• 제목/요약/키워드: Asian Countries

검색결과 2,368건 처리시간 0.031초

NSC(국가안전보장회의) 체제의 한미일 비교 (Comparison of NSC system in the U.S., Japan, and the Republic of Korea)

  • 권혁빈
    • 시큐리티연구
    • /
    • 제37호
    • /
    • pp.29-50
    • /
    • 2013
  • 최근 동북아시아 각국은 천안함 피격, 연평도 포격 등 북한의 대남 도발, 북한의 장거리미사일 발사와 핵실험 등 군사적 위협, 센카쿠 열도(댜오위다오)를 둘러싼 중국과 일본 간의 충돌 등 심각한 안보 위기를 맞고 있다. 특히 한국과 일본은 각기 2013년 2월 박근혜 정부, 2012년 12월 제2차 아베 신조(안부보삼(安部普三)) 내각 등 새로운 정권 출범을 맞아, 공히 주요 선거공약으로 제시한바 있는 위기관리 및 안보 정책의 정비 강화를 시도하고 있다. 그 핵심 중 하나는 최근 미국의 모델을 참조로 한 안보 및 위기관리 정책에서의 NSC 또는 그 유사 기구의 기능 확대 및 강화이다. 해당 각국의 NSC 조직은 각기 다른 특성을 가지고 있으나, 현 정치 안보 상황에서 안보 및 위기관리 정책의 컨트롤 타워로서 주된 역할을 담당할 수 있는 잠재성이 있다고 볼 수 있다. 따라서 이 논문에서는 한국, 미국, 일본 등 3개 국가 정부의 NSC 기구를 그 조직, 기능, 역사를 중심으로 비교 분석하고, 최근 이 3개 국가들, 특히 대한민국이 직면한 정치 안보 상황에 비추어 시사점을 도출해 보고자 한다.

  • PDF

원지 추출물의 랫드에서 2주 반복 경구투여 독성평가 (Toxicity Assessment of Polygalae Radix Aqueous Extract Orally Administered to Rats for 2 Consecutive Weeks)

  • 한형윤;김수남;양영수;한수철;석지현;노항식;이종권;정자영;정연우;김정아;민병선
    • 생약학회지
    • /
    • 제46권1호
    • /
    • pp.44-51
    • /
    • 2015
  • The objective of this study is to characterize a toxicity of Polygalae Radix (PR) in F344 rats and to find a dose levels for the 13 weeks toxicity study. PR is well known as medicinal herb in many Asian countries for treatment of expectorant, tonic, tranquillizer, antipsychotic agent and functional diet for improving memory. However, there is insufficient background information on toxicological evaluation of PR extract to support its safe use. Therefore, we conducted toxicological evaluation of this drug in compliance with OECD and KFDA guideline in this study. The extract of PR was administered orally to F344 rats at dose levels of 0, 500, 1000, 2000, 3500 and 5000 mg/kg/day for 2 weeks. Each group was composed to five male and five female rats. In the result, there were no treatment PR-related adverse changes in food consumption, hematology, clinical chemistry, urinalysis, gross finding at necropsy, organ weight examination. Four males at 5000 mg/kg/day were found dead during the treatment period. These animals showed salivation. The cause of death is still under investigation. The animals treated at 500, 1000, 2000, 3500 and 5000 mg/kg/day showed salivation and all animals at 5000 mg/kg/day exhibited lower body weight and cumulative weight gain in compared to those of control animals. Therefore, we recommend that a dose group of 3500 mg/kg/day is a highest treatment group in 13-week exposure study.

C2C12 근육세포의 산화적 손상에 대한 홍경천-홍삼 추출물 혼합액 발효물의 보호효과 (Protective Effect of Ferments of Hot-water Extract Mixture from Rhodiola sachalinensis and Red Ginseng on Oxidative Stress-induced C2C12 Myoblast)

  • 윤보라;김영현;이종석;홍희도;이영경;조장원;김영찬;이옥환
    • 한국식품영양학회지
    • /
    • 제26권3호
    • /
    • pp.485-491
    • /
    • 2013
  • 본 연구에서는 피로 회복 또는 원기 회복에 효능이 있는 것으로 알려진 홍경천과 홍삼을 이용하여 홍경천-홍삼 복합 발효물의 산화적 손상 억제 효과를 평가하고자 $H_2O_2$로 산화적 스트레스를 유도시킨 C2C12 근육세포에 홍경천-홍삼 복합 발효물의 처리한 후, 세포의 morphology, cell viability 및 항산화 효소들의 유전자 발현 양상을 비교, 분석하였다. 홍경천-홍삼 복합 발효물은 C2C12 근육세포의 cell viability를 유의적으로 증가시켰으며, Cu/Zn-SOD, Mn-SOD 및 GPx 등과 같은 세포내 항산화 효소의 발현을 증가시킬 뿐만 아니라, 근육세포 분화의 주요 전사인자인 Myo D의 발현 또한 증가시키는 것으로 나타났다. 이상의 결과로, 홍경천-홍삼 복합 발효물은 세포내 항산화 효소 시스템을 증가시켜 외부로부터의 산화적 손상에 대한 방어효능을 갖는 것으로 나타났으며, 향후 in vivo 시스템 이용한 추가적인 연구가 수행된다면, 홍경천-홍삼 복합 발효물을 이용한 항피로 건강기능식품의 소재개발이 가능할 것으로 판단된다.

New Directions in Communicating Better Nutrition to Older Adults

  • Guldan, Georgia-Sue;Wendy Wai-Hing Hui
    • Journal of Community Nutrition
    • /
    • 제2권1호
    • /
    • pp.62-70
    • /
    • 2000
  • Nutrition education should be an important component of ongoing health promotion for older adults and their caregivers. This is because prevention through sound nutrition and food hygiene practices and regular excercise is the most cost-effective way to reduce risks for and deal with their major health problems. nutritions education services should effectively promote optimum intake and successful self-care. Unfortunately, however relative to other vulnerable groups, nutrition education for older adults has not been systematically developed or evaluated. Usually oder adults care a lot about their health, so this should be a relatively easy group to teach - but their increasing numbers, longevity and great diversity with respect to health, physical, and economic status and educational level present challenges. Some older adults may not perceive they would benefit from nutrition education, so interesting and motivating them is a challenge. The food and nutrition knowledge of older people has been acquired through a lifetime of experience. For most older adults in the Asian region, their sources are restricted by their restricted education, so that their major sources of information have been informal sources, such as television, radio, friends, family, and perhaps newspapers and magazines if they are literature. Nonetheless, dietary advice for older people should build on their existing knowledge and ingrained values. It should provide information useful in daily food selection, and focus on food, not nutrients - the same foods and groups considered appropriate for younger people, with consistent messages as given throughout the population. Attention must also be paid to discovering learning styles in older people. When we teach in schools, the young students are a captive audience resigned to their learning role. Learning by an older adult, however, reflects an effort to meet his or her perceived needs. Therefore, nutrition education should be a positive experience in a non-threatening environment, relaxed and non-competitive, and perhaps even social environment. The messages also need to be practical and achievable. A needs assessment is essential, because our ability to provide the most effective nutrition education will depend on our success in matching the needs, both perceived and unperceived. of this vulnerable group. Therefore, go to the potential older learners to assess their interest and preferences. Nutrition education activities for older adults are widespread, but few have been evaluated. Evaluation is therefore also recommended, particularly when new methods are used. Tips from other countries for giving successful nutrition education will be given, including some examples of applications as attempted in Hong Kong. Research needs will also be described. In conclusion, successful nutrition education for older adults depends on positive needs-based messages. This is may be hard to do, as few good examples are available to illustrate these principles.

  • PDF

Inhibition of Production of Reactive Oxygen Species and Gene Expression Profiles by Cirsii Japonici Herba Extract Treatment in HepG2 Cells

  • Rho, Sam-Woong;Chung, Hwan-Suck;Kang, Moon-Kyu;Na, Young-In;Cho, Chong-Woon;Kim, Hyung-Min;Jung, Hyuk-Sang;Park, Hi-Joon;Kim, Hong-Yeoul;Hong, Moo-Chang;Shin, Min-Kyu;Kim, Sung-Soo;Bae, Hyun-Su
    • Molecular & Cellular Toxicology
    • /
    • 제1권4호
    • /
    • pp.224-229
    • /
    • 2005
  • Cirsii Japonici Herba (CJH) extract has been used for hundreds of years in Asian countries as a treatment for pollutant, radiation, and alcohol-induced liver damage. The reducing effect of CJH on hydrogen peroxide-induced reactive oxygen species (ROS) production, the main cause of cell damage or death, was evaluated using the HepG2 cell line. Cell survival was determined using MTS assay. The viability of cells treated with CJH was not significantly different from oxidative-stressed HepG2 cells. A dose-dependent inhibitory effect by CJH on ROS production was shown in oxidative-stressed cells using the $H_{2}DCFDA$ assay. To identify candidate genes responsible for the anti-oxidative effects of CJH on HepG2 cells, an oligonucleotide microarray analysis was performed. The expressions of five genes were decreased, whereas nineteen genes were up-regulated in CJH plus hydrogen peroxide treated cells, compared to only hydrogen peroxide treated cells. Among them, the expression of 5 genes was decreased in hydrogen peroxide treatment when compared to control. These genes are known to regulate cell survival and progression. On the other hand, it was shown that its main compounds were not a sylimarin or its analogs. The list of differentially expressed genes may provide further insight on the action and mechanism behind the anti-oxidative effects of Cirsii Japonici Herba.

Modulation of Nrf2/ARE and Inflammatory Signaling Pathways by Hericium erinaceus Mycelia Extract

  • Jin, Kyong-Suk;Park, Ji-Young;Cho, Mi-Kyung;Jang, Ji-Hyun;Jeong, Jae-Han;Ok, Seon;Bak, Min-Ji;Song, Young-Sun;Kim, Myo-Jeong;Cho, Chung-Won;Jeong, Woo-Sik
    • Food Science and Biotechnology
    • /
    • 제18권5호
    • /
    • pp.1204-1211
    • /
    • 2009
  • Hericium erinaceus is an edible mushroom used as a medicinal food in Asian countries. In this study, the chemopreventive effects of H. erinaceus mycelia hot water extract (HEW) were evaluated. HEW remarkably induced the luciferase activity of the antioxidant response element (ARE), located in the promoter region of phase 2 and antioxidant genes and regulated by nuclear factor E2-related factor 2 (Nrf2). The up-regulation of ARE activity by HEW corresponded with the induction of Nrf2 and the antioxidant enzyme, hemeoxygenase-1. The inhibition of cyclooxygenase-2 (COX-2) activity is a promising effective approach in cancer chemoprevention, and HEW prominently suppressed COX-2 protein expression in HepG2 cells. Furthermore, HEW showed anti-inflammatory activity by modulating inflammatory mediators such as nitric oxide (NO), inducible NO synthase, tumor necrosis factor-${\alpha}$, interleukin-$1{\beta}$, and the transcription factor, nuclear factor-${\kappa}B$, in lipopolysaccharide-stimulated RAW 264.7 cells. These results suggest that H. erinaceus possessed anti-tumor and anti-inflammatory effects via the modulation of Nrf2/ARE and inflammatory signaling pathways, and may therefore have potential use as a natural chemopreventive agent.

전처리 방법에 따른 참외와인의 품질특성과 항산화능 (Quality characteristics and antioxidant capacities of oriental melon wine depending on pretreatments)

  • 황희영;하형태;하세비;성기운;황인욱;정신교
    • 한국식품저장유통학회지
    • /
    • 제22권3호
    • /
    • pp.421-427
    • /
    • 2015
  • 고품질 참외와인을 제조하기 위하여 브랜칭 및 착즙 처리를 하여 발효와 숙성에 따른 이화학적 특성 및 항산화능을 조사하였다. 발효 중 참외와인의 이화학적 특성은 모든 처리구가 유사한 추이를 보였으며, 브랜칭 및 착즙 처리가 알코올 발효에 영향을 미치지 않았다. 숙성 후 이화학적 특성을 측정한 결과는 알코올 함량, 가용성 고형분 함량, 환원당 함량, 적정 산도, pH가 각각 11.5~11.8%, 10.7~11.2%, 0.25~0.49 g/100 mL, 0.60~0.81%, 3.75~3.89 범위로 나타났으며, 숙성 전에 비하여 가용성 고형분, 환원당, 알코올 함량, 적정산도는 감소하고 pH는 증가하는 것으로 나타났다. 항산화능은 DPPH 라디칼 소거 활성, FRAP 활성이 각각 $563.00{\sim}785.00{\mu}M\;TE$, $504.60{\sim}811.93{\mu}M\;TE$ 범위로 나타났으며, 브랜칭 처리구의 항산화 활성이 높았다. 총페놀성 화합물 함량은 287.53~312.08 mg/L 범위로 전처리 방법에 따른 유의적인 차이가 나타나지 않았으며(p<0.05), 총플라보노이드 함량은 39.06~141.03 mg/L 범위로 브랜칭 처리구의 함량이 높았다. 또한 QDA profile 결과는 색, 맛, 풋내, 이취, 종합적 기호도 항목에서 모두 브랜칭 처리구가 더 높은 점수를 얻었다. 브랜칭 처리는 참외와인의 항산화능을 증가시키고 기호성을 좋게 하는 반면, 착즙 처리는 참외와인 제조 시 영향을 미치지 않는 것으로 나타났다.

몽골에서 최초로 분리된 뉴캣슬병 바이러스의 분자생물학적 특성 (Molecular Biological Characterization of the First Newcastle Disease Virus Isolated in Mongolia)

  • 최강석;이은경;전우진;;;박미자;유예나;권준헌
    • 한국가금학회지
    • /
    • 제38권2호
    • /
    • pp.89-96
    • /
    • 2011
  • 몽골 산란계 농장에서 발생한 뉴캣슬병 사례로부터 뉴캣슬병 바이러스를 분리하고 그 특성을 조사하였다. 그 결과, 발생 농장 산란계 폐사계의 뇌 및 폐 조직으로부터 뉴캣슬병 바이러스 MN1/10 주가 분리되었다. 이 바이러스는 F 단백질 분절 부위가 특징적인 병원성 motif(RRQKRF)를 가지고 있었으며 종란 평균 치사 지수(MDT)가 54.7시간으로 강독형 NDV이었다. 또한 발생 농장 내 생존하고 있는 산란계에서 고역가의 NDV 특이항체가 검출되었다. 유적학적 계통 분석을 실시한 결과, 몽골 분리주는 Class II에 속하는 genotype VIId 바이러스로 확인되었다. 유전학적 계통 분석 결과, 몽골 분리주는 몽골과 인접한 중국에서 유행하는 바이러스 그룹(CN2)에 속하는 것으로 분류되었다. 우리의 연구 결과는 몽골에서의 뉴캣슬병 최초 발생은 동북아시아 지역에서 유행하는 강독형 NDV의 유입에 의해서 이루어졌음을 말해 준다.

Protective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils

  • Bae, Minkyung;Jang, Sungil;Lim, Joo Weon;Kang, Jieun;Bak, Eun Jung;Cha, Jeong-Heon;Kim, Hyeyoung
    • Journal of Ginseng Research
    • /
    • 제38권1호
    • /
    • pp.8-15
    • /
    • 2014
  • Helicobacter pylori-induced gastric inflammation includes induction of inflammatory mediators interleukin (IL)-8 and inducible nitric oxide synthase (iNOS), which are mediated by oxidant-sensitive transcription factor NF-${\kappa}B$. High levels of lipid peroxide (LPO) and increased activity of myeloperoxidase (MPO), a biomarker of neutrophil infiltration, are observed in H. pylori-infected gastric mucosa. Panax ginseng Meyer, a Korean herb medicine, is widely used in Asian countries for its biological activities including anti-inflammatory efficacy. The present study aims to investigate whether Korean Red Ginseng extract (RGE) inhibits H. pylori-induced gastric inflammation in Mongolian gerbils. One wk after intragastric inoculation with H. pylori, Mongolian gerbils were fed with either the control diet or the diet containing RGE (200 mg RGE/gerbil) for 6 wk. The following were determined in gastric mucosa: the number of viable H. pylori in stomach; MPO activity; LPO level; mRNA and protein levels of keratinocyte chemoattractant factor (KC, a rodent IL-8 homolog), IL-$1{\beta}$, and iNOS; protein level of phospho-$I{\kappa}B{\alpha}$(which reflects the activation of NF-${\kappa}B$); and histology. As a result, RGE suppressed H. pylori-induced mRNA and protein levels of KC, IL-$1{\beta}$, and iNOS in gastric mucosa. RGE also inhibited H. pylori-induced phosphorylation of $I{\kappa}B{\alpha}$ and increases in LPO level and MPO activity of gastric mucosa. RGE did not affect viable H. pylori colonization in the stomach, but improved the histological grade of infiltration of poly-morphonuclear neutrophils, intestinal metaplasia, and hyperplasia. In conclusion, RGE inhibits H. pyloriinduced gastric inflammation by suppressing induction of inflammatory mediators (KC, IL-$1{\beta}$, iNOS), MPO activity, and LPO level in H. pylori-infected gastric mucosa.

표고버섯 품종 산마루1호, 천장3호를 구분할 수 있는 CAPS Marker 개발 (Development of Cleaved Amplified Polymorphic Sequence Markers for the Identification of Lentinula edodes Cultivars Sanmaru 1ho and Chunjang 3ho)

  • 문수윤;이화용;김명길;가강현;고한규;정종욱;구창덕;류호진
    • 한국균학회지
    • /
    • 제45권2호
    • /
    • pp.114-120
    • /
    • 2017
  • 표고버섯은 주로 아시아 국가에서 재배되는 식용 버섯이다. 표고버섯은 최근 국내에서 신품종의 개발이 활발히 이루어지고 있으며, 국내외적으로 품종의 보호가 중요해짐에 따라 표고의 품종을 구분할 수 있는 효율적인 마커 개발이 요구되고 있다. 본 연구에서는 산마루1호와 천장3호를 구분할 수 있는 CAPS (cleaved amplified polymorphic sequence) 마커를 개발하였다. 이 연구에서 개발된 CAPS 마커는 단핵균주인 B17의 표준유전체 정보와 연구에 사용된 10개 균주의 resequencing 정보를 바탕으로 개발되었다. 산마루1호는 scaffold9번, 1630048의 염기서열 G가 T로 변한 SNP를 포함하여 PCR 후 제한효소 TspR I을, 천장3호는 scaffold13번, 920681의 염기서열 G가 A로 변한 single nucleotide polymorphism (SNP)를 포함하여 PCR 후, 제한효소 Xho I을 처리하였을 때 다른 균주들과 구분되었다. 따라서 이를 마커로 개발하였다.