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An Experimental Study on the Anti-stress Effect by Soyangin Hyeongbangdojeok-san and Yanggyeoksanhwa-tang (소양인 형방도적산과 양격산화탕의 항 스트레스효과에 관한 실험적 연구)

  • Lee, Seung-Yeop;Choi, Ae-Ryun;Ha, Jin-Ho;Lee, Jung-Hwan;Kim, Pan-Joon;Goo, Deok-Mo
    • Journal of Sasang Constitutional Medicine
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    • v.20 no.3
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    • pp.151-163
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    • 2008
  • 1. Objective This study was done to identify the anti-stress effect of Hyeongbangdojeok-san (HDS), Yanggyeoksanhwa-tang(YST) in Soyangin. 2. Methods Experimental animals were composed of YST, HDS+stress groups which were administered each by 200mg/kg, 400mg/kg and the Saline+stress group. On the 1st day, making the rats forced swim and on the 2nd day, applying Forced swimming test to the rats. After FST, the levels of Corticosterone in the blood were measured. For the study of learning retardation, memory ability and anxiety reaction, experimental animals were composed of YST, HDS+restraint stress groups which were administered each by 400mg/kg, no stress group and the Saline+restraint stress group. Restraint stress were applied 2 hours a day for 3 weeks. On the last day of the 3rd week, Elevated Plus Maze(EPM) was applied to the groups and Morris Water Maze(MWM) was applied to the groups for 7 days. 3. Results 1. As the results of measuring FST which reflects depression, the YST+stress group and the HDS+stress group showed significant effect in comparison with the Saline+stress group. The levels of Corticosterone in the blood were decreased only in the 400mg/kg YST+stress group. 2. As the results of measuring how long EPM which reflects anxiety reaction stayed in the open arm, there was the trend which can suppress anxiety reaction in the HDS+restraint stress group bur no statistical significance. But there was any suppression of anxiety reaction in the YST+restraint stress group. 3. According to the result of MWM, the saline+restraint stress group showed the learning retardation which means increased time arriving at goal compared to the normal group at the second and third day of measurement. On the contrary, a learning retardation was significantly decreased in the YST+restraint stress group at the third day of measurement. 4. Among the Probe trial test a memory loss occurred in the saline+restraint stress group, but memory ability was significantly increased in the YST+restraint stress group. 4. Conclusion: As the results above, Soyangin Yanggyeoksanhwa-tang has significant influence to the antidepression effect, the learning retardation, the anxiety reaction and also in the Hormone level. Hyeongbangdojeok-san has significant influence to the antidepression effect, in the Hormone level, bur not to the learning retardation and anxiety reaction. prefer to drink cold water, and who are suffering from chronic gastritis.

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Pseudo-Static Behaviors of U-shaped PSC Girder with Wide Flanges (확폭플랜지를 갖는 U형 프리스트레스 거더의 유사정적거동)

  • Rhee, In-Kyu;Lee, Joo-Beom;Kim, Lee-Hyeon;Park, Joo-Nam;Kwak, Jong-Won
    • Proceedings of the KSR Conference
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    • 2008.11b
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    • pp.993-999
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    • 2008
  • A girder height limitation is the critical parameter for rapid construction of bridge deck and construction space limitation especially in urban area such as high population area and high density habitats. A standard post-tensioned I-shaped concrete girder usually demands relatively higher girder height in order to retain sufficient moment arm between compression force and tensile force. To elaborate this issue, a small U-shaped section with wide flanges can be used as a possible replacement of I-shaped standard girder. This prestressed concrete box girder allows more flexible girder height adjustment rather than standard I-shaped post-tensioned girder plus additional torsion resistance benefits of closed section. A 30m-long, 1.7m-high and 3.63m-wide actual small prestressed concrete box girder is designed and a laboratory test for its static behaviors by applying 6,200kN amount of load in the form of 4-point bending test was performed. The load-deflection curve and crack patterns at different loading stage are recorded. In addition, to extracting the dynamic characteristics such as natural frequency and damping ratio of this girder, several excitation tests with artificial mechanical exciter with un-symmetric mass are carried out using operational frequency sweep-up. Nonlinear finite element analysis of this 4 point bending test under monotonic static load is investigated and discussed with aids of concrete damaged plasticity formulation using ABAQUS program.

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Protocol Monitor System Between Cortex M7 Based PLC And HMI

  • Kim, Ki-Su;Lee, Jong-Chan;Ha, Heon-Seong
    • Journal of the Korea Society of Computer and Information
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    • v.25 no.6
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    • pp.17-23
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    • 2020
  • In this paper, collecting real-time data frames that occur during RS232 communication between an HMI and PLC of automation equipment by sniffing real-time information data frames through MCU without modification of the HMI or PLC, a method is proposed that allows users to collect data without being dependent on the modification of PLC and HMI systems. The user collects necessary information from the sniffing data through the parsing operation, and the original communication interface is maintained by transmitting the corresponding sniffing frame to the destination. The MCU's UART communication interface circuit is physically designed according to the RS232 communication standard, and this additionally improves efficiency more so than an interrupt-based system by using the DMA device inside the MCU. In addition, the data frame IO operation is performed by logically separating the work of the DMA interrupt service routine from the work of the main thread using the circular queue. Through this method, the user receives the sniffing data frame between the HMI and PLC in RS232 format, and the frame transfer between PLC and HMI arrives normally at the original destination. By sniffing the data frame without further modification of the PLC and HMI, it can be confirmed that it arrives at the user system normally.

Karyotype Analysis and Physical Mapping of rDNAs Using Bicolor-FISH in Tiarella polyphylla D. Don (헐떡이풀의 핵형분석과 Bicolor FISH를 이용한 물리적 지도 작성)

  • Kim, Soo-Young;Lee, Joong-Ku
    • Korean Journal of Plant Resources
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    • v.20 no.5
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    • pp.446-450
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    • 2007
  • Tiarella polyphylla D. Don(Saxifragaceae) is a perennial herb and distributed in China, Japan, Taiwan and Korea. Especially, it only grows in Ulleung island of Korea. It has been using for asthma, bruise and audition troubles with main components of some Triterpenoids and seven oleanolic Saponins. There is only known its chromosomal number rarely and cytogenetic study was not done. From this study, karyotype analysis and chromosomal localization of 5S and 45S rDNAs using bicolor-FISH(fluorescence in situ hybridization) were carried out. The somatic metaphase chromosome number was 2n=2x=14 and the size of chromosomes ranged $1.66{\sim}3.50{\mu}m$. The chromosome complement consisted of four pairs of submetacentrics(chromosomes 1, 2, 3 and 6), two pairs of subtelocentrics(chromosomes 5 and 7) and one pair of telocentrics(chromosome 4). We also observed NOR(nucleolus organizer region) on the chromosome 4. In bicolor-FISH, one pair of 55 and 45S rDNA sites was detected on the centromeric region of chromosome 3 and short arm of chromosome 4, respectively. Bicolor FISH was very useful tool for the localization and identification of rDNAs on the chromosomes in Tiarella polyphylla.

The Relationship between the Personality of Elementary School Students and the Safety Accidents in the School (초등학생의 성격특성과 학교안전사고)

  • Kim, Chang-Hee;Park, Young-Soo
    • The Journal of Korean Society for School & Community Health Education
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    • v.4
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    • pp.1-20
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    • 2003
  • This study was not intended to analyze out the realities of the safety accidents in school. The purpose of this study was to find out the personality of elementary school students in 6th grade and analyze the relationship between the personality of elementary school students and the safety accidents in the school. We made a visit 12 elementary school personally in the B city of Gyeonggi Province and gave out 552 questionaries in order to accomplish the purpose of this study. And we analyzed the 501 answer data except the unfittable data 51 sheets-in case of no answer or untruthfulness. The inspection of the personality used the Eysenck Personality Questionnaire(EPQ) and the questionnaires of the safety accidents in the school were reorganized of the questionnaires which were used in Chun-Ok, Joen(1997) and One-Yong, Kim(1999)'s study to correspond with our purpose of study. Answer sheets were gone through the t and x2 test by using the program of SPPS. First, elementary school students are in the formative period in the life of a man. So many students's personality was in the middle group rather than in high and low group. In regard of the distintion between the boy students and the girl students, the boy students had higher score in Psychoticism(P) but the girl students had higher score in Neutroticism(N). And Lie(L) was showing a little more score in the girl students. Second, there was significant difference in the investigation of safety accidents in school according to sex distinction. 1) Comparing the boy students and the girl students, the rate of accidents was higher in boy rather than girl. And there was significant difference. 2) Comparing the grade of the school, the rate of accidents was higher in upper grade than lower grade both girls and boys. 3) In the kind of accidents, the traumatic Injuries were very popular and the next were contusions. There was significant difference in the traumatic injury and nosebleed. 4) The results of injured parts showed that the injuries of foot, leg, hand, arm hold a large majority. And there was a significant difference in head, face, foot, leg and etc. 5) Most accidents broke out during the break time and then accidents happened after school were the next. The flowings were lunch time and class time. There was a significant difference in accidents happened during the class, break time and lunch time. 6) Comparing the subjects, the most accidents broke out in the class of physics. 7) Among the cause of accidents, one's own carelessness was showing the highest rate. There was a significant distintion in the fight and game. 8) The safety accidents took place most in playground, and there was a significant difference. 9) Being slight wound was showing almost in the degrees of damage. And there was a significant difference. Third, the boy students were not showing the significant difference in relation to the personality, the frequency of accidents and the degrees of damage. But the girl students were showing the significant difference in relation to the Extraversion-Introversion(E) and the frequency of accidents. And there were a significant difference between E and N. Also they were showing the intense damages.

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Fabrication of a Mach-Zehnder interferometer for education using a rotating glass plate and a 3D printer (회전 유리판과 3D 프린터를 이용한 교육용 마흐젠더 간섭계 제작)

  • Jang, Seong-Hun;Ju, Young-G
    • Korean Journal of Optics and Photonics
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    • v.28 no.5
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    • pp.213-220
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    • 2017
  • This paper proposes how to fabricate an educational Mach-Zehnder interferometer that is easy to align and inexpensive, using 3D printers and semiconductor lasers. The interferometer consists of a body $165mm{\times}120mm{\times}57mm$ in size, mirror mounts, a laser holder, beam splitters, and so on. The laser path is adjusted by 4 mirror mounts, each comprised of rubber bands, small metal wires, and a screw. The interference fringe is enlarged by the lens at the final stage. The refractive index of a slide glass was measured by counting the number of moving interference fringes while the slide glass, inserted into one of the two interferometer arms, is rotating. The formula for the refractive index as a function of the optical-path difference and rotation angle was obtained, and used to calculate the refractive index of glass from the interferometer experiment. The use of a rotating glass in one arm of the interferometer nullifies the need for a precision stage, which despite its high cost is often required to observe the moving interference fringe in the classroom. Therefore, the 3D-printed Mach-Zehnder interferometer proposed in this paper can be very useful for education, because of its affordability and performance. It enables students to perform both qualitative and quantitative studies using a 3D-printed interferometer, such as measuring the refractive index of a glass sample, and the wavelength of light.

Effects of 16-week Combined Exercise on Blood Dopamine Concentrations, Functional Fitness and Qol in Patients with Parkinson's Disease (16주간의 복합운동이 파킨슨병 환자의 혈중 도파민 농도, 기능적 체력 및 삶의 질에 미치는 영향)

  • Kim, Do-Yeon;Park, Chan-Ho;Kim, Ji-Sun;Cheon, Ji-Un
    • Journal of the Korean Applied Science and Technology
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    • v.38 no.4
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    • pp.1081-1092
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    • 2021
  • The purpose of the study was to examine the effects of the 16-week combined exercise on the blood dopamine concentrations, functional fitness and QOL in patients with parkinson's disease. To this end, 24 persons parkinson's disease in over 60 years old who participated in this study were classified in to the exercise group(n=12) and control group(n=12), and then the exercise group was twice a week for 16-weeks, 70 min per session combined exercise was applied. The test dada were analyzed by two-way repeated measures ANOVA, paired t-test, and independent t-test. The alpha level of .05 of significance. As a result, first, parkinson's disease who regularly participated in the combined exercise significantly increased blood dopamine concentrations(p<.001). Second, parkinson's disease who regularly participated in the combined exercise significantly improved grip strength(p<.001), arm curl(p<.001), stand up and sit down a chair(p<.001), 3m walk and come back(p<.01). Third, parkinson's disease who regularly participated in the combined exercise significantly improved QOL(p<.001). Thus, the combined exercise had the positive effects and may be helpful to increased the blood dopamine concentration and improved functional fitness and QOL.

A Study on the Evaluation Method to Flexural-bonding Behavior of FRP-Rebar Concrete Member (FRP를 보강근으로 사용한 콘크리트 부재의 휨-부착 거동 평가방법에 관한 연구)

  • Choi, So-Yoeng;Choi, Myoung-Sung;Kim, Il-Sun;Yang, Eun-Ik
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.25 no.5
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    • pp.149-156
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    • 2021
  • FRP has been proposed to replace the steel as a reinforcement in the concrete structures for addressing the corrosion issue. However, FRP-Rebar does not behave in the same manner as steel because the properties of FRP are different. For example, FRP-Rebar has a high tensile strength, low stiffness, and linear elastic behavior which results in a difference bonding mechanism to transfer the load between the reinforcement and the surrounding concrete. Therefore, bonding behavior between FRP-Rebar and concrete has to be investigated using the bonding test. So, Pull-out test has been used to estimate bond behavior because it is simple. However, the results of pull-out test have a difference with flexural-boding behavior of FRP-Rebar concrete member. So, it is needed to evaluate the real fleuxral-bonding behavior. In this study, the evaluation method to flexural-bonding behavior of FRP-Rebar concrete member was reviewed and compared. It was found that the most accurate evaluation method for the fleuxral-bonding behavior of FRP-Rebar concrete member was splice beam test, however, the size and length of specimen have to increase than other test method and the design and analysis of splice beam is complex. Meanwhile, characteristics of concrete could be reflected by using arched beam test, unlike hinged beam test which is based on the ignored change of moment arm length in equilibrium equation. However, the possibility of shear failure exists before the flexural-bonding failure occur.

Use of Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in Patients with Axillary Node-Positive Breast Cancer in Diagnosis

  • Choi, Hee Jun;Kim, Isaac;Alsharif, Emad;Park, Sungmin;Kim, Jae-Myung;Ryu, Jai Min;Nam, Seok Jin;Kim, Seok Won;Yu, Jonghan;Lee, Se Kyung;Lee, Jeong Eon
    • Journal of Breast Cancer
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    • v.21 no.4
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    • pp.433-4341
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    • 2018
  • Purpose: This study aimed to evaluate the effects of sentinel lymph node biopsy (SLNB) on recurrence and survival after neoadjuvant chemotherapy (NAC) in breast cancer patients with cytology-proven axillary node metastasis. Methods: We selected patients who were diagnosed with invasive breast cancer and axillary lymph node metastasis and were treated with NAC followed by curative surgery between January 2007 and December 2014. We classified patients into three groups: group A, negative sentinel lymph node (SLN) status and no further dissection; group B, negative SLN status with backup axillary lymph node dissection (ALND); and group C, no residual axillary metastasis on pathology with standard ALND. Results: The median follow-up time was 51 months (range, 3-122 months) and the median number of retrieved SLNs was 5 (range, 2-9). The SLN identification rate was 98.3% (234/238 patients), and the false negative rate of SLNB after NAC was 7.5%. There was no significant difference in axillary recurrence-free survival (p=0.118), disease-free survival (DFS; p=0.578) or overall survival (OS; p=0.149) among groups A, B, and C. In the subgroup analysis of breast pathologic complete response (pCR) status, there was no significant difference in DFS (p=0.271, p=0.892) or OS (p=0.207, p=0.300) in the breast pCR and non-pCR patients. Conclusion: These results suggest that SLNB can be feasible and oncologically safe after NAC for cytology-determined axillary node metastasis patients and could help reduce arm morbidity and lymphedema by avoiding ALND in SLN-negative patients.

Ultrasound-Guided Injections in the Lumbar and Sacral Spine (요추 및 천추부에 대한 초음파 유도하 중재 시술)

  • Ko, Kwang Pyo;Song, Jae Hwang;Kim, Whoan Jeang;Kim, Sang Bum;Min, Young Ki
    • Journal of Korean Society of Spine Surgery
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    • v.25 no.4
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    • pp.185-195
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    • 2018
  • Study Design: Literature review. Objective: Ultrasound-guided injections are a common clinical treatment for lower lumbosacral pain that are usually performed before surgical treatment if conservative treatment fails. The aim of this article was to review ultrasound-guided injections in the lumbar and sacral spine. Summary of Literature Review: Ultrasound-guided injections, unlike conventional interventions using computed tomography or C-arm fluoroscopy, can be performed under simultaneous observation of muscles, ligaments, vessels, and nerves. Additionally, they have no radiation exposure and do not require a large space for the installation of equipment, so they are increasingly selected as an alternative method. Materials and Methods: We searched for and reviewed studies related to the use of ultrasound-guided injections in the lumbar and sacral spine. Results: In order to perform accurate ultrasound-guided injections, it is necessary to understand the patient's posture during the intervention, the relevant anatomy, and normal and abnormal ultrasonographic findings. Facet joint intra-articular injections, medial branch block, epidural block, selective nerve root block, and sacroiliac joint injections can be effectively performed under ultrasound guidance. Conclusions: Ultrasound-guided injections in the lumbar and sacral spine are an efficient method for treating lumbosacral pain.