• 제목/요약/키워드: Arterial blood pressure

검색결과 604건 처리시간 0.031초

혈압 파형 재현을 위한 인공 대동맥 기반 모의 순환계 로봇 (Mock Circulatory Robot with Artificial Aorta for Reproduction of Blood Pressure Waveform)

  • 정재학;박용화
    • 로봇학회논문지
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    • 제19권2호
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    • pp.221-228
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    • 2024
  • As the importance of cardiovascular health is highlighted, research on its correlation with blood pressure, the most important indicator, is being actively conducted. Therefore, extensive clinical data is essential, but the measurement of the central arterial blood pressure waveform must be performed invasively within the artery, so the quantity and quality are limited. This study suggested a mock circulatory robot and artificial aorta to reproduce the blood pressure waveform generated by the overlap of forward and reflected waves. The artificial aorta was fabricated with biomimetic silicone to mimic the physiological structure and vascular stiffness of the human. A pressurizing chamber was implemented to prevent distortion of the blood pressure waveform due to the strain-softening of biomimetic silicone. The reproduced central arterial blood pressure waveforms have similar magnitude, shape, and propagation characteristics to humans. In addition, changes in blood pressure waveform due to aging were also reproduced by replacing an artificial aorta with various stiffness. It can be expanded to construct a biosignal database and health sensor testing platform, a core technology for cardiovascular health-related research.

급성 실혈성 쇽시의 (hypovolemic shock) 구강조직의 혈류량 변동에 관한 연구

  • 박흥기;김수경
    • 대한치과의사협회지
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    • 제19권4호통권143호
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    • pp.347-352
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    • 1981
  • This experiment was performed to estimate the changes on blood flow of the oral structures in hemorrhagic shock. Rabbits were anesthetized by intravenous injection of nembutal(30mg/kg). The Femoral artery was exposed and cannulated with polyethylene tubing filled with heparinized saline. Hypovolemic shock was induced by collecting the bloos of which amount was equaled as 2 % of body weight through arterial cannula for about 30 minutes. During hemorrhage, arterial blood pressure was recorded on recorder. In hypovolemic shock, arterial blood pressure decreased from 116.2±4.1 mmHg to 62.6±4.0 mmHg. Distribution of blood flow in oral tissues decreased to 30-50 % of control group. But blood flow of the masseter muscle was increased and the mandibular angle was not changed.

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청훈화담탕가형개로 인해 변동된 국소뇌혈류량 및 평균혈압의 작용기전 (Mechanism on the Changed-Regional Cerebral Blood Flow and Mean Arterial Blood Pressure by CheonghunHwadam-tang Adding Schiznepetae Herba in Rats)

  • 민병일;임광모;정현우
    • 동의생리병리학회지
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    • 제16권4호
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    • pp.701-706
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    • 2002
  • CheonghunHwadam-tang(CHT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo by wind, fire and phlegm. CHTS was CHT adding Schizonepetae Herba. The effects of CHTS on the cerebral blood flow and blood pressure is not known. The purpose of this Study was to investigate effects of CHTS on the regional cerebral blood flow(rCBF) and mean arterial blood pressure(BP), action-mechanism of CHTS-induced changed-rCBF and BP. The changes of rCBF and BP was determinated by Laser-Doppler Flowmetry(LDF). The results were as follows ; CHTS extract was increased significantly rCBF in a dose-dependent, but was not changed BP compared with CHTS non-treated group. Pretreatment with propranolol, indomethacin and methylene blue were inhibited CHTS induced increase of rCBF, propranolol(all CHTS-treated group) and indomethacin(CHTS 0.01 mg/kg) of them were significantly decreased. Pretreatment with propranonol and indomethacin were inhibited CHTS induced increase of BP, but pretreated with methylene blue was significantly accelerated BP in high dosage. This results suggest that CHTS increased rCBF by dilating pial arterial diameter and the action of CHTS is also mediated by adrenergic β -receptor and cyclooxygenase.

폐내압증가시(肺內壓增加時)의 동맥혈압(動脈血壓) 및 심박변동(心搏變動)에 관(關)하여 (Responses of Systemic Arterial Blood Pressure and Heart Rates to Graded Increase of Positive Lung Inflation)

  • 김규수;오상유;최병옥;이중길
    • The Korean Journal of Physiology
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    • 제3권2호
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    • pp.25-31
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    • 1969
  • Effects of graded increase of positive lung inflation upon heart rates and arterial blood pressure were observed in the anesthetized dogs to analyze the mechanical and neural regulatory factor in response to the positive inflation of the lung. The results obtained were summarized as followings: 1) When the low grade of positive lung inflation was employed under the mild to moderate anesthesia, central venous pressure was linearly increased while heart rate was decreased. After bilateral vagotomy, central venous pressure was obviously increased while heart rate was constant. 2) When the high degree of positive lung inflation was employed, changes of central venous pressure and heart rate were not significant. 3) The low grade of intrapulmonary pressure increase caused reflex tachycardia in phase 2 and overshooting in phase 4 in response to the systemic arterial blood pressure change. 4) On the other hand, the high degree of intrapulmonary pressure increase caused paradoxical bradycardia in phase 2 and lack of overshooting in phase 4 in response to the systemic arterial blood pressure change. 5) It may be noted that the experimental model employed in the present study is a useful tool to evaluate and analyze the neural and mechanical regulatory factor in response to the graded increase of the positive lung inflation.

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혈위자침(穴位刺鍼)이 백서(白鼠)의 국소뇌혈류량(局所腦血流量)과 혈압(血壓)에 미치는 실험적(實驗的) 효과(效果) (Exterimental Effects of Acupuncture on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats)

  • 안영선;박춘하;조명래;윤여충
    • Journal of Acupuncture Research
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    • 제18권5호
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    • pp.147-154
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    • 2001
  • Amun(GV15), Habkook(LI4) and Shinsu(B23) have been used as a meridian point for apoplexy, hypertention, vertigo etc. The effects of GV 15, LI4 and B23 on the vascular system is not known. The purpose of this Study was to investigate the effect of several meridian points on the regional cerebral bloof flow(rCBF), mean arterial blood pressure(BP) in rats. The changes of BP and rCBF were tested Laser-Doppler Flowmetry(LDF). Results : The results of this Study were obtained as follows ; 1. GV15 and LI4 were increased significantly rCBF. 2. GV15, LI4 and B23 were increased BP, but have not significance. Conclusion : This results suggest that GV15 was increased rCBF by increasing pial arterial diameter, and LI4 was increased rCBF by increasing BP.

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체위변화에 수반되는 심맥관계반응에 관한연구 (A Study of Circulatory Responses to Postural Changes)

  • 서석완;채의업
    • The Korean Journal of Physiology
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    • 제5권2호
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    • pp.71-78
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    • 1971
  • Anesthetized dogs were tilted from horizontal to the upright and head down position. Tilting to the upright position was followed by an increase in heart rate. In the head down position a decreased heart rate was obtained. The arterial blood pressure was decreased in the upright position and was decreased markedly in the head down position. The central venous pressure was decreased in the upright position and was markedly decreased down to the negative pressure in the head down position. The respiratory rate was slightly increased in the upright position comparing to that in the horizontal position. No remarkable changes were noted in the head down position. From the above results the following factors were discussed The decreased arterial blood pressure during the upright position was supposed to be the secondary effect from the diminished venous return that was suggested by the decreased central venous pressure. The decreased arterial blood pressure in the head down position was also supposed as the above reason as the diminished central venous pressure during the tilt. In addition the cardioinhibitory effects originated from the baroreceptors might have been operated during head down tilting. In the heart rate there was slight tachycardia in the upright position this was assumed as the abolished cardioinhibitory impulses from the baroreceptor in the upright position. On the contrary, despite of the decrease of arterial blood pressure in the head down position as well as in the upright, the bradycardia have been appeared. This was suggestive of cardioinhibitory impulses from the baroreceptors which was stretched during head down tilting. From the above findings there is a possibility of continous cardioinhibitory responses during head down tilting for this kind of the short period of 10 minutes which was chosed in this study.

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전기 자극으로 유발한 음경 발기력 측정 흰쥐 모델에 대한 HTE001의 발기력 상승효과 (Effect of HTE001, an Herbal Formulation, on Electric Stimulation-induced Penile Erection in Rats)

  • 임동욱;이동헌;송미경;김미연;부영민;김호철
    • 대한본초학회지
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    • 제24권3호
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    • pp.139-146
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    • 2009
  • Objectives : This study was conducted to investigate the effect of HTE001, a multi-herbal mixture consisting of 10 herbs, Cornus Frutus, Schizandrae Fructus, Rubi Fructus, Cnidi Fructus, Acanthopanacis senticosi Radix, Cinnamomi Cortex, Eucommiae Cortex, Allii Bulbus, Rehmanniae Radix and Ginseng Radix, on electrostimulation-induced penile erection in rats. Methods : Intracavernous pressure (ICP) and mean arterial blood pressure (MAP) were simultaneously monitored through electric stimulation of the cavernous nerve after the oral administration of HTE001 (30, 100, 300 mg/kg) in normal rats. Statistical analysis was performed on maximal intracavernous pressure (ICP), maximal intracavernous pressure/mean arterial blood pressure (ICP/MAP) ratio, and the area under the curve (AUC) of ICP/MAP ratio. Results : Oral administration of HTE001 300 mg/kg caused the ICP to increase in a frequency-dependent manner. And HTE001 300 mg/kg treatment group showed the highest value in the ICP/MAP ratio and the AUC value of the ICP/MAP ratio compared to the control group at 2 Hz, 6 Hz and 10 Hz, respectively without an effect on the mean arterial blood pressure under the same stimulation of the cavernous nerve. Conclusions : These results show that HTE001 improve penile erection and prolong the decay period in normal rats without affecting mean arterial blood pressure, and suggest that HTE001 could be a good therapeutic candidate to treat erectile dysfunction.

육군자탕(六君子湯)과 죽력(竹瀝) 혼합물이 국소 뇌혈류량 및 평균혈압에 미치는 효과 (Effects of Mixture of Yukgunja-tang and Bambusae Caulis in Liquamen on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats)

  • 이석진;정현우
    • 동의생리병리학회지
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    • 제21권1호
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    • pp.54-61
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    • 2007
  • The study was designed to investigate the effects of Mixture of Yukgunja-tang and Bambusae Caulis in Liquamen (YTBCL) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats, and further to determine the mechanism of action of YTBCL. The results in rats were as follows ; YTBCL 25 ${\mu}l$ significantly decreased rCBF and MABP compared with basal condition. YTBCL 100 ${\mu}l$ significantly increased rCBF compared with basal condition, but decreased MABP compared with basal condition. YTBCL 50 ${\mu}l$ significantly increased rCBF compared with basal condition, but MABP was somewhat decreased compared with basal condition. The VTBCL 50 ${\mu}l$-induced increase in rCBF was significantly inhibited by pretreatment with methylene blue (10 ${\mu}g$/kg, i.p.), an inhibitor of guanylate cyclase and indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase. The YTBCL 50 ${\mu}l$-induced decreased MABP significantly increased by pretreatment with methylene blue but was inhibited by indomethacin. This results were suggested that the mechanism of YTBCL was mediated Dy guanylate cyclase.

유풍양영탕(愈風養營湯)이 정상 흰쥐의 국소 뇌혈류량 및 평균혈압에 미치는 영향(影響) (Effects of Yupoongyangyeong-tang(YYT) on the Changes of Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats)

  • 조국령;안가영;전상윤
    • 대한한방내과학회지
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    • 제30권2호
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    • pp.298-305
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    • 2009
  • Objectives: The present study was carried out to investigate the effects of Yupoongyangyeong-tang(YYT) on changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. In addition, the author also investigated action mechanisms of YYT on changes in rCBF and MABP. Methods and Results : In this study, treatment with YYT elevated rCBF in a dose-dependent manner, but MABP levels were elevated only in the 10 mg/ml treatment group. Pre-treatment with indomethacin. an inhibitor of cyclooxygenase, inhibited increase of rCBF effectively. Pre-treatment with methylene blue, an inhibitor of guanylate cyclase, inhibited increase of rCBF induced by YYT, too. In addition. pre-treatment with indomethacin also inhibited increase of MABP. However, pre-treatment with methylene blue did not affect MABP levels. Conclusion : These results suggest that YYT is useful to treat patients with diseases related to cerebral ischemia, because YYT can increase rCBF. In addition, the mechanisms are thought to be related to both cyclooxygenase and guanylate cyclase.

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삼부탕(蔘附湯) 및 구성약물(構成藥物)이 백서(白鼠)의 국소뇌혈류량(局所腦血流量)과 혈압(血壓)에 미치는 영향(影響) (Effects of Sambutang and Consitituent Herbs on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats)

  • 홍석;강화정;김경선;김경수;전홍열
    • 대한한의학방제학회지
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    • 제10권1호
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    • pp.93-103
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    • 2002
  • This experimental studies were done to investigate the effects of Sambutang(SBT) and consitituent herbs on the regional cerebral blood flow(rCBF) and mean arterial blood pressure(BP) in rats. The results are as follows: SBT and consitituent herbs(SBT omitting Zingiberis Rhizoma Recens, Zingiberis Rhizoma Recens. Ginseng Radix and Aconiti iateralis preparata Radix) was increased rCBF significantly in a dose-dependent manner. SBT omitting Zingiberis Rhizoma Recens and Ginseng Radix were decreased significantly BP in rats. But, SBT, Aconiti iateralis preparata Radix and Zingiberis Rhizoma Recens were not affected BP in rats. According to the above findings. it is suggested that SBT causes a diverse response of rCBF, and specially the rCBF by increasing SBT is mediated action of Zingiberis Rhizoma Recens.

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