• 한국콘텐츠학회논문지
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• 제8권11호
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• pp.171-181
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• 2008

최근 의료분야의 많은 발전과 난치성질환에 대한 여러 노력들에도 불구하고 아토피 피부염은 줄어들지 않고 있으며 오히려 그 수가 늘어가고 있다. 또한 아토피로 인한 사회적 이슈는 더 이상 방치할 수 없는 상황에 이르렀으므로 더 다각적인 아토피 피해 감소에 노력하여야 할 것이다. 이에 이 연구에서는 기존 의학체계에서 다루고 있지 않은 직 간접적 아토피 피해사례를 살펴보고 대체의학 중 수기요법을 활용하여 적용할 수 있는 분야들에 대하여 그 방안들을 제언하므로 미래 직 간접적 아토피 피부염 피해 사례를 줄이고 의료서비스 시장을 늘릴 수 있는 방법을 모색코자 하였다.

• 한방안이비인후피부과학회지
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• 제33권1호
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• pp.45-55
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• 2020

Objectives : The objective of this study is to review the Trend of clinical trials conducted with the acupuncture treatment on Atopic Dermatitis. Methods : Through 4 foreign online databases(PubMed, Cochrane library, EMBASE, CNKI) and 3 domestic online databases(NDSL, RISS, OASIS), we searched for clinical studies performed acupuncture treatment for Atopic Dermatitis from 2010 to December 2019. Only randomized controlled trials(RCT) was selected and anlayzed according to the research method. Results : A total 4 studies were reviewed. LI11, ST36, SP10 were most frequently used acupoints in acupuncture treatment. Among the evaluation indexes, SCORAD, VAS, DLQI were used most. In most of the 4 studies, acupuncture treatment showed significant therapeutic effects. Conclusions : These results suggest that it is necessary to develop more detailed standards about Acupuncture treatment method as the method of acupuncture is getting more diverse, and objective tools are needed in evaluating Atopic Dermatitis.

• 대한한의학회지
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• 제29권5호
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• pp.41-51
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• 2008

Objective : To observe the efficacy and safety of CheungYeolYiSeup-tang and Hwangbaek external dressings on dampness-heat pattern atopic dermatitis(AD) in a non-comparative study. Methods : 10 patients with AD were included for 4 weeks of treatment. Efficacy and safety assessment included the scoring atopic dermatitis index(SCORAD), typical signs and symptoms of AD, results of some laboratory tests related to toxicity, and the incidence of adverse events. Results : Improvements in efficacy parameters were observed and produced no significant changes in laboratory tests related to toxicity in these patients. Their SCORAD results significantly decreased after 4weeks(P value<.01, according to the Wilcoxon sum of ranks test). Similarly, significant reductions from baseline in subjective pruritus scores and (P value<.05 by the Wilcoxon sum of ranks test) and the mean average of individual signs and symptoms of AD were reported after 4 weeks(P value<.05, P<0.01 by the Wilcoxon sum of ranks test). There were no significant changes in eosinophil, neutrophil, lymphocyte, immunoglobulin E and ESR in blood serum by paired ttest. Conclusion :CheungYeolYiSeup-tang administration and Hwangbaek external dressings are an effective and safe treatment for the management of dampness-heat pattern atopic dermatitis.

• 사상체질의학회지
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• 제25권2호
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• pp.115-123
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• 2013

Objectives The purpose of this case study is to report that a Soeumin patient diagnosed as adult atopic dermatitis was treated with Sipyimigwanjung-tang and then his symptoms improved. Methods We diagnosed the patient as Soeumin Greater Yin Pattern based on his nature & emotion, physical characteristics, symptoms. So we treated him with Sipyimigwanjung-tang and used Visual Analogue Scale(VAS), SCORAD(Scoring of Atopic Dermatitis) index and pictures of the affected part for the assessment. Results & Conclusions After treatment, his SCORAD index results significantly decreased from 76.3 to 41.8, VAS of itching decreased from 10 to 4 and the patient's subjective symptom and general condition considerably improved. This case study describe the effectiveness of Sipyimigwanjung-tang on Soeumin adult atopic dermatitis symptoms.

• 한방안이비인후피부과학회지
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• 제22권1호
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• pp.172-180
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• 2009

Objective : to investigate the modalities and treatments with atopic dermatitis. Methods : We made up a questionnaire consisting of symptoms, birth, family history, previous treatments of atopic dermatitis. We interviewed mild to severe 60 atopic dermatitis patients with questionnaire, from August to October, 2008 who were participating in clinical trials of Kyunghee University East-west neo medical center. Results : The results obtained are summarized as follows: 1. 49(81.7%) out of 60 patients reported previous or current use of medical treatment, and most common type of medical treatment was topical corticosteroid (95.9%). Oral antihistamine (61.2%), oral corticosteroid (61.2%) were also commonly used. 2. 31(51.7%) out of 60 patients reported previous or current use of oriental medical treatment, and most common type of oriental medical treatment was herbal medicine(100%). Acupuncture (41.9%), Herbal external supplements (22.6%) were also used. 3. 36(60.11% ) out of 60 patients reported previous or current use of folk remedies, and the most common type of folk remedy was extract of tree(Mokcho-ak)(75.0%). Aloe(61.1%), Charcoal(22.2%) were also commonly used. Conclusion : It seems the frequency of folk remedies used were related to severity of AD. However, there were no significant difference between medical treatment and oriental medical treatment.

• Food Science and Biotechnology
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• 제17권6호
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• pp.1272-1278
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• 2008

The purpose of this study was to investigate the effects of Kyung Hee Allergic Disease Herbal Formula (KAHF) on atopic dermatitis (AD) and its mode of action. Our clinical study showed KAHF reduced Severity Scoring of Atopic Dermatitis (SCORAD) indexes and subjective symptom scores. In parallel, the decreased levels of interferon (IFN)-$\gamma$ and interleukin (IL)-5 in serum, which contributed to its AD-mitigating effect was observed. To reveal the underlying mechanisms of KAHF in AD, its anti-inflammatory effect on lipopolysaccharide (LPS)-induced responses in RAW 264.7 cells was examined. KAHF was found to significantly inhibit the productions of nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and IL-$1{\beta}$ in LPS-stimulated RAW 264.7 macrophages. Consistently, KAHF potently inhibited protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, KAHF inhibited LPS-induced activation of nuclear factor (NF)-$\kappa}B$. Taken together, our data suggest that KAHF has a beneficial effect on several eicosanoid-related skin inflammations, such as atopic dermatitis.

• 방사선산업학회지
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• 제17권4호
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• pp.489-499
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• 2023

Isoegomaketone(IK), isolated from the radiation-induced mutant cultivar of Perilla frutescens var. crispa, is a major phytochemical compound that has attracted attention in pharmacological research. In this study, we demonstrated that IK exerts anti-inflammatory and protective effects on human mast cells and in an atopic dermatitis mouse model. IK inhibited tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), and IL-8 expression in human mast cells (HMC-1) stimulated with phorbol myristate acetate(PMA) and calcium ionophore A23187 (PMACI). IK significantly reduced the PMACI-induced phosphorylation of ERK and JNK, but not p38. IK also inhibited the PMACI-induced phosphorylation of STAT1 and STAT3. Oral administration of IK in atopic dermatitis mouse model ameliorated skin inflammation severity, as measured by skin thickness and pro-inflammatory cytokine levels such as TNF-α, IL-8, IL-4, and IL-13. These results might suggest that IK is a potent therapeutic agent against skin inflammation and atopic dermatitis.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권sup1호
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• pp.1-6
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• 2008

Previous infant feeding guidelines recommended a delayed introduction of solids to beyond 6 months of age to prevent atopic diseases. However, scientific evidence supporting a delayed introduction of solids for prevention of atopic diseases is scarce and inconsistent. Current evidence does not support a major role for maternal dietary restrictions during pregnancy or lactation in the prevention of atopic disease. In studies of infants at high risk of developing atopic disease, there is evidence that exclusive breastfeeding for at least 4 months compared with feeding intact cow milk protein decreases the incidence of atopic dermatitis, cow milk allergy, and wheezing in early childhood. For infants at high risk of developing atopic disease who are not breastfed exclusively for 4 to 6 months, there is modest evidence that atopic dermatitis may be delayed or prevented by the use of extensively or partially hydrolyzed formulas, compared with cow milk formula, in early childhood. There is no convincing evidence that a delayed introduction of solid foods beyond 4 to 6 months of age prevents the development of atopic disease. For infants after 4 to 6 months of age, there are insufficient data to support a protective effect of any dietary intervention for the development of atopic disease.

• Journal of Veterinary Science
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• 제24권1호
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• pp.6.1-6.6
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• 2023

Two Shih-Tzu dogs with atopic dermatitis presented with delayed periocular dermatitis (PD) following the instillation of dorzolamide and dorzolamide/timolol combination eyedrops; the development of dermatologic signs took 94 and 104 d in cases 1 and 2, respectively. Hypersensitivity to anti-glaucoma eyedrops was highly suspected, and treatment was discontinued. Delayed PD was significantly relieved in cases 1 and 2, at days 155 and 64 after discontinuation, respectively. In this study, the clinical characteristics and progression of delayed PD were described to inform clinicians who may encounter this rare side effect.

• 대한상한금궤의학회지
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• 제4권1호
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• pp.75-82
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• 2012

Objective : We considered Astragali Radix(黃耆) can be used to cure serious atopic dermatitis. so we treated this patient with prescriptions contained Astragali Radix(黃耆). By this case, we got effective results and report this case and index of choice Astragali Radix(黃耆) Method : After treatment with prescription contained Astragali Radix(黃耆), we observe the changes and analyze results. Results : 1. Atopic dermatitis can be cured with Astragali Radix's efficiency on Sanghanron(傷寒論) 2. We considered Astragali Radix(黃耆) can be used when Chronic damage to the nasal mucosa is appeared by rhinoscopy and Sneezing, runny nose that lasts all year round is shown Conclusion : Gaeji-Ka-Hwangki-Tang(桂枝加黃耆湯) has most effect on this case. So, We need to study combination Astragali Radix(黃耆) with Glycyrrhizae Radix(甘草) and the efficacy of herbs belonged to leguminosae.