Journal of Industrial and Engineering Chemistry

  • Volume 67
  • /
  • Pages.469-477
  • /
  • 2018
  • /
  • 1226-086X(pISSN)
  • /
  • 1876-794X(eISSN)
The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment

  • Choi, Sung Yoon (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University) ;
  • Kim, Byung Hwi (Department of Biomedical Engineering, College of Medicine and Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University) ;
  • Huh, Beom Kang (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University) ;
  • Jeong, Woong (Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital) ;
  • Park, Min (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University) ;
  • Park, Hyo Jin (Department of Pathology, Seoul National University Bundang Hospital) ;
  • Park, Ji-Ho (Department of Bio and Brain Engineering and KAIST Institute of Health Science and Technology, Korea Advanced Institute of Science and Technology) ;
  • Heo, Chan Yeong (Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital) ;
  • Choy, Young Bin (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University)
  • Received : 2018.06.05
  • Accepted : 2018.07.18
  • Published : 2018.11.25
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Abstract

We describe surgical sutures enabled with the local, sustained delivery of a TGF-${\beta}$ inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly (lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-${\beta}$ expression and fibroblast numbers during the entire 21 day testing period.

Keywords

Acknowledgement

Supported by : Korea Health Industry Development Institute (KHIDI), SNUBH

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