• Journal of Acupuncture Research
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• 제24권5호
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• pp.1-12
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• 2007

목적 : 양심안영(養心安營), 청신녕지(淸神寧志), 조리기혈(調理氣血)의 효능을 가진 심유혈(心兪穴)($BL_{15}$)이 자율신경의 안정에 기여할 수 있다는 것을 입증하기 위하여 객관적으로 자율신경의 활성과 심장의 많은 연관성이 있다고 알려진 HRV(Heart Rate Variability)를 이용하였다. 방법 : 안정을 취한 후 29명의 남자 대상자를 HRV가 먼저 측정하였다. HRV 측정 후 대상자의 량측(兩側) 심유혈(心兪穴)에 자침하고 전침으로 지속적인 자극을 주었으며, 15분간 이 상태로 류침(留鍼)하였다. 발침(拔鍼) 후 다시 HRV를 측정하여 이를 측정 전과 비교하였다. 측정 결과의 비교 항목은 MHRT, SDNN, RMSSD, TP, VLF, LF, HF, Norm LF, Norm HF, LF/HF ratio로 하였다. 결과 : MHRT는 유의성이 있었다. SDNN은 유의성이 없었다. RMSSD는 증가하였으나, 유의성이 없었다. TP는 감소하였으나, 유의성이 없었다. VLF는 감소하였으나, 유의성이 없었다. LF는 감소하였으나, 유의성이 없었다. HF는 증가하였으나, 유의성은 없었다. Norm LF는 감소하였으나, 유의성이 없었다. Norm HF는 증가하였으나, 유의성은 없었다. LF/HF ratio는 감소하였으나, 유의성이 없었다. 결론 : 심유혈(心兪穴) 자침 결과는 교감 신경의 흥분을 가라앉히고 부교감 신경의 안정성을 증대하여, 심장의 안정도에 기여하는 것으로 보이나, 이는 통계적으로 의미가 없었다. 본 연구의 대상 집단이 소규모이며 스트레스가 아주 심하지 않은 집단이라는 점에서 유의성이 상대적으로 부각되지 못했다. 향후 비교할 만한 대조군을 설정하여 더 심한 스트레스를 받은 큰 집단을 대상으로 한 연구가 필요할 것으로 사료된다.

• Journal of Acupuncture Research
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• 제23권5호
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• pp.207-218
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• 2006

목적 : 심박수 변이도(Heart Rate Variability. HRV)를 통해 사암침법 치료법 중 심신 질환에 많이 적용되는 심정격 자침법과 자율신경계와의 관계를 살펴보고자 하였다. 방법 : 2006년 5월 1일부터 2006년 6월 31일까지 2개월간 특별한 과거력이 없는 건강인을 대상으로 실험군 37명을 사암침법 심정격을 자침하고 시술 전후에 HRV를 측정하여 별무처치 상태로 안정을 취한 후 측정한 대조군 21명과 비교하였다. 결과로 얻은 MHRT, SDNN, RMSSD, TP, LF, HF, LF/HF ratio 등의 수치 변화를 비교해 기록 시간 동안의 평균 심박수, 외부 스트레스에 대한 심박동의 변화상태, 심장에 관여하는 자율신경 중 부교감신경의 활동, 교감신경과 부교감신경의 균형 상태 등을 분석하였다. 결과 1. MHRT는 실험군에서 유의성이 있는 것으로 나타났다. 2. SDNN는 실험군 대조군 모두 통계적인 유의성이 없었다. 3. RMSSD은 실험군 대조군 모두 통계적인 유의성이 없었다. 4. TP는 실험군 대조군 모두 통계적인 유의성이 없었다. 5. LF, HF은 실험군 대조군 모두 통계적인 유의성이 없었다. 6. LF/HF ratio는 실험군에서 유의성이 있는 것으로 나타났다. 결론 : 부교감신경과 교감신경의 비교 지표로 다용되는 LF/HF ratio가 유의한 차이를 보여 심정격 자침이 자율신경계의 항진을 완화시키는 것으로 사료된다. 향후 환자의 병인과 상태에 따라 실증과 허증으로 구분하여 시술하는 등의 추가적인 연구가 필요할 것으로 사료된다.

• 대한물리치료과학회지
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• 제4권3호
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• pp.475-489
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• 1997

Connective tissue massage(CTM, Bindegewebs massage) are developed and named by Mrs. Elizabeth Dicke, a German physical therapist. The CTM is used primarily for internal disorder such as myocarditis, coronary insufficiency, high blood pressure, functional stomach and intestinal disorders, inflamma-tion of the gallbladder, and hepatitis, arterial circulatory problems, venous disorders, headache, particularly trauma to the head, and some gynecologic disorder, etc. Which is performed with special stroking technique of the subcutaneous tissue of the trunk, extremities, and face. The mechanism of effectiveness of CTM is based on a viscerocutaneous reflex. The stroking stimulates the nerve end-ings of the autonomic nervous system. The impulses activated by stroking travel to the sympathetic trunk and the spinal cord and brain, which causes a change in reaction susceptibility. The most important for apply CTM is necessary to know the reflex zone (Head's zone, Mackenzie's zone and Dicke's connective tissue zone). Dicke's connective tissue zones are only found by the special dia-gnostic stroking. Because the connective tissue zones no discomfort when unmanipulated, and thus the patient is unaware of them. It is characterized by diagnostic stroking that causes a sharp pain in the tissue. As a general rule, all treatment are preceded by the basic stroke from the level of the coccyx to the first lumbar vertebra and each stroke is done three times. The right side is done first, then the left side.

• 동의신경정신과학회지
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• 제20권4호
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• pp.127-135
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• 2009

Objectives : This study was conducted to assess the effect of Chunwangbosim-dan(CB) on the autonomic nervous system by using heart rate variability measurement. Methods : The eligible subjects were composed of the healthy female group of ages 25 to 30 years. They were divided into two groups, the CB group(n=16) and the control group(n=16). We measured the heart rate variability respectively for 3 times at 14:00, 16:00, and 17:00. In the CB group, subjects were administered CB at 15:00. For the measurement values, Mean Heart Rate and SDNN(standard deviation of the NN intervals) were used as time domain analysis, and HF(high frequency), LF(low frequency), and LF / HF ratio were used as frequency domain analysis. Results : The degree of LF changes in the CB group was significantly lower than control group at 1 hour after administration. Conclusions : We suggest that Chunwangbosim-dan may be useful for stabilization of the autonomic nervous system by controlling sympathetic nerve in healthy people.

• 한국한의학연구원논문집
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• 제16권1호
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• pp.157-171
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• 2010

This study aimed to investigate the effect of four common types of Qigong position (standing, sitting, supine, and horse-riding position) on the autonomic nervous system. Thirty healthy subjects participated in this study once a week for four weeks. Electroencephalogram (EEG) was measured three times (before, during, and after the position) while the subject maintained one of four positions for ten minutes. There were significant changes in HRV components compared with EEG power spectra in the standing position. Especially, the ratio of low-to-high frequency (LF/HF) which represents a state of balance of autonomic nervous system was increased. In the sitting position, $\beta$ wave which reflects a state of alert consciousness was increased and both the sympathetic and parasympathetic nerves were activated. On the other hand, in the spine position, $\theta$ wave which signifies a state of relaxation was increased and heart rate (HR) was decreased. Activation of sympathetic and parasympathetic nerves was also observed in this position. Significant increases of indices related to awakening and concentration were observed accompanied by increase of HR and a sympathetic nerve was activated in the riding-horse position. In the present study, it was shown that each Qigong position caused various and significant changes in autonomic nervous system. It would be expected that these results can be applied in the choice of appropriate Qigong position according to objective of Qigong therapy although it is remained to further evaluate the effects of long-term maintenance of Qigong positions and repeated Qigong training.

• 대한인간공학회지
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• 제21권3호
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• pp.35-46
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• 2002

In this study, emotion changes were induced by four imaginations- pleasantness, unpleasantness, arousal, relaxation and it was examined using subjective evaluation and analysis of the physiological signals of the central and autonomic nerve systems whether the intended emotions were appropriately achieved, and whether these emotion changes could be distinguished from the analysis of physiological signals. Each of the four imaginations was implemented on 32 subjects for 30 seconds, while that Electroencephalogram (EEG), Eelectrocardiogram (RSP) were measured, and a subjective evaluation was implemented following the completion of the measurement. The analysis of the subjective evaluation revealed that the subjects underwent the four clearly differentiated imaginations, and the pleasantness level was classified into four imagination stages, pleasantness>relaxation>arousal=comfort>unpleasantness, and arousal level was classified into four imagination stages in the order of arousal>unpleasantness${\approx}$pleasantness>comfort>relaxation. The analysis of the EEG revealed that three stages of pleasantness level, pleasantness>relaxation=arousal=comfort>unpleasantness were classified from the values of ${\alpha}/{\alpha}+{\beta}\;and\;{\beta}/{\alpha}+{\beta}$, and about tour distinguishable stages of arousal level were obtained from the autonomic nervous system responses following the order of arousal>unpleasantness${\approx}$pleasantness> comfort> relaxation. It was found that intended emotion could be induced from the imagination, and these induced emotion changes could be differentiated using the physiological signals of the EEG and autonomic nervous system.

• 감성과학
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• 제23권3호
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• pp.3-10
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• 2020

본 연구에서는 기존의 신호체계에서 발생하는 황색 신호 딜레마 상황에서 운전자의 상태를 파악하고 새로운 신호체계를 제안하고자 한다. 특히, 생체신호 분석을 통해 운전자 중심의 대처모형을 제안한다. 이를 위해 자동차 그래픽 시뮬레이터를 통해 교차로 도로 주행상황을 구현하여 기존의 신호체계와 본 연구에서 제안하는 신호체계에서 운전자의 생리적 반응을 관찰하여 규명하고자 한다. 따라서 대조군(기존 신호체계)과 새로운 황색 신호체계를 실험군(새로운 신호체계)으로 나누어 20대 초보 운전자를 중심으로 실험을 진행하였다. 그 결과, 대조군보다 실험군에서 교감신경의 출현이 우세하였으며 통계적으로 유의차가 인정되었다(p<0.05). 이를 통해 새로운 신호체계가 운전자가 긴장감을 유발하는 것처럼 보이지만 교감신경과 부교감신경의 비율이 6:4로 이상적인 균형으로 해석할 수 있다. 결론적으로, 본 연구에서 제안하는 대처 신호체계를 교통체계에 적용한다면 운전자가 더욱 안정적인 주행이 가능할 것으로 보인다.

• 대한한방내과학회지
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• 제44권3호
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• pp.455-465
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• 2023

Inflammatory bowel disease (IBD) is defined as a chronic inflammatory-mediated disease that causes ulceration and inflammation in the gastrointestinal tract. Among most patients, the course of chronic inflammation repeatedly shows intermittent exacerbations and alternating remissions. However, despite the various therapeutic options to relieve symptoms, such as corticosteroids, TNF-α inhibitors, and antibiotic drugs, there is no known cure for IBD. Nonetheless, previous research has revealed that the autonomic nervous system is involved in the pathophysiology of IBD. In this study, we reviewed clinical trials confirming the therapeutic effect of vagus nerve stimulation (VNS) on IBD in vivo. We searched in vivo and human studies on Pubmed using keywords combined with "vagus nerve stimulation", "VNS", and "inflammatory bowel disease". All studies included in this review reported that direct VNS is effective in relieving symptoms of IBD and has no severe adverse effects. The most frequently stimulated site was the unilateral cervical vagus nerve area, and parameters for stimulation were set as 5-20 Hz. Based on the results, we aim to summarize the evidence for the efficacy of VNS on IBD and suggest the possibility of auricular electroacupuncture treatment as a therapeutic option for IBD.

• 동의생리병리학회지
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• 제26권5호
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• pp.797-802
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• 2012

Alcoholic polyneuropathy is a disorder of the peripheral nervous system that interferes with sensory, motor, and autonomic nerve function. This study was to report the effect of Oriental medical treatment on a patient with alcoholic polyneuropathy. Conservative Oriental medical treatment was done to a man of 84 years who was diagnosed as a alcoholic polyneuropathy and suffered from both distal dominant leg weakness & symmetrical paresthesia and ataxic gait. The changes of symptoms, reflexes and sensory test were checked by Toronto Clinical Neuropathy Scoring System(TCNSS). Reflexes, motor and sensory impairments were improved after the Oriental medical treatment. I reported good effects of Oriental medical treatment on alcoholic polyneuropathy. Oriental medical treatment can be helpful to improve the symptoms of alcoholic polyneuropathy.

• Journal of Korean Neurosurgical Society
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• 제65권5호
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• pp.640-651
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• 2022

Clinical studies on neuromodulation intervention for trigeminal neuralgia have not yet shown promising results. This might be due to the fact that the pathophysiology of chronic trigeminal neuropathy is not yet fully understood. Chronic trigeminal neuropathy includes trigeminal autonomic neuropathy, painful trigeminal neuropathy, and persistent idiopathic facial pain. This disorder is caused by complex abnormalities in the pain processing system, which is comprised of the affective, emotional, and sensory components, rather than mere abnormal sensation. Therefore, integrative understanding of the pain system is necessary for appropriate neuromodulation of chronic trigeminal neuropathy. The possible neuromodulation targets that participate in complex pain processing are as follows : the ventral posterior medial nucleus, periaqueductal gray, motor cortex, nucleus accumbens, subthalamic nucleus, globus pallidus internus, anterior cingulate cortex, hypothalamus, sphenopalatine ganglion, and occipital nerve. In conclusion, neuromodulation interventions for trigeminal neuralgia is yet to be elucidated; future advancements in this area are required.