• Environmental Engineering Research
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• 제22권1호
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• pp.61-74
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• 2017

This study investigated the effect of various cations ($Ca^{2+}$, $Mg^{2+}$, $Al^{3+}$, $Mn^{2+}$, $Zn^{2+}$) on the autoaggregation (AAg) and surface hydrophobicity (SHb) of three different bacteria (Brevibacillus panacihumi strain (ZB1), Lysinibacillus fusiformis strain (ZB2) and Enterococcus faecalis strain (ZL)) using a 2-level factorial design. The AAg ratio was measured from the changes in the absorbance of the media. Results show that ZB2 had maximum AAg for the three bacteria investigated. A microscopic clustering of cells was observed when $Ca^{2+}$ was added to ZB2. The AAg was in the range of 62%, 58% and 34% for ZB2, ZB1 and ZL, respectively and correlated to the SHb. The aggregation and SHb of the microbial cells increased with increasing ionic strength due to the repulsive steric or overlap forces between the polymer covered surfaces. $Ca^{2+}$ demonstrated a more significant effect on aggregation and SHb of microbial cells due to an attractive binding force.

• 통합자연과학논문집
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• 제6권3호
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• pp.163-169
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• 2013

The chemokine receptor CCR1 a GPCR super family protein contains seven transmembrane domains. It plays an important role in rheumatoid arthritis, organ transplant rejection, Alzheimer's disease and also causes inflammation. Because of its role in disease processes, antagonism of CCR1 became an attractive therapeutic target. In the current study, we have taken a novel series of recently reported CCR1 antagonist of 1-(4-Phenylpiperazin-1-yl_-2-(1H-Pyrazol-1-yl) ethanone derivatives and performed a HQSAR analysis. The model was developed with Atom (A) and bond (B) parameters and with different set of atom counts to improve the model. The results of HQSAR showed good predictive ability in terms of $r^2$ (0.904) and $q^2$ (0.590) with 0.710 as standard error of prediction and 0.344 as standard error of estimate. The contribution map depicted the atom contribution in inhibitory effect. Compound-14 which was reported to be a highly active compound showed positive atom contribution in three R groups ($R^3$. $R^{5a}$ and $R^{2b}$) in inhibitory effect, which could be the reason why this compound is highly active compound whereas, the lowest active compound-6 showed negative contribution to inhibitory effect.

• 한국식생활문화학회지
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• 제29권6호
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• pp.593-598
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• 2014

Brands play a critical role as a core asset and the primary driver for corporate growth because of their power of identity and influence on customers' perceptions in restaurant industry. However, in spite of diverse and dynamically changing recent brand portfolio strategies of restaurants, a study on the effect of brand diversification on financial performance has been rarely conducted in the restaurant industry context. Considering competing viewpoints regarding diversification's influence on financial performance, the purpose of this study is, therefore, to examine the effect of brand diversification on firm performance of restaurants. The results indicated that brand diversification is positive effect to profitability. Brand diversification seems to be attractive and might be a reasonable growth strategy to expand market power by satisfying diverse consumer needs. Therefore, restaurant managers should be consider in implementing brand diversification strategy especially in dynamically changing trend of brand diversification in the current restaurant industry.

• 한국가정과학회지
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• 제2권1호
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• pp.99-109
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• 1999

The purpose of this study is to evaluate the combination of tailored suit details through visual evaluation which helps compensating middle aged women＇s body defects for their more attractive fashion styles. The data evaluated by a multiple ranking test were analyzed using mean, paired t-test, general linear measure and Duncan＇s multiple raged test. The results of this study are as follows: 1) The middle aged woman wearing the opened flap pocket-jacket and slacks looks longer(p〈0.001) in lower part of her body and taller(P〈0.01) as a whole than when wearing others. And, opened jacket makes a middle aged woman be seen with less appeared abdomen(p〈0.01) than that wearing others. 2) The middle aged woman wearing the opened flap pocket-jacket and skirt looks more elegant(p〈0.001), more graceful(p〈0.001), and a bit more balanced(p〈0.05) than that wearing the opened flap pocket-jacket and slacks suits. According to situation(TPO). the middle aged women wearing the opened flap pocket-jacket, and slacks or skirt looks more effective the visual effect in combination of details on Tailored suits. (Korean J of Human Ecology 2(1) : 99-109, 1999)

• Korea-Australia Rheology Journal
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• 제15권2호
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• pp.83-90
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• 2003

In cases of the microfluidic channel, the electrokinetic influence on the transport behavior can be found. The externally applied body force originated from the electrostatic interaction between the nonlinear Poisson-Boltzmann field and the flow-induced electrical field is applied in the equation of motion. The electrostatic potential profile is computed a priori by applying the finite difference scheme, and an analytical solution to the Navier-Stokes equation of motion for slit-like microchannel is obtained via the Green's function. An explicit analytical expression for the induced electrokinetic potential is derived as functions of relevant physicochemical parameters. The effects of the electric double layer, the zeta potential of the solid surface, and the charge condition of the channel wall on the velocity profile as well as the electroviscous behavior are examined. With increases in either electric double layer or zeta potential, the average fluid velocity in the channel of same charge is entirely reduced, whereas the electroviscous effect becomes stronger. We observed an opposite behavior in the channel of opposite charge, where the attractive electrostatic interactions are presented.

• 생약학회지
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• 제52권3호
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• pp.127-133
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• 2021

Platelet activation plays a major role in cardiovascular disorders (CVDs). Thus, disrupting platelet activation represents an attractive therapeutic target on CVDs. Esculetin, a bioactive 6,7-dihydroxy derivative of coumarin, possesses pharmacological activities against obesity, diabetes, renal failure, and CVDs. In other report, the effect of esculetin has been examined in human platelet activation and experimental mouse models, and esculetin inhibited collagen- and arachidonic acid-induced platelet aggregation in washed human platelets. However, it had no effects on other agonists such as thrombin and U46619, and its mechanism is not also clearly known. This study investigated the effect of esculetin on collagen-induced human platelet aggregation, and we clarified the mechanism. Esuletin has effects on the down regulation of PI3K/Akt and MAPK, phosphoproteins that act in the signaling process in platelet aggregation. The effects of esculetin reduced of TXA₂ production and phospholipase A₂ activation, and intracellular granule secretion including ATP and serotonin, leading to inhibit platelet aggregation. These results clearly clarified the effect of esculetin in inhibiting platelet activity and thrombus formation in humans.

• 산경연구논집
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• 제13권12호
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• pp.1-8
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• 2022

Purpose: This study aims to analyze the importance of customers' selection attributes for meal kits, which is rapidly increasing in the home meal replacement food market, and empirically analyze the effect of food selection attributes on consumer satisfaction and repurchase intention toward meal kits. Research design, data, and methodology: Based on the results of previous research, factors that customers consider the most when purchasing a meal kit are nutritional components, ingredients, hygiene, taste, and price. The empirical analysis is conducted by using structural equation modeling to determine the extent that customer selection attributes for meal kits affect customer satisfaction and repurchase intention. The survey is conducted online from January 1 to March 15, 2022, and 282 valid samples are used for the analysis. Results: The result of the analysis confirms that nutritional components, hygiene, taste, and price have a statistically significant effect on customer satisfaction and repurchase intention. However, the effect of food ingredients on customer satisfaction and repurchase intention is rejected because no statistically significant results are obtained. Conclusions: As an empirical analysis of the importance of customer selection attributes of meal kits, this study has meaningful implications for related industries and business-to-business operators and provides basic data for the strategic development of related industries.

• 유통과학연구
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• 제21권7호
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• pp.73-82
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• 2023

Purpose: Social networking services have been recognized as an attractive distribution channel at a time when efforts to deliver effective messages to consumers are essential amid a flood of advertisements in the multi-media era. In that sense, this study investigated the effect of the scarcity message type (limited-time vs. limited-quantity) and sender type (corporate vs. consumer) on the intention to purchase golf equipment by Instagram distribution channel. Research design, data and methodology: Data from 108 college students in their 20s and 30s with experience using Instagram were collected online through convenience sampling. A frequency analysis, exploratory factor analysis, reliability analysis, independent sample t-test, and two-way analysis of variance were performed using SPSS 23.0. Results: The results showed that limited-quantity messages induce a higher purchase intention than limited-time messages. Similarly, consumer-sent advertisements induce a higher purchase intention than corporate-sent advertisements. Further, there is no statistically significant interaction effect of the scarcity message type and sender type on the intention to purchase golf equipment. Conclusions: This study is meaningful in verifying consumers' purchase intention depending on the type of scarcity message and the type of sender in Instagram advertisements. The results yield significant implications for marketers and several directions for future research.

• Smart Structures and Systems
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• 제3권1호
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• pp.51-68
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• 2007

High-strength concrete (HSC) is becoming increasingly attractive for various construction projects since it offers a multitude of benefits over normal-strength concrete (NSC). Unfortunately, current design provisions for shear capacity of RC slender beams are generally based on data developed for NSC members having a compressive strength of up to 50 MPa, with limited recommendations on the use of HSC. The failure of HSC beams is noticeably different than that of NSC beams since the transition zone between the cement paste and aggregates is much denser in HSC. Thus, unlike NSC beams in which micro-cracks propagate around aggregates, providing significant aggregate interlock, micro-cracks in HSC are trans-granular, resulting in relatively smoother fracture surfaces, thereby inhibiting aggregate interlock as a shear transfer mechanism and reducing the influence of compressive strength on the ultimate shear strength of HSC beams. In this study, a new approach based on genetic algorithms (GAs) was used to predict the shear capacity of both NSC and HSC slender beams without shear reinforcement. Shear capacity predictions of the GA model were compared to calculations of four other commonly used methods: the ACI method, CSA method, Eurocode-2, and Zsutty's equation. A parametric study was conducted to evaluate the ability of the GA model to capture the effect of basic shear design parameters on the behaviour of reinforced concrete (RC) beams under shear loading. The parameters investigated include compressivestrength, amount of longitudinal reinforcement, and beam's depth. It was found that the GA model provided more accurate evaluation of shear capacity compared to that of the other common methods and better captured the influence of the significant shear design parameters. Therefore, the GA model offers an attractive user-friendly alternative to conventional shear design methods.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 1997년도 제20회 화학물질의 환경독성과 건강영향
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• pp.101-101
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• 1997

Comet assay, single cell gel electrophoresis has been known as useful, rapid, simple, visual, and sensitive technique for measuring the DNA breakage in mammalian ce1ls. For evaluation of DNA damage using comet assay, early studies reported a change in comet length and intensity with DNA damage using simple visual technique, such as fluorescence microscopy with eyespiece. In recent, some workers are observing and analyzing nucleotide of comets using quantitative fluorescence image analysis system to estimate 'tail moment', which is defined as the product of the tail length and the fraction of total DNA in tail. Our laboratory also adopted the image analysis software for qualification. In addition, many of the practical features of comet assay render it potentially attractive as useful tool for molecular toxicology and carcinogenesis, because the system is already showing considerable promise as rapid predictor in both in vitro and in vivo experimental designs. Recently, the comet assay becomes a attractive technique to study of apoptosis, because apoptotic fragmentation of nuclear DNA into nucleosomal sizes can be evaluated by the comet assay. So, we attempted to apply the comet assay to studying the effect of various stress on the apoptosis-sensitive cell lines. Particularly, focusing on the hyperthermic apoptosis, we could find that heat shock(44˚C for 60 minutes) was sufficient to induced apoptosis in these cell lines. But using the highly sensitive comet assay, we could not detect DNA breaks immediately after heat shock.