• KSBB Journal
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• 제22권4호
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• pp.265-269
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• 2007

다시마 fucoidan의 식이섬유로서의 생리기능성 탐색연구의 일환으로, 다시마의 건조 분말로부터 fucoidan을 열수 추출하여 분리하고 부분정제하였으며, 이의 in-vitro 포도당 및 담즙산 흡수 지연 효과를 조사하였다. 다시마 fucoidan은 투석막을 이용한 2시간 동안의 in-vitro glucose 및 bile acid 흡수 지연 실험에서 각각 25.36$\sim$22.68% 및 27.03$\sim$33.50%의 흡수지연효과를 나타내었다. 이들 효과는 타 식이섬유와 비교하여 비교적 우수하거나 매우 우수한 효과로, 어느 정도 당뇨 및 동맥경화 억제에의 효과를 나타낼 것이 기대되어 추가 검토의 필요성이 높았다.

• 산업식품공학
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• 제13권4호
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• pp.282-288
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• 2009

A dark brownish pigment from fruit body of Auricularia auricula was isolated and characterized in this report. The pigment was obtained with a yield of 0.61%(w/w) by alkaline extraction and subsequent purification steps. It showed the positive $FeCl_3$ test which was the indication of phenolic compounds. A synthetic melanin showed a similar spectrometric characteristics to the pigment extract regarding a characteristic UV absorption between 200-250 nm and infrared absorptions profiles in the finger print region including absorption peaks at 1701 and 1624 $cm^{-1}$. Its element analysis indicated that its atomic copmposition is close to that of DOPA melanin (eumelanin). With the result of its antioxidant activity in the TNBT (5-thio-2-nitrobenzoic acid) assay, we concluded that the dark brownish pigment from A. auricula is a melanin-like compound having a powerful antioxidative activity.

• Nuclear Engineering and Technology
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• 제56권1호
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• pp.357-357
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• 2024

• 한국고분자학회지:고분자과학과기술
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• 제23권1호
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• pp.13-20
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• 2012

• 한국고분자학회지:고분자과학과기술
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• 제22권5호
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• pp.439-446
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• 2011

• Food Science and Biotechnology
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• 제18권3호
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• pp.782-787
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• 2009

In prion disease, spongiform neurodegeneration is preceded by earlier synaptic dysfunction. There is evidence that soluble N-ethylmaleimide sensitive factor attachment receptor (SNARE) complex formation is reduced in scrapie-infected in vivo models, which might explain this synaptic dysfunction because SNARE complex plays a crucial role in neuroexocytosis. In the present study, however, it is shown that prion protein (PrP) does not interfere with SNARE complex formation of 3 SNARE proteins: syntaxin 1a, SNAP-25, and synaptobrevin. Sodium dodecyl sulfate-resistant complex formation, SNAREdriven membrane fusion, and neuroexocytosis of PC12 cells were not altered by PrP. Thus, PrP does not alter synaptic function by directly interfering with SNARE complex formation.

• 한국고분자학회지:고분자과학과기술
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• 제18권5호
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• pp.458-464
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• 2007

• Journal of Microbiology and Biotechnology
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• 제26권10호
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• pp.1696-1700
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• 2016

In order to discover plant-derived signaling pathway inhibitors with antifungal properties, a two-component screening system utilizing the calcineurin and Hog1 mitogen-activated protein kinase pathways responsible for the virulence networks of Cryptococcus neoformans was employed, owing to the counter-regulatory actions of these pathways. Of the 1,000 plant extracts tested, two bioactive compounds from Miliusa sinensis were found to act specifically on the calcineurin pathway of C. neoformans. These compounds, identified as pashanone and 5-hydroxy-6,7-dimethoxyflavanone, exhibited potent antifungal activities against various human pathogenic fungi with minimum inhibitory concentration values ranging from 4.0 to >128 μg/ml.

• Journal of Industrial and Engineering Chemistry
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• 제67권
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• pp.469-477
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• 2018

We describe surgical sutures enabled with the local, sustained delivery of a TGF-${\beta}$ inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly (lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-${\beta}$ expression and fibroblast numbers during the entire 21 day testing period.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권4호
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• pp.351-356
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• 2006

This study developed an artificial neural network (ANN) to estimate the growth of microorganisms during a fermentation process. The ANN relies solely on the cumulative consumption of alkali and the buffer capacity, which were measured on-line from the on/off control signal and pH values through automatic pH control. The two input variables were monitored on-line from a series of different batch cultivations and used to train the ANN to estimate biomass. The ANN was refined by optimizing the network structure and by adopting various algorithms for its training. The software estimator successfully generated growth profiles that showed good agreement with the measured biomass of separate batch cultures carried out between at 25 and $35^{\circ}C$.