Inhibitory effects of the atypical antipsychotic, clozapine, on voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells |
Kang, Minji
(Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine)
Heo, Ryeon (Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine) Park, Seojin (Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine) Mun, Seo-Yeong (Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine) Park, Minju (Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine) Han, Eun-Taek (Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine) Han, Jin-Hee (Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine) Chun, Wanjoo (Department of Pharmacology, Kangwon National University School of Medicine) Ha, Kwon-Soo (Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicin) Park, Hongzoo (Institute of Medical Sciences, Department of Urology, Kangwon National University School of Medicine) Jung, Won-Kyo (Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University) Choi, Il-Whan (Department of Microbiology, College of Medicine, Inje University) Park, Won Sun (Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine) |
1 | Howell S, Yarovova E, Khwanda A, Rosen SD. Cardiovascular effects of psychotic illnesses and antipsychotic therapy. Heart. 2019;105:1852-1859. DOI |
2 | Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol. 1995;268(4 Pt 1):C799-C822. DOI |
3 | Cook NS. Effect of some potassium channel blockers on contractile responses of the rabbit aorta. J Cardiovasc Pharmacol. 1989;13:299-306. DOI |
4 | Nieves-Cintron M, Syed AU, Nystoriak MA, Navedo MF. Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders. Microcirculation. 2018;25:e12423. DOI |
5 | Kang M, An JR, Seo MS, Jung HS, Heo R, Park H, Song G, Jung WK, Choi IW, Park WS. Atypical antipsychotic olanzapine inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells. Pharmacol Rep. 2021;73:1724-1733. DOI |
6 | An JR, Seo MS, Jung HS, Heo R, Kang M, Ha KS, Park H, Park WS. The inhibitory effect of ziprasidone on voltage-dependent K+ channels in coronary arterial smooth muscle cells. Biochem Biophys Res Commun. 2020;529:191-197. DOI |
7 | An JR, Seo MS, Jung HS, Li H, Jung WK, Choi IW, Ha KS, Han ET, Hong SH, Park H, Bae YM, Park WS. Inhibition by the atypical antipsychotic risperidone of voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. Eur J Pharmacol. 2020;874:173027. DOI |
8 | Dogan MF, Yildiz O, Arslan SO, Ulusoy KG. Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective. Fundam Clin Pharmacol. 2019;33:504-523. DOI |
9 | Kim HS, Li H, Kim HW, Shin SE, Seo MS, An JR, Ha KS, Han ET, Hong SH, Choi IW, Choi G, Lee DS, Park WS. Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells. Korean J Physiol Pharmacol. 2017;21:415-421. DOI |
10 | Lagrutta A, Wang J, Fermini B, Salata JJ. Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current. J Pharmacol Exp Ther. 2006;317:1054-1063. DOI |
11 | Miyamoto S, Duncan GE, Marx CE, Lieberman JA. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry. 2005;10:79-104. DOI |
12 | Young CR, Bowers MB Jr, Mazure CM. Management of the adverse effects of clozapine. Schizophr Bull. 1998;24:381-390. DOI |
13 | Leung JY, Barr AM, Procyshyn RM, Honer WG, Pang CC. Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous system. Pharmacol Ther. 2012;135:113-122. DOI |
14 | Keynes RD. The ionic channels in excitable membranes. Ciba Found Symp. 1975;(31):191-203. |
15 | Jackson WF. KV channels and the regulation of vascular smooth muscle tone. Microcirculation. 2018;25:e12421. DOI |
16 | An JR, Seo MS, Jung HS, Kang M, Heo R, Bae YM, Han ET, Yang SR, Park WS. Inhibition of voltage-dependent K+ channels by iloperidone in coronary arterial smooth muscle cells. J Appl Toxicol. 2020;40:1297-1305. DOI |
17 | Sobey CG. Potassium channel function in vascular disease. Arterioscler Thromb Vasc Biol. 2001;21:28-38. DOI |
18 | An JR, Li H, Seo MS, Park WS. Inhibition of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone. Korean J Physiol Pharmacol. 2018;22:597-605. DOI |
19 | Schnee ME, Brown BS. Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J Pharmacol Exp Ther. 1998;286:709-717. |
20 | Fitton A, Heel RC. Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia. Drugs. 1990;40:722-747. DOI |
21 | Meltzer HY, Massey BW. The role of serotonin receptors in the action of atypical antipsychotic drugs. Curr Opin Pharmacol. 2011;11:59-67. DOI |
22 | Khokhar JY, Henricks AM, Sullivan EDK, Green AI. Unique effects of clozapine: a pharmacological perspective. Adv Pharmacol. 2018;82:137-162. DOI |
23 | Krupp P, Barnes P. Clozapine-associated agranulocytosis: risk and aetiology. Br J Psychiatry Suppl. 1992;(17):38-40. |
24 | Choi KH, Rhim H. Inhibition of recombinant Ca(v)3.1 (alpha(1G)) T-type calcium channels by the antipsychotic drug clozapine. Eur J Pharmacol. 2010;626:123-130. DOI |
25 | Lee SY, Kim YJ, Kim KT, Choe H, Jo SH. Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine. Br J Pharmacol. 2006;148:499-509. DOI |
26 | Li Q, Zhang R, Lu CL, Liu Y, Wang Z, Zhu DL. [The role of subtypes of voltage-gated K+ channels in pulmonary vasoconstriction induced by 15-hydroeicosatetraenoic acid]. Yao Xue Xue Bao. 2006;41:412-417. Chinese. |
27 | Morales-Cano D, Moreno L, Barreira B, Pandolfi R, Chamorro V, Jimenez R, Villamor E, Duarte J, Perez-Vizcaino F, Cogolludo A. Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia. Cardiovasc Res. 2015;106:98-108. DOI |
28 | Herrington J. Gating modifier peptides as probes of pancreatic beta-cell physiology. Toxicon. 2007;49:231-238. DOI |
29 | Tassaneeyakul W, Kittiwattanagul K, Vannaprasaht S, Kampan J, Tawalee A, Puapairoj P, Tiamkao S, Juthagridsada S, Kukongviriyapan V, Tassaneeyakul W. Steady-state bioequivalence study of clozapine tablet in schizophrenic patients. J Pharm Pharm Sci. 2005;8:47-53. |
30 | Park WS, Ko JH, Kim N, Son YK, Kang SH, Warda M, Jung ID, Park YM, Han J. Increased inhibition of inward rectifier K+ channels by angiotensin II in small-diameter coronary artery of isoproterenol-induced hypertrophied model. Arterioscler Thromb Vasc Biol. 2007;27:1768-1775. DOI |
31 | Thorneloe KS, Chen TT, Kerr PM, Grier EF, Horowitz B, Cole WC, Walsh MP. Molecular composition of 4-aminopyridine-sensitive voltage-gated K+ channels of vascular smooth muscle. Circ Res. 2001;89:1030-1037. DOI |
![]() |