Toxicity Assessment of Polygalae Radix Aqueous Extract Orally Administered to Rats for 2 Consecutive Weeks
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Han, Hyoung-Yun
(Korea Institute of Toxicology)
Kim, Soo Nam (Korea Institute of Toxicology) Yang, Young-Su (Korea Institute of Toxicology) Han, Su-Cheol (Korea Institute of Toxicology) Seok, Ji-Hyeon (Toxicological Evaluation and Research Department, Korea Food & Drug Administration) Roh, Hang Sik (Toxicological Evaluation and Research Department, Korea Food & Drug Administration) Lee, Jong-Kwon (Toxicological Evaluation and Research Department, Korea Food & Drug Administration) Jeong, Jayoung (Toxicological Evaluation and Research Department, Korea Food & Drug Administration) Jeong, Yeon Woo (College of Pharmacy, Drug Research and Development Center Catholic University of Daegu) Kim, Jeong Ah (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) Min, Byung Sun (College of Pharmacy, Drug Research and Development Center Catholic University of Daegu) |
1 | Kuroda, M., Shizume, T. and Mimaki, Y. (2014) New acylated triterpene glycosides from the roots of Polygala tenuifolia. Nat. Prod. Commun. 9: 379-382. |
2 | Jiang, Y., Zhang, W., Tu, P. and Xu, X. (2005) Xanthone glycosides from Polygala tenuifolia and their conformational analyses. J. Nat. Prod. 68: 875-879. DOI |
3 | Tasaki, M., Umemura, T., Maeda, M., Ishii, Y., Okamura, T., Inoue, T., Kuroiwa, Y., Hirose, M. and Nishikawa, A. (2008) Safety assessment of ellagic acid, a food additive, in a subchronic toxicity study using F344 rats. Food Chem. Toxicol. 46: 1119-1124. DOI |
4 | Niho, N., Shibutani, M., Tamura, T., Toyoda, K., Uneyama, C., Takahashi, N. and Hirose, M. (2001) Subchronic toxicity study of gallic acid by oral administration in F344 rats. Food Chem. Toxicol. 39: 1063-1070. DOI |
5 | Cheong, M. H., Lee, S. R., Yoo, H. S., Jeong, J. W., Kim, G. Y., Kim, W. J., Jung, I. C. and Choi, Y. H. (2011) Antiinflammatory effects of Polygala tenuifolia root through inhibition of NF-kB activation in lipopolysaccharide-induced BV2 microglial cells. J. Ethnopharmacol. 137: 1402-1408. DOI ScienceOn |
6 | Xin, T., Zhang, F., Jiang, Q., Chen, C., Huang, D., Lv, Y., Shen, W. and Jin, Y (2012) Purification and antitumor activity of two acidic polysaccharides from the roots of Polygala tenuifolia. Carbohydr. Polym. 90: 1671-1676. DOI ScienceOn |
7 | 식품의약품안전처고시 2003-17, 안전성유효성심사규정. |
8 | Keum, J. H., Han, H. Y., Roh, H. S., Seok, J. H., Lee, J. K., Jeong, J., Kim, J. A., Woo, M. H., Choi, J. S. and Min, B. S. (2014) Analysis and stability test of the extracts from Epimedii Herba, Atractylodis Rhizoma Alba and Polygalae Radix for toxicity study. Kor. J. Pharmacogn. 45: 135-140. |
9 | Jiang, Y. and Tu, P. (2005) Four new phenones from the cortexes of Polygala tenuifolia. Chem. Pharm. Bull. 53: 1164-1166. DOI ScienceOn |
10 | Li, C., Yang, J., Yu, S., Chen, N., Xue, W., Hu, J. and Zhang, D. (2008) Triterpenoid saponins with neuroprotective effects from the roots of Polygala tenuifolia. Planta Med. 74: 133-141. DOI ScienceOn |
11 | Park, H. K., Jeon, S. G., Kim, T. B., Kang, H. R., Chang, Y. S., Kim, Y. K., Cho, S. H., Min, K. U. and Kim, Y. Y. (2005) Occupational asthma and rhinitis induced by a herbal medicine, Wonji (Polygala tenuifolia). J. Korean Med. Sci. 20: 46-49. DOI |
12 | Kim, K. S., Lee, D. S., Bae, G. S., Park, S. J., Kang, D. G., Lee, H. S., Oh, H. and Kim, Y. C. (2013) The inhibition of JNK MAPK and NF-kB signaling by tenuifoliside A isolated from Ploygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect. Eur. J. Pharmacol. 721: 267-276. DOI ScienceOn |
13 | Kim, S. H., Choi, E. J., Kim, D. H., Lee, K. Y., Lee, M., Baek, S. W., Kwak, S. J., Kang, T. S., Kim, Y. C. and Sung, S. H. (2008) Stability test of the extracts of Cimicifugae Rhizoma, Achyranthis Radix, Artemisia Capillaris Herba, Moutan Cortex Radicis and Arecae Semen for toxicity study. Kor. J. Pharmacogn. 39: 241-245. |
14 | Jin, Z. L., Gao, N., Zhang, J. R., Li, X. R., Chen, H. X., Xiong, J., Li, Y. F. and Tang, Y. (2014) The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity. Prog. Neuropsychopharmacol. Biol. Psychiaty 12(53C): 9-14. DOI |
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