• 제목/요약/키워드: BCR

검색결과 161건 처리시간 0.027초

Incidence and Risk Factors of Chronic Subdural Hematoma after Surgical Clipping for Unruptured Anterior Circulation Aneurysms

  • Lee, Won Jae;Jo, Kyung-Il;Yeon, Je Young;Hong, Seung-Chyul;Kim, Jong-Soo
    • Journal of Korean Neurosurgical Society
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    • 제57권4호
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    • pp.271-275
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    • 2015
  • Objective : Chronic subdural hematoma (CSDH) is a rare complication of unruptured aneurysm clipping surgery. The purpose of this study was to identify the incidence and risk factors of postoperative CSDH after surgical clipping for unruptured anterior circulation aneurysms. Methods : This retrospective study included 518 patients from a single tertiary institute from January 2008 to December 2013. CSDH was defined as subdural hemorrhage which needed surgical treatment. The degree of brain atrophy was estimated using the bicaudate ratio (BCR) index. We used uni- and multivariate analyses to identify risk factors correlated with CSDH. Results : Sixteen (3.1%) patients experienced postoperative CSDH that required burr hole drainage surgery. In univariate analyses, male gender (p<0.001), size of aneurysm (p=0.030), higher BCR index (p=0.004), and the use of antithrombotic medication (p=0.006) were associated with postoperative CSDH. In multivariate analyses using logistic regression test, male gender [odds ratio (OR) 4.037, range 1.287-12.688], high BCR index (OR 5.376, range 1.170-25.000), and the use of antithrombotic medication (OR 4.854, range 1.658-14.085) were associated with postoperative CSDH (p<0.05). Postoperative subdural fluid collection and arachnoid plasty were not showed statistically significant difference in this study. Conclusion : The incidence of CSDH was 3.1% in unruptured anterior circulation aneurysm surgery. This study shows that male gender, degree of brain atrophy, and the use of antithrombotic medication were associated with postoperative CSDH.

경제성 확보를 위한 빗물이용시설의 규모 산정 및 민감도 분석 (Evaluation of Tank Capacity of Rainwater Harvesting System to Secure Economic Feasibility and Sensitivity Analysis)

  • 문정수;김하나;박종빈;이정훈;김이호
    • 상하수도학회지
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    • 제26권2호
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    • pp.191-199
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    • 2012
  • Rainwater harvesting systems (RWHS), one of measures for on site rainwater management, have been promoted by laws, regulations and guidelines and have been increased. However, more evaluation of economic feasibility on RWHS is still needed due to seasonal imbalance of rainfall and little experiences and analysis on design and operation of RWHS. In this study, we investigated tank capacity of RWHS to secure economic validity considering catchment area and water demand, which is affected by building scale. Moreover, sensitivity analysis was performed to examine the effect of design factors, cost items and increase rate of water service charge on economic feasibility. The BCR (benefit cost ratio) is proportional to the increase in tank capacity. It is increased steeply in small tank capacity due to the effect of cost and, since then, gently in middle and large tank capacity. In case of 0.05 in the rate of tank volume to catchment area and 0.005 in water demand to catchment area, BCR was over one from the tank capacity of 160 $m^{3}$ taking into account of private benefits and from the tank capacity of 100 $m^{3}$ taking into account of private and public benefits. Sensitivity analysis shows that increase of water demand can improve BCR values with little cost so that it is needed to extend application of rainwater use and select a proper range of design factor. Decrease of construction and maintenance cost reduced the tank volume to secure economic validity. Finally, increase rate of water service charge had considerable impact on economic feasibility.

생물 저류 방법 적용을 통한 비점오염원 처리시설의 성능평가에 관한 연구 (A Study on Performance Evaluation for the Bio-retention Non-point Source Pollution Treatment System)

  • 이장수;박연수;조욱상
    • 청정기술
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    • 제19권3호
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    • pp.295-299
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    • 2013
  • 미국 환경 보호청(Environmental Protection Agency, EPA)의 생물저류 설계기준에 근거한 비점오염원 처리시설의 제거효율 및 성능을 분석하고자 기본 모형 실험장치(basic column reactor, BCR)와 파일럿 규모의 식생 실험 장치를 대상으로 각각 수행하였다. BCR을 이용하여 초기강우 유출수의 유입속도(유량), 식재 층의 조성 및 구성 비율, 등 처리시설의 설계에 필요한 적정인자 값을 도출하였으며 이를 식생 실험 장치에 적용하여 비점오염원의 제거 효율을 분석하였다. 비점오염원으로는 합성된 강우(synthetic rainfall)와 실제 현장(도로변과 주차장)에서 채수한 초기강우 유출수(first rainfall runoff)를 각각 사용하였다. 부유물질(Suspended Solid, SS), 생물학적 산소 요구량(Biochemical oxygen demand, BOD), 화학적 산소요구량(Chemical Oxygen Demand, COD), 총질소(Total Nitrogen, T-N), 총인(Total Phosphorus, T-P) 분석항목 모두 80% 이상을 상회하는 제거효율을 보이고 있음을 확인하였다.

모래지반에서 모형 지오셀에 의한 보강 효과 (Reinfocing Effects Using Model Geocell in Sand)

  • 윤여원;김풍식;천성한
    • 한국지반환경공학회 논문집
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    • 제4권3호
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    • pp.51-59
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    • 2003
  • 지오셀 시스템의 사질토 지반에서의 보강효과를 규명하기 위하여 높이 대 폭비(H/W), 상대밀도, 재료의 강도, 복토의 두께를 다르게 하여 모형 재하시험을 수행하였다. 연구 결과 지오셀 시스템은 지오셀의 인장강도보다는 연결부의 강도가 작게 나타나 더 중요한 인자로 판단되었다. 모래의 상대밀도, 재료의 강도와 복토두께가 동일한 경우 모형 지오셀의 극한지지력은 높이 대 폭비(H/W)가 클수록 증가하는 경향을 나타내었으며 복토두께 변화에 따른 지지력비(BCR)는 낮은 상대밀도에서 더 크게 나타났다. 또한 모래의 상대밀도, 높이 대 폭비(H/W)와 복토두께가 동일한 경우 모형 지오셀의 재료의 인장강도가 커짐에 따라 극한지지력은 증가하였으며 인장강도의 영향은 조밀한 모래에서 더 두드러진 것으로 나타났다. 또한 복토층의 두께가 작을수록 지지력비는 큰 값을 나타내었다. 재료의 인장강도가 작은 특별한 경우에 Koerner공식의 적용은 주의가 필요할 것으로 사료된다.

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Evaluation of Pheromone Trap Settings for Managing Brinjal Shoot and Fruit Borer (Leucinodes orbonalis) in Brinjal

  • Rahman, Mizanur;Ali, Razzab;Islam, Mohammad Saiful;Wang, Myeong-Hyeon
    • 한국자원식물학회지
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    • 제22권3호
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    • pp.220-226
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    • 2009
  • An experiment was conducted to find out among 9 trap settings the most appropriate site for trap placement in the Brinjal field based on Brinjal shoot and fruit borer trapping efficiency, shoot and fruit infestation, healthy and total fruit yield, and BCR. The efficiency of different trap setting positions varied significantly. Trapping efficiency observed the $T_{1}$ ensured the minimum shoot and fruit infestation 10.02% and 20.95%, respectively, minimum infested fruit yield (4.75 ton/ha), maximum healthy and total fruit yield (26.72 and 31.47 ton/ha) and the maximum BCR (1.70), which was followed by $T_{2}$ and $T_{4}$. The minimum trapping efficiency of $T_{9}$ treatment led the maximum shoot and fruit infestation 13.89 and 29.26%, respectively, maximum infested fruit yield (7.59 ton/ha), minimum healthy and total fruit yield (17.74 and 25.32 ton/ha) and the minimum BCR (1.00). A correlation between the number of BSFB adults trapped from the most efficient trap setting and the shoot and fruit infestation recorded and found a linear positive correlation between number of BSFB adults trapped and shoot infestation (r = 0.781) and fruit infestation (r = 0.810). The effect of pheromone trap positions observed in this study may be attributed to the easy accessibility of the lures and traps, when they are placed at the canopy.

정지궤도 위성용 전력공급 모듈의 버스 전압 안정화를 위한 최적동작 제어에 관한 연구 (A Study on Adaptive Operation Control to Stabilize bus Voltage of GEO Satellite Power Supply Module)

  • 안태영;최현수
    • 전자공학회논문지
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    • 제53권2호
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    • pp.123-129
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    • 2016
  • 본 논문에서는 PCU(Power Control Unit)의 성능을 최적화 시킬 수 있는 동작모드를 제안하고 제작하여 그 결과를 보고 하였다. 특히 세 개의 기능별 모듈이 최적의 동작 상태를 유지할 수 있도록 버스의 전압과 연동되게 제어회로를 구성하여 동작 우선순위를 정하고 필요에 따라 자동적으로 동작하도록 최적 동작 제어 방식을 제안하였다. PCU는 태양광 전력을 부하와 연결된 버스에 정전압으로 변환시키는 S3R(Sequential Switching Shunt Regulator)과 보조 에너지 저장장치인 배터리에 잉여 전력을 저장하는 BCR(Battery Charge Regulator) 및 배터리에 충전되어 있던 전력을 부하에 공급하는 BDR(Battery Discharge Regulator)로 구성되어 있다. 세 개의 전력변환 모듈은 위성용 전원장치의 특성상 높은 신뢰성을 유지하기 위해서 각각의 모듈이 병렬로 동작하며, 특히 각 모듈의 기능이 최적의 상태를 유지하기 위해서 안정된 버스 전압이 상시 유지되어야 한다.

Prostatectomy Provides Better Symptom-Free Survival Than Radiotherapy Among Patients With High-Risk or Locally Advanced Prostate Cancer After Neoadjuvant Hormonal Therapy

  • Kim, Sung Han;Song, Mi Kyung;Park, Weon Seo;Joung, Jae Young;Seo, Ho Kyung;Chung, Jinsoo;Lee, Kang Hyun
    • 대한비뇨기종양학회지
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    • 제16권3호
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    • pp.126-134
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    • 2018
  • Purpose: The purpose of this study is to compare the radiation therapy (RT) and radical prostatectomy (RP) of high-risk or locally advanced prostate cancer (PC) patients after neoadjuvant hormonal therapy (NHT). Materials and Methods: This retrospective study evaluated patients underwent RT (42 patients) or RP (152 patients) after NHT at a single center during 2003-2014. Times to biochemical recurrence (BCR), pelvic local recurrence (PLR), metastasis, clinical painful symptom progression (CPSP), castration-resistant PC (CRPC), and overall survival were compared between the RT and RP groups, after adjustment for TN stage, using the Kaplan-Meier method and log-rank test. Results: Significant inter-group differences were observed for age, Gleason score, initial PSA, and clinical and pathological T stages (all p<0.05). During a median follow-up of 71.7 months, the overall incidences of BCR, PLR, metastasis, CPSP, CRPC, and death were 49.5%, 16.5%, 8.3%, 7.7%, 7.7%, and 17.5%, respectively. The median times to BCR were 100 months for RT and 36.2 months for RP (p=0.004), although the median times were not reached for the other outcomes (all p>0.05). The independent predictor of CPSP was RP (hazard ratio, 0.291; p=0.013). Conclusions: Despite significantly different baseline parameters, RP provided better CPSP-free survival than RT among patients with localized high-risk or locally advanced PC.

비용-편익 분석을 이용한 빗물이용시설의 저류 용량 결정 도구 및 사용자 편의 환경 개발 (Development of a graphical user interface and a tool to determine the storage of a rainwater harvesting system using cost-benefit analysis)

  • 진영규;서효원;강태욱;이상호
    • 한국수자원학회:학술대회논문집
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    • 한국수자원학회 2022년도 학술발표회
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    • pp.386-386
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    • 2022
  • 우리나라에서는 '물의 재이용 촉진 및 지원에 관한 법률 시행규칙' 등 다양한 법률에 따라 특정 규모 이상의 시설에 빗물이용시설을 설치하도록 규정하고 있으며, 지자체에서는 빗물이용시설의 이용을 장려하고자 설치비 및 시설 운영비를 지원하고 있다. 현업에서 빗물이용시설의 설계는 간편식을 이용하여 목표 우수이용률 또는 공급보장률을 만족하는 용량으로 결정하고 있다. 또한, 산정된 빗물이용시설의 용량에 대해서만 경제성 분석을 하고 있으며, 경제성 분석에 포함된 수식에 대한 근거가 부족한 실정이다. 본 연구에서는 기 개발된 빗물이용시설 설계 프로그램인 CARAH(capacity design aid for rainwater harvesting)의 추가 기능으로 경제성 분석을 통한 빗물이용시설의 적정 용량 결정 도구 및 사용자 편의 환경 개발 결과를 제시하고자 한다. 본 연구를 통해 개발된 CARAH의 경제성 분석 도구는 빗물이용시설의 용량, 설치비, 유지보수비용, 지자체의 설치비 지원 및 빗물 이용에 따른 요금 감면액 등을 고려하여 빗물이용시설의 비용편익 비율(benefit cost ratio; BCR) 산정 결과를 제시하는 기능이다. 본 연구에서는 개발된 CARAH의 경제성 분석 도구를 이용하여 기 설치된 광교 신도시의 빗물저류조 5호를 대상으로 경제성 분석을 수행하였으며, 경제성을 고려한 적정 저류 용량을 제시하였다. 경제성 분석 기간은 빗물이용시설의 내용 연수인 30년으로 하였으며, 여러 목표 공급보장률에 따른 최소 저류 용량별 BCR 결과를 비교하여 광교 신도시의 빗물저류조 5호의 적정 저류 용량을 결정하였다. 그 결과, 공급보장률이 60%에 해당하는 저류 용량 341 m3의 BCR이 7.28로 가장 경제적인 빗물이용시설의 저류 용량으로 산정되었다.

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Five Most Common Prognostically Important Fusion Oncogenes are Detected in the Majority of Pakistani Pediatric Acute Lymphoblastic Leukemia Patients and are Strongly Associated with Disease Biology and Treatment Outcome

  • Awan, Tashfeen;Iqbal, Zafar;Aleem, Aamer;Sabir, Noreen;Absar, Muhammad;Rasool, Mahmood;Tahir, Ammara H.;Basit, Sulman;Khalid, Ahmad Mukhtar;Sabar, Muhammad Farooq;Asad, Sultan;Ali, Agha Shabbir;Mahmood, Amer;Akram, Muhammad;Saeed, Tariq;Saleem, Arsalan;Mohsin, Danish;Shah, Ijaz Hussain;Khalid, Muhammad;Asif, Muhammad;Haq, Riazul;Iqbal, Mudassar;Akhtar, Tanveer
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권11호
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    • pp.5469-5475
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    • 2012
  • Background and Objectives: Acute lymphoblastic leukemia (ALL) is a complex genetic disease involving many fusion oncogenes (FO) having prognostic significance. The frequency of various FO can vary in different ethnic groups, with important implications for prognosis, drug selection and treatment outcome. Method: We studied fusion oncogenes in 101 pediatric ALL patients using interphase FISH and RT-PCR, and their associations with clinical features and treatment outcome. Results: Five most common fusion genes i.e. BCR-ABL t (22; 9), TCF3-PBX1 (t 1; 19), ETV6-RUNX1 (t 12; 21), MLL-AF4 (t 4; 11) and SIL-TAL1 (del 1p32) were found in 89/101 (88.1%) patients. Frequency of BCR-ABL was 44.5% (45/101). BCR-ABL positive patients had a significantly lower survival ($43.7{\pm}4.24$ weeks) and higher white cell count as compared to others, except patients with MLL-AF4. The highest relapse-free survival was documented with ETV6-RUNX1 (14.2 months) followed closely by those cases in which no gene was detected (13.100). RFS with BCR-ABL, MLL-AF4, TCF3-PBX1 and SIL-TAL1 was less than 10 months (8.0, 3.6, 5.5 and 8.1 months, respectively). Conclusions: This is the first study from Pakistan correlating molecular markers with disease biology and treatment outcome in pediatric ALL. It revealed the highest reported frequency of BCR-ABL FO in pediatric ALL, associated with poor overall survival. Our data indicate an immediate need for incorporation of tyrosine kinase inhibitors in the treatment of BCR-ABL+ pediatric ALL in this population and the development of facilities for stem cell transplantation.