• 대한의용생체공학회:의공학회지
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• 제42권6호
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• pp.287-294
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• 2021

Cardiotoxicity assessment of all drugs has been performed according to the ICH guidelines since 2005. Non-clinical evaluation S7B has focused on the hERG assay, which has a low specificity problem. The comprehensive in vitro proarrhythmia assay (CiPA) project was initiated to correct this problem, which presented a model for classifying the Torsade de pointes (TdP)-induced risk of drugs as biomarkers calculated through an in silico ventricular model. In this study, we propose a TdP-induced risk group classifier of artificial neural network (ANN)-based. The model was trained with 12 drugs and tested with 16 drugs. The ANN model was performed according to nine features, seven features, five features as an individual ANN model input, and the model with the highest performance was selected and compared with the classification performance of the qNet input logistic regression model. When the five features model was used, the results were AUC 0.93 in the high-risk group, AUC 0.73 in the intermediate-risk group, and 0.92 in the low-risk group. The model's performance using qNet was lower than the ANN model in the high-risk group by 17.6% and in the low-risk group by 29.5%. This study was able to express performance in the three risk groups, and it is a model that solved the problem of low specificity, which is the problem of hERG assay.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제6권8호
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• pp.379-384
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• 2017

현실 소프트웨어 비즈니스 환경에서 많은 벤처/중소기업의 소프트웨어의 사용 범위가 넓어지고 품질에 대한 검증이 요구되고 있다. 소프트웨어 품질 검증은 제품과 프로세스 품질이다. 그리고 현실에 맞게 전체 조직보다는 테스트 조직의 성숙도(Test Maturity Model)에 초점을 둔다. 하지만 기존 모델은 국내 벤처/중소기업에게 적용이 부적합한 부분이 존재한다. 이를 위해 테스트 성숙도 모델의 경량화를 제안한다. 우리의 경량 모델은 기존 테스트 성숙도 모델과 테스트 프로세스 개선(TPI Next) 모델을 기반으로 재정의된 모델이다. 하지만 대부분 모델은 성숙도 레벨을 정의하고, 레벨을 달성하기 위한 목표 및 세부 활동만 제공할 뿐이다. 평가단을 위한 평가 가이드 및 정형화된 평가 절차가 존재하지 않는다. 그렇기 때문에 심사위원과 기업이 정형화된 심사 과정 및 평가를 진행하기 어렵다. 본 논문은 경량화된 테스트 성숙도 모델의 평가 가이드를 제안한다. 평가를 위한 진단 절차를 정의와 평가 가이드, 그리고 평가 절차 및 절차별 활동과 산출물의 정의한다. 이 평가 가이드는 심사 위원에게는 정형화된 심사가 가능하게 하고, 자체 평가 가이드는 자체 테스트 조직에 심사 준비를 좀더 빠르고 바르게 진행하게 한다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1995년도 봄 학술발표회 논문집
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• pp.286-291
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• 1995

The deterioration of PC box girder may cause serious effect on the durability of PC structure compared to that of RC structures. In the durability assessment of PC box girder bridges, a quantitive model on crack width is considered as a measure of durability. This study suggests a durability limit state model for PC box girder bridges. This durability limit state model in formulated based on the conventional models on the cracks in concrete. And the allowable crack width is taken as an assumed value established by the design specification or provided by the maintenance authority of the structure.

• 환경영향평가
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• 제14권6호
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• pp.427-441
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• 2005

In order to choose proper dispersion model and emission factors suitable in Korea in evaluating the effect of pollutants emitted by the vehicles in highway on nearby area, various road dispersion models and vehicle emission factors were reviewed. With theoretical inter-comparisons of the exiting models for line source, CALINE 3 and CALINE 4 models which were suggested by US EPA were selected as the road dispersion models for further evaluation with the measurement. The emission factors suggested by Korean Ministry of Environment was turned out to be appropriate since the classification of vehicle kinds was simple and easy to apply in Korea. The comparisons of predicted concentrations by CALINE 3 and 4 models with the measurements in flat, fill and bridge road types showed that CO and PM-10 were in good agreements with experiments and the differences between CALINE 3 and 4 models are negligible. The model concentrations of $NO_2$ by CALINE 4 were also in good agreement with the measurement but those by CALINE 3 were over-predicted. The discrepancies in CALINE 3 model were due to rapid decay reaction of $NO_2$ near the highway, which was not included in CALINE 3 model. For the road type with one & two side cutting grounds, the similar patterns as the flat & fill road type for CO, PM10, & $NO_2$ were observed but the number of data for comparison in these cases were not enough to draw the conclusion. These results lead to the conclusion that CALINE4 model is proper in road environmental impact assessment near the highway in flat, fill and bridge road types.

• 한국통신학회논문지
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• 제39B권12호
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• pp.842-855
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• 2014

스마트폰 시장이 성숙기에 들어서면서 새로운 성장동력으로 웨어러블 컴퓨터가 주목받고 있다. 웨어러블 컴퓨팅 시스템은 무선 네트워크 기술, 임베디드 기술, 센서 기술, 신소재 기술 등 다양한 기술의 복합적인 융합체이다. 이러한 특징들은 기존의 소프트웨어가 가지고 있는 품질특성 이외에 활용성, 이동성 등의 특성을 내포하고 있기 때문에 국제표준인 ISO/IEC 9126의 표준만으로 정확한 품질 평가를 하기에는 어려움이 따른다. 본 논문에서는 이러한 필요성에 따라 기존의 ISO/IEC 9126과 웨어러블 컴퓨팅의 특징에 의해 도출된 품질특성을 추가해 웨어러블 컴퓨터 품질평가모델을 제안하였다. 웨어러블 컴퓨터 품질평가모델의 개발을 위해 웨어러블 컴퓨터의 기능적 요구사항과 품질특성을 도출하여 메트릭과 품질 기준을 제안하였다. 본 연구에서는 시나리오에 제안된 모델을 적용하고 S사, L사, G사의 웨어러블 기기의 품질을 비교하여 품질평가모델의 실용성을 확인하였다. 본 연구에서 제안한 평가모델은 웨어러블 컴퓨터의 품질평가를 위한 가이드라인으로 활용할 수 있을 것으로 기대된다.

• 한국농공학회논문집
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• 제63권4호
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• pp.55-64
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• 2021

The expansion of upland crop cultivation in rice paddy fields is recommended by the Korean government to solve the problem of falling rice price and reduction of rice farmer's income due to oversupply of rice. However, water use efficiency is significantly influenced by the land use change from paddy field to upland. Therefore, this study aimed to evaluate the water budget of soybean grown in using APEX (Agricultural Policy and Environmental eXtender) model. The amount of runoff was measured in a test bed located in Iksan, Jeollabu-do and used to calibrate and validate the simulated runoff by APEX model. From 2019 to 2020, the water budget of soybean grown in uplands were estimated and compared with the one grown in paddy fields. The calibration result of AP EX model for runoff showed that R² (Coefficient of determination) and NSE (Nash-Sutcliffe efficiency) were 0.90 and 0.89, respectively. In addition, the validated results of R² and NSE were 0.81 and 0.62, respectively. The comparative study of each component in water budget showed that the amounts of evapotranspiration and percolation estimated by APEX model were 549.1 mm and 375.8mm, respectively. The direct runoff amount from upland was 390.1 mm, which was less than that from paddy fields. The average amount of irrigation water was 28.7 mm, which was very small compared to the one from paddy fields.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2008년도 정기총회 및 학술발표대회
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• pp.545-548
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• 2008

In this study, the concept of safety impact assessment to achieve 'Design-for-Safety' in design phase is introduced. For this purpose, safety impact assessment model was devised and a methodology using the risk-based safety impact assessment approach for NATM of tunnel projects is suggested. The suggested methodology includes safety information survey, classification of safety impact factors caused by design and construction, and quantitative estimation of magnitude and frequency of safety impact factors. A real-world case study on the safety impact assessment of a tunnel construction project is also provided in the paper.

• 환경영향평가
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• 제15권6호
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• pp.385-394
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• 2006

Land resources should be managed not only for human utilizations but also for environmental preservation. Based on that, environmental capacity should be estimated in both environmental and developmental ways. This study was performed for developing an estimation model for relative environmental capacity, considering both Development Tolerance Index(DTI), which shows environmental and ecological conservation value and is based on national environmental assessment indicators of the Korea Ministry of Environment, and Development Attractiveness Index(DAI), which shows topographical characteristics and geographical accessibility. The relative environmental capacity in this study can be helpful to coping with the conflict in planning and managing the use of land resources. The relative environmental capacity in this study, however, did not include either environmental or ecological sensitivity of land resources. This limitation should be solved through further research.

• 한국대기환경학회지
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• 제18권5호
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• pp.373-381
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• 2002

Benzene, Ethyl-benzene, Toluene and Xylene (BTEX) can be released to a groundwater in case of the oil leakage from underground storage tank of a gas station. These chemicals are found to contribute to the total inhalation risk from contaminated indoor air. This study presents the assessment of a human exposure to such chemicals released from the groundwater into indoor air. At first, a 2-compartment model is developed to describe the transfer and distribution of the chemicals released from groundwater in a house through showering, washing clothes, and flushing toilets. The model is used to estimate a daily human exposure through inhalation of such BTEX for adults based on two sets of exposure scenarios. Finally, a sensitivity analysis is used to identify important parameters. The results obtained from the study would help to increase the understanding of risk assessment issues associated with the indoor pollution by BTEX released from contaminated groundwater.

• 한국대기환경학회지
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• 제17권3호
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• pp.241-249
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• 2001

A report by the National Research Council in the United States suggested that many lung cancer deaths each year are associated with breathing radon in indoor air. Most of the indoor radon comes directly from soil beneath the basement of foundation. Recently, radon released from groundwater is found to contribute to the total inhalation risk from indoor air. This study presents the assessment of a exposure to radon released from the groundwater into indoor air. At first, a 3-compartment model is describe the transfer and distribution if radon released from groundwater in a house through showering, washing clothes, and flushing toilets. The model is used to estimate a daily human exposure through inhalation of such radon for adults based on two sets of exposure scenarios, Finally, a sensitivity analysis is used to identify important parameters. The results obtained from the study would help to increase the understanding of risk assessment issues associated with the indoor radon released from groundwater.