• Archives of Pharmacal Research
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• v.22 no.6
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• pp.592-607
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• 1999

2-(1-Aryl-1-hydroxymethyl)-and 2-aroyl-DHAQ derivatives (DHAQ, 1,4-dihydroxy-,10-anthraquinone), and 2-(1-aryl-1-hydroxymethyl)-ATO derivatives (ATO, anthraceneactivity (T/C 125~128%), though their cytotoxicity was not further improved compared to that of 2-(1-aryl-1-dydroxymethyl)-1,4-dihydroxy-9,10-anthraquinones. They manifested no correlation between the cytotoxicity and the antitumor activity. In case of 2-[1-hydroxy-1-(4-propylphenyl)-methyl]-ATO, the most bioactive one in viv-1,4,9,10-tetraone) were synthesized and their antitumor activities were determined. 2-(1-Aryl-1-hydroxymethyl)-DHAQ derivatives showed a stronger cytotoxicity compared to the series of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone derivatives. It was suggested that the presence of aryl group at the side chain accelerated the bioreductive activation leading to cell death. 2-Aroyl-DHAQ derivatives, despite their higher electrophilicity, revealed smaller cytotoxicity and antitumor activity (expressed by T/C value) than 2-(1-aryl-1-hydroxymethyl)-DHAQ derivatives. Thus, no consistent relationship between the electronic effect on aromatic side chain and the cytotoxicity was observed. ATO series exhibited a higher antitumor o among the same series, it showed an $ED_{50}$ value of 10.2 mg/mL and a T/C value of 218%. It is assumed that the anthrancene1,4,9,10-tetraones after uptake into cellular tissues might be transformed to a cytotoxic metabolite(s).

• Journal of the Society of Naval Architects of Korea
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• v.51 no.2
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• pp.122-129
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• 2014

Identification of the whipping response out of the combined wave-vibration response of a flexible sea going vessel is one of the most interesting research topic from ship designer's point of view. In order to achieve this goal, a novel methodology based on the wavelet cross-correlation technique was proposed in this paper. The cross-correlation of the wavelet power spectrum averaged across the frequency axis was introduced to check the similarity between the combined wave-vibration response and impulse response. The calculated cross-correlation of the wavelet power spectrum was normalized by the auto-correlation of the each spectrum with zero time lag, eventually providing the cross-correlation coefficient that stays between 0 and 1, precisely indicating the existence of the impulse response buried in the combined wave-vibration response. Additionally, the weight function was introduced while calculating the cross-correlation of the two spectrums in order to filter out the signal of lower frequency so that the accuracy of the similarity check becomes as high as possible. The validity of the proposed methodology was checked through the application to the artificially generated ideal combined wave-vibration signal, together with the more realistic signal obtained by running 3D hydroelasticity program WISH-Flex. The correspondence of the identified whipping instances between the results, one from the proposed method and the other from the calculated slamming modal force, was excellent.

• Proceedings of the KIEE Conference
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• 2007.10a
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• pp.299-300
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• 2007

In this paper, slip wear phenomenon of train was studied by traction force of acceleration and braking force of deceleration. First, the slip wear phenomenon on train operation mode was analyzed when powering, coasting and braking each and then rail wear was analyzed from the slip wear data. Especially, the data proved correlation between slip wear and deceleration rather than acceleration. Second, If velocity of a train is constant, even though the velocity is high, ATO logging data and measurement data proved that the rail wear is not serious. It will help for efficient braking force operation providing fundamental data to braking step control.

• The Korean Journal of Air & Space Law and Policy
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• v.26 no.2
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• pp.149-179
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• 2011

Statistics of aviation accident in Korea show that safety level of training flights is high. However, more than 80% of aviation accidents happen owing to human factors. And because most reasons of them are concerned with pilot error, it is very important for student pilots who will transport a lot of passengers to develop the knowledge of safety and abilities of risk management for preventing accidents. In this study, in order to investigate the Human Factors which affect safety in training student pilots for flight, verified the correlationbetween experiences of accident, the differences according to the experience level of training flight and the differences between college student pilots and ordinary student pilots on the basis of human factors that composes the SHELL models. For the study, Using SPSS 17.0, conducted Correlation Analysis, Analysis of Variance(ANOVA) and t-test. To sum up the result of this study, student pilot's ability and equipment in the cockpit are the important factors for safety when pilots are training flight. Also the analysis of the differences between human factors according to the characters of student pilots' groups shows that college student pilots are affected by immanent factors and organizational cultures. So far, there haven't been any accidents which is related with human casualties when training at the ATO(Approved Training Organization). But accidents can occur at any time and anywhere. Especially the human factors which comprises most of aviation accident have a wide reach and are impossible to be eliminated, therefore, it is best to minimize them. Because ATO is the starting point to lead the aviation industry of Korea, we will have to be aware of problems and improve education/training of human factors.