30~39 yr decreased to 0.447 (2010~2011) from 0.106(2008~2009) and in 50~59 yr decreased to 0.234 from 0.033. Age was negatively associated with BMD (T-score 0.361 of 20~29 yr group and -0.894 of ${\geq}80yr$ group in total femoral). According to increase of weight, BMI and waist circumference continuously increased BMD. High value of total cholesterol (T-score 0.157 of 201~<230 mg/dL group and 0.064 of ${\geq}230mg/dL$ group in total femoral) and alkaline phosphatase (T-score 0.337 of ${\leq}102IU/L$ group and -0.270 of ${\geq}336IU/L$ group in total femoral) were associated with lower BMD. Overall height, weight and BMI were positively associated with BMD, and ALP were negatively associated with BMD. Finding of the present study showed that bone loss may be associated with various factors such as age, weight, BMI, total cholesterol, vitamin D and ALP density and that much attention should be paid to bone health of adult men. Therefore, practical and systematic programs are required to improve the BMD of adult men as well as to maintain bone health.

• Journal of the Korean Dietetic Association
• /
• v.20 no.3
• /
• pp.157-173
• /
• 2014

The main purpose of this study was to investigate factors that affect bone mineral density (BMD) in Korean adult women ($20{\sim}80{\leq}yr$). Data on BMD, anthropometric (height, weight, body mass index, waist circumference, and body fat), and biochemical (total cholesterol, vitamin D, and alkaline phosphatase) measurements were obtained from the Fourth and Fifth Korea National Health and Nutrition Examination Surveys (KNHANES, 2008~2011). Overall, the BMD of subjects had decreased from year to year: the T-scores decreased from 0.657 (2008~2009) to 0.295 (2010~2011) in 40~49 yr group and from 0.076 to -0.081 in 50~59 yr group. Age was negatively associated with BMD (T-scores of 0.388 in 20~29 yr group and -1.952 in ${\geq}80yr$ group for total femoral). BMD continuously increased with increased weight and body mass index (BMI). High values of total cholesterol (T-scores of -0.005 in 201~229 mg/dL group and -0.094 in ${\geq}230mg/dL$ group for total femoral) and alkaline phosphatase (T-scores of 0.481 in ${\geq}102IU/L$ group and -0.674 in ${\geq}336IU/L$ group for total femoral) were associated with lower BMD. Overall height, weight, and BMI were positively associated with BMD, whereas total cholesterol and alkaline phosphatase (ALP) were negatively associated with BMD. Findings of the present study show that bone loss may be associated with various factors such as age, weight, BMI, total cholesterol, and ALP et al., and that much attention should be paid to bone health of adult women. Therefore, practical and systematic programs are required to improve the BMD of adult women as well as to maintain healthy bone levels.

• Journal of Korean Medicine for Obesity Research
• /
• v.5 no.1
• /
• pp.47-56
• /
• 2005

Objectives : This study was performed to investigate the change of bone mineral density(BMD) after 1 month Kirindiet therapy including very low calory diet(VLCD) in middle-aged obese women$(65>age{\geqq}40,\;BMI{\geqq}25)$ under normal $BMD(T-score{\leqq}0)$. Methods : We examined body weight, body fat, protein mass and BMD of 13 middle-aged obese women who visited to Kirin Oriental Hospital from Sep. 7. 2004 to Oct. 12. 2005 before and after 1 month Kirindiet therapy. Body weight, body fat and protein mass was checked by Inbody 4.0 and BMD was checked by quantitated computed tomography. Wilcoxon signed rank test was used for analyzing changes of body weight, body fat, protein mass and BMD before and after treatment. Results : Alter 1 month treatment body weight(-4.89Kg, -6.74%, p=0.001), body fat(-3.47Kg, p=0.001) and protein mass(-0.97Kg, p=0.006) was significantly reduced. BMD was significantly increased in all cases(+4.87mg/cc, +4.16%, p=0.001). Though body weight, body fat and protein mass were significantly reduced, BMD was significantly increased(p<0.01). Conclusions : In this study, we can conclude that after 1 month Kirindiet therapy including VLCD, BMD in middle-aged obese women under normal BMD was significantly increased inspite of reduction of body weight, body fat and protein mass.

• Journal of radiological science and technology
• /
• v.41 no.1
• /
• pp.47-51
• /
• 2018

To evaluate the applicability of osteoporosis management by statistical analysis of the correlation between bone mineral density (BMD) changes after menopause by dividing the T-score of bone mineral density measured by dual energy X-ray absorptiometry do. Between January 1, 2016 and July 31, 2017, women who visited the medical center of W Medical Center were enrolled in this study. The postmenopausal period was divided into 5 groups, There were 18 patients within 5 years, 44 patients in 6~10 years, 134 patients in 11~15 years, 109 patients in 16~20 years and 21 patients in 21 years or older. And postmenopausal women. Bone mineral density (BMD) of the lumbar spine and femur was measured using a dual energy X-ray absorptiometry. The lowest value among lumbar spine 1, 2, 3 and 4 and the lowest value among the femoral neck, greater trochanter, total femur, and ward Values were measured. The statistical significance was analyzed by using bivariate correlation coefficient method and one - way ANOVA. In 326 patients who underwent BMD, the correlation between bone mineral density and postmenopausal BMD showed a negative correlation (-.159, p<.01) with BMD of femur and BMD of lumbar spine The correlation between the menopausal period and negative (-.208, p<.01) was shown. There was a significant difference (p<.012) between the postmenopausal femur bone density and the mean value of the lumbar spine BMD (p<.000). The relationship between bone mineral density (BMD) and postmenopausal women's postmenopausal status can be estimated by estimating the bone mineral density and using it as a basic data for osteoporosis management.

• Journal of Radiation Industry
• /
• v.11 no.1
• /
• pp.27-31
• /
• 2017

Reliable follow-up of bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) is essential in clinical practice. When there is a difference in the BMD values from DXA systems in the same patient, cross calibration equation is required for the reliable follow-up. Unfortunately, no equation is existed in BMD measure between GE Lunar Prodigy Advance (US, GE Healthcare; LPA) and Osteosys Dexxum T (Korea, Osteosys; ODT) DXA systems. In this study, we evaluate the agreement of BMD values between LPA and ODT and suggest the cross calibration equation using European spine phantom (ESP) with two systems. We performed BMD measurements using ten scans with ESP in each DXA systems. We compared BMD values and calculated cross calibration equation by linear regression analysis. The comparison between the LPA and ODT bone densitometers used the ESP. Compared to the ESP BMD values, ODT underestimated 14.36% and LPA overestimated 12.96%. The average of total BMD measurement values acquired with ODT were 21.44% lower than those from LPA. Cross-calibration equation for LPA and ODT was derived from ESP. We calculated simple cross calibration equation for LPA and ODT DXA systems. Cross-calibration equation is necessary for the reliable follow-up of BMD values in two different systems.

• Journal of the Korean Society of Radiology
• /
• v.16 no.1
• /
• pp.53-59
• /
• 2022

DEXA, as the standard areal bone mineral density (aBMD) measurement method, often shows an insuficient correlation between aBMDs of the measured bones and referring bones and is inaccurate due to the mass effect. In contrast, quantitative computer tomography (QCT), as a volumetric BMD (vBMD) measurement method, is being advanced so that it uses less radiation before, owing to improved CT device and computer imaging technology. Because dual-energy CTs can modulate the image signals showing tumor or specific chemicals as well as the ability to measure vBMD, they are expanding their application. For pre-checking vBMD of surgeon-specific bone volume at implantation candidate sites, a finite element creation-based local vBMD measurement technique was developed. The local vBMD measurement function for surgeon-specific shape volumes will be added to clinical imaging systems.