• 대한한방내과학회지
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• 제27권4호
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• pp.822-826
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• 2006

Objectives : Essential hyperhidrosis is a socially and occupationally disabling disorder. There are many suggestions that hyperhidrosis is associated with the autonomic nervous system, especiallythe sympathetic system. This study was designed to investigate the autonomic nerve system in patients with essential hyperhidrosis and healthy controls by the frequency domain analysis of heart rate variability (HRV). Methods : 17 head-hyperhidrosis patients in the ambulatory care were investigated. All were inspected at the first medical examination. using the PSA of HRV. HRV was measured for minutes after 5 minutes bed rest. We checked the frequency domain analysis of HRV (i.e. TP, VLF, LF, HF) which were transformed into natural logarithm of patients against the standard measures of the HRV components. Then we compared the values of patients with means of normal Korean subjects. Results : The values of natural logarithmic measure of HRV (LnTP, LnHF, LnLF, LnVLF) of patients With head-hyperhidrosis we examined were $6.85{\pm}1.61$, $4.93{\pm}$2.00, $5.40{\pm}1.83$, and $6.13{\pm}1.37$, respectively. None of these values were higher than means of normal subjects. Conclusions : This study suggests that the function of the autonomic nervous system does not increase in patients with head-hyperhidrosis.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.237-242
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• 1999

The nature of the interactions between the vestibular and autonomic systems is complex and has not been fully defined. Vestibuloocular reflex induced by sinusoidal rotation and activity of the autonomic nerves in the heart were measured to investigate the interactions between the vestibular system and the autonomic nervous system in healthy adults. Eye movement induced by sinusoidal rotation of the whole body or optokinetic stimulation at 0.04 Hz was analyzed in gain, phase, and symmetry. EKG was measured during vestibular stimulation and analyzed in heart rate variability including mean R-R interval, standard deviation (SD) and coefficient of variance (CV) of R-R interval, and power spectrum of low frequency region (LF) and high frequency region (HF). Gain of eye movement was 0.65${\pm}$0.03 by ratatory stimulation, 0.70${\pm}$0.02 in optokinetic stimulation, 0.08${\pm}$0.02 in visual suppression, and 0.84${\pm}$0.04 in visual enhancement. In R-R interval, resting condition (control) was 0.82${\pm}$0.03 sec, and visual suppression showed significant increase and visual enhancement did significant decrease compared with control (p<0.01).CV was 0.06${\pm}$0.02 in control and visual enhancement increased significantly (p<0.05). In LF/HF control was 1.40${\pm}$0.23, which was not different from rotatory or optokinetic stimulation. But visual suppression decreased LF/HF significantly and visual enhancement increased significantly compared with control (p<0.01). These results suggest that degree of gain corresponds with LF/HF and increased gain in visual enhancement is deeply related to the activity of sympathetic nerves.

• Journal of Korean Biological Nursing Science
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• 제23권3호
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• pp.237-246
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• 2021

Purpose: To determine effects of family conflict mitigation documentary programs on conflicts, autonomic nerve activation (ANA), and happiness of elderly in long-term care hospitals. Methods: This study used a non-equivalent control group with a pretest-posttest design. It was conducted on 39 elderly patients (19 in the experimental group and 20 in the control group) in long-term care hospitals. The experimental group (n=19) received family conflict mitigation documentary programs. The family conflict mitigation documentary programs consisted of four sessions (40-50 minutes per session). These programs were implemented in small groups, with each group having five elderly. Data were analyzed by sing the conflict checklist, the Oxford Happiness Questionnaire, Chi-square test with Fisher's exact test, independent t-test, paired t-test, and repeated measure ANOVA using the SPSS/WIN 21.0 program. Results: The participants in the experimental group showed significantly decreased scores of conflict (t=-2.31, p=.028) and the value of sympathetic nervous system activity (t=8.36, p=.007) compared with those of the control group. The participants in the experimental group showed significantly increased the value of parasympathetic nervous system activity (t=-2.91, p=.008) and scores of happiness (t=5.46, p<.001). Conclusion: The family conflict mitigation documentary programs on conflicts, ANA, and happiness of the elderly in long-term care hospitals are effective intervention programs for mitigating conflicts between elderlies and their families and for improving happiness of the elderly in long-term care hospitals.

• 대한의용생체공학회:의공학회지
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• 제42권5호
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• pp.211-224
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• 2021

Purpose: The purpose of this study is to present a way to alleviate motion sickness(MS) by stimulating acupoint through PEMFs, and to assess the effectiveness of PEMFs against stimulation previously used to stimulate acupoint using biosignal evaluations and surveys. Materials and Methods: Thirteen healthy men participated in the experiment. MS was induced in the participants, and MS relief stimulation was applied for 30 minutes. There were 4 types of MS relief stimulation, and Sham, Reliefband, Transcutaneous electrical nerve stimulation(TENS), and Pulsed electromagnetic fields stimulation(PEMFs) were used. The biosignals were measured during 30 minutes of applying MS relief stimulation, and the symptoms of MS were evaluated through a questionnaire survey. The measured biosignals are Electrocardiogram(ECG), Electrodermal activity(EDA), Respiration, Skin temperature(SKT), and Electrogastrogram(EGG). A one-way ANOVA test was performed for the rate of change by stimulation for MS relief over time. Results: Participants who were stimulated had a sharp decrease in MS symptoms. Biosignals were analyzed to evaluate autonomic nervous system activity, and the parasympathetic nervous system could be activated through stimulation. Conclusion: TENS and PEMFs were more effective in relieving MS symptoms than Reliefband. It is believed that PEMFs will be effective in consideration of the comfort of participants to be applied to actual vehicles, and studies to further verify the effects of PEMFs on MS should be conducted.

• 대한한방내과학회지
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• 제27권4호
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• pp.798-810
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• 2006

Objectives : This study was designed to investigate heart rate variability(HRV) in patients with abnormality on EKG by power spectrum analysis of HRV. Methods : The patient group consisted of 147 patients diagnosed as abnormal on EKG at the Oriental Medical Hospital of Dong-eui University from November 2003 to September 2005. We divided the patient group into 9 subgroups (bradycardia, arrhythmia, PVC, AF, AV block, RBBB, LVH, cardiac ischemia, LAD ). The control group consisted of 117 patients who were diagnosed as normal on EKG at the same hospital during the same period. We checked HRV of the two groups over 5 minutes and compared the HRV index between groups. Results and Conclusions : In the time domain analysis, SDNN was significantly higher in the PVC and AF groups than control group and RMSSD was significantly higher in the all patient group and the bradycardia, PVC and AF groups than in the control group. In the frequency domain analysis, Ln(LF) was significantly higher in the all patient group and the PVC and AF groups than the control group but lower in the LAD group. Ln(HF) was significantly higher in The all patient group and bradycardia, PVE and AF groups than control group. LF/HF ratio was significantly lower in the all patient group and bradycardia, arrhythmia, AF, AV block and LAD groups than control group. The autonomic nerve system and parasympathetic nerve system were higher in the patient group with abnormal EKG compared with the control group.

• The Korean Journal of Physiology and Pharmacology
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• 제20권1호
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• pp.111-117
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• 2016

Vagal nerve activity has been known to play a crucial role in the induction and maintenance of atrial fibrillation (AF). However, it is unclear how the distribution and concentration of local acetylcholine (ACh) promotes AF. In this study, we investigated the effect of the spatial distribution and concentration of ACh on fibrillation patterns in an in silico human atrial model. A human atrial action potential model with an ACh-dependent $K^+$ current ($I_{KAch}$) was used to examine the effect of vagal activation. A simulation of cardiac wave dynamics was performed in a realistic 3D model of the atrium. A model of the ganglionated plexus (GP) and nerve was developed based on the "octopus hypothesis". The pattern of cardiac wave dynamics was examined by applying vagal activation to the GP areas or randomly. AF inducibility in the octopus hypothesis-based GP and nerve model was tested. The effect of the ACh concentration level was also examined. In the single cell simulation, an increase in the ACh concentration shortened $APD_{90}$ and increased the maximal slope of the restitution curve. In the 3D simulation, a random distribution of vagal activation promoted wavebreaks while ACh secretion limited to the GP areas did not induce a noticeable change in wave dynamics. The octopus hypothesis-based model of the GP and nerve exhibited AF inducibility at higher ACh concentrations. In conclusion, a 3D in silico model of the GP and parasympathetic nerve based on the octopus model exhibited higher AF inducibility with higher ACh concentrations.

• 한국융합학회논문지
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• 제12권2호
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• pp.61-66
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• 2021

본 연구의 목적은 지연성근육통의 통증 변화가 자율신경계와 뇌파에 미치는 영향을 알아보고자 하였다. 지연성 근육통이 유발된 28명을 대조군(n=14)과 실험군(경피신경자극과 키네시오테이핑 적용, n=14)으로 구분하였다. 중재는 지연성근육통 유발 1일 후부터 5일 동안 실시하였다. 평가는 VAS(visual analog scale), 심박변이, 뇌파를 사용하여 지연성근육통 유발 전, 유발 24시간 후, 5일 치료 후, 치료 중단 3일 후에 측정하였다. 실험 결과 지연성근육통이 발생하면 교감신경계의 활성 증가 또는 부교감신경계 활성 억제가 되며, 중재로 인한 통증 감소는 반대의 활동이 나타났다. 통증 발생 시 alpha파의 감소가 나타났으나 유의하지 않았다. 본 연구 결과 통증 변화는 자율신경계와 뇌파에 영향을 미침을 알 수 있었으며, 이러한 결과는 통증 관리와 치료 전략 개발 및 연구에 도움이 될 것이다.

• Journal of Chest Surgery
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• 제27권1호
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• pp.9-14
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• 1994

Substance P[SP] has been known to be a peptide which may be plays a role as a neurotransmitter in central nervous system as well as peripheral autonomic nervous system. It has been reported that SP was widely distributed in the nerve of the tracheal smooth muscle and induced the muscle contraction. However, definite action mechanism of SP in the tracheal smooth muscle was not clear, yet. Thus, present experiment was performed to elucidate an effect of substance P and an action mechanism on contraction of the smooth muscle in rabbits. In order to find a neural mechanism to the effect of SP on the tracheal smooth muscle contraction, atropine sulfate, tetrodotoxin, propranol and phentolamine were administered at 10 min before the addition of SP. Otherwise,to find effect of SP antagonists on the action of SP, [D-Pro2, D-Try7,9]SP, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]SP and [D-Pro4, D-Trp7,9]SP were administered as a same fashion. These following results were obtained. 1] SP induced contraction of the tracheal smooth muscle under resting condition and the contraction was increased dose-dependently. 2] Cholinergic blocker[atropine], neural blocker[tetrodotoxin] and adrenergic blocker[propranol and phentolamine] didn`t have an effect on the contractile response. 3] Three SP antagonists inhibited the contractile response. 4] Isoproterenol relaxed the contraction induced by SP. The above results suggested that SP induced contraction of the tracheal smooth muscle directly act to the smooth muscle in rabbits. The autonomic nervous system did not seem to participate in the SP action.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1929-1932
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• 2005

We investigated the activities of autonomic nervous system during foot bathing. The effect of foot bathing was evaluated for four subjects by observing the characteristic of heart rate variability and bodily temperatures. The foot bathing was done with a commercial foot spa (Duches Co.) utilizing the four functional modes of the spa for two different temperatures of $35^{\circ}C\;and\;40^{\circ}C$. The four functional modes were clam, vibration, air bubbles, and both vibration and air bubbles. The experimental results showed that the temperature of foot and that of face right after foot bathing were not that different from each other. But, for heart rate variability, the activation of parasympathetic nerve showed distinctive increase at $40^{\circ}C$ of water temperature. In the analysis of heart rate variability for different functional modes, the change was not distinctive for different modes at $35^{\circ}$ of water temperature. However, at $40^{\circ}C$, the activation of sympathetic nerve showed distinctive increases with the increase in the complexity of functional modes.

• 동의신경정신과학회지
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• 제16권2호
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• pp.259-266
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• 2005

상기 환자는 25세 여환으로 유학 준비 중 경제적 이유로 유학이 좌절되면서 취업과 유학 준비의 문제로 부모님과 마찰이 있던 상태에서 2005년 7월 19일 두통(頭痛)이 발생하여 양방 내과 및 신경정신과 치료를 받으나 별무호전하고 2005년 7월 23일 악심(惡心) 및 구토(嘔吐)가 추가 발생하여 2005년 7윌 25일부터 2005년 8월 3일까지 동서한방병원 한방신경정신과로 입원한 환자로 한방적으로는 간기울결(肝氣鬱結)로 인한 두통(頭痛)으로, 양방적으로는 긴장형(緊張型) 두통(頭痛)으로 진단받고 한방치료를 통해 호전된 환자이다. 내원당시 다양한 양방적 검사를 시행하여 기질성 질환 여부를 배제하였고, 두통(頭痛)과 겸발한 구토(嘔吐)에 초점을 두고 향묘평위산(香妙平胃散)을 투여하여 빠른 치료효과를 나타낼 수 있었다. 이러한 자율신경계의 균형 이상에서 발생하는 증상의 경우 환자 및 보호자와의 면담 도구로서 HRV의 사용이 상당한 설득력을 보였으나, 보편성의 확보를 위해서는 많은 임상연구 및 치험례의 보고가 필요할 것으로 사려된다