• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2008.05a
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• pp.114-114
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• 2008

• Bulletin of the Korean Chemical Society
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• v.33 no.12
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• pp.4007-4014
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• 2012

Efficient synthetic route to novel 4'-fluorinated 5'-deoxythreosyl phosphonic acid nucleosides was described from glyceraldehyde using Horner-Emmons reaction in the presence of triethyl ${\alpha}$-fluorophosphonoacetate. Glycosylation reaction of nucleosidic bases with glycosly donor 14 gave the nucleosides which were further phosphonated and hydrolyzed to reach desired nucleoside analogues. Synthesized nucleoside analogues 18, 21, 25 and 28 were tested for anti-HIV activity as well as cytotoxicity. Adenine derivatives 18 and 21 showed significant anti-HIV activity up to $100{\mu}M$.

• 대한치주과학회:학술대회논문집
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• 2006.11a
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• pp.128-128
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• 2006

• 대한치주과학회:학술대회논문집
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• 2006.11a
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• pp.129-129
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• 2006

• (The)Korea Educational Review
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• v.14 no.2
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• pp.155-179
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• 2008

The objective of this study was to analyze the satisfaction of graduate students participating in the Brain Korea21 (BK21) project in five supporting areas of the project: curriculum, job searching and career development, academic development, the globalization of education, and educational environment. A further objective was to find efficient methods of providing students with stable academic and financial support for their research in order to develop them as distinguished researchers. In order to answer research questions, this study conducted a survey of the BK21 project satisfaction with students majoring in humanities or social sciences and analyzed the survey results. The tool has 7 dimensions: 'curriculum', 'job searching and career development', 'stable support for academic development', 'support for academic activities out of school', 'globalization of education', 'lectures in English', and 'educational environment'. The survey found that survey participants were in general satisfied with the BK21 project. Of these 7 dimensions, the results showed remarkably high satisfaction dimensions for 'stable support for academic development' and 'support for academic activities out of school' while indicating a comparatively low satisfaction for 'job searching and career development'. The result and analysis of this study suggests that the BK21 project needs to emphasize the following: PR for the project, provide opportunities for the training for career development and job information to students, modify the areas of academic support, remodel programs of short- and long-term studies in foreign countries, improve the educational service system for lectures in English, and secure research facilities.

• Bulletin of the Korean Chemical Society
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• v.33 no.8
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• pp.2574-2580
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• 2012

The discovery that threosyl phosphonate nucleoside (PMDTA, $EC_{50}=2.53{\mu}M$) is a potent anti-HIV agent has led to the synthesis and biological evaluation of 5'-deoxy versions of threosyl phosphonate nucleosides. In the present study, (E)-3'-phosphonoalkenyl and 3'-phosphonoalkyl nucleoside analogues 13, 16, 20 and 23 were synthesized from acetol and tested for anti-HIV activity and cytotoxicity. The adenine analogue 16 was found to exhibit moderate in vitro anti-HIV-1 activity ($EC_{50}=22.2{\mu}M$).

• Journal of Pharmaceutical Investigation
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• v.41 no.1
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• pp.1-7
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• 2011

The effects of different formulation variables including pressure sensitive adhesive (PSA), permeation enhancer, thickness of the matrix and loading amount of drug on the transdermal absorption of galantamine were investigated across the hairless mouse skin. The permeation profile of galantamine was different depending on the types of PSA, loading amount of drug, thickness of the matrix and type of enhancer used. Highest flux of galantamine was obtained from acrylic PSA but crystals were formed in the patch within 72 h. Among the PSAs screened, crystal formation was not observed only in the patches formulated in Styrene Butadiene Styrene (SBS) matrix. Permeation rate increased linearly as the concentration of galantamine in SBS matrix increased from 2.5 to 15% w/w. Among the enhancers screened, Brij$^{(R)}$ 30 provided highest flux of galantamine. Matrix thickness of 80 ${\mu}m$ was optimum for maintaining adhesiveness as well as consistently delivering galantamine for longer period of time.

• Journal of Veterinary Clinics
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• v.35 no.6
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• pp.302-307
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• 2018

This report describes the unusual ultrasonography features of chronic hypertrophic pyloric gastropathy in two dogs - a 12-year-old neutered male Pekingese (case 1) and an 11-year-old spayed female Shih Tzu (case 2) - with chronic vomiting and weight loss. Chronic hypertrophic pyloric gastropathy can be observed as the focal thickening of the pyloric wall with normal layers on ultrasonography images. However, in case 1, gastric neoplasia could not be ruled out because of the presence of regional lymph node enlargement; in case 2, an intussusception was tentatively diagnosed because of a mass within the pylorus, which appeared to be connected to the descending duodenum on the longitudinal image. In both cases, focally thickened pyloric walls were demonstrated through exploratory laparotomy, and the histopathological diagnosis of chronic hypertrophic pyloric gastropathy was made. Ultrasonography is useful for imaging the gastrointestinal tract, and the typical ultrasonographic features of chronic hypertrophic pyloric gastropathy have been reported. However, the possibility, that chronic hypertrophic pyloric gastropathy can present unusual ultrasonographic findings similar to those of tumors or intussusception, should also be considered.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.45-60
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• 2020

The Brain Korea 21 (i.e., BK21) is a state-led higher education funding project that started in 2013. Previous literature investigating the effectiveness of the project mainly focused on massive quantitative outcomes of funded teams, and many studies reporting only self-reported data of graduate students who participated in the project. Therefore, there were not many BK21 studies that thoroughly examined the graduate students' performance, ability, satisfaction, etc. This study aims to determine the effect of the BK21 project participation on graduate students' academic performance, using objective (the number of published papers), self-rating (graduates' satisfaction), and other-rating (advisor's performance evaluation) data, which were sampled from 2013 to 2019 from a single funded team on a one-departmental-unit. The results showed that the participating graduate students had more published papers, and had higher performance evaluation scores in research, and overall abilities, than the non-participating graduate students. Further, participating students were largely satisfied with BK21 supports. This study has significance in that it demonstrates the positive influence of the BK21 project on graduate students' academic performance and satisfaction by the thorough investigation of a single social science funded team.

• Biomolecules & Therapeutics
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• v.15 no.2
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• pp.73-77
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• 2007

N,N-Dimethyl-D-ribo-phytosphingosine (DMPH) is an N-methyl derivative of sphingosine. In the present paper, we studied effects of DMPH on intracellular Ca$^{2+}$ concentration, pH, glutamate uptake, and cell viability in human 1321N1 astrocytes. DMPH increased intracellular Ca$^{2+}$ concentration and cytosolic pH significantly in a dose-dependent manner. DMPH also inhibited glutamate uptake by 1321N1 astrocytes. Finally, treatment of cells with DMPH for 24 h reduced viability of cells largely and concentration-dependently. In summary, DMPH increased intracellular Ca$^{2+}$ concentration and pH, inhibited glutamate uptake and evoked cytotoxicity in 1321N1 astrocytes. Our observations with DMPH in the 1321N1 astrocytes would enhance understanding of DMPH actions in the brain.