• 한국산학기술학회논문지
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• 제18권6호
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• pp.343-355
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• 2017

본 연구의 목적은 성별에 따라 한국 청소년의 개인적, 가족적 및 환경적 특성과 수면충족감 정도를 비교하고, 개인적, 가족적 및 환경적 특성과 주관적 수면충족감과의 관련성을 파악하기 위함이다. 본 연구는 2016년 제 12차 청소년건강행태온라인조사의 원시자료를 활용하였고, 남학생 33,803명, 여학생 31,725명, 총 65,528명의 자료를 분석하였다. 연구결과, 수면충족감을 나타낸 비율은 남학생 33.4%, 여학생은 19.5%로 나타났다. 남학생과 여학생 모두, 개인적 특성은 우울경험, 자살생각, 학업성적, 스트레스, 주관적 행복감, 주관적 건강인지, 음주 및 흡연, 약물 경험, 알레르기비염 및 아토피피부염 진단여부, 가족적 특성은 경제 상태, 부모님 학력, 주거형태, 환경적 특성은 학교급, 학교유형, 고민상담자 유무가 주관적 수면충족감에 영향을 미치는 요인으로 나타났다. 개인적 특성 중 아침식사 빈도와 천식 진단 여부는 남학생에서만, 신체활동 여부는 여학생의 수면충족감에만 영향을 주는 것으로 나타났다. 개인적 특성의 정신건강이 청소년의 주관적 수면충족감에 가장 큰 영향을 주는 것으로 나타났다. 그러므로, 한국 청소년의 주관적 수면충족감을 증진시키기 위한 간호 중재는 성별에 따른 차이를 고려해 적용해 나가야 할 것이다.

• 대한한의학방제학회지
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• 제25권2호
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• pp.223-251
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• 2017

Objectives : A lot of experiment results of Yugmijihwangtang(YM) are reported in various kinds of journals. Many of them report on the new effects that are not recorded in the traditional medical texts. So it is necessary to take it into consideration that newly reported effects could be of help to clinical practice, because this process of comparison of Donguibogam and scientific experiment results will have basis to lead into the evidence based medicine. Methods : We compared the effects of in Donguibogam and the experiment results of YM. Results : The effects of YM in Donguibogam are to replenish essence and marrow, and to treat red wen, fatigue, treat hypouresis, urinary sediment, urinary urgency, hematuria, hydrocephalus, speech and movement retardation, yin-deficiency, diabetes mellitus, nonalcoholic fatty liver, melanoma, disability to see near and far sight, tinnitus, hearing loss, alopecia, angiogenesis, cough, cough at night, trachyphonia, and, infantile convulsion. The experiment results of YM since 2000 in both Korea and China are to inhibit atopic dermatitis, renal interstitial fibrosis, anti-oxidant, emphysema, stress, glomerulosclerosis, diabetic nephropathy, chronic glomerulonephritis, hemorrhage, plantar sweating, dermal aging, kidney aging, bone loss, breast cancer, pathological myocardial cell, primary liver cancer, thrombosis, osteoporosis, intrauterine growth retardation, chronic renal failure, IgA nepropathy, slow cerebral development, and hippocampal tissue lesions on the one hand, and to help bone formation, renin-angiotensin- aldosterone system, cerebral recovery, cognitive function and expression, osteoblast proliferation and differentiation, learning and memory, cold-tolerance and oxygen deficit-tolerance and anti-fatigue, endometrial formation, humoral and cell-mediated immunity, immune regulation effect, Hypothalamus-Pituitary-Ovary Axis, and spermatogenesis, on the other hand. Conclusion : When we compared the effects of YM with the experiment results of YM, there existed a considerable gap between them. So, from now on, it is expected that a great effort and consideration are needed to solve these gaps from an academic and clinical point of view.

• 대한한의학회지
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• 제21권4호
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• pp.174-182
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• 2000

Objectives : In order to apply herbal medicine to aroma-therapy, we observed clinically remedical effect for allergic rhinitis of aroma-therapy using herbal medicine. Methods : Twenty-four allergic rhinitis patients were treated in the Kun-po Oriental Medical Hospital of Wonkwang University from September 2000 to October 2000. They were treated with aroma-therapy and analyzed clinically. Results : 1. 25.0% (6 cases) of all cases involved pre-teenagers; teenagers 29.2% (7 cases); patients in their 20s, 20.8% (5 cases); patients in their 30s, 12.5% (3 cases); patients in their 40s, 8.3% (2 cases); patients in their 50s, 4.2% (1 cases). 2. The ratio of male to female patients was 58.3%(14 cases) to 41.7%(10 cases). 3. Cases involving patients under the age of six months was 0%; under 1 year 12.5% (3 cases); under 2 years 33.3%(8 cases); under 3 years 16.7%(4 cases); over 3 years 37.5%(9 cases). 4. Past history : The cases of sinusitis were 33.3%(8 cases); otitis media 20.8%(5 cases), bronchitis 16.7%(4 cases), atopic dermatitis 12.5%(3 cases), asthma 8.3%(2 cases). 5. The ratio of allergic onset based on seasons were : spring 16.7%(4 cases), summer 0%, fall 29.2%(7 cases), winter 16.7%(4 cases), and not defined 37.5%(9 cases). 6. The cases of nasal obstruction was 91.7%(22 cases); followed by : sneezing 83.3(20 cases), white rhinorrhea 70.8%(17 cases), eye itching 66.7%(16 cases), nasal itching 58.3%(14 cases), rhinalgia 58.3%(14 cases), postnasal drip 50.0%(12 cases), headache 41.7%(10 cases), yellow rhinorrhea 33.3%(8 cases), cough 33.3%(8 cases), fatigue 29.2%(7 cases). 7. The cases of familial factor was 66.7%(16 cases); the non-familial factor 33.3%(8 cases). 8. The remedical effect of the treatment showed an improvement in 58.4% of the total cases studied. 9. The improvement-rate of the 1st group (mahwang group) was 66.7%; of the 2nd group (hwangkum group) 48.5%, and of the 3rd group (pine group) 55.8%. Conclusions : Considering the above results, we have concluded that the remedical effect for allergic rhinitis of aroma-therapy using herbal medicine showed to be intentional in comparison with aroma-therapy using aroma-oil.

• 대한한방소아과학회지
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• 제16권2호
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• pp.69-81
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• 2002

The Purpose of this study was to collect statistics of pediatric problems, and so to investigate the new effective oriental medicine treatments in pediatric disease and its clinical applicability. The Study was composed of 698 new patient who had been treated at the pediatric unit in th Dong Sea Oriental Medical Hospital for 1 year, from 1 September 2001 to 31 October 2002, and aged between 0 and 18 years. The Chief complaints and their care-givers. Result: 1. In the study, male children are 403 and female children are 295. So the sex ratio between male and female is 1.37 : 1. 2. In age distribution, 0-3 years : 317(45.4%), 4-6 years : 148(21.2%). 7-9 years 98(14.0%), 10-12 years: 66(9.5%), 13-15 years : 40(5.7%), 16-18 years 29(4.2%). 3. The chief complaint according to systemic division was Respiratory diseases covers 30.1%, Digestive diseases covers 20.8%, Physique diseases covers 10.6%. 4. The Respiratory diseases tended to increase in autumn and appeared mostly in the age group between 0 and 9 years. The Digestive diseases increase in summer and appeared mostly in the age group between 10 and 12 years. The physique diseases increase in winter and appeared mostly in he age group between 13 and 18 years. 5. Most of patient came to the hospital from diseases such as common cold, weakness, dyspepsia, atopic dermatitis, rhinitis, take a easy cold, short stature, sweating, Bell's palsy, abdominal pain, etc. Conclusion : 1. The chief complaint In pediatric diseases that needed an oriental medical treatment was mainly the disease that tends to take long time and the weakness, and appeared frequency in respiratory and digestive disease. 2. The oriental medical treatment was still preferred as a way to improve the weakness by patients, rather than a way to overcome their disease. in particular, the study shows that the oriental medical treatment should be emphasized in terms of preventing the disease. 3. The new disease, which were developed with change of human life and environment, should be investigated as a new fie of oriental medical treatment.

• Clinical and Experimental Pediatrics
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• 제49권10호
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• pp.1061-1066
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• 2006

목 적 : 신생아에서 우유 알레르기가 의심되는 경우 우유 특이 IgE 항체 측정이 우유 알레르기 진단에 유용한지 알아보고자 하였다. 또한 추적관찰이 가능한 경우 우유 특이 IgE 항체 검사결과와 다른 알레르기 질환의 발현과의 연관성도 알아보고자 하였다. 방 법 : 생후 4주이내의 신생아로 우유 특이 IgE 항체 검사양성을 보인 87명을 대상으로 하였다. 대상 환아는 병력 청취와 진찰 소견에서 우유 알레르기가 의심되어 우유 단백 제거 요법을 시행하여 증세의 호전을 보이고 우유 특이 IgE 항체 검사에서 양성을 보인 환아로 하였다. 또한 이들 87명의 환아 중 추적관찰이 가능했던 40명을 대상으로 우유 특이 IgE 항체 검사결과와 알레르기 질환 발현과의 상관관계를 알아보았고 이들 항체와 알레르기 질환의 가족력과의 상관관계도 알아보았다. 결 과 : 대상 환아의 평균 나이는 $17.2{\pm}5.4$일 이었다. 우유 특이 IgE 항체 검사 결과 milk 양성은 87명이었고 casein 양성은 24명, ${\alpha}$-lactoalbuminn 양성은 38명, ${\beta}$-lactoglobulin 양성은 75명이었다. 6개월 이상의 추적관찰이 가능했던 환아는 40명(45.9%)이었고 부모가 알레르기 질환을 가진 경우는 10명(25%), 환아의 추적 관찰 결과 알레르기 질환을 가진 경우가 15명(37.5%)으로 천식 4명, 아토피 피부염 11명이었다. 추적관찰 결과 신생아기에 casein에 양성을 보인 경우 알레르기 질환의 발현과 연관성이 통계적으로 유의하게 높았다. 그러나 우유 특이 IgE 항체 양성과 알레르기 가족력과의 연관성은 통계적 유의성이 없었다. 결 론 : 신생아에서 IgE 매개성 및 혼합성 우유 알레르기가 의심되는 경우는 우유 제거 식이 요법과 우유 특이 IgE 항체 검사를 시행한다면 진단에 도움이 될 수 있다고 생각된다.

• Clinical and Experimental Pediatrics
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• 제52권10호
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• pp.1103-1108
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• 2009

목 적:만성질환자가 아닌 일반 학동기 아동을 대상으로 보완대체요법 이용실태를 파악하며 소아청소년과 의사로서 대처 방향을 모색하고자 연구를 실시하였다. 방 법:3개 초등학교 1학년부터 6학년 1,688명의 학부모를 대상으로 설문조사를 시행하였다. 그중 설문지가 회수된 794명(47%)을 분석하였다. 결 과:일반적인 학동기 아동에서 보완대체요법의 이용률은 278명(35%)이었고, 보완대체요법의 종류는 한약제 62.6%, 보조식품 31.3%, 비타민 30.2%, 선식 11.2%, 침술 11.2%, 체 냄, 수지침 순이었다. 보완대체요법의 이용률은 어머니의 학력이 대학 이상 일 때, 종교가 있을 때, 가정 월 총수입이 100만 원 이상일 때 의미 있게 높았으며 이용하게 된 동기는 질병예방목적이 가장 많았고, 주로 주변 사람이나 매체를 통해 이용하였다. 보완대체요법에 대한 만족하지 못하는 경우는 16%였고, 재사용 의향이 없는 경우는 20.5%였고, 환아가 건강할 때 주로 사용하는 경향을 보였다. 환아가 영양결핍, 아토피 피부염, 관절통증, 알레르기비염, 비만, 천식 때 주로 이용하는 경향을 보였다. 결 론:보완대체 의학의 사용이 아이의 건강상태와는 밀접하지 않으며 사용 경로 또한 주변 사람의 권유나 방송 매체 등을 통해 이루어지고, 병원치료와 병행 시 좋을 것이라는 막연한 기대감으로 사용되고 있는 경우가 많아 보완대체요법에 대한 부작용, 효과, 안전성에 대한 연구가 필요하며 만성질환 및 알레르기 질환의 경우 소아청소년과 의사로서 현대의학의 적극적인 치료 및 교육이 필요할 것으로 사료된다.

• 한방안이비인후피부과학회지
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• 제31권3호
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• pp.50-59
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• 2018

Objectives : The aim of this review is to investigate studies on skin adverse reactions and to demonstrate subjects related to the adverse effects in dermatology. Methods : Electric searches were performed with KISS(Korean studies Information Search System) and the key words were combination of 'skin' and 'adverse effect'. 87 literatures investigated in this review were issued from 1900 to 2016. Results : Among the 87 papers, dermatologic adverse reactions were reported in 83 papers in medicine, accounting for 95.4%. Of the adverse effects seen on the skin, 84 discoloration such as erythema, pigmentation and hemotelangiosis were the most common, accounting for 21%. Among the medical adverse reactions not seen on the skin, 21 infection were the most common, accounting for 25%. Among the subjective adverse reactions, of which 32 pruritus were the most common, accounting for 43%. Among the 87 papers, there were 3 cases with underlying diabetes and 3 cases with underlying hypertension, followed by 2 cases with chronic renal failure, HBV, atopic dermatitis and respectively 1 case with alcoholism, depression addiction, multiple myeloma, arthritis and psoriasis. The most frequent period until adverse reactions appeared was within 2 weeks, accounting for 13 papers. And 4 were the most frequent adverse reactions lasting less than 1 month, and 4 were more than 3 months and less than 6 months. There were 48 cases where adverse reactions were caused by nonmedical practioner's treatment. The adverse reactions by the pharmacist were the highest at 11 cases (23%). There were 17 cases of adverse reactions due to medical treatment, among which dermatologists and nondermatologists accounted for the majority of 5 cases, 29%. The most common cause of adverse reactions was the application of external medicine (41 cases), followed by 36 cases of foreign body implantation, eyebrow tattooing, ear piercing, etc. Conclusions : In this report, we demonstrated patterns of adverse reactions in the medical field of dermatology caused by non-medical personnel than medical personnel. We suggest that more effort should be followed by medical personnel to establish clear awareness of skin disease and by patients to be aware of the risks of the illegal medical treatment by non-medical personnel.

• 한국환경과학회지
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• 제26권5호
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• pp.675-684
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• 2017

Provider-oriented weather information has been rapidly changing to become more customer-oriented and personalized. Given the increasing interest in wellness and health topics, the demand for health weather information, and biometeorology, also increased. However, research on changes in the human body according to weather conditions is still insufficient due to various constraints, and interdisciplinary research is also lacking. As part of an effort to change that, this study surveyed medical practitioners at an actual treatment site, using questionnaires, to investigate what kind of weather information they could utilize. Although there was a limit to the empirical awareness that medical staff had about weather information, most respondents noted that there is a correlation between disease and weather, with cardiovascular diseases (coronary artery disease (98.5%) and hypertension (95.9% ), skin diseases (atopic dermatitis (100%), sunburn (93.8%)) being the most common weather-sensitive ailments. Although there are subject-specific differences, most weather-sensitive diseases tend to be affected by temperature and humidity in general. Respiratory and skin diseases are affected by wind and solar radiation, respectively.

• 대한한방소아과학회지
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• 제19권1호
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• pp.185-201
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• 2005

Objective : This experimental study was performed to examine the anti-allergic infiammatory effects of Mori Folium. Method : Macrophage 264.7 cells were pretreated for 1hour with Sangyup. After pretreatment, macrophage were incubated with lipopolysaccharide(LPS) $100ng/m{\ell}$ 12h and media collected and $TNF-{\alpha}$, $IL-1{\beta}$, IL-6, IL-10 concentrations in supernatants were measured each by Enzyme linked immuno-sorbent assay. Sangyup were used $1mg/m{\ell}$, $500{\mu}g/m{\ell}$, $250{\mu}g/m{\ell}$, $100{\mu}g/m{\ell}$, $50{\mu}g/m{\ell}$. Hydrocortisones were used $10^{-4}M,\;10^{-5}M,\;10^{-6}M,\;10^{-6}M,\;10^{-6}M$. Results : Macrophage 264.7 cells were pretreated with Hydrocortisones and Sangyup. After pretreatment, macrophage were incubated with lipopolysaccharide(LPS). To investigate the anti-inflammatory effect of Sangyup, we measured the amount of cytokines, and the results are as follows; 1. Mori Folium. showed statistically significant inhibitory effect on antiinflammation in $TNF-{\alpha}(p<0.02)$ in all five concentrations compared with the (-)controls treated with LPS. Mori Folium showed inhibitory effect on antiinflammation in $TNF-{\alpha}$ in similarpattern in all five concentrations compared with the (+)control pretreated with hydrocortisone. 2. Mori Folium. showed statistically significant inhibitory effect on antiinflammation in IL-6(p<0.01) in all five concentrations compared the (-)controls treated with LPS. Mori Folium. showed inhibitory effect on antiinflammation IL-6 similar pattern in all five concentrations compared with the (+)control pretreated with hydrocortisone. 3. Experimental Group pretreated with Mori Folium. showed statistically significant difference of antiinflammation in $IL-1{\beta}$ in concentrations of $50{\mu}g/m{\ell}(p<0.01)$, $250{\mu}g/m{\ell}(p<0.05)$ compared with the (-)control treated with LPS. Experimental Group pretreated with Mori Folium. showed increased level of $IL-1{\beta}$ in all concentrations compared the (+)control treated with hydrocortisone. 4. Experimental Group pretreated with Mori Folium. did not show statistically significant effect on IL-10 compared with the (-)control. Conclusion : By the findings of this experiment, Mori Folium is observed to have antiallergic and antiinflammation effect.

• 한국유기농업학회지
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• 제19권2호
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• pp.245-253
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• 2011

유기농재배 콩을 다양한 용매에서 추출하여 그 추출물에 대한 항산화 효과, 항염증 효과, 대식세포의 세포사멸 보호 효과, 그리고 알레르기 저해효과를 비교하였다. DPPH 법과 SOD 효소의 활성 측정으로 항산화 능력을 평가하였으며, 항염증 효과는 LPS로 유도시킨 Raw 264.7 세포주에서 염증 매개 단백질인 Cox-2와 iNOS의 발현량을 Western blotting으로 조사하여 분석하였다. 또한 대식세포 보호 효과를 세포사멸 조절 단백질인 Bcl-xl의 발현량조사로 평가하였고, 1mM $H_2O_2$ 처리로 유도되는 세포사멸의 보호효과를 세포 수 측정법으로 조사하였다. 항알레르기 효과는 흰쥐의 비만세포인 RBL-2H3 세포주를 사용하여 IgE로 매개되는 비만세포의 탈과립화를 OPT assay로 측정하여 분석하였다. 그 결과, 유기 재배 콩의 다양한 추출물에서 항산화, 세포사멸 보호, 항염증 효과를 나타내었다. 특히 유기농 콩의 열수 추출물은 LPS로 유도시킨 염증반응을 효과적으로 억제하는 것으로 나타났다. 그러나 항알레르기 효과는 모든 추출물에서 히스타민 유리량이 약간 감소하는 것으로 나타나 유기농 콩의 특별한 효과를 확인할 수 없었다. 콩에는 많은 유용한 생리활성물질 뿐 만 아니라 알레르기 유발 물질도 존재하는 것으로 알려져 있지만 조추출물 상태에서는 특이적인 알레르기 유발보다 오히려 항알레르기 효과가 나타났다. 결론적으로, 만성 염증 및 천식, 그리고 아토피피부염과 같은 염증관련 질환에는 유기 재배된 콩이 좋은 억제 효과를 가지고 있다고 판단된다.