• 한국임상수의학회지
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• 제33권2호
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• pp.97-101
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• 2016

In the field of clinical medicine, diagnostic accuracy studies refer to the degree of agreement between the index test and the reference standard for the discriminatory ability to identify a target disorder of interest in a patient. The receiver operating characteristic (ROC) curve offers a graphical display the trade-off between sensitivity and specificity at each cutoff for a diagnostic test and is useful in assigning the best cutoff for clinical use. In this end, the ROC curve analysis is a useful tool for estimating and comparing the accuracy of competing diagnostic tests. This paper reviews briefly the measures of diagnostic accuracy such as sensitivity, specificity, and area under the ROC curve (AUC) that is a summary measure for diagnostic accuracy across the spectrum of test results. In addition, the methods of creating an ROC curve in single diagnostic test with five-category discrete scale for disease classification from healthy individuals, meaningful interpretation of the AUC, and the applications of ROC methodology in clinical medicine to determine the optimal cutoff values have been discussed using a hypothetical example as an illustration.

• 충청수학회지
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• 제16권2호
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• pp.43-57
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• 2003

The boundary of a typical period-2 component in the degree-3 bifurcation set is formulated by a parametrization of its image which is the unit circle under the multiplier map. Some properties on the geometry of the boundary are investigated including the root point, the cusp and the length as well as the area bounded by the boundary curve. The centroid of the area for the period-2 component was numerically found with high accuracy and compared with its center. An algorithm drawing the boundary curve with Mathematica codes is proposed and its implementation exhibits a good agreement with the analysis presented here.

• 대한전자공학회논문지
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• 제27권9호
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• pp.1336-1343
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• 1990

In this paper the theoretical analysis of the site attenuation was made on the concept of mutual impedance of antennas and the cause of characteristic hump in the site attenuation curve below 80 MHz is explained. The deviation between the FCC site attenuatios and the experimental results of an ideal open area test site at low frequencies(below 80MHz) was found to be the mutual coupling effects of the antennas under the FCC's measurement conditions. It seems desirable that the site attenuations curve of FCC document be revicused to the theoretical curves presented in this paper is long as the FCC's measurement conditions are to the applied.

• 대한수학회논문집
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• 제33권1호
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• pp.237-245
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• 2018

For every interval [a, b], we denote by $({\bar{x}}_A,{\bar{y}}_A)$ and $({\bar{x}}_L,{\bar{y}}_L)$ the geometric centroid of the area under a catenary curve y = k cosh((x-c)/k) defined on this interval and the centroid of the curve itself, respectively. Then, it is well-known that ${\bar{x}}_L={\bar{x}}_A$ and ${\bar{y}}_L=2{\bar{y}}_A$. In this paper, we fix an end point, say 0, and we show that one of ${\bar{x}}_L={\bar{x}}_A$ and ${\bar{y}}_L=2{\bar{y}}_A$ for every interval with an end point 0 characterizes the family of catenaries among nonconstant $C^2$ functions.

• 약학회지
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• 제48권4호
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• pp.226-230
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• 2004

The pharmacokinetics of orally administered paclitlxel (50 mg/kg) was studied in six rabbits after 1hr pretreatment (2.0 mg/kg and 10 mg/kg) of tetramethoxyflavone or coadministration of (2.0 mg/kg, 10 mg/kg and 20 mg/kg) tetramethoxyflavone. The area under the plasma concentration-tine curve (AUC) and plasma concentration of paclitaxe1 coadministered with tetramethoxyflavone (10 mglkg) were increased significantly (p<0.05) compared with control. However, coadministration of tetramethoxyflavone (2 and 20 mg/kg) showed no significant effect on the pharmacokinetic parameters of paclitaxel. Pretreatment with tetramethoxyflavone significantly (p<0.05) increased the plasma concentration of paclitaxel. The area under the plasma concentration-time curve (AUC) and the peak concentration (C$_{max}$) of paclitaxel pretreated with tetramethoxyflavone were increased significantly (p<0.01, p<0.05) compared with control. The terminal half. life of paclitaxel pretreated with tetramethoxyflavone (2 mg/kg and 10 mg/kg) was significantly (p<0.05) prolonged compared with control. Pretreatment with tetramethoxyflavone (2.0 mg/kg, 10 mg/kg) significantly (p<0.01, p<0.05) increased the absolute bioavailability of paclitaxel compared with the control (154∼179%). On the basis of the results, it might be considered that tetramethoxyflavone may inhibit cytochrome P450 or P-glycoprotein efflux pump which are engaged in paclitaxel metabolism, result in increased AUC and t$_{1}$2/ of paclitaxel. However, further study should be conducted to clarify the roles of cytochrome P450 and P-glycoprotein on paclitaxel bioavailability with/or without tetramethoxyflavone. P-glycoprotein on paclitaxel bioavailability with/or without tetramethoxyflavone.

• 오토저널
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• 제12권5호
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• pp.76-84
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• 1990

To study diesel fuel spray behavior, an experimental study was undertaken to investigate injection characteristics in vary ing back pressure and atomization mechanism in a non-evaporating diesel spray. Generally, injection characteristics is the curve of fuel flow plotted against time. The area under this curve is equal to the total quantity of fuel discharged for one injection. The method that measures rate of injection is long tube-type fuel rate indicator. Diesel spray injected into a quiescent gaseous environment under high pressure is observed by taking high speed camera by the focused shadow photographs. The results show that, at the start of injection, as the injected fuel rushes into the quiescent atmosphere the spray angle becomes large. Finally the spray stabilizes at a constant cone angle. Spray penetration length increases with the injection pressure.

• 대한간호학회지
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• 제46권1호
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• pp.59-68
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• 2016

Purpose: Increase in suicide rate for senior citizens which has become widespread in our society today. It is not a normal social phenomenon and is beyond the danger level. The contents of this study include Korean senior citizens' suicide related risk factors and warning signs, and the development of a simple Geriatric Suicide Risk Scale. Methods: This study is Methodological Research to verify reliability and validity of the Geriatric Suicide Risk Scale according to the tool development process suggested by Devellis (2012). Results: For predictive validity assessment, high suicide screening accuracy was showed with an Area under the ROC curve (AUC) of .93. For the optimal cutoff point of 11, sensitivity was 93.9%, and specificity, 75.7% which are excellence levels. Cross validity for assessment of generalization possibility showed the Area under the ROC curve (AUC) as .82 and in case of a cutoff point of 11, sensitivity was 73.7%, and specificity, 65.9%. Conclusion: When it comes to practical nursing, it is significant that the Korean Geriatric Suicide Risk Scale has high reliability and validity through adequate tool development and the tool assessment step to select degree of suicide risk of senior citizens. Also, it can be easily applied and does not take a long time to administer. Further, it can be used by health care personnel or the general public.

• 약학회지
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• 제44권2호
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• pp.189-192
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• 2000

We examined a dermal pharmacokinetics for a new SYC-fentanyl patch in rabbits. Determination of fentanyl in the plasma was performed using a gas chromatography with nitrogen-phosphorus detection system and a capillary column. One patch per animal (fentanyl 2.5 mg) was applied to clipped back skin for 72 hours. The plasma fentanyl concentration profile of SYC-patch was similar to that of a conventional patch (Durogesi $c^{R}$, Janssen Co.). No significant difference was observed in the pharmacokinetic parameters, the area under the concentration-time curve (AU $C^{0-}$72hrs/) and the total area under the first moment-time curve (AUM $C^{0-}$7hrs/), between the two patch types. The AU $C^{0-}$7hrs/ and AUM $C^{0-}$72hrs/ of durogesi $c^{R}$ were 183.3$\pm$46.28 ng＊hr/ml and 6,450$\pm$1,939ng＊h$r^2$/ml, and those of SYC-fentany patch were 217.2$\pm$50.51$\pm$ng＊hr/ml and 8,022$\pm$2,245ng＊h$r^2$/ml, respectively (n=3). This result indicates that the new SYC patch has a similar bioavailability compared to durogesi $c^{R}$ patch. Therefore, the SYC-patch may be considered as a bioequivalent fentanyl patch.patch.tch.

• Biomolecules & Therapeutics
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• 제7권4호
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• pp.342-346
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• 1999

This study was performed to investigate the effect of cyclosporine (CsA) on glucose tolerance and peripheral insulin sensitivity in normal Sprague-Dawley rats. After daily treament of CsA (10 mg/kg, i.p.) for two weeks, glucose tolerance tests were carried out by the treatment of glucose (Glu, 2 g/kg, i.p.) alone or in conjunction with exogenous insulin (Ins; human regular insulin, 5 U/kg, s.c.) and measured the decrement of area under the time-plasma glucose concentration curve ($AUC_{o\longrightarrow120}$; g.min/ml) by the trapezoidal rule. The rats were divided into three groups (Glu- (Control), Ins+Glu- and CsA+Ins+Glu-, n=7 in each group). The $AUC_{o\longrightarrow120}$ of the CsA+Ins+Glu-group was significantly (p<0.01) lower than that of Glu-group (61.0% of control) and significantly (p<0.05) higher than that of Ins+Glu-group (197.4% of Ins+Glu-). The CsA+Ins+Glu- grou showed higher levels of maximal blood glucose concentration and higher $AUC_{o\longrightarrow120}$ than those of Ins+Glu-group in normal rats. Besides direct pancreatic toxicity of CsA previously reported (Hahn et al., 1972), these results suggest that CsA also make the possibility to induce peripheral insulin insensitivity and glucose intolerance in normal rats.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2021년도 추계학술발표대회
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• pp.805-807
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• 2021

In-hospital cardiac arrest is a significant problem for medical systems. Although the traditional early warning systems have been widely applied, they still contain many drawbacks, such as the high false warning rate and low sensitivity. This paper proposed a strategy that involves a deep learning approach based on a novel interpretable deep tabular data learning architecture, named TabNet, for the Rapid Response System. This study has been processed and validated on a dataset collected from two hospitals of Chonnam National University, Korea, in over 10 years. The learning metrics used for the experiment are the area under the receiver operating characteristic curve score (AUROC) and the area under the precision-recall curve score (AUPRC). The experiment on a large real-time dataset shows that our method improves compared to other machine learning-based approaches.