• International Journal of Precision Engineering and Manufacturing
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• v.2 no.4
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• pp.5-11
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• 2001

Vibration and noise of gears is doc to the transmission error and the vibration exciting force caused by the periodically alternating tooth stiffness. Transmission error is the rotation delay between driving and driven gear caused by manufacturing error, alignment error in assembly and so on. Tooth stiffness changes with the proceeding mesh of teeth. The purpose of this study is to develop how to calculate simultaneously the optimum amounts of tooth profile modification. end relief and crowning by minimizing the vibration exciting force of helical gears. We estimate the vibration exciting force by the meshing analysis of gears. Formulated constraints of this problem consist of contact ratio and strengths of gear teeth such as tooth bending strength, surface durability, and scoring. ADS(Automated Design Synthesis) is used as an optimization tool. We also investigate the relation between the aspect ratio and the optimum values of tooth modification. The proposed method can calculate the optimum amount of tooth modification automatically and is expected to be practically useful to resolve the problem of vibration of helical gears.

• Archives of Pharmacal Research
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• v.23 no.2
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• pp.139-146
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• 2000

7- Bromomethylbenz[a]anthracene is a known mutagen and carcinogen. The two major DNA adducts produced by this carcinogen, i.e., $N^2$-(benz[a]anthracen-7-yl methyl)-2'-deoxyguanosine (2, b[a]$a^2$G) and $N^6$-(benz[a]anthracen-7-ylmethyl)-2'-deoxyadenosine (4, b[a]$a^6$/A), as wel 1 as the simpler benzylated analogs,$N^2$-benzyl-2'deoxyguanosine (1, $bn^2$G) and $N^6$-benzyl-2'-deoxyadenosine (3, $bn^6$/A), were prepared by direct aralkylation of 2'-deoxyguanosine and 2'-deoxyadenosine. To determine the site-specific mutagenicity of these bulky exocyclic amino-substituted adducts, the suitably protected nucleosides were incorporated into 16-base oligodeoxyribonucleotides in place of a normal guanine or adenine residues which respectively are part of the ATG initiation codon for the lac Z' \alpha-complementation gene by using an in situ activation approach and automated phosphite triester synthetic methods. The base composition and the incorporation of the bulky adducts into synthetic oligonucleotides were characterized after purification of the modified oligonucleotides by enzymatic digestion and HPLC analysis.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1998.04a
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• pp.262-271
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• 1998

Recent, more and more steel deck bridges are adopted for the design of long span bridges and the upgrading of existing concrete deck bridges, mainly because of reduced self weight, higher stiffness and efficient erection compared to concrete decks. The main objective of this study is to propose on formulation of the design optimizations to develop an optimal desist program required for optimum desist for orthotropic steel-deck bridges. The objective function of the optimization is formulated as a minimum initial cost design problem. The behavior and design constraints are formulated based on the ASD and LRFD criteria of the Korean Bridge Design Code(1996). The optimum design program developed in this study consists of two steps. In the first step the system optimization of the steel box girder bridges is carried out. And in the second step the program provided the optimum design of the orthotropic steel-deck with close ribs. In the optimal design program the analysis module for the deck optimization is based on the Pelican Esslinger method. The optimizer module of the program utilizes the ADS(Automated Desist Synthesis) routines using the optimization techniques fuor constrained optimization. From the results of real application examples, The cost effectiveness of optimum orthotropic steel-deck bridges designs based on both ASD and LRFD methods is investigated by comparing the results with those of conventional designs, and it may be concluded that the design developed in this study seems efficient and robust for the optimization of orthotropic steel-deck bridges

• Journal of Korean Society of Industrial and Systems Engineering
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• v.28 no.3
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• pp.133-141
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• 2005

The previous research has been mainly focused on individual technology of voice recognition, voice synthesis, translation, and bone transmission technical. Recently, commercial models have been produced using aforementioned technologies. In this research, a new automated translation support system concept has been proposed by combining established technology of bone transmission and wireless system. The proposed system has following three major components. First, the hybrid system consist of headset, bone transmission and other technologies will recognize user's voice. Second, computer recognized voice (using small server attached to the user) of the user will be converted into digital signal. Then it will be translated into other user's language by translation algorithm. Third, the translated language will be wirelessly transmitted to the other party. The transmitted signal will be converted into voice in the other party's computer using the hybrid system. This hybrid system will transmit the clear message regardless of the noise level in the environment or user's hearing ability. By using the network technology, communication between users can also be clearly transmitted despite the distance.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.11
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• pp.199-205
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• 2000

The vibration and noise of gears is due to the vibration exciting force caused by the tooth stiffness which changes periodically as the mesh of teeth proceeds and by the transmission error, that is, the rotation delay between driving gear and driven gear caused by manufacturing error and alignment error in assembly and so on. The purpose of this study is to develop how to calculate simultaneously the optimum amounts of tooth profile modification, end relief and crowning by minimizing the vibration exciting force of helical gears. We estimate the vibration exciting force by the mesh analysis of gears. The constraints of this problem consist of contact ratio and strengths of gear teeth such as tooth fillet stress, surface durability and scoring. ADS(Automated Design Synthesis) is used as an optimization tool. And, since the aspect ratio is an important parameter of tooth modification, we investigate the relation between it and the optimum values of tooth modification. The proposed method can calculate the optimum amount of tooth modification automatically and is to be utilized to resolve the problem of vibration of helical gears.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.8 no.1
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• pp.3-8
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• 2022

Alteration of the mGluR5 density is closely related to various brain diseases including schizophrenia, depression, Parkinson's disease, and Alzheimer's disease. Therefore, mGluR5 is considered as a valuable imaging biomarker for brain disease and many radiopharmaceuticals have been developed so far. Among them, [¹⁸F]FPEB has favorable pharmacokinetic characteristics, and this is the most frequently used radiopharmaceutical for preclinical and clinical studies. In the present study, we want to introduce the optimized radiosynthetic method for the routine production of [¹⁸F]FPEB using a GE TRACERlabTM FXFN pro module. In addition, the entire process was monitored with a webcam to solve the problems arising from the synthetic process. As a result, [¹⁸F]FPEB was prepared by nucleophilic substitution from its nitro- precursor at 120℃ for 20 min in dimethyl sulfoxide. Radiochemical yield was 13.7 ± 5.1% (decay-corrected, n = 91) with the molar activity of 84 ± 17 GBq/µmol at the end of synthesis. The radiochemical purity was determined to be above 96%. The manufactured [¹⁸F]FPEB injection for quality controls were carried out in accordance with an KIRAMS approved protocol, as per ICH and USP guidelines.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.05a
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• pp.494-496
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• 2021

최근 경량 딥러닝 기반 키워드 음성인식은 가전, 완구, 키오스크 등 다양한 응용에 음성 인터페이스를 쉽게 적용할 수 있는 기술로서 주목받고 있다. 키워드 음성인식은 일부 키워드만 인식 가능한 음성인식 기술로서 저성능 디바이스에서 활용 가능한 장점이 있다. 그러나 응용에 따라 필요한 키워드에 대하여 다시 음성데이터를 수집해야하고 이를 학습하여 모델을 새로 준비해야하는 단점이 있다. 따라서 본 연구에서는 음성데이터 수집 없이 음성합성을 통해 생성한 음성으로만 키워드 음성인식 모델을 학습하는 음성합성 기반 자동 학습 기법을 제안하였다. 생성한 음성데이터를 활용하고자하는 시도가 활발히 이루어지고 있으나, 기존 연구에서는 정확도를 유지하기 위하여 수집한 실제 음성데이터가 필요한 한계가 있다. 제안한 자동 학습 기법은 생성한 음성데이터에 대해 복합 데이터 증대 기법을 적용하여 실제 음성데이터 없이 키워드 음성인식의 정확도를 높였다. 제안한 기법에 대하여 상용 음성합성 서비스를 기반으로 수집한 한국어 키워드 데이터세트를 활용하여 성능평가를 진행하였다. 20개 한국어 키워드에 대해 실험한 결과, 제안한 기법을 적용하여 학습시킨 키워드 음성인식 모델의 정확도는 86.44%임을 확인하였다.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.2
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• pp.174-182
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• 2002

The object-oriented design methods and their CASE tools are widely used in practice by many real-time software developers. However, object-oriented CASE tools require an additional step of identifying tasks from a given design model. Unfortunately, it is difficult to automate this step for a couple of reasons: (1) there are inherent discrepancies between objects and tasks; and (2) it is hard to derive tasks while maximizing real-time schedulability since this problem makes a non-trivial optimization problem. As a result, in practical object-oriented CASE tools, task identification is usually performed in an ad-hoc manner using hints provided by human designers. In this paper, we present a systematic, schedulability-aware approach that can help mapping real-time object-oriented models to multi-threaded implementations. In our approach, a task contains a group of mutually exclusive transactions that may possess different periods and deadline. For this new task model, we provide a new schedulability analysis algorithm. We also show how the run-time system is implemented and how executable code is generated in our frame work. We have performed a case study. It shows the difficulty of task derivation problem and the utility of the automated synthesis of implementations as well as the Inappropriateness of the single-threaded implementations.

• Korean Journal of Clinical Laboratory Science
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• v.56 no.1
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• pp.43-51
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• 2024

[⁶⁸Ga]Ga-FAPI-04 is a promising radiopharmaceutical that binds specifically to fibroblast activation protein, which is overexpressed in more than 90% of malignant epithelial tumors but not in normal healthy tissue. This study aimed to develop an efficient method for producing ⁶⁸Ga-labelled FAPI-04 using a cassette-based automated synthesizer. [⁶⁸Ga]GaCl₃ was eluted from an Eckert & Ziegler Medical germanium-68/gallium-68 generator using 2.5 mL of 0.1 M HCl. The synthesis of the [⁶⁸Ga]Ga-FAPI-04 was performed using different concentrations of HEPES (1~2.5 M; 4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) in 3~10 minutes; amounts of FAPI-04 precursor (5~50 ㎍) and reaction temperature (25℃~100℃) were optimized on the BIKBox^® synthesizer. The labeling efficiency of [⁶⁸Ga]Ga-FAPI-04 was greater than 96% (decay corrected) using 25 ㎍ FAPI-04 synthesized in 10 minutes at 100℃ in 2 M HEPES (pH 3.85), and its stability was greater than 99% at 6 hours. The total synthesis time of [⁶⁸Ga]Ga-FAPI-04 was 32.4 minutes, and the product met all quality control criteria. In this study, we developed and optimized a labeling method using [⁶⁸Ga]Ga-FAPI-04 using a cassette-based synthesizer. The devised method is expected to be useful for supplying [⁶⁸Ga]Ga-FAPI-04 for diagnosis in clinical practice.

• Journal of the Korean Vacuum Society
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• v.15 no.5
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• pp.506-511
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• 2006

ZnO nanorods were prepared by the hydrothermal reaction of a solution containing $Zn(NO_3)_2{\cdot}6H_2O$, NaOH, cyclohexylamine, ethanol and water, and their $NO_2$ and CO sensing behaviors were investigated. By the control of water concentration in solution, the morphology and agglomeration of ZnO nanorods could be manipulated, which is associated with the variation of $[OH^-]$ resulted from an interaction between water and cyclohexylamine. Sea-urchin-like and well-dispersed ZnO nanorods were prepared at low and high water content, respectively. Well-dispersed ZnO nanorods showed 1.8 fold change in resistance at 1 ppm $NO_2$ while there was no significant change in resistance at 50 ppm CO. This selective detection of $NO_2$ in the presence of CO can be used in automated car ventilation systems.