• Journal of People, Plants, and Environment
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• v.22 no.6
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• pp.629-639
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• 2019

This study was conducted to analyze the characteristics of visitors to Hadong Bukcheon Iceland Poppy (BIP) Festival in order to sustain and enhance local flower festivals as a garden tourism. A questionnaire was distributed to BIP Festival visitors from May 18 to 27, 2018. A total of 167 responses were subject to be analyzed. Descriptive statistics analysis was mainly used and focused on describing the results in direct to explain the BIP Festival as a garden tourism. The number of female visitors and those in their 40s and 50s was high. Most of the visitors were found to live in other cities or counties near the area where BIP Festival was held and to prefer festivals held on the theme of nature and local features. The revisit rate and awareness of BIP Festival were 52.1% and 72.5% respectively. They mainly obtained the information on BIP Festival from people around them including family members, friends and colleagues, or from the Internet. Most answered that BIP festival was the most important destination on their trip. The major motives of BIP Festival visit included "spending quality time with family or friends (34.1%)", "appreciating Iceland poppy and gardens (25.6%)", and "enjoying oneself (tranquility, mental rest, etc.; 21.3%). As a companion, family and friends/colleagues accounted for 62.3% and 26.3% respectively. Most were found to spend 1-2 hours on visiting BIP festival and stay in Hadong county for a quarter of a day. In satisfaction of BIP Festival itself, "display and maintenance of Iceland poppy (3.76)" and "easiness of viewing (places arrangement, path, etc.) (3.57)" were high. In satisfaction of public relation and information, "service and hospitality of guides and desk clerks (3.66)" was high. The intention to revisit BIP Festival was nearly affirmative (3.73-3.80).

• Animal cells and systems
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• v.12 no.4
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• pp.211-217
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• 2008

Bax, a pro-apoptotic member of Bcl-2 family proteins, plays a central role in the mitochondria-dependent apoptosis. Apoptotic signals induce the translocation of Bax from cytosol into the mitochondria, which triggers the release of apoptogenic molecules such as cytochrome C and apoptosis-inducing factor, AIF. Bax-inhibiting peptide(BIP) is a cell permeable peptide comprised of five amino acids designed from the Bax-interaction domain of Ku70. Because BIP inhibits Bax translocation and Bax-mediated release of cytochrome C, BIP suppresses Bax-dependent apoptosis. In this study, we observed that BIP inhibited staurosporine-induced neuronal death in cultured cerebral cortex and cerebellar granule cells, but BIP failed to rescue granule cells from trophic signal deprivation-induced neuronal death, although both staurosporine-induced and trophic signal deprivation-induced neuronal death are dependent on Bax. These findings suggest that the mechanisms of the Bax activation may differ depending on the type of cell death induction, and thus BIP exhibits selective suppression of a subtype of Bax-dependent neuronal death.

• Development and Reproduction
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• v.21 no.4
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• pp.407-415
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• 2017

In the present study, we investigated the role of binding immunoglobulin protein/glucose-regulated protein, 78-kDa (BIP/GRP78)-regulated endoplasmic reticulum (ER)-stress on meiotic maturation and cumulus cells expansion in porcine cumulus-oocyte complexes (COCs). Previously, it has been demonstrated that unfolded protein response (UPR)-related genes, such as molecules involved in ER-stress defense mechanisms, were expressed in matured oocytes and cumulus cells during in vitro maturation (IVM) of porcine oocytes. However, BIP/GRP78-mediated regulation of ER stress in porcine oocytes has not been reported. Firstly, we observed the effects of knockdown of BIP/GRP78 (an UPR initiation marker) using porcine-specific siRNAs (#909, #693, and #1570) on oocyte maturation. Among all siRNAs, siRNA #693 significantly reduced the protein levels of UPR marker proteins (BIP/GRP78, ATF4, and P90ATF6) in porcine COCs observed by Western blotting and immunofluorescence analysis. We also observed that the reduction of BIP/GRP78 levels by siRNA#693 significantly inhibited the meiotic maturation of oocytes (siRNA #693: $32.5{\pm}10.1%$ vs control: $77.8{\pm}5.3%$). In addition, we also checked the effect of ER-stress inhibitors, tauroursodeoxycholic acid (TUDCA, $200{\mu}M$) and melatonin ($0.1{\mu}M$), in BIP/GRP78-knockdown oocytes. TUDCA and melatonin treatment could restore the expression levels of ER-stress marker proteins (BIP/GRP78, $p-eIF2{\alpha}$, $eIF2{\alpha}$, ATF4, and P90ATF6) in siRNA #693-transfected matured COCs. In conclusion, these results demonstrated that BIP/GRP78-mediated regulation of UPR signaling and ER stress plays an important role in in vitro maturation of porcine oocytes.

• Bulletin of the Korean Chemical Society
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• v.34 no.7
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• pp.2117-2124
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• 2013

The binding properties and sequence selectivities of ${\Delta}{\Delta}$- and ${\Lambda}{\Lambda}-[{\mu}-Ru_2(phen)_4(bip)]^{4+}$ (bip = 4,4'-biphenylene (imidazo [4,4-f][1,10]phenanthroline) complexes with $poly[d(A-T)_2]$ and $poly[d(G-C)_2]$ were investigated using conventional spectroscopic methods. When bound to $poly[d(A-T)_2]$, a large positive circular dichroism (CD) spectrum was induced in absorption region of the bridging moiety for both the ${\Delta}{\Delta}$- and ${\Lambda}{\Lambda}-[{\mu}-Ru_2(phen)_4(bip)]^{4+}$ complexes, which suggested that the bridging moiety sits in the minor groove of the polynucleotide. As luminescence intensity increased, decay times became longer and complexes were well-protected from the negatively charged iodide quencher compared to that in the absence of $poly[d(A-T)_2]$. These luminescence measurements indicated that Ru(II) enantiomers were in a less polar environment compared to that in water and supported by minor groove binding. An angle of $45^{\circ}$ between the molecular plane of the bridging moiety of the ${\Delta}{\Delta}-[{\mu}-Ru_2(phen)_4(bip)]^{4+}$ complex and the local DNA helix axis calculated from reduced linear dichroism ($LD^r$) spectrum further supported the minor groove binding mode. In the case of ${\Lambda}{\Lambda}-[{\mu}-Ru_2(phen)_4(bip)]^{4+}$ complex, this angle was $55^{\circ}$, suggesting a tilt of DNA stem near the binding site and bridging moiety sit in the minor groove of the $poly[d(A-T)_2]$. In contrast, neither ${\Delta}{\Delta}$-nor ${\Lambda}{\Lambda}-[{\mu}-Ru_2(phen)_4(bip)]^{4+}$ complex produced significant CD or $LD^r$ signal in the absorption region of the bridging moiety. Luminescence measurements revealed that both the ${\Delta}{\Delta}$- and ${\Lambda}{\Lambda}-[{\mu}-Ru_2(phen)_4(bip)]^{4+}$ complexes were partially accessible to the $I^-$ quencher. Furthermore, decay times became shorter when bis-Ru(II) complexes bound to $poly[d(G-C)_2]$. These observations suggest that both the ${\Delta}{\Delta}$- and ${\Lambda}{\Lambda}-[{\mu}-Ru_2(phen)_4(bip)]^{4+}$ complexes bind at the surface of $poly[d(G-C)_2]$, probably electrostatically to phosphate group. The results indicate that ${\Delta}{\Delta}$- and ${\Lambda}{\Lambda}-[{\mu}-Ru_2(phen)_4(bip)]^{4+}$ are able to discriminate between AT and GC base pairs.

• Review of KIISC
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• v.17 no.5
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• pp.50-56
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• 2007

X.tsm은 템플릿 관리 위치와 바이오인식 인증 위치에 따라 9개의 모델을 제시한 바이오 인증 프로토콜로, 2006년 12월 제네바 ITU-T SG17 Q.8 회의에서 First of Recomanda-tion 단계로 채택된 표준이다. 바이오인식 제품 응용 인터페이스(BioAPI)에 입각하여 6개의 모델을 제시한 BIP(BioAPI Interworking Protocol)은 2007년 1월 뉴질랜드 ISO/IEC JTC1 SC37 WG2 회의에서 FCD로 제정된 국제표준이다. X.tsm과 BIP간의 중복성 문제가 제기됨에 따라 ITU-T SG17 Q8(Telebiometrics)에서 2006년 4월 제주에서 두 표준과제의 공통사항을 반영한 X.bip가 채택되어 표준화가 진행되고 있다. 이 논문에서는 바이오 주요 컴포넌트의 개념을 명확하고, 모델 간 중복성을 제거하기 위해 13개의 새로운 모델을 제안한다. 두 표준에서 새로운 모델을 공통적으로 수용하게 되면, 표준안을 준용하는 사용자 입장에서 구현을 용이하게 할 수 있다.

• Asian-Australasian Journal of Animal Sciences
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• v.27 no.4
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• pp.567-573
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• 2014

Hormonal and nutrient signals regulate leptin synthesis and secretion. In rodents, leptin is stored in cytosolic pools of adipocytes. However, not much information is available regarding the regulation of intracellular leptin in ruminants. Recently, we demonstrated that leptin mRNA was expressed in bovine intramuscular preadipocyte cells (BIP cells) and that a cytoplasmic leptin pool may be present in preadipocytes. In the present study, we investigated the expression of cytoplasmic leptin protein in BIP cells during differentiation as well as the effects of various factors added to the differentiation medium on its expression in BIP cells. Leptin mRNA expression was observed only at 6 and 8 days after adipogenic induction, whereas the cytoplasmic leptin concentration was the highest on day 0 and decreased gradually thereafter. Cytoplasmic leptin was detected at 6 and 8 days after adipogenic induction, but not at 4 days after adipogenic induction. The cytoplasmic leptin concentration was reduced in BIP cells at 4 days after treatment with dexamethasone, whereas cytoplasmic leptin was not observed at 8 days after treatment. In contrast, acetate significantly enhanced the cytoplasmic leptin concentration in BIP cells at 8 days after treatment, although acetate alone did not induce adipocyte differentiation in BIP cells. These results suggest that dexamethasone and acetate modulate the cytoplasmic leptin concentration in bovine preadipocytes.

• Tuberculosis and Respiratory Diseases
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• v.67 no.4
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• pp.364-368
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• 2009

Bronchiolitis interstitial pneumonitis (BIP), an unclassified and newly described interstitial pneumonia, has a combined feature of prominent bronchiolitis, interstitial inflammation, and fibrosis. It is distinct from bronchiolitis obliterans or bronchiolitis obliterans organizing pneumonia (BOOP). BIP has a better prognosis than common cases of interstitial pneumonia. However, BIP has a poorer prognosis than BOOP. BIP's response to corticosteroids is not as successful as BOOP's response to this treatment. We encountered the case of a 31-year-old woman with BIP with an initial presentation of dyspnea and a cough that had lasted for 3 months. The patient's chest CT scan demonstrated patchy ground glass opacities and multiple ill-defined centrilobular nodules in both lungs, suggesting military tuberculosis or nontuberculous mycobacterial infection. A video-assisted thoracoscopic lung biopsy resulted in the diagnosis of BIP. Clinical symptoms, pulmonary lesions, and pulmonary function tests were improved after oral glucocorticoid therapy.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.47 no.2
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• pp.51-59
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• 2010

Two logic transformations, De Morgan and re-substitution, are sufficient to convert a unate gate network (UGN) to a more general balanced inversion parity (BIP) network. Circuit classes of interest are discussed in detail. We prove that De Morgan and re-substitution transformations are test-set preserving for path delay faults. Using the results of this paper, we can easily show that a high-level test set for a function z that detects all path delay faults in any UGN realizing z also detects all path delay faults in any BIP realization of z.

• ETRI Journal
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• v.32 no.5
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• pp.687-694
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• 2010

Breaks in presence (BIP) are those moments during virtual environment (VE) exposure in which participants become aware of their real world setting and their sense of presence in the VE becomes disrupted. In this study, we investigate participants' experience when they encounter technical anomalies during game play. We induced four technical anomalies and compared the BIP responses of a navigation mode game to that of a combat mode game. In our analysis, we applied a linear mixed model (LMM) and compared the results with those of a conventional regression model. Results indicate that participants felt varied levels of impact and recovery when experiencing the various technical anomalies. The impact of BIPs was clearly affected by the game mode, whereas recovery appears to be independent of game mode. The results obtained using the LMM did not differ significantly from those obtained using the general regression model; however, it was shown that treatment effects could be improved by consideration of random effects in the regression model.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.744-748
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• 2003

Developing an interactive satellite multi­media system, such as a digital video broadcasting (DVB) return channel via satellite (RCS) system, is gaining popularity over the world To accommodate the increasing traffic demand we are motivated to investigate an alternative for improving return channel utilization We develop an efficient method for optimal packet scheduling in an interactive satellite multimedia system using hybrid CDMA/TDMA channels. We formulate the timeslot-code assignment problem as a binary integer programming (BIP) problem, where the throughput maximization is the objective, and decompose this BIP problem into two sub-problems for the purpose of solution efficiency. With this decomposition, we promote the computational efficiency in finding the optimal solution of the original BIP problem Since 2001, ETRI has been involved in a development project where we have successfully completed an initial system integration test on broadband mobile Internet access via Ku-band channels using the proposed resource allocation algorithm.