• 제목/요약/키워드: B7H3

검색결과 3,832건 처리시간 0.038초

Thienobenzothiopyranones 111-New 4H-thieno[2,3-b][1]benzothiopyran-4-ones Carrying Different Heterocyclic Moieties of Expected Pharmacological Interest

  • El-Subbagh, H.I.;El-Emam, A.A.;El-Ashmawy, M.B.;Shehata, I.A.
    • Archives of Pharmacal Research
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    • 제13권1호
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    • pp.24-27
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    • 1990
  • Reaction of 2-formyl-4H-thieno [2, 3-b] benzothiopyran-4-one (1) with different heterocyclic amines afforded the corresponding Schiff's bases (2-4). Diethyl malonate, ethyl cyanoacetate and malononitrile were reached with 1 to afford compounds 5, 7 and 8, respectively. Compound 5 was cyclized to the pyrazolidin-3, 4-dione (6) by the action of hydrazine hydrate, whereas compound 7 was utilized for the synthesis of the thiazolin-4 one derivatives (9-13).

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(${\pm}$)-cis-8-Amino-2,3,4,4a,5,10b-hexahydrothiazolo[4,5-f]indeno [1,2-b][1,4]oxazine의 합성 (Synthesis of (${\pm}$)-cis-8-amino-l-2,3,4,4a,5,10b-hexahydrothiazolo[4,5-f]indeno [1,2-b][1,4]oxazine)

  • 마은숙
    • 약학회지
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    • 제52권6호
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    • pp.488-493
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    • 2008
  • 2-Aminothiazole ring as a bioisoster of catechol in dopamine has provided with good oral availability and lipophilic property. 2-Aminoindan, is a rigid form of dopamine, was evaluated as a dopamine D3 agonist with low neurotoxicity. Dopamine D3 agonist was evaluated as selective for the treatment of Parkinson's disease. In order to develop a novel dopamine D3 agonist, we tried to synthesize the aminothiazoloindenoxazine derivative that is a hybrid structure of aminoindenoxazine and thiazole ring. cis-2-Amino-1-indanol (2) was synthesized from 1,2-indandione-2-oxime by catalytic hydrogenation and it was treated with chloroacetyl chloride and NaH in benzene solution to give (${\pm}$)-cis-4,4a,5,9b-tetrahydroindeno[1,2-b][1,4]oxazin-3(2H)-one (6). Nitration of 6 by the mixed acid gave 8-nitro compound (7) and the carbonyl group of 7 was reduced with $LiAlH_4$ to afford compound (8). 8 was reduced to form (${\pm}$)-cis-8-amino-2,3,4,4a,5,9b-hexahydroindeno[1,2-b][1,4]oxazine (9) and finally it was cyclized with KSCN in glacial acetic acid to yield (${\pm}$)-cis-8-amino-2,3,4,4a,5,10b-hexahydrothiazolo[4,5-f]indeno[1,2-b][1,4]oxazine (10).

한국형 육가공 제품류의 물리적 및 관능적 품질 특성 (Physical and Sensory Characteristics of Korean Style Meat Products)

  • 김일석;진상근;하경희;류현지;박기훈
    • Journal of Animal Science and Technology
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    • 제47권1호
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    • pp.49-56
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    • 2005
  • The Korean styled meat products such as grilled and/or roasted ham(Jikhwagui: J), Bulgogi ham(B), Kimbab ham(K) and sliced roasted ham(DDukgalbi: D) were obtained from different Korean meat processing companies and investigated for their salinity, saccharinity, pH, moisture and fat content, meat color and sensory evaluation. The results obtained were as follows; Percentage of saccharinity in J, B, K and D ranged 7.5 %(13) - 12.7% (J2), 5.3 0/«B2) -7.5 o/«BI), 5.2 0/«K4) - 6.6 o/«KI, K2, KS), and 6.60/«04) - 14.4o/«Dl), respectively. Percentage of salinity in J, B, K and D ranged 2.260/«13)- 2.38 0/«J4), 1.850/«B2) - 2.45 0/«B3), 1.94o/«KI) - 2.40% (K3), and 1.830/«02) - 2.19 o/«Dl), respectively. The pH value of J, B and K were ranged 6.30 - 6.44, 6.266.37 and 6.20 - 6.42, respectively, which are slightly higher than that of D(5.86 - 6.25). Content of average moisture were higher in B(61.0 %), K(59.94%) and J(59.63%) compared to the D(55.93%). In crude fat, B and D were ranged 14-21 %, which are very lower than those of K(59.94%) and J(59.63%). In meat color, $L^*$ value were above 50.0, except D2 and D3. $a^*$ value of B were slightly higher than those of other meat products. Compared to sensory evaluation, the overall acceptability of J is excellent in the range of saccharinity 12.7%, salinity 2.3 %, moisture 61 %, crude fat II - 12%, $L^*$ value 52 - 54, and $a^*$ value 12.3- 12.7. In the case of B, the overall acceptability is excellent in the range of saccharinity 6.6 - 7.5 %, salinity 1.90- 2.45 %, moisture 60 %, crude fat 15 %, $L^*$ value 56, and $a^*$ value 15. In the case of K, the overall acceptability is excellent in the range of saccharinity 6.5 %, salinity 2.4 %, moisture 61 %, crude fat 16%, $L^*$ value 53, and $a^*$ valuce 15. In the case of D, the overall acceptability is excellent in the range of saccharinity 14.0%, salinity 2.1 %, moisture 55%, crude fat 55%, $L^*$ value 50, and $a^*$ value 13.

당느릅나무로부터 Sesquiterpene o-Naphthoquinone류 화합물, Mansonone E, F 및 H의 분리와 구조결정 (Isolation and Identification of Sesquiterpene o-Naphthoquinones, Mansonones E, F and H, from the Root Bark of Ulmus davidiana Planch)

  • 김종평;김원곤;;박종희;정진;유익동
    • Applied Biological Chemistry
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    • 제39권1호
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    • pp.89-94
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    • 1996
  • 한방에서 종기, 치질, 위암 및 염증의 치료목적으로 사용되어온 당느릅나무 (Ulmus davidiana Planch) 근피의 메탄을 추출물로부터 sesquiterpene o-naphthoquinone류 화합물 세가지를 분리 정제하였다. 이들의 구조를 UV-vis, IR, EIMS, HR-EIMS 및 여러 가지 NMR 스펙트럼, 특히 새로운 기법인 pulse field gradient (PFG)-HMQC 및 HMBC 스펙트럼의 분석에 의하여 결정하였다. 그 결과 이들은 2,3-dihydro-3,6,9-trimethylnaphtho(1,8-b,c)pyran-7,8-dione, 3,6,9-trimethylnaphtho(1,8-b,c)pyran-7,8-dione 및 2,3-dihydro-4-hydroxy-3,6,9-trimethylnaphtho(1,8-b,c)pyran-7,8-dione으로 동정 되었으며, 각각 mansonone E, F 및 H로 밝혀졌다. 이 화합물들은 당느릅나무에서는 처음 분리되었으며, 특히 mansonone H는 아프리카 열대식물인 Mansonia altissima Chev 및 Helicters angustifolia에서 분리된 후 자연계에서 처음으로 분리되었다. 문헌에 잘못 보고된 mansonone E 와 F의 C-3a, C-6a 및 C-9b의 세 사급탄소의 chemical shift를 최신 PFG-NMR기법에 의하여 동정하여 교정하였다.

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급냉응고된 $Sm_{2}Co_{3}B_{7}$ 화합물의 결정구조와 저온 자기특성 (Crystal Structure and Low Temperature Magnetic Properties of Melt-Spun $Sm_{2}Co_{7}B_{3}$ Compound)

  • 양충진;이우영;최승덕
    • 한국자기학회지
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    • 제3권4호
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    • pp.284-288
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    • 1993
  • 급속냉각기술로 제조된 $Sm_{2}Co_{3}B_{7}$ 화합물의 저온자기특성(77~450 K 범위)과 결정구조를 연구하여 경자성 재료로서의 응용가능성을 조사하였다. P6/mmm 공간격자의 $Sm_{2}Co_{3}B_{7}$은 150~160 K에서 spin-reorientation 현상을 보였으며, 결정자기이방성 자계(Ha)는 300 k 에서 135 kOe, 77 K 에서 725 kOe의 거대 이방화 에너지를 보였다. 그러나 자기능률(magnetic moment)은 25 emu/g에 그쳤다. Rietveld 분석에 의하여 $Sm_{2}Co_{3}B_{7}$의 결정구조를 밝혔으며 B(4h) 원자는 지금까지 보고된 바와는 달리 Sm(2e) 면에 위치한 것이 아니고 Sm(2e) 면에서 $0.792\;{\AA}$ 떨어져 Sm(2e)면과 Co($6i_{1}$) 면 사이에 위치함을 알았다.

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Kernel 특성에 따른 MTF 평가 및 임상적 적용에 관한 연구 (MTF Evaluation and Clinical Application according to the Characteristic Kernels in the Computed Tomogrsphy)

  • 유병규;이종석;권대철
    • 한국의학물리학회지:의학물리
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    • 제18권2호
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    • pp.55-64
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    • 2007
  • CT에서 커널에 따른 노이즈, 공간분해능 및 MTF를 측정하고 임상에 적용하여 영상의 질을 평가하였다. 커널은 B30 (body medium smooth), H30 (head medium smooth), S80 (special), U95 (ultra sharp)를 이용하여 측정하였다. 커널에 따른 결과에서 노이즈는 B30 (7.6 HU), U95 (38.2 HU)이었고, 공간분해능은 H30, B30 커널이 0.8 mm, U95 커널은 0.6 mm로 33.3% 영상의 질이 향상되었다. MTF (50%, 10%, 2%)에서 H30 커널은 3.25 5.68, 7.45 Ip/cm, B30 커널은 3.84, 6.25, 7.72 Ip/cm, S80 커널에서는 4.69, 9.49, 12.34 Ip/cm, U95 커널은 14.19, 20.31, 24.67 Ip/cm이었다. 커널 종류별로 영상의 임상 적용에서 두부는 H30 커널, 복부는 B30 커널, 측두골 및 폐에서는 U95 커널이 임상적 평가가 높았다. 임상에서 진단에 적용하기 위해서는 검사 부위에 맞는 커널을 선택하여 검사하여야 한다.

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Konjac Glucomannan 가수분해 올리고당의 중합도별 Bifidobacterium spp.에 대한 대사활성 (Metabolism Activity of Bifidobacterium spp. by D.Ps of Konjac Glucomannan Hydrolysates)

  • 최준영;박귀근
    • 한국식품영양과학회지
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    • 제33권7호
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    • pp.1186-1191
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    • 2004
  • DEAE-sephadex ion exchange column chromatography에 의해 Bacillus sp. 유래 h-mannanase의 정제를 수행하여 비활성은 21.57 units/mg, 정제배율은 93.78배를 나타내었다. 최적 온도는 5$0^{\circ}C$, 최적 pH는 6.0이며, 온도 안정성에서는 30∼5$0^{\circ}C$에서는 90%이상의 잔존활성을 나타내었고,70∼8$0^{\circ}C$에서는 30%이하의 잔존활성을 나타내었다. pH 안정성에서는 pH 5.5∼7.0에서 100%의 잔존활성을 나타낸 반면 pH 2.0∼4.0에서는 40%이하로 감소되 었다. 정제효소에 의해 konjac glucomannan을 가수분해하여 1차 activated carbon column chromatography와 2차 sephadex G-25 gel filtration 에 의해 당가수분해물을 분리 회수하여 TLC및 FACE에 의해 주요 당가수분해물은 중합도 5와 7로 확인되었다. B. iongum, B. btfidum, B. infantis, E. adolescentis, B. animalis, B. breve의 생육활성에 대한 중합도5와7의 영향을 검토하기 위하여 modified-MRS배지상에 탄소원으로 중합도 5와 7을 대체하여 생육활성을 비교한 결과 B. longum의 경우 특징적으로 각각 4.67, 5.33배의 상대활성을 나타내어 우수한 생육활성을 나타내었다. 또한 B. breve에 대해서는 중합도 5 glucomannooligosaccharide를 처리시 2.42배의 생육활성을 나타내었으나 B. infantis와 B. adolescentis에 대해서는 중합도 5와 7의 올리고당을 탄소원으로 대체시 오히려 생육활성이 현저히 감소되었다.

A Co-inhibitory Molecule, B7-H4, Synergistically Potentiates Oral Tolerance by Inducing CD4+CD25+FoxP3+ T Cells

  • Wen, Lanying;Yang, Sung-Yeun;Choi, Jae-Kyoung;Kim, Young-Hee;Kwon, Eun-Hee;Lee, Hyun-Ji;Jeoung, Hae-Young;Hwang, Du-Hyeon;Hwang, Dong-Jin;Choi, In-Hak
    • IMMUNE NETWORK
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    • 제8권1호
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    • pp.21-28
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    • 2008
  • Background: A co-inhibitory molecule, B7-H4, is believed to negatively regulate T cell immunity by suppressing T cell proliferation and inhibiting cytokine production. However, the mechanism behind B7-H4-mediated tolerance remains unclear. Methods: Balb/c $(H-2^d)$ mice were fed with dendritic cell line, DC2.4 $(H-2^d)$ every day for 10 days. Meantime, mice were hydrodynamically injected with recombinant plasmid expressing B7-H4 fusion protein (B7-H4.hFc) or hFc via tail vein. One day after last feeding, mice were immunized with allogeneic B6 spleen cells. 14 days following immunization, mice were challenged with B6 spleen cells to ear back and the ear swelling was determined the next day. Subsequently, a mixed lymphocyte reaction (MLR) was also performed and cytokines profiles from the reaction were examined by sandwich ELISA. Frequency of immunosuppressive cell population was assayed with flow cytometry and mRNA for FoxP3 was determined by RT-PCR. Results: Tolerant mice given plasmid expressing B7-H4.hFc showed a significant reduction in ear swelling compared to control mice. In addition, T cells from mice given B7-H4.hFc plasmid revealed a significant hyporesponsiveness of T cells against allogeneic spleen cells and showed a significant decrease in Th1 and Th2 cytokines such as IFN-${\gamma}$, IL-5, and TNF-${\alpha}$. Interestingly, flow cytometric analysis showed that the frequency of CD4+CD25+FoxP3+ Tregs in spleen was increased in tolerant mice given recombinant B7-H4.hFc plasmid compared to control group. Conclusion: Our results demonstrate that B7-H4 synergistically potentiates oral tolerance induced by allogeneic cells by increasing the frequency of FoxP3+ CD4+CD25+ Treg and reducing Th1 and Th2 cytokine production.

SiO$_2$-B$_2$O$_3$ 막에 의한 수소/질소 혼합기체 분리 (Separation of $H_2$/$N_2$ Gas Mixture by SiO$_2$-B$_2$O$_3$ Membrane)

  • 강태범;박진호
    • 멤브레인
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    • 제14권4호
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    • pp.312-319
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    • 2004
  • 졸겔법에 의해 Si(OC$_2$$H_5$/)$_4$-($CH_3$O)$_3$B-C$_2$$H_5$OH-$H_2O$계로부터 다공성의 SiO$_2$-B$_2$O$_3$ 막을 제조하였다. SiO$_2$-B$_2$O$_3$막의 특성을 BET, IR spectrophotometer, X-ray diffractometer, SEM 과 TEM을 사용하여 조사하였다. $700^{\circ}C$에서 얻어진 SiO$_2$-B$_2$O$_3$ 막의 평균 기공직경은 0.0048 $\mu\textrm{m}$이고, 표면적은 354.398 $m^2$/g이었으며, 입자의 크기는 7 nm인 무정형의 다공체이었다. SiO$_2$-B$_2$O$_3$ 막의 수소/질소 혼합 기체 분리 특성은 기체분리 압력을 달리하여 조사하였다. $25^{\circ}C$, ΔP 155.15cmHg에서 수소/질소 혼합 기체를 분리하여 본 결과 SiO$_2$-B$_2$O$_3$ 막의 수소에 대한 real separation factor($\alpha$)는 4.68이었다. 그리고 투과셀의 압력차(ΔP)값이 증가할수록 real separation factor($\alpha$), head separation factor($\beta$), tail separation factor((equation omitted))값이 증가하였다.

Newborn traits associated with pre-weaning growth and survival in piglets

  • Nuntapaitoon, Morakot;Muns, Ramon;Tummaruk, Padet
    • Asian-Australasian Journal of Animal Sciences
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    • 제31권2호
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    • pp.237-244
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    • 2018
  • Objective: Piglet pre-weaning mortality is an important variable indicating the efficacy of farrowing management and animal well-being during lactation. The present study determined the association of newborn traits measured soon after birth with piglet pre-weaning mortality and growth. Methods: In total, 805 piglets born from 57 multiparous sows were investigated. Their blood oxygen saturation, blood glucose and rectal temperature at 24 h after birth (RT24h) were monitored. Birth order, sex, skin color, integrity of the umbilical cord, attempts to stand and birth intervention were monitored. Piglets were weighed at day 0, 7, and 21 to evaluate average daily gain (ADG). Results: Piglet pre-weaning mortality for lactation period was 12.6% and cumulative mortality during the first 7 days of age was 8.6%. A higher proportion of piglets with pale skin color died compared to piglets with normal skin color (26.7% vs 7.7%, p<0.001). A higher (p<0.001) proportion of piglets that attempted to stand after 5 min (38.5%) died compared to piglets that attempted to stand within 1 min (6.3%) after birth. Piglet body weight at birth ($BW_B$), blood glucose and the number of piglets born alive (BA) were correlated with ADG (p<0.05). Piglets with $BW_B$ <1.30 kg had higher (p<0.001) mortality rate than piglets with $BW_B{\geq}1.80 kg$ (19.0% vs 3.3%) and piglets with $BW_B$ 1.30 to 1.79 kg (4.0%). Piglet with RT24h <$37.0^{\circ}C$ had higher (p<0.001) mortality rate (86.2%) than piglets with RT24h >$38.5^{\circ}C$ (3.9%). Conclusion: Low $BW_B$ and low RT24h compromise piglet survival during the lactation period in the tropical conditions. Piglets in the litters with a high BA, low $BW_B$ and low blood glucose have reduced ADG.