• Journal of Korea Multimedia Society
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• v.14 no.1
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• pp.144-152
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• 2011

As IPv4 addresses are exhausting, the use of IPv6 addresses is increasing. IPv6 environment provides address auto-configuration function. If addresses are allocated to each host automatically, network management system has difficulty in inspecting every IP of all devices and keeping the relevant informations. Also, as IP addresses are configured automatically, problems such as malicious users accessing network devices with no restriction can occur. To solve these problems, managing and blocking of malicious user is necessary. In this paper, we suggest agent system for searching of host computer and blocking network access which manages and protects the major network resources efficiently by searching host and blocking unauthorized host access to network in IPv6 environment. According to the test results of function of this agent system in IPv6 environment, we have checked that this system performs searching and blocking function normally.

• Journal of KIISE:Information Networking
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• v.35 no.4
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• pp.282-291
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• 2008

This paper focuses on message complexity performance analysis of MANET AAPs in reference to link errors generated by the mobile wireless nodes. To obtain the message complexity performance of AAPs in reference to the link error probability ($P_e$), an enhancement was made by proposing the retransmission limit (S) to be computed for error recovery (based on the link error probability), and then for each of the AAPs the control procedures for the retransmission limit have been properly included. The O-notation has been applied in analyzing the upper bound of the number of messages generated by a MANET group of N nodes. Based on a link error probability range of $P_e=0$ to 0.8, the AAPs investigated in this paper are Strong DAD, Weak DAD with proactive routing protocol (WDP), Weak DAD with on-demand routing protocol (WDO), and MANETconf. Based on the simulation results and analysis of the message complexity, for nominal situations, the message complexity of WDP was lowest, closely followed by WDO. The message complexity of MANETconf is higher than that of WDO, and Strong DAD results to be most complex among the four AAPs.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.8
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• pp.1456-1463
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• 2010

The safety critical systems in nuclear power plants should be designed to have a high level of fault tolerant capability because those systems are used for protection or mitigation of the postulated accidents of nuclear reactor. Due to increasing of the system complexity of the digital based system in nuclear fields, the reliability of the digital based systems without an auto-test or a self-diagnostic feature is generally lower than those of analog system. To overcome this problem, additional redundant architectures in each redundant channel and self-diagnostic features are commonly integrated into the digital safety systems. The self diagnostic function is a key factor for increasing fault tolerant capabilities in the digital based safety system. This paper presents an availability and safety evaluation model to analyze the effect to the system's fault tolerant capabilities depending on self-diagnostic features when the loss or erroneous behaviors of self-diagnostic function are expected to occur. The analysis result of the proposed model on the several modules of a safety platform shows that the improvement effect on unavailability of each module has generally become smaller than the result of usage of conventional models and the unavailability itself has changed significantly depending on the characteristics of failures or errors of self-diagnostic function.

• Clinical and Experimental Pediatrics
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• v.48 no.5
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• pp.551-556
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• 2005

Wiskott-Aldrich syndrome(WAS) is an X-linked recessive immunodeficiency characterized by thrombocytopenia with small platelet volume, eczema, and recurrent infections, and is also characterized by increased incidence of auto immune diseases and malignancies. The phenotype observed in this syndrome is caused by mutation in the Wiskott-Aldrich syndrome protein(WASP) gene localized to the proximal short arm of the X chromosome and recently isolated through positional cloning. The gene encodes a 502 amino acid protein, which contains 12 exons and spans 9 kb of genomic DNA. The function of the encoded protein is not well understood. The clinical diagnosis of WAS can be difficult and is usually confirmed by the detection of WASP gene mutations and the expression of WSAP in patient blood sample using genetic analysis. We reported a case of a 13-month old boy with WAS who was identified with the novel mutation in exon 2 of WASP gene by direct sequencing and the complete absence of WASP expression by immunoblotting.

• Smart Structures and Systems
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• v.8 no.1
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• pp.119-137
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• 2011

A bio-inspired two-mode structural health monitoring (SHM) system based on the Na$\ddot{i}$ve Bayes (NB) classification method is discussed in this paper. To implement the molecular biology based Deoxyribonucleic acid (DNA) array concept in structural health monitoring, which has been demonstrated to be superior in disease detection, two types of array expression data have been proposed for the development of the SHM algorithm. For the micro-vibration mode, a two-tier auto-regression with exogenous (AR-ARX) process is used to extract the expression array from the recorded structural time history while an ARX process is applied for the analysis of the earthquake mode. The health condition of the structure is then determined using the NB classification method. In addition, the union concept in probability is used to improve the accuracy of the system. To verify the performance and reliability of the SHM algorithm, a downscaled eight-storey steel building located at the shaking table of the National Center for Research on Earthquake Engineering (NCREE) was used as the benchmark structure. The structural response from different damage levels and locations was collected and incorporated in the database to aid the structural health monitoring process. Preliminary verification has demonstrated that the structure health condition can be precisely detected by the proposed algorithm. To implement the developed SHM system in a practical application, a SHM prototype consisting of the input sensing module, the transmission module, and the SHM platform was developed. The vibration data were first measured by the deployed sensor, and subsequently the SHM mode corresponding to the desired excitation is chosen automatically to quickly evaluate the health condition of the structure. Test results from the ambient vibration and shaking table test showed that the condition and location of the benchmark structure damage can be successfully detected by the proposed SHM prototype system, and the information is instantaneously transmitted to a remote server to facilitate real-time monitoring. Implementing the bio-inspired two-mode SHM practically has been successfully demonstrated.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.23 no.3
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• pp.501-514
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• 2013

A grouping process through the similarity comparison is required to effectively classify and respond a malicious code. When we have a use of the past similarity criteria to be used in the comparison method or properties it happens a increased problem of false negatives and false positives. Therefore, in this paper we apply to choose variety of properties to complement the problem of behavior analysis on the heuristic-based of 2nd step in malicious code auto analysis system, and we suggest a similarity comparison method applying AHP (analytic hierarchy process) for properties weights that reflect the decision-making technique. Through the similarity comparison of malicious code, configured threshold is set to the optimum point between detection rates and false positives rates. As a grouping experiment about unknown malicious it distinguishes each group made by malicious code generator. We expect to apply it as the malicious group information which includes a tracing of hacking types and the origin of malicious codes in the future.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.44 no.3
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• pp.74-80
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• 2007

Advances in electronic and computer technologies have paved the way for the proliferation of WSN(wireless sensor networks). Accordingly, necessity of anti-collusion and authentication technology is increasing on the sensor network system. Some of the algorithm developed for the anti-collision sensor network can be easily adopted to wireless sensor network platforms and in the same time they can meet the requirements for sensor networks like: simple parallel distributed computation, distributed storage, data robustness and auto-classification of sensor readings. To achieve security in wireless sensor networks, it is important to be able to establish safely channel among sensor nodes. In this paper, we proposed the USN(Ubiquitous Sensor Network) channel establishment algorithm for sensor's authentication and anti-collision. Two different data aggregation architectures will be presented, with algorithms which use wavelet filter to establish channels among sensor nodes and BIBD (Balanced Incomplete Block Design) which use anti-collision methods of the sensors. As a result, the proposed algorithm based on BIBD and wavelet filter was made for 98% collision detection rate on the ideal environment.

• Journal of KSNVE
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• v.9 no.1
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• pp.85-96
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• 1999

For ASME Code pumps in nuclear power plants, inservice test is required to assess the operational readiness in accordance with ASME code and related regulations. The objective of this study therefore, is to develop the technical background of the degradation of pump performances and conditions due to low flow rate operation. In addition. the detection techniques of pump operating conditions are to be developed to enhance the safety and economy of nuclear power plants. A test loop consisted of pump, motor. water tank, flow rate measurements and piping system with flow control devices was established for this study. Two typical pumps, 1-stage volute pump and 3-stage turbine pump, were selected and the test was performed upon two major point of views ; i.e., pump discharge pressure pulsations analysis and pump vibration spectrum analysis. From the test results, it is concluded that (1) the pump vibration affected by the natural frequency of operating pump is significant in the low frequency zone (around 1 Hz) : the vibration amplitude. especially. is an important factor during low flow rate operation. and shall be monitored to ensure that it is within the limit of ASME OM code Part 6, (2) the vibration frequency and pump discharge pressure are affected by vane pass frequency and running speed, (3) the wave phenomena due to the compressiblity of water is anticipated during low flow rate operation. and the pump system shall be designed to prevent it and. finally, (4) the technical background of the degradation of pump performances and conditions due to low flow rate operation is provided.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.04a
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• pp.139-149
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• 2006

Amyloid beta (A$\beta$) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of A$\beta$ is considered a primary therapeutic target. Immunization with A$\beta$ can reduce A$\beta$ burden and pathological features in transgenic AD model mouse. This means anti-A$\beta$ autoantibodies may have a role in AD pathology. Recent findings suggest anti-A$\beta$ autoantibodies level decrease in AD patients. The early detection of AD is important for treatment of this disease. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. To investigate whether it was possible to detect the presence and different levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma of patients with AD and age-matched controls. An advanced ELISA was performed to detect levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma. The level of anti-A$\beta$ auto-antibodies from patients with idiopathic Parkinson's disease or stroke and from normal controls were compared to that of AD patients. Our results showed a significantly lower anti-A$\beta$ autoantibodies level in AD compared to those with other neurological diseases or control. The level of anti-A$\beta$ autoantibodies in the serum may be used to diagnose the presence of AD.

• The Korea Journal of Herbology
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• v.30 no.3
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• pp.19-24
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• 2015

Objectives : HPL-1, a novel herbal medicine which is composed of five herbs such as Kalopanacis Cortex, Chaenomelis Fructus, Raphani Semen, Atractylodis Rhizoma and Pulvis Aconiti Tuberis Purificatum, was developed for treatment of osteoarthritis. This study is aimed to develop analytical method for consistent quality control of HPL-1 and validate chromatographic method. Methods : Chromatographic analysis was performed using ultra-high performance liquid chromatography - diode array detector (UHPLC-DAD) equipped with RP-amide column, column oven, and auto sampler. Marker compounds [protocatechuic acid, chlorogenic acid, liriodendrin, 3,5-dicaffeoylquinic acid, ${\beta}$-D-(3-O-sinapoyl)-fructofuranosyl-$\alpha$-D-(6-O-sinapoyl)glucopyranoside and benzoylmesaconine] were separated by step gradient elution of acetonitrile and 0.1% phosphoric acid/water. The method validation was evaluated by quantitative validation parameters of linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) according to KFDA guideline.Results : An optimized method for six marker compounds in HPL-1 was established by UHPLC-DAD. The correlation coefficient (R²) with each calibration curve was greater than 0.99. The LOD and LOQ were within the range of 0.008-0.090 and $0.023-0.274{\mu}g/mL$, respectively. The relative standard deviation (RSD) of intra- and inter-day variability were less than 4.0%. The result of recovery test was range from 93.3-106.3% with RSD < 4.0%.Conclusions : These results suggest that the quantitative UHPLC method is precise, accurate, effective for quality evaluation of HPL-1. The method may also contribute to improve quality of crude drug preparations used for treatment of various diseases.