• Korean Journal of Clinical Laboratory Science
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• v.51 no.2
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• pp.260-264
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• 2019

An 84-year-old woman presented to the emergency department with a chief complaint of pressure sores of the anus. She had a urine catheter when she showed pyuria three times but had no fever. A microscopic examination revealed many grapevine-like Gram positive strains and neutrophils. After 24 hours of urine culture on blood agar, non-hemolytic mucous colonies were found and further enlarged after 48 hours of culture. The capsules were identified after India ink stain. The catalase was positive, but the tube coagulase and latex coagulase were both negative. The S. aureus was identified by Vitek-2 and mass spectrometer Vitek MS V-3 IVD. The strain was confirmed by 16S rRNA gene sequencing and multilocus sequence typing (MLST). The phenotypically atypical MRSA found in the tube coagulase and latex coagulase were both negative. MRSA often show no beta hemolysis as in this case but are rarely latex coagulase-negative. We report a woman whose urine culture showed non-hemolytic, tube coagulase-negative, and latex coagulase-negative MRSA.

• Korean Journal of Biological Psychiatry
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• v.28 no.2
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• pp.50-57
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• 2021

Objectives Clozapine is the most effective atypical antipsychotic agent for the treatment-resistant schizophrenia (TRS), however, only 40%-70% of TRS patients respond to clozapine. Moreover, TRS encompasses various symptom dimensions. Therefore, augmentation with other medications for clozapine is frequently applied. However, the prescription pattern of clozapine and combined medications in Korea is yet to be examined. This study aims to investigate the maintenance treatment pattern of clozapine and augmentation agents in one Korean tertiary hospital. Methods The patients with schizophrenia spectrum disorders under clozapine maintenance, defined as one-year clozapine continuation, were subjected for analysis. Medication data at one-year time-point after clozapine initiation was extracted and analyzed. Results Among total 2897 patients having clozapine prescription experience from January 2000 to December 2018, 1011 patients were on clozapine maintenance. The mean age of clozapine initiation was 30.2 ± 11.3 years, and the maintenance dose of clozapine was 217.8 ± 124.3 mg/day. Combination rate of antipsychotics, mood stabilizers, and antidepressants were 43.5%, 25.3%, 38.6%, respectively. Most frequently prescribed drugs in each category were aripiprazole, valproate, and sertraline. Olanzapine equivalent dose of combined antipsychotics was 10.4 ± 7.7 mg/day. Male patients were prescribed higher dose of combined antipsychotics and higher rate of antidepressants. Female patients had later onset of clozapine prescription. Patients with two or more combined antipsychotics were prescribed higher dose of clozapine and higher rate of antidepressants compared to patients with one combined antipsychotic. Conclusions Taken together, among the patients taking clozapine, a substantial rate of patients were under polypharmacy. The present findings based on the real-world prescription pattern could provide the valuable clinical information on the treatment of TRS-related conditions.

• Obstetrics & gynecology science
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• v.61 no.6
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• pp.662-668
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• 2018

Objective This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL). Methods We analyzed data from women infected with the human papillomavirus (HPV) who participated in the Korean HPV cohort study. The cohort recruited women aged 20-60 years with abnormal cervical cytology (ASC-US or LSIL) from April 2010. All women were followed-up at every 6-month intervals with cervical cytology and HPV DNA testing. Results Of the 1,158 women included, 654 (56.5%) and 504 (43.5%) women showed ASC-US and LSIL, respectively. At the time of enrollment, 143 women tested positive for HPV 16 (85 single and 58 multiple infections). Cervical cytology performed in the HPV 16-positive women showed progression in 27%, no change in 23%, and regression in 50% of the women at the six-month follow-up. The progression rate associated with HPV 16 infection was higher than that with infection caused by other HPV types (relative risk [RR], 1.75; 95% confidence interval [CI], 1.08-2.84; P=0.028). The cytological progression rate in women with persistent HPV 16 infection was higher than that in women with incidental or cleared infections (P<0.001). Logistic regression analysis showed a significant relationship between cigarette smoking and cytological progression (RR, 4.15; 95% CI, 1.01-17.00). Conclusion The cytological progression rate in HPV 16-positive women with ASC-US or LSIL is higher than that in women infected with other HPV types. Additionally, cigarette smoking may play a role in cytological progression.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.1
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• pp.52-60
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• 2021

The aim of this study was to derive a new trend by analyzing installations using 3D printing that are out of the limits of size and design according to the trends of developing 3D printing technology. This paper classified the types of installations using 3D printing and analyzed them with two trends: the trend of design and the trend of output. The trends of installations using 3D printing derived from this study are as follows. First, as the implementation of design through an algorithm is accomplished, the transformation appears with the atypical design that is prominent in complex expression. Second, Robotics and FDM 3D Printing is fused, which is changing the existing paradigm. Therefore, the production and utilization of installations using 3D printing proceeded at a faster pace through the interaction between the algorithm design method and freeform 3D printing technology. This study was conducted on installations using 3D printing around the world and played a basic role in the research on the production of installations using 3D printing along with domestic 3D printing technology to be developed in the future. Follow-up studies in various aspects, such as materials and combination methods, will be needed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.548-557
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• 2021

The purpose of this study was to determine the statistical usefulness of using atypical text data collected from media that are easy to collect to overcoming limits of the existing data related to economic activities of disabled people. In addition, by performing semantic network analysis, major issues by period that could not be grasped by statistical analysis were also identified. As a result, semantic network analysis revealed that the initiative of the public sector, such as the central and local government bodies, was strongly shown. On the other hand, in the private purchase sector, it was also possible to confirm the consumption revitalization trend and changes in production activities in the recent issue of Covid-19. While the term "priority purchase" had a statistically significant relation with the other two terms "vocational rehabilitation" and "employment for the disabled". For the regression results, while the term "priority purchase" had a statistically significant association with the other two terms "vocational rehabilitation" and "employment for the disabled". Further, some statistical analyses reveal that keyword data taken from media channels can serve as an alternative indicator. Implications for issue detection in the field of welfare economy for the disabled is also discussed.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.1
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• pp.9-21
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• 2021

In this study, the difference between the preservative efficacy test (PET) used for water dispersion formulations and PCPC (personal care products council) guidelines alternative test method, direct contact membrane method, and surface mold test should be studied to determine what should be considered during preservative efficacy test of water non-dispersible formulations. We conducted improved PETs when using the alternative test method compared with the test methods used for stick and pressed powder. There was no significant improvement between water-in-silicon emulsions and loose powder using alternative test methods. When we checked the results of the presence and absence of the preservative system for each product, we could see that there were differences in testing methods. As a result, improved levels of results could be obtained using both existing and alternative test methods when measuring preservatives for water non-dispersible formulations. In addition, in the case of stick and pressed powder, the results were more effective when the preservative test method applied to the consumer's method of use was applied.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.4
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• pp.277-285
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• 2022

To investigate the adverse effects of clozapine on cardiovascular ion channels, we examined the inhibitory effect of clozapine on voltage-dependent K⁺ (Kv) channels in rabbit coronary arterial smooth muscle cells. Clozapine-induced inhibition of Kv channels occurred in a concentration-dependent manner with an half-inhibitory concentration value of 7.84 ± 4.86 µM and a Hill coefficient of 0.47 ± 0.06. Clozapine did not shift the steady-state activation or inactivation curves, suggesting that it inhibited Kv channels regardless of gating properties. Application of train pulses (1 and 2 Hz) progressively augmented the clozapine-induced inhibition of Kv channels in the presence of the drug. Furthermore, the recovery time constant from inactivation was increased in the presence of clozapine, suggesting that clozapine-induced inhibition of Kv channels is use (state)-dependent. Pretreatment of a Kv1.5 subtype inhibitor decreased the Kv current amplitudes, but additional application of clozapine did not further inhibit the Kv current. Pretreatment with Kv2.1 or Kv7 subtype inhibitors partially blocked the inhibitory effect of clozapine. Based on these results, we conclude that clozapine inhibits arterial Kv channels in a concentration-and use (state)-dependent manner. Kv1.5 is the major subtype involved in clozapine-induced inhibition of Kv channels, and Kv2.1 and Kv7 subtypes are partially involved.

• Journal of the Korea Society of Computer and Information
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• v.27 no.8
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• pp.241-251
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• 2022

Diagnosis and management of customer's skin condition is an important essential function in the cosmetics and beauty industry. As the social media environment spreads and generalizes to all fields of society, the interaction of questions and answers to various and delicate concerns and requirements regarding the diagnosis and management of skin conditions is being actively dealt with in the social media community. However, since social media information is very diverse and atypical big data, an intelligent skin condition diagnosis system that combines appropriate skin condition information analysis and artificial intelligence technology is necessary. In this paper, we developed the skin condition diagnosis system SCDIS to intelligently diagnose and manage the skin condition of customers by processing the text analysis information of social media into learning data. In SCDIS, an artificial neural network model, AnnTFIDF, that automatically diagnoses skin condition types using artificial neural network technology, a deep learning machine learning method, was built up and used. The performance of the artificial neural network model AnnTFIDF was analyzed using test sample data, and the accuracy of the skin condition type diagnosis prediction value showed a high performance of about 95%. Through the experimental and performance analysis results of this paper, SCDIS can be evaluated as an intelligent tool that can be used efficiently in the skin condition analysis and diagnosis management process in the cosmetic and beauty industry. And this study can be used as a basic research to solve the new technology trend, customized cosmetics manufacturing and consumer-oriented beauty industry technology demand.

• Journal of Life Science
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• v.32 no.2
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• pp.86-93
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• 2022

Lupeol is a type of pentacyclic triterpene and has been reported to have pharmacological activities against various diseases; however, the effect of lupeol on glucose absorption has not been elucidated yet. This study aimed to investigate the effect of lupeol on glucose uptake in 3T3-L1 adipocytes. Lupeol significantly facilitated glucose uptake by translocating glucose transporter type 4 (GLUT4) to the plasma membrane of the 3T3-L1 adipocytes, which was related to activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) and 5 'adenosine monophosphate-activated protein kinase (AMPK) pathways. In the PI3K/AKT pathway, lupeol stimulates the phosphorylation of insulin receptor substrate 1 (IRS-1), which activates PI3K. Its activation by lupeol promotes the phosphorylation of AKT, but not the atypical protein kinase C isoforms ζ and λ. Lupeol also promoted the phosphorylation of AMPK. The activation of AMPK increased the expressions of the plasma membrane GLUT4 and the intracellular glucose uptake. The increase in the glucose uptake by lupeol was suppressed by wortmannin (PI3K inhibitor) and compound C (AMPK inhibitor) in the 3T3-L1 adipocytes. The results indicate that lupeol can facilitate glucose uptake by increasing insulin sensitivity through the stimulation of the expression of plasma membrane glucose transporter type 4 via the PI3K/AKT and AMPK pathways in the 3T3-L1 adipocytes.

• Journal of the korean academy of Pediatric Dentistry
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• v.50 no.1
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• pp.13-23
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• 2023

The purpose of this study was to compare the values of tongue pressure (TP), lip closing pressure (LCP), right buccal pressure (RBP), and left buccal pressure (LBP) and check the intraoral muscle imbalance and observe the changed values according to the myofunctional therapy (MFT) period. The MFT with a prefabricated appliance was performed on patients with certain muscular dysfunctions due to oral habits. And the improvement of perioral muscles was evaluated using a balloon-based pressure measurement. The group consisted of 21 patients with oral habits such as chronic mouth breathing, finger sucking, lip sucking, tongue thrusting, and atypical swallowing habits. When comparing the two groups before treatment, there was a significant difference in TP and LCP values. The TP increased the most in the first month since the start of myofunctional therapy, and the LCP increased the most between 3 and 6 months after treatment began. The values of TP, LCP, RBP, and LBP in the control group measured before treatment were very similar to the results of the experimental group 6 months after the myofunctional therapy. When the MFT was steadily performed, it was possible to observe a noticeable increase in the tongue and lip closing pressure. At least 6 months of myofunctional therapy is recommended for patients with intraoral muscle imbalance due to oral habits.