• 대한의료기공학회지
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• 제10권1호
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• pp.130-157
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• 2007

The purpose of this research is to seek for efficient health maintenance device and to suggest desirable daily habit, based on the inquiry on interrelationship between workers' daily lives and their heartbeat change level. The paper survey about general features, case history and daily habits was conducted on workers during medical examination in Jeollabukdo, and examined their change of heartbeat as well. The results of research deducted from data analysis are as follows; 1. There found very positive interrelations between time-domain analysis and frequency-domain analysis, and MHR and LF/HF ratio had negative connection with other analyses. 2. The recipient showed high time-domain analysis when they are younger, have worked shorter or have spouse, and it contributes to stable sympathetic nerve and parasympathetic nerve as it stimulates autonomic nervous system. 3. According to the result of frequency-domain analysis, recipients showed higher TP and LF when they are younger, and the highest HF when they are under 34.The level of VLF was higher for university graduates than the ones who finished high school. The recipients showed higher TP and HF when they don't have spouse, and lower TP, LF and HF when they have worked longer. 4. The level of RMSSD and TSRD was high for the people who don't have case history, and HF was high when they don't have any disease in progress. 5. According to the result concerning correlation of daily habits with time-domain analysis and frequency-domain analysis, cigarette, alcohol and sleeping hours don't affect heartbeat change, but the ones who regularly workout showed higher result in every analysis. It shows that the autonomic nervous system of recipients who regularly exercise response more actively. The result mentioned above suggests that the change of heartbeat is a direct index which shows the change of autonomic nervous system, and it depends on the exercise the most. Thus, workout is proved to be the best method in order for workers to take care of their health.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 B
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• pp.991-993
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• 1999

This study proposed a new algorithm to assess autonomic function activity using Time-Frequency Representation(TFR). TFR is a way of describing the time-valiant energy of a signal. A discrete Wigner representation that is capable of filtering out any cross terms occuring in the Wigner-Ville Distribution(WVD) is used for time-variant energy distribution of heart rate variability(HRV) signals. And the marginal condition are evaluated to estimate power spectrum of HRV signals. The proposed algorithm showed that estimated power spectrum of HRV signals well describe the autonomic nerve system function and also showed the dynamics of autonomic nervous system response.

• Journal of Chest Surgery
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• 제27권1호
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• pp.9-14
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• 1994

Substance P[SP] has been known to be a peptide which may be plays a role as a neurotransmitter in central nervous system as well as peripheral autonomic nervous system. It has been reported that SP was widely distributed in the nerve of the tracheal smooth muscle and induced the muscle contraction. However, definite action mechanism of SP in the tracheal smooth muscle was not clear, yet. Thus, present experiment was performed to elucidate an effect of substance P and an action mechanism on contraction of the smooth muscle in rabbits. In order to find a neural mechanism to the effect of SP on the tracheal smooth muscle contraction, atropine sulfate, tetrodotoxin, propranol and phentolamine were administered at 10 min before the addition of SP. Otherwise,to find effect of SP antagonists on the action of SP, [D-Pro2, D-Try7,9]SP, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]SP and [D-Pro4, D-Trp7,9]SP were administered as a same fashion. These following results were obtained. 1] SP induced contraction of the tracheal smooth muscle under resting condition and the contraction was increased dose-dependently. 2] Cholinergic blocker[atropine], neural blocker[tetrodotoxin] and adrenergic blocker[propranol and phentolamine] didn`t have an effect on the contractile response. 3] Three SP antagonists inhibited the contractile response. 4] Isoproterenol relaxed the contraction induced by SP. The above results suggested that SP induced contraction of the tracheal smooth muscle directly act to the smooth muscle in rabbits. The autonomic nervous system did not seem to participate in the SP action.

• Korean Journal of Acupuncture
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• 제17권1호
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• pp.101-121
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• 2000

The purpose of this morphological studies was to investigate the relation to the meridian, acupoint and nerve. The common locations of the spinal cord and brain projecting to the the gallbladder, GB34 and common peroneal nerve were observed following injection of transsynaptic neurotropic virus, pseudorabies virus(PRV), into the gallbladder, GB34 and common peroneal nerve of the rabbit. After survival times of 96 hours following injection of PRV, the thirty rabbits were perfused, and their spinal cord and brain were frozen sectioned($30{\mu}m$). These sections were stained by PRV immunohistochemical staining method, and observed with light microscope. The results were as follows: 1. In spinal cord, PRV labeled neurons projecting to the gallbladder, GB34 and common peroneal nerve were founded in thoracic, lumbar and sacral spinal segments. Densely labeled areas of each spinal cord segment were founded in lamina V, VII, X, intermediolateral nucleus and dorsal nucleus. 2. In medulla oblongata, The PRV labeled neurons projecting to the gallbladder, GB34 and common peroneal nerve were founded in the A1 noradrenalin cells/C1 adrenalin cells/caudoventrolateral reticular nucleus, rostroventrolateral reticular nucleus, medullary reticular nucleus, dorsal motor nucleus of vagus nerve, nucleus tractus solitarius, raphe obscurus nucleus, raphe pallidus nucleus, raphe magnus nucleus, gigantocellular nucleus, lateral paragigantocellular nucleus, principal sensory trigeminal nucleus and spinal trigeminal nucleus. 3. In Pons, PRV labeled neurons were parabrachial nucleus, Kolliker-Fuse nucleus and cochlear nucleus. 4. In midbrain, PRV labeled neurons were founded in central gray matter and substantia nigra. 5. In diencephalon, PRV labeled neurons were founded in lateral hypothalamic nucleus, suprachiasmatic nucleus and paraventricular hypothalamic nucleus. 6. In cerebral cortex, PRV labeled neuron were founded in hind limb area.This results suggest that PRV labeled common areas of the spinal cord projecting to the gallbladder, GB34 and common peroneal nerve may be first-order neurons related to the somatic sensory, viscero-somatic sensory and symapathetic preganglionic neurons, and PRV labeled common area of the brain may be first, second and third-order neurons response to the movement of smooth muscle in gallbladder and blood vessels.These PRV labeled neurons may be central autonomic center related to the integration and modulation of reflex control linked to the sensory system monitoring the internal environment, including both visceral sensation and various chemical and physical qualities of the bloodstream. The present morphological results provide that gallbladder meridian and acupoint may be related to the central autonomic pathways.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.237-242
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• 1999

The nature of the interactions between the vestibular and autonomic systems is complex and has not been fully defined. Vestibuloocular reflex induced by sinusoidal rotation and activity of the autonomic nerves in the heart were measured to investigate the interactions between the vestibular system and the autonomic nervous system in healthy adults. Eye movement induced by sinusoidal rotation of the whole body or optokinetic stimulation at 0.04 Hz was analyzed in gain, phase, and symmetry. EKG was measured during vestibular stimulation and analyzed in heart rate variability including mean R-R interval, standard deviation (SD) and coefficient of variance (CV) of R-R interval, and power spectrum of low frequency region (LF) and high frequency region (HF). Gain of eye movement was 0.65${\pm}$0.03 by ratatory stimulation, 0.70${\pm}$0.02 in optokinetic stimulation, 0.08${\pm}$0.02 in visual suppression, and 0.84${\pm}$0.04 in visual enhancement. In R-R interval, resting condition (control) was 0.82${\pm}$0.03 sec, and visual suppression showed significant increase and visual enhancement did significant decrease compared with control (p<0.01).CV was 0.06${\pm}$0.02 in control and visual enhancement increased significantly (p<0.05). In LF/HF control was 1.40${\pm}$0.23, which was not different from rotatory or optokinetic stimulation. But visual suppression decreased LF/HF significantly and visual enhancement increased significantly compared with control (p<0.01). These results suggest that degree of gain corresponds with LF/HF and increased gain in visual enhancement is deeply related to the activity of sympathetic nerves.

• 대한핵의학회지
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• 제38권5호
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• pp.331-337
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• 2004

Cardiac neurotransmission imaging allows in vivo assessment of presynaptic reuptake, neurotransmitter storage and postsynaptic receptors. Among the various neurotransmitter, I-123 MIBG is most available and relatively well-established. Metaiodobenzylguanidine (MIBG) is an analogue of the false neurotransmitter guanethidine. It is taken up to adrenergic neurons by uptake-1 mechanism as same as norepinephrine. As tagged with I-123, it can be used to image sympathetic function in various organs including heart with planar or SPECT techniques. I-123 MIBG imaging has a unique advantage to evaluate myocardial neuronal activity in which the heart has no significant structural abnormality or even no functional derangement measured with other conventional examination. In patients with cardiomyopathy and heart failure, this imaging has most sensitive technique to predict prognosis and treatment response of betablocker or ACE inhibitor. In diabetic patients, it allow very early detection of autonomic neuropathy. In patients with dangerous arrhythmia such as ventricular tachycardia or fibrillation, MIBG imaging may be only an abnormal result among various exams. In patients with ischemic heart disease, sympathetic derangement may be used as the method of risk stratification. In heart transplanted patients, sympathetic reinnervation is well evaluated. Adriamycin-induced cardiotoxicity is detected earlier than ventricular dysfunction with sympathetic dysfunction. Neurodegenerative disorder such as Parkinson's disease or dementia with Lewy bodies has also cardiac sympathetic dysfunction. Noninvasive assessment of cardiac sympathetic nerve activity with I-123 MIBG imaging nay be improve understanding of the pathophysiology of cardiac disease and make a contribution to predict survival and therapy efficacy.

• 동의신경정신과학회지
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• 제16권2호
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• pp.259-266
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• 2005

상기 환자는 25세 여환으로 유학 준비 중 경제적 이유로 유학이 좌절되면서 취업과 유학 준비의 문제로 부모님과 마찰이 있던 상태에서 2005년 7월 19일 두통(頭痛)이 발생하여 양방 내과 및 신경정신과 치료를 받으나 별무호전하고 2005년 7월 23일 악심(惡心) 및 구토(嘔吐)가 추가 발생하여 2005년 7윌 25일부터 2005년 8월 3일까지 동서한방병원 한방신경정신과로 입원한 환자로 한방적으로는 간기울결(肝氣鬱結)로 인한 두통(頭痛)으로, 양방적으로는 긴장형(緊張型) 두통(頭痛)으로 진단받고 한방치료를 통해 호전된 환자이다. 내원당시 다양한 양방적 검사를 시행하여 기질성 질환 여부를 배제하였고, 두통(頭痛)과 겸발한 구토(嘔吐)에 초점을 두고 향묘평위산(香妙平胃散)을 투여하여 빠른 치료효과를 나타낼 수 있었다. 이러한 자율신경계의 균형 이상에서 발생하는 증상의 경우 환자 및 보호자와의 면담 도구로서 HRV의 사용이 상당한 설득력을 보였으나, 보편성의 확보를 위해서는 많은 임상연구 및 치험례의 보고가 필요할 것으로 사려된다

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2001년도 추계학술대회 논문집
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• pp.127-133
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• 2001

본 연구는 향에 대한 연령별 감성 구조를 밝히고, 향 감성에 따른 자율신경계 반응을 밝히려는 것이다. 실험 참여자는 연령별(10대, 20대, 40대)로 24명씩, 총 72명이고 자극향은 cederwood, grapegruit, teebaum, peppermint, rose 향을 사용하였다. 향이 제시되는 동안 혈류량, 피부온도, 피부전기반응, 심전도 반응을 측정하였고, 향에 대한 주관적 감성을 측정하였다. 향에 의한 심리적 감성 구조는 심미성, 강도, 자연성, 개성성, 낭만성의 다섯 요인이 확인되었고, 연령별로 차이가 나타나지 않았다. 향 선호도를 예측하는 감성요인은 연령별로 차이가 났다. 감성적으로 "나쁜"향은 "좋은"향보다 교감신경계 활동에 의한 자율신경계 반응이 더 크게 일어났다.

• 감성과학
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• 제23권3호
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• pp.3-10
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• 2020

본 연구에서는 기존의 신호체계에서 발생하는 황색 신호 딜레마 상황에서 운전자의 상태를 파악하고 새로운 신호체계를 제안하고자 한다. 특히, 생체신호 분석을 통해 운전자 중심의 대처모형을 제안한다. 이를 위해 자동차 그래픽 시뮬레이터를 통해 교차로 도로 주행상황을 구현하여 기존의 신호체계와 본 연구에서 제안하는 신호체계에서 운전자의 생리적 반응을 관찰하여 규명하고자 한다. 따라서 대조군(기존 신호체계)과 새로운 황색 신호체계를 실험군(새로운 신호체계)으로 나누어 20대 초보 운전자를 중심으로 실험을 진행하였다. 그 결과, 대조군보다 실험군에서 교감신경의 출현이 우세하였으며 통계적으로 유의차가 인정되었다(p<0.05). 이를 통해 새로운 신호체계가 운전자가 긴장감을 유발하는 것처럼 보이지만 교감신경과 부교감신경의 비율이 6:4로 이상적인 균형으로 해석할 수 있다. 결론적으로, 본 연구에서 제안하는 대처 신호체계를 교통체계에 적용한다면 운전자가 더욱 안정적인 주행이 가능할 것으로 보인다.

• Archives of Plastic Surgery
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• 제32권4호
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• pp.408-415
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• 2005

Following a transverse rectus abdominis musculocutaneous(TRAM) flap breast reconstruction, denervated state of the flap causes the flap skin prone to thermal injury, calling for special attention. During the last 5 years, 69 breast reconstruction with 72 free TRAM flaps, were performed. Four out of thesse 69 patients sustained burn injury. Heat sources were a warm bag(n=2), heating pad(n=1) and warming light (n=1). The thermal injuries occured from 2 days to 3 months following the reconstruction. Three patients healed with conservative treatment, but one patient required debridement and skin graft. Initially 3 out of 4 patients with the burn had shown superficial 2nd degree burn with small blebs or bullae. However all 4 patients healed with scars. Mechanism of burn injuries of the denervated flap are known to be resulting from; 1) loss of behavioral protection due to denervation of flap with flap elevation and transfer, 2) loss of autonomic thermoregulatory control with heat dissipation on skin flap vasculature contributing to susceptibility of burn injury. 3) changes of immunologic and normal inflammatory response increasing thromboxane, and a fall in substance P & NGF (nerve growth factor). Including the abdominal flap donor site, sensory recovery of the reconstructed breast varies individually from 6 month even to 5 years postoperatively. During this period, wound healing is delayed, resulting in easier scarring compared to that observed in the sensate skin. Patients should be carefully informed and warned of possible burn injuries and taught to avoid exposure to heat source at least until 3 years postoperatively.