• 한국멀티미디어학회논문지
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• 제14권1호
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• pp.144-152
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• 2011

IPv4 주소가 고갈되어가고 있기 때문에 IPv6 주소의 사용이 늘어나고 있다. IPv6 환경에서는 주소자동설정 기능이 제공된다. 주소가 각 호스트(host)에 자동으로 할당될 경우, 네트워크 관리 시스템은 모든 장비의 IP주소를 조사하고 해당 정보를 유지해야 하는 어려움이 따른다. 또한, IP주소가 자동으로 설정되기 때문에 악의적 사용자가 아무런 제약 없이 네트워크 주요장비에 접근할 수 있는 문제가 발생한다. 이런 문제를 해결하기 위해 악의적 사용자들에 대한 관리 및 차단이 필요하다. 본 논문에서는, IPv6 환경에서 호스트를 탐색하고 인가되지 않은 호스트가 네트워크에 접속하는 것을 차단함으로써, 네트워크 주요 자원을 효율적으로 관리하고 보호하는 호스트 탐색 및 네트워크 접속 차단 에이전트 시스템을 제안한다. IPv6 환경에서 본 에이전트 시스템의 성능을 테스트한 결과, 본 시스템은 정상적으로 탐색과 차단 기능을 수행하였다.

• 한국정보과학회논문지:정보통신
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• 제35권4호
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• pp.282-291
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• 2008

본 논문에서는 무선 노드의 이동성에 따른 링크 에러로 인한 Mobile Ad hoc Network (MANET) IP 자동 네트워크 프로토콜(Address Autoconfiguration Protocol: AAP)의 메시지 복잡도를 분석하고자 한다. 링크 에러로 인해 목적지까지 전달되지 못한 메시지는 재전송되어야 하고, 이러한 재전송 횟수 (S)를 링크 에러 확률 ($P_e$)에 따라 계산하는 알고리즘을 제안하였다. 또한, O-표기법에 따라 N개의 노드에 의해 발생된 메시지의 Upper Bound를 각 AAP에서 유도하였다. 본 연구에서 검토된 AAP는 Strong Duplicate Address Detection (DAD), Weak DAD with proactive routing protocol (WDP), Weak DAD with on-demand routing protocol (WDO), MANETconf이다. 컴퓨터 기반 시뮬레이션에서, 제안된 알고리즘에 의해 링크 에러가 있을 때, 각 AAP의 성능을 분석해본 결과, WDP가 가장 낮은 메시지 복잡도를 가졌고, MANETconf가 가장 높은 메시지 복잡도를 보였다.

• 전기학회논문지
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• 제59권8호
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• pp.1456-1463
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• 2010

The safety critical systems in nuclear power plants should be designed to have a high level of fault tolerant capability because those systems are used for protection or mitigation of the postulated accidents of nuclear reactor. Due to increasing of the system complexity of the digital based system in nuclear fields, the reliability of the digital based systems without an auto-test or a self-diagnostic feature is generally lower than those of analog system. To overcome this problem, additional redundant architectures in each redundant channel and self-diagnostic features are commonly integrated into the digital safety systems. The self diagnostic function is a key factor for increasing fault tolerant capabilities in the digital based safety system. This paper presents an availability and safety evaluation model to analyze the effect to the system's fault tolerant capabilities depending on self-diagnostic features when the loss or erroneous behaviors of self-diagnostic function are expected to occur. The analysis result of the proposed model on the several modules of a safety platform shows that the improvement effect on unavailability of each module has generally become smaller than the result of usage of conventional models and the unavailability itself has changed significantly depending on the characteristics of failures or errors of self-diagnostic function.

• Clinical and Experimental Pediatrics
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• 제48권5호
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• pp.551-556
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• 2005

저자들은 혈소판 평균용적 및 혈소판 수의 감소, 심한 아토피 피부염 및 반복 감염을 임상적 증상으로 추정 진단된 WAS 환아로부터 WAS의 확진에 필수적인 분자학적 분석을 실시하여 WASP 단백질의 발현이 감소되어 있으며, WASP 유전자의 Exon 2, 번역 개시점으로부터 208번째의 염기서열 구아닌(g)이 아데닌(a)으로 변이되어 70번째 아미노산인 글라이신(Gly)이 알지닌(Arg)으로 변화된 missense 변이(G70A)를 발견하여 확진된 WAS 환자를 경험하였기에 문헌 고찰과 함께 이를 보고하는 바이다.

• Smart Structures and Systems
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• 제8권1호
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• pp.119-137
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• 2011

A bio-inspired two-mode structural health monitoring (SHM) system based on the Na$\ddot{i}$ve Bayes (NB) classification method is discussed in this paper. To implement the molecular biology based Deoxyribonucleic acid (DNA) array concept in structural health monitoring, which has been demonstrated to be superior in disease detection, two types of array expression data have been proposed for the development of the SHM algorithm. For the micro-vibration mode, a two-tier auto-regression with exogenous (AR-ARX) process is used to extract the expression array from the recorded structural time history while an ARX process is applied for the analysis of the earthquake mode. The health condition of the structure is then determined using the NB classification method. In addition, the union concept in probability is used to improve the accuracy of the system. To verify the performance and reliability of the SHM algorithm, a downscaled eight-storey steel building located at the shaking table of the National Center for Research on Earthquake Engineering (NCREE) was used as the benchmark structure. The structural response from different damage levels and locations was collected and incorporated in the database to aid the structural health monitoring process. Preliminary verification has demonstrated that the structure health condition can be precisely detected by the proposed algorithm. To implement the developed SHM system in a practical application, a SHM prototype consisting of the input sensing module, the transmission module, and the SHM platform was developed. The vibration data were first measured by the deployed sensor, and subsequently the SHM mode corresponding to the desired excitation is chosen automatically to quickly evaluate the health condition of the structure. Test results from the ambient vibration and shaking table test showed that the condition and location of the benchmark structure damage can be successfully detected by the proposed SHM prototype system, and the information is instantaneously transmitted to a remote server to facilitate real-time monitoring. Implementing the bio-inspired two-mode SHM practically has been successfully demonstrated.

• 정보보호학회논문지
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• 제23권3호
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• pp.501-514
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• 2013

악성코드를 효과적으로 분류 및 대응하기 위해서 유사도 비교를 통한 그룹화 과정이 요구된다. 기존 유사도 비교 방법에서 사용되는 기준 또는 속성만을 이용했을 경우, 미탐 및 오탐이 증가하는 문제점이 발생한다. 그러므로, 본 논문에서는 악성코드 자동분석시스템의 2차적인 휴리스틱 기반 행위분석의 문제점을 보완하기 위해 다양한 속성을 선택하여 사용하고, 속성별 가중치 적용을 위해 AHP(Analytic Hierarchy Process) 의사결정기법을 반영한 유사도 비교 방법을 제안한다. 악성코드의 유사도 비교를 통하여 탐지율과 오탐율의 최적 임계치를 설정하고, 새로운 악성코드에 대한 분류 실험으로 악성코드생성기로 생성된 그룹을 결정함을 보이므로 향후 해킹 유형 및 악성코드 근원지를 추적 할 수 있는 악성코드 그룹 정보로서 활용할 수 있기를 기대한다.

• 전자공학회논문지CI
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• 제44권3호
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• pp.74-80
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• 2007

전자와 컴퓨터 기술의 발전은 무선 센서 네트워크 증대의 토대를 마련하였다. 이에 따라, 센서 네트워크상의 충돌 방지와 인증 기술의 필요성이 증대되어 지고 있다. 센서 네트워크의 충돌 방지를 위해 개발될 알고리즘은 무선 센서 네트워크 플랫폼 상에 쉽게 적용될 수 있으며 또한 동시에 분산 연산, 분산 저장, 데이터 강인성, 센싱된 데이터를 자동 분류할 수 있어야한다. 그리고 무선 센서 네트워크에서 보안을 유지하기 위하여 여러 센서 간에 안전하게 채널을 확립할 수 있어야한다. 본 논문 우리는 센서의 인증과 충돌 방지를 위하여 유비쿼터스 센서 네트워크 채널 확립 알고리즘을 제안하였다. 본 논문에서는 두 가지 다른 형태의 구조를 제안하였으며, 각 구조에서는 센서 노드 사이에서 채널을 확립하기위하여 웨이블렛 필터를 사용한 알고리즘과 센서의 충돌 방지를 위하여 BIBD(Balanced Incomplete Block Design) 코드를 사용하였다. 결과적으로, BIBD와 웨이블렛 필터 기반으로 제안된 알고리즘은 이상적인 환경에서 98% 충돌 검출율을 가졌다.

• 소음진동
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• 제9권1호
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• pp.85-96
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• 1999

For ASME Code pumps in nuclear power plants, inservice test is required to assess the operational readiness in accordance with ASME code and related regulations. The objective of this study therefore, is to develop the technical background of the degradation of pump performances and conditions due to low flow rate operation. In addition. the detection techniques of pump operating conditions are to be developed to enhance the safety and economy of nuclear power plants. A test loop consisted of pump, motor. water tank, flow rate measurements and piping system with flow control devices was established for this study. Two typical pumps, 1-stage volute pump and 3-stage turbine pump, were selected and the test was performed upon two major point of views ; i.e., pump discharge pressure pulsations analysis and pump vibration spectrum analysis. From the test results, it is concluded that (1) the pump vibration affected by the natural frequency of operating pump is significant in the low frequency zone (around 1 Hz) : the vibration amplitude. especially. is an important factor during low flow rate operation. and shall be monitored to ensure that it is within the limit of ASME OM code Part 6, (2) the vibration frequency and pump discharge pressure are affected by vane pass frequency and running speed, (3) the wave phenomena due to the compressiblity of water is anticipated during low flow rate operation. and the pump system shall be designed to prevent it and. finally, (4) the technical background of the degradation of pump performances and conditions due to low flow rate operation is provided.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2006년도 Spring Conference
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• pp.139-149
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• 2006

Amyloid beta (A$\beta$) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of A$\beta$ is considered a primary therapeutic target. Immunization with A$\beta$ can reduce A$\beta$ burden and pathological features in transgenic AD model mouse. This means anti-A$\beta$ autoantibodies may have a role in AD pathology. Recent findings suggest anti-A$\beta$ autoantibodies level decrease in AD patients. The early detection of AD is important for treatment of this disease. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. To investigate whether it was possible to detect the presence and different levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma of patients with AD and age-matched controls. An advanced ELISA was performed to detect levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma. The level of anti-A$\beta$ auto-antibodies from patients with idiopathic Parkinson's disease or stroke and from normal controls were compared to that of AD patients. Our results showed a significantly lower anti-A$\beta$ autoantibodies level in AD compared to those with other neurological diseases or control. The level of anti-A$\beta$ autoantibodies in the serum may be used to diagnose the presence of AD.

• 대한본초학회지
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• 제30권3호
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• pp.19-24
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• 2015

Objectives : HPL-1, a novel herbal medicine which is composed of five herbs such as Kalopanacis Cortex, Chaenomelis Fructus, Raphani Semen, Atractylodis Rhizoma and Pulvis Aconiti Tuberis Purificatum, was developed for treatment of osteoarthritis. This study is aimed to develop analytical method for consistent quality control of HPL-1 and validate chromatographic method. Methods : Chromatographic analysis was performed using ultra-high performance liquid chromatography - diode array detector (UHPLC-DAD) equipped with RP-amide column, column oven, and auto sampler. Marker compounds [protocatechuic acid, chlorogenic acid, liriodendrin, 3,5-dicaffeoylquinic acid, ${\beta}$-D-(3-O-sinapoyl)-fructofuranosyl-$\alpha$-D-(6-O-sinapoyl)glucopyranoside and benzoylmesaconine] were separated by step gradient elution of acetonitrile and 0.1% phosphoric acid/water. The method validation was evaluated by quantitative validation parameters of linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) according to KFDA guideline.Results : An optimized method for six marker compounds in HPL-1 was established by UHPLC-DAD. The correlation coefficient (R²) with each calibration curve was greater than 0.99. The LOD and LOQ were within the range of 0.008-0.090 and $0.023-0.274{\mu}g/mL$, respectively. The relative standard deviation (RSD) of intra- and inter-day variability were less than 4.0%. The result of recovery test was range from 93.3-106.3% with RSD < 4.0%.Conclusions : These results suggest that the quantitative UHPLC method is precise, accurate, effective for quality evaluation of HPL-1. The method may also contribute to improve quality of crude drug preparations used for treatment of various diseases.