• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권1호
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• pp.28-34
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• 2021

Objectives: This study aimed to examine the effect of maternal adverse childhood experiences (ACEs) on the attention-deficit/hyperactivity disorder (ADHD) symptoms in the offspring and to examine the mediating role of antepartum health risk on the intergenerational transmission of maternal ACEs. Methods: The participants consisted of 461 mother-child dyads. Mothers completed the ACEs questionnaire and Diagnostic Predictive Scales. Multivariate logistic regression analysis was used to estimate the risk of ADHD symptoms in the offspring of mothers with ACEs and the mediating effect of antepartum health risks by path analysis. Results: In all, 35.4% (n=163) had at least one maternal ACE, and 11.1% (n=51) had three or more. Compared to the non-ADHD symptom group, the group of offspring with ADHD symptoms showed a significant association with maternal ACE score (p<0.001) and antepartum health risks (p<0.001). Multivariate analysis further showed a significant association between the sum of maternal ACEs [odds ratio (OR)=1.264, 95% confidence interval (CI)= 1.060-1.516, p=0.009], antepartum health risks (OR=1.236, 95% CI=1.036-1.475, p=0.019), and ADHD symptoms in the offspring. In the mediation model in which the mother's ACE score affected the offspring's ADHD symptoms, partial mediation through antepartum health risks was found to be significant (B=0.041, 95% CI=0.011-0.124). Conclusion: Maternal ACEs are significantly related to the incidence of ADHD symptoms in the offspring and antepartum health risks exert an indirect effect. These findings suggest that maternal ACEs have a negative impact on the offspring's brain development through intergenerational transmission, resulting in neurodevelopmental disorders such as ADHD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권3호
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• pp.118-125
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• 2021

Objectives: Childhood adversity is a risk factor for anxiety symptoms, but it affects anxiety symptoms in attention-deficit/hyperactivity disorder (ADHD). The current study aimed to examine the association between childhood adversity and anxiety symptoms in participants with and without ADHD. Methods: Data were obtained from a school-based epidemiological study of 1017 randomly selected children and adolescents. The ADHD and non-ADHD groups were divided using the Diagnostic Interview Schedule for Children Predictive Scale (DPS). The DPS was also used to assess comorbidities such as anxiety and mood disorders. The childhood adversities were assessed using the Early Trauma Inventory Self Report-Short Form, and the anxiety symptoms were assessed using the Screen for Child Anxiety Related Disorders. Linear and logistic regression models were used to investigate the association between childhood adversity and anxiety in the ADHD and non-ADHD groups with adjustments for age and sex. Results: This study found that the ADHD group did not show any significant association between anxiety symptoms and childhood adversities, whereas the non-ADHD group always showed a significant association. In a subgroup analysis of the non-ADHD group, the normal group without any psychiatric disorders assessed with DPS demonstrated a statistically significant association between childhood adversities and anxiety symptoms. These results were consistent with the association between childhood adversities and anxiety disorders assessed using DPS, as shown by logistic regression. Conclusion: The association between anxiety symptoms and childhood adversities statistically disappears in ADHD; ADHD may mask or block the association. Further longitudinal research is necessary to investigate this relationship.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제33권1호
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• pp.2-15
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• 2022

Objectives: Children with attention-deficit/hyperactivity disorder (ADHD) tend to be noisy and violate rules with their disruptive behaviors, resulting in greater difficulties with off-task behaviors and being at risk for social refusal. The visual activity schedule (VAS) intervention program is a frequently used method to teach multiple skills involving on-task, use of schedules, transition behaviors, social initiation, independent play skills, classroom skills, and academic skills. The current systematic review aimed to examine the efficacy of using VAS intervention in reducing problem behaviors in children with ADHD between 5 and 12 years of age. Methods: Systematic searches were conducted using two electronic databases (PubMed and Scopus) to identify relevant studies published in English between 2010 and 2020. Four studies met the inclusion criteria: two studies examined the effect of schedule-based tasks and the use of an iPad on classroom skills, while the other two examined randomized clinical trials (RCTs) of psychosocial treatment for ADHD inattentive type and a cross-sectional study examined the impact of the group size on task behavior and work productivity in children with ADHD. Results: The findings indicate that the interventions used in all four studies could lead to increased satisfaction among participants and parents, as well as a reduction in problem behavior. In terms of the research indicators, the RCT had low quality, while the others were of high quality. Conclusion: A larger number of studies and the ADHD clinical population would help to increase the generalizability of future reviews of treatments in this context.

• 생물정신의학
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• 제27권2호
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• pp.74-83
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• 2020

Objectives Psychological resilience plays a significant role in many aspects of mental health. The aim of this study was to find an association between childhood attention deficit hyperactivity disorder (ADHD) features and adulthood psychological resilience in patients with mood disorders. Methods A total of 213 patients with mood disorders including major depressive disorder or bipolar I, II disorder and 909 healthy controls were included. We assessed childhood ADHD features using the Wender Utah Rating Scale (WURS), adulthood psychological resilience using the Connor-Davidson Resilience Scale (CD-RISC), and current depressive mood using the Beck Depression Inventory (BDI). Pearson's correlation, multiple linear regression and a mediation analyses were performed to examine the relationships between three WURS factor (impulsivity, inattention, and mood instability) scores, the BDI score, and the CD-RISC score. Results The CD-RISC score was negatively correlated with the WURS childhood inattention factor score and current BDI score in patients with mood disorders. BDI score mediated the influence of the inattention factor score on CD-RISC score among patients with mood disorders. The CD-RISC score was significantly lower in patients with mood disorders than in controls even after controlling for age, WURS scores, and the BDI score. Conclusions An evaluation of psychological resilience is important for enhancing recovery and quality of life in patients with mood disorders. When assessing psychological resilience, current depression and ADHD features in childhood, particularly inattention, should be considered.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제33권4호
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• pp.113-121
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• 2022

Objectives: This study aimed to compare the quality of life (QoL) of children with attention-deficit/hyperactivity disorder (ADHD) before and during coronavirus disease-2019 (COVID-19) and to examine how their QoL is affected by emotional and environmental factors during COVID-19. Methods: Participants in the pre-COVID-19 (n=43) and COVID-19 (n=36) groups were recruited from the same university hospital. The Pediatric Quality of Life Inventory (PedsQL) 4.0 Child Self-report, the Children's Depression Inventory (CDI), the Revised Children's Manifest Anxiety Scale (RCMAS), the PedsQL 4.0 Parent Proxy Report, and the Conners' Parent Rating Scale (CPRS) were employed. Independent t-tests, Pearson's correlation analysis, and multiple regression analysis were conducted. Results: Caregivers assessed the children's QoL more negatively than the children themselves in both groups. Children with ADHD evaluated their physical function more negatively and anxiety was significantly higher in the COVID-19 group. In the COVID-19 group, the PedsQL child self-report was significantly predicted by the CPRS, the CDI, and environmental factors (i.e., relation to child and monthly household income). Conclusion: Children with ADHD in the COVID-19 group had a numerically lower QoL and significantly higher anxiety. To improve QoL, it is important to deal with not only depression but also ADHD symptoms and environmental factors.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권4호
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• pp.129-136
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• 2021

Objectives: To investigate the relationship between brain structure and empathy in early adolescents with attention-deficit/hyperactivity disorder (ADHD). Methods: Nineteen early adolescents with ADHD and 20 healthy controls underwent 3T MRI. All the participants were assessed for different aspects of empathy using measures including the Interpersonal Reactivity Index and Empathy Quotient. Cortical thickness and subcortical structural volume based on T1-weighted scans were analyzed using FreeSurfer. Results: Cognitive empathy (t=-2.52, p=0.016) and perspective taking (t=-2.10, p=0.043) were impaired in the ADHD group compared with the control group. The cluster encompassing the left posterior insular, supramarginal, and transverse temporal cortices [cluster-wise p-value (CWP)=0.001], which are associated with emotional empathy, was significantly smaller in the ADHD group, and the volume of the left nucleus accumbens was greater than that of the control group (F=10.12, p=0.003, effect size=0.22). In the control group, the left superior temporal (CWP=0.002) and lingual cortical (CWP=0.035) thicknesses were positively associated with cognitive empathy, while the right amygdala volume was positively associated with empathic concern (Coef=14.26, t=3.92, p=0.001). However, there was no significant correlation between empathy and brain structure in the ADHD group. Conclusion: The ADHD group had a smaller volume of the cortical area associated with emotional empathy than the control group, and there was no brain region showing significant correlation with empathy, unlike in the control group.

• Clinical and Experimental Pediatrics
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• 제65권2호
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• pp.85-89
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• 2022

Background: There is evidence of a relationship between prenatal excess androgen exposure and central nervous developmental problems and attention-deficit/hyperactivity disorder (ADHD) in the offspring of mothers with polycystic ovary syndrome (PCOS). Purpose: Here we aimed to use a meta-analysis to investigate whether the offspring of mothers with PCOS are at an increased chance of developing ADHD. Methods: Three main English databases were searched for articles published through December 2020. The Newcastle-Ottawa Scale was used to assess study quality. Study heterogeneity was determined using I² statistics and publication bias was assessed using Begg and Egger tests. The results are presented as odds ratio (OR) and relative ratio (RR) estimates with 95% confidence intervals (CIs) using a random-effects model. Results: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on OR and RR (OR, 1.42; 95% CI, 1.27-1.57) and (RR, 1.43; 95% CI, 1.35-1.51), respectively. There was no heterogeneity among the included articles based on OR (I²=0.0%, P=0.588) and RR (I²=0.0%, P=0.878). Conclusion: Our study showed that maternal PCOS is a risk factor for ADHD. Therefore, screening their offspring for ADHD should be considered part of the comprehensive clinical care of women with PCOS.

• 응용통계연구
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• 제25권3호
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• pp.389-401
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• 2012

This paper derives a benchmark dose(BMD) and its 95% lower confidence limit(BMDL) using a semi-parametric regression model for small lead based changes in attention-deficit hyperactivity disorder(ADHD) scores in the first wave of the Children's Health and Environment Research(CHEER) survey data, which have been regularly collected in South Korea since 2005. Ha et al. (2009) showed that the appearance of ADHD symptoms had a borderline trend of increasing with the blood lead concentration. Butdz-J${\o}$rgensen (EFSA, 2010a) derived the BMDL of lead corresponding to a benchmark region of 1 full intelligent quotient (IQ) score using the raw data in Lanphear et al. (2005, EHP). European Food Safety Authority (EFSA, 2010b) determined the BMDL of $1.2{\mu}g/dl$ as a reference point for the characterization of lead when assessing the risk of the intellectual deficit measured by IQ scores. Kim et al. (2011) indicated that an even lower BMDL could be obtained based on the ADHD score; however, the BMDLs depended heavily upon the model assumptions. We show in this paper that a semi-parametric approach resolves the model dependence of BMDLs.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권2호
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• pp.192-198
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• 2005

본 고찰에서는 DSM-IV의 주의력결핍과잉행동장애(attention-deficit hyperactivity disorder, ADHD)와 ICD-10의 과잉행동장애(hyperkinetic disorder, HKD)의 진단 체계를 비교하였고 그 차이점을 분석하여 임상 및 연구 측면에서 어떠한 의의가 있는지를 살펴보았다. 아직까지 DSM의 ADHD와 ICD의 HKD를 직접 비교한 연구들은 매우 부족한 상태이지만, DSM-IV의 ADHD가 ICD-10의 HKD 보다 광범위한 ADHD의 한 아형라는 것을 알 수 있었다. DSM-IV ADHD의 유병율은 ICD-10 HKD과 비교했을 때 더 높았으며 그 차이는 뚜렷했다. 이러한 결과가 DSM-IV 진단 알고리즘에서 부주의 우세형과 과잉행동-충동성 우세형이 포함되어 ADHD의 범위가 더욱 확장되어 나타난 것인지에 대해서는 아직까지 알 수 없다. 그리고 현재까지 진행된 연구들을 종합해 보았을 때, DSM-IV HKD와 DSM-IV ADHD가 질적으로 같거나 혹은 다르다고 주장할 수는 있는 충분한 근거는 없어 보인다. 다만 HKD가 보다 심한 형태의 ADHD의 한 아형일 가능성이 시사되고 있다. 그러므로 현재로써는 임상에서 환자를 진단하는데 있어 DSM-IV 혹은 ICD-10 중 일방에만 의존하여 ADHD/HKD 장애를 과다하게 진단 내리거나 혹은 실제보다 적게 진단내리는 것을 경계하여야 할 것이다. 특히 질병통계와 보험체계는 WHO의 ICD진단 체계에 맞춰져 있으나 대학이나 전공의 과정 중에는 주로 APA의 DSM진단 기준에 맞춰 학습하는 우리나라의 현실을 감안했을 때 과연 ADHD/HKD에 대한 진단율이 실제 유병율에 비해 과다한지 혹은 부족한지에 대해서도 관심을 기울일 필요가 있다. DSM-IV ADHD와 ICD-10 HKD가 진단적으로 얼마만큼 근접하고 있는지에 대해서는 주요 임상 변인과 endophenotype을 포함한 진단적 타당성에 대한 연구들이 더 진행되고, 관련된 가족연구와 장기 추적 연구들이 뒷받침 되었을 때 보다 명확해질 것으로 생각되며, 또한 ADHD/HKD에 대한 APA와 WHO가 보다 근접하고 일치되는 진단 알고리즘이 개발될 수 있을 것이라 예상된다.

• 대한감각통합치료학회지
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• 제16권1호
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• pp.14-24
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• 2018

목적 : 본 연구는 Attention Deficit Hyperactivity Disorder(ADHD) 아동에게 시행한 상호작용식 메트로놈(Interactive Metronome; IM) 중재가 자세조절과 글씨쓰기에 미치는 영향에 대해 알아보고자 하였다. 연구방법 : 본 연구는 ADHD로 진단받은 초등학교 3학년 아동 1명을 대상으로 시행하였다. 개별실험 연구방법 중에서 ABA 설계를 사용하였고, 총 30회기로 매주 3회기 씩 총 10주 진행하였다. 기초선과 재기초선 기간에는 글씨쓰기 과제의 측정만 실시하였고, 중재기 동안에 IM 훈련을 40~50분간 실시하고 난 후에 글씨쓰기의 명료도와 속도를 평가하였다. 기초선을 시작하기 전과 재기초선이 끝나고 한 달 이내에 Clinical Observation of Motor and Postural Skills(COMPS)를 실시하여 자세조절의 변화를 알아보았다. 결과 : IM 중재를 시행한 후 대상자의 자세조절 변화는 하위항목 중 슬로모션, 손가락-코 운동, 비대칭 경반사의 점수가 향상되었고, 글씨쓰기 명료도와 속도는 중재 기간 동안 상승하는 경향을 보였으나 유의하게 변화되지 않았다. 결론 : 본 연구를 통해 ADHD 아동을 대상으로 한 IM 훈련의 중재가 자세조절과 글씨쓰기 수행능력을 향상시키는데 긍정적인 효과를 확인할 수 있었고, 향후 연구에 새로운 방향에 접근할 수 있는 기회를 제공하였다는 근거로 사용될 수 있을 것이다.