• 한국결정학회지
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• 제17권1호
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• pp.6-9
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• 2006

Bis(N-Methylphenazinium)-Tetracyanopalladate(II) Hydrate $(C_{13}H_{11}N_2){_2}[Pd(CN)_4]{\cdot}H_2O$의 단위 착이온 및 결정의 구조들을 X-선 회절법으로 연구하였다. 이 결정은 사방정계이고 공간군은 $P2_1/b$(군번호=14)이다. 단위세포 a=9.783(4), b=10.788(4), c=13.666(4) ${\AA},\;{\beta}=104.59(5),\;V=1392.9{\AA}{^3},\;Z=2,\;Dc=1.476gcm^{-3},\;F(000)=632,\;{\mu}=7.05cm^{-1}$이다. 구조분석은 중금속법으로 풀었으며, 최소자승법으로 정밀화 하였고, 최종 신뢰도 값들은 1930 회절반점에 대하여 R=0.0257, Rw=0.0732, Rall=0.0283 및 S=1.07 이었다. 두 이온들은 근본적인 평면구조로써, 이들의 충진구조는 착음이온을 두개의 양이온들이 거의 평행하게 둘러싸고 있는 삼중체들을 형성하고 있다. 양이온과 음이온들의 이면각은 $10.16(4)^{\circ}$인 삼중체들이 b축을 따라서 배열되어 있다, 삼중체내 및 삼면체간의 면간 거리들은 3.419(3)와 $3.402(4){\AA}$이었다.

• 한국수정란이식학회지
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• 제31권1호
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• pp.19-25
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• 2016

This study was conducted to evaluate the effects of type of culture media (BM, G2, OS, TCM, and MEM) on B6D2F1 mice oogenesis. In the present study, B6D2F1/CrljOri $F_1$ mice were utilized in order to maximize oogenesis. Also we used TCM-199, Dulbecco's medified Eagle's medium (DMEM), embryo culture medium (Fertilization medium, Cleavage medium, Blastocyst medium), G series medium and One step medium. In vitro maturation was highest in BM followed by the order of OS, MEM, TCM and G2 ($90{\pm}2.8%>88{\pm}3.2%>85{\pm}4.9%>78{\pm}10.2%>64{\pm}7.7%$, respectively). To note, the G2 group was statistically different compared to other groups (p<0.05). On the other hand the fertilization rate was highest in the G2 group followed by BM, OS, TCM, and MEM ($87{\pm}7.2%>85{\pm}6.9%>74{\pm}14.0%>71{\pm}13.8%>2{\pm}1.4%$, respectively). The MEM group was significantly lower compared to other groups (p<0.05). The developmental rate was highest in the OS group followed by the G2 group and the BM group albeit no statistical significance was noted ($73{\pm}11.6%>71{\pm}9.2%>66{\pm}10.4%$). Of note, all cells of the TCM and MEM groups were died during embryonic development. The zona hatched rate ($51{\pm}9.8%$ vs. $50{\pm}9.1%$ vs. $47{\pm}7.2%$ for BM, G2, and OS respectively) and attached rate ($45{\pm}12.3%$ vs. $38{\pm}16.1%$ vs. $37{\pm}11.5%$ for BM, G2, and OS respectively) were not different amongst groups. No difference was found in total cell numbers ($74{\pm}13.9$ vs. $64{\pm}9.2$ vs. $76{\pm}6.7$ for BM, G2, and OS respectively), ICM cell numbers ($20{\pm}1.9$ vs. $14{\pm}1.8$ vs. $15{\pm}2.1$), TE cell numbers ($55{\pm}12.5$ vs. $49{\pm}10.7$ vs. $61{\pm}5.9$), % ICM ($30{\pm}2.8%$ vs. $24{\pm}7.0%$ vs. $22.8{\pm}2.2%$) and ICM:TE ratio ($1:2{\pm}0.5$ vs. $1:3.1{\pm}0.8$ vs. $1:3.1{\pm}0.5$) amongst groups. In summary, these results can provide fundamental data to maximize culture condition for in vitro fertilization on B6D2F1 mice.

• Archives of Pharmacal Research
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• 제13권1호
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• pp.82-96
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• 1990

Ten (E)-and (Z)-isomers of 2-phenylcyclopropylamine (PCA), 1-Me PCA, 2-Me-PCA, N-Me-PCA, and N, N-diMe PCA and fifteen o-. m-, p- isomers of (E) PCA with substituents of Me, Cl, F, OMe, OH were synthesized in this laboratory and tested for the inhibition of rat brain mitochondrial MAO-A and MAO-B. The effects of substituents, their positions, and stereochemistry on the inhibition were assessed for the compounds with substituents at cyclopropyl and amino groups and QSAR analyses were performed using the potency data of ring-substituted compounds. The best correlated QSAR equations are as follows : pI$_{50}$ = 0.804 $\pi^2$-0.834 Blo-1.069 Blm + 0.334 Lp-1.709 HDp +7.897 (r = 0.945, s =0.211, F = 16.691, p = 0.000) for the inhibition of MAO-A;PI$_{50}$= 1.815$\pi$-0.825 $\pi^2$-1.203R + 0.900 Es$^2$ + 0.869 Es$^3$ + 0.796 Es$^4$-0.992 HDp + 0.562 HAo + 3.893 (r = 0.982, s =0.178, F = 23.351, p = 0.000) for the inhibition of MAO-B. Based on the potency difference between stereoisomers of cyclopropylamine-modified compounds and an QSAR cavity near para position, two hydrophobic carities interacting with Me group, a hydrophobic site near para position, and an amino group binding site and that in addition to the same two hydrophotic cavities, hydrophotic area, steric boundaries, hydrogen-acceptor site, and amino group binding site, another steric boundary near para position and a hydrogen donating site near ortho position constitute active sites of MAO-B.

• Plant Resources
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• 제3권3호
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• pp.184-193
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• 2000

Soybean [Glycine max (L.) Merr.] seed weight is a important trait in cultivar development. Objective of this study was to identify and confirm quantitative trait loci (QTLs) for seed weight variation in the F2 and F2:3 generations. QTLs for seed weight were identified in F2 and F2:3 generations using interval mapping (MapMaker/QTL) and single-factor analysis of variance (ANOVA). In the F2 plant generation (i.e., F3 seed), three markers, OPL9a, OPM7a, and OPAC12 were significantly (P<0.01) associated with seed weight QTLs. In the F2:3 plant row generation (i.e., F4 seed), five markers, OPA9a, OPG19, OPL9b, OPP11, and Sat_085 were significantly (P<0.01) associated with seed weight QTLs. Two markers, OPL9a and OPL9b were significantly (P<0.05) associated with seed weight QTLs in both generations. Two QTLs on USDA soybean linkage group C1 and R were identified in both F2 and F2:3 generations using interval mapping. The linkage group C1 QTL explained 16% of the variation in seed weight in both generations, and the linkage group R QTL explained 39% and 41% of the variation for F2 and F2:3 generation, respectively. The linkage group C2 QTL identified in F2:3 generation explained 14.9% of variation. Linkage groups C1, C2 and R had previously been identified as harbouring seed size QTLs. The consistency of QTLs across generations and populations indicates that marker-assisted selection is possible in a soybean breeding program.

• 전자공학회논문지D
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• 제34D권12호
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• pp.14-21
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• 1997

This study was conducte dto fabricate 2GHz circulator using Ca,Sn substituted UIG(yttrium iron garnet)ceramics. When the electric, magnetic and microwave properties were measured in Ca, Sn substituted YIG, the measured perimittivity and perfmeability in microwave frequencies were 16.25, 0.8964. For $Y_{2.4}$C $a_{0.3}$A $n_{0.3}$F $e_{3.5}$A $l_{1.5}$ $O_{12}$ garnet ceramics sintered at 1400.deg. C, the ferrimagnetic resonance line width (.DELTA.H) at 10GHz was 53 Oe and saturation magnetization was 375G. The strip-line circulator was simulated with 3-D FEM (finite element method) software and designed at the center frequency of 2GHz. The fabricated strip-line junction circulator using above YIG ceramics had insertion loss of 1.271dB, return loss of 23.843dB, isolation of 21.751dB at the center frequency 1.855GHz.z.z.z.z.z.z.

• 한국결정학회지
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• 제9권2호
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• pp.114-119
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• 1998

Imperatorin, 9-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one의 분자 및 결정구조를 X-선 회절법으로 연구하였다. 이 결정의 분자식은 C16H14O4, 결정계는 삼사정계이고 공간군은 P이다. 단위포상수는 a=11.818(1) , b=11.906(1) , c=11.059(1) 이며, α=96.32(1)o, β=90.74(1)o, γ=64.88(1)o, V=13.993(2) 3, T=293 K, Z=4이다. 구조해석에 사용한 X-선은 CuKα선(λ=1.5418 )을 사용하였다. 구조는 직접법으로 풀었으며 최소자승법으로 정밀화하였다. 최종 신뢰도 R 값은 F0>4σ(F0)인 3951개의 독립회절데이타로 356개 파라메타에 대해 R=7.02%이다.

• 지질공학
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• 제17권1호
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• pp.1-13
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• 2007

역사 지진으로 인해 성칩이 붕괴되었던 국내 두 읍성 지역에 대한 국부적 부지 효과를 평가하기 위하여, 현장 시추 조사 및 탄성파 시험을 통해 전단파속도($V_s$) 주상을 포함한 지반 특성을 결정하고 이를 토대로 등가 선형 기법의 부지 응답 해석을 수행하였다. 대상 부지는 심도 30m까지의 평균 전단파속도가 $500{\sim}850m/s$의 분포를 보임에 따라 지반 분류C와 B로 구분되었고, 부지 고유주기는 성벽과 성첩의 고유주기를 포함하는 범위인 $0.06{\sim}0.16$초의 단주기 분포를 보였다. 대상 영역에서의 부지 응답 해석 결과, 지반 분류 B와는 달리 대부분의 부지 조건인 지반 분류 C의 경우 부지 고유 지진 응답 특성인 단주기에서의 큰 증폭으로 인해, 국내 내진 설계 기준의 단주기($0.1{\sim}0.5$초) 증폭계수 $F_a$와 중장주기 ($0.4{\sim}2.0$초) 증폭계수 $F_v$는 각각 지반 운동을 단주기 영역에서는 과소평가하고 중장주기 영역에서는 과대평가함을 확인하였다. 이러한 부지 고유 응답 특성은 단주기 고유 응답을 보이는 성벽 구조물이 지진 발생 시 공진이 발생할 가능성이 높음을 의미하며, 그에 따라 역사 지진 피해 사례인 성첩 붕괴의 지배적인 영향 인자로서 작용했을 것으로 판단된다.

• 대한전자공학회논문지SD
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• 제37권8호
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• pp.9-16
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• 2000

0.35m CMOS공정을 이용하여 MOSFET의 RF특성을 평가하였다. 채널길이(L-0.25~0.8m)와 채널폭(W=50~600m) 및 바이어스 전압의 변화에 따른 RF특성을 분석하였으며, 차단주파수$f_T$는 최대 22GHz, 최대공진주파수($f_{max}$)는 최대 28GHz의 값을 얻었다. 채널폭의 변화에 대해서 차단주파수는 영향을 받지 않았으며, 최대공진주파수는 감소하는 경향을 보였고, 채널길이 증가에 대해서는 차단주파수 및 최대공진주파수 모두 감소하는 경향을 나타내었다. 최소잡음지수는 채널폭이 증가할수록 감소하고 채널길이가 증가할수록 증가하는 경향을 얻었는데, 2GHz에서 최소 0.45dB의 값을 얻었다. 평가결과로부터 0.35m CMOS공정이 2GHz대역의 상업용 RFIC 구현에 충분한 RF특성을 보유하고 있음을 확인할 수 있었으며, 바이어스 및 채널폭과 길이변화에 대한 CMOS 트랜지스터의 RF 특성분석을 통하여 RF 회로설계에 대한 지침을 제시하였다.

• IMMUNE NETWORK
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• 제6권3호
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• pp.154-162
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• 2006

Background: Dendritic cell (DC)-based cancer immunotherapy is studied for several years. However, it is mainly derived from autologous PBMC or leukapheresis from patient, which has limitations about yield and ability of DC production according to individual status. In order to solve these problems, inquiries about allogeneic DCs are performed but there are no preclinical trial answers for effect or toxicity of allogeneic DC to use for clinical trial. In this study, we compared the anti-tumor effect of allogeneic and autologous DCs from mouse bone marrow stem cells in mouse metastatic melanoma model. Methods: B16F10 melanoma cells ($5{\times}10^4$/mouse) were injected intravenously into the C57BL/6 mouse. Therapeutic DCs were differentiated from autologous (C57BL/6: CDC) or allogeneic (B6C3F1: BDC) bone marrow stem cells with GM-CSF, SCF and IL-4 for 13days and pulsed with B16F10 tumor cell lysate (Blys) for 18hrs. DC intra-peritoneal injections began on the 8th day after the tumor cell injection by twice with one week interval. Results: Anti-tumor response was observed by DC treatment without any toxicity especially in allogeneic DC treated mice (tumor burden score: $2.667{\pm}0.184,\;2.500{\pm}0.463,\;2.000{\pm}0.286,\;1.500{\pm}0.286,\;1.667 {\pm}0.297$ for saline, CDC/unpulsed-DC: U-DC, CDC/Blys-DC, BDC/U-DC and BDC/Blys-DC, respectively). IFN-${\gamma}$ secretion was significantly increased in allogeneic DC group stimulated with B16F10 cell lysate ($2,643.3{\pm}5,89.7,\;8,561.5{\pm}2,204.9.\;6,901.2{\pm}141.1pg/1{\times}10^6$ cells for saline, BDC/U-DC and BDC/Blys-DC, respectively) with increased NK cell activity. Conclusion: Conclusively, promising data was obtained that allogeneic DC can be used for DC-based cancer immunotherapy.

• 한국융합학회논문지
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• 제9권10호
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• pp.1-6
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• 2018

본 논문은 항공기 축소모델에 장착된 상관형 위상비교 방향 탐지장치의 방위각 측정 정확도에 대해서 기술하였다. 항공기 하부면에 안테나를 설치하면 날개 등에 의한 전파 반사가 일어나서 방위각 측정오차가 발생한다. 본 연구에서는 F-16 전투기 5:1 축소 모델의 하부면에 5개 안테나를 원형으로 배치한 다음에 $0-360^{\circ}$ 방위각에서 $1^{\circ}$ 간격으로 전파를 송신할 때 5개 안테나에 수신되는 전파의 위상을 수치해석으로 구한 다음 상관형 위상비교방식으로 데이터를 융합하여 방위각 측정 정확도를 계산하였다. F-16 전투기 축소 모델의 상관형 위상비교방식의 방위각 측정오차는 신호잡음세기가 3dB 이상인 경우 평균 $1.0^{\circ}$ 이하로 양호하게 나타나서 항공기용 상관형 위상비교 방향 탐지장치 설계에 매우 유용하게 활용할 수 있을 것으로 판단된다.