• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.111-116
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• 2013

Background: Cigarette smoking is the major risk factor for development of lung cancer. Identification of effects of tobacco on airway gene expression may provide insight into the causes. This research aimed to compare gene expression of large airway epithelium cells in normal smokers (n=13) and non-smokers (n=9) in order to find genes which discriminate the two groups and assess cigarette smoking effects on large airway epithelium cells.Materials and Methods: Genes discriminating smokers from non-smokers were identified by applying a neural network clustering method, growing self-organizing maps (GSOM), to microarray data according to class discrimination scores. An index was computed based on differentiation between each mean of gene expression in the two groups. This clustering approach provided the possibility of comparing thousands of genes simultaneously. Results: The applied approach compared the mean of 7,129 genes in smokers and non-smokers simultaneously and classified the genes of large airway epithelium cells which had differently expressed in smokers comparing with non-smokers. Seven genes were identified which had the highest different expression in smokers compared with the non-smokers group: NQO1, H19, ALDH3A1, AKR1C1, ABHD2, GPX2 and ADH7. Most (NQO1, ALDH3A1, AKR1C1, H19 and GPX2) are known to be clinically notable in lung cancer studies. Furthermore, statistical discriminate analysis showed that these genes could classify samples in smokers and non-smokers correctly with 100% accuracy. With the performed GSOM map, other nodes with high average discriminate scores included genes with alterations strongly related to the lung cancer such as AKR1C3, CYP1B1, UCHL1 and AKR1B10. Conclusions: This clustering by comparing expression of thousands of genes at the same time revealed alteration in normal smokers. Most of the identified genes were strongly relevant to lung cancer in the existing literature. The genes may be utilized to identify smokers with increased risk for lung cancer. A large sample study is now recommended to determine relations between the genes ABHD2 and ADH7 and smoking.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.240.2-240.2
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• 2008

• Communications of the Korean Mathematical Society
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• v.34 no.1
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• pp.95-103
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• 2019

In this paper we study certain modules whose prime spectrums are Noetherian or/and spectral spaces. In particular, we investigate the relationship between topological properties of prime spectra of torsion modules and algebraic properties of them.

• Journal of Power Electronics
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• v.15 no.5
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• pp.1329-1337
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• 2015

By placing distributed generation power sources beside a big nonlinear load, these sources can be used as a power quality enhancer, while injecting some active power to the network. In this paper, a new scheme to use the distributed generation power source in both operation modes is presented. In this scheme, a fuzzy controller is added to adjust the optimal set point of inverter between compensating mode and maximum active power injection mode, which works based on the harmonic content of the nonlinear load. As the high order current harmonics can be easily rejected using passive filters, the DG is used to compensate the low order harmonics of the load current. Multilevel transformerless cascade inverters are preferred in such utilization, as they have more flexibility in current/voltage waveform. The proposed scheme is simulated in MATLAB/SIMULINK to evaluate the circuit performance. Then, a 1kw single phase prototype of the circuit is used for experimental evaluation of the paper. Both simulative and experimental results prove that such a circuit can inject a well-controlled current with desired harmonics and THD, while having a smaller switching frequency and better efficiency, related to previous 3-phase inverter schemes in the literature.

• Membrane and Water Treatment
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• v.7 no.4
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• pp.297-311
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• 2016

Modeling and simulation of air humidification by hollow fiber membrane contactors are investigated in the current study. A computational fluid dynamic model was developed by solving the k-epsilon turbulence 2D Navier-Stokes equations as well as mass conservation equations for steady-state conditions in membrane contactors. Finite element method is used for the study of the air humidification under different operating conditions, with a focus on the humidity density, total mass transfer flux and velocity field. There has been good agreement between simulation results and experimental data obtained from literature. It is found that the enhancement of air stream decreases the outlet humidity from 0.392 to 0.340 (module 1) and from 0.467 to 0.337 (module 2). The results also indicated that there has been an increase in air velocity in the narrow space of shell side compared with air velocity wide space of shell side. Also, irregular arrangement has lower dead zones than regular arrangement which leads to higher water flux.

• Membrane and Water Treatment
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• v.7 no.5
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• pp.463-476
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• 2016

In this study, application of polypropylene hollow fiber membrane contactors for $CO_2$ removal from water in liquid-liquid extraction (LLE) mode was simulated. For this purpose, a steady state 2D mathematical model was developed. In this model axial and radial diffusion was considered to $CO_2$ permeation through the hollow fibers. $CO_2$ laden water is fed at a constant flow rate into the lumen side, permeated through the pores of membrane and at the end of this process, $CO_2$ solution in the lumen side was extracted by means of aqueous diethanolamine (DEA) and chemical reaction. The simulation results were validated with the experimental data and it was found a good agreement between them, which confirmed the reliability of the proposed model. Both simulation and experimental results confirmed the reduction in the percentage of $CO_2$ removal by increment of feed flow rate.

• Computers and Concrete
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• v.21 no.5
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• pp.539-546
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• 2018

Making a transverse opening in concrete beams in order to accommodate utility services through the member instead of below or above of that, sometimes may be necessary. It is obvious that inclusions of an opening in a beam decreases its flexural and shear strengths. Fabricated steel bars are usually used to increase the capacity of the opening section, but details of reinforcements around the opening are dense and complex resulting in laborious pouring and setup process. The goal of this study was to investigate the possibility of using steel fibers in concrete mixture instead of complex reinforcement detailing order to strengthen opening section. Nonlinear finite element method was employed to investigate the behavior of steel fiber reinforced concrete beams. The numerical models were validated by comparison with experimental measurements tested by other investigators and then used to study the influence of fiber length, fiber aspect ratio and fiber content on the shear performance of SFRC slender beams with opening. Finally, it was concluded that the predicted shear strength enhancement is considerably influenced by use of steel fibers in concrete mixture but the effect of fiber length and fiber aspect ratio wasn't significant.

• Asian Journal of Business Environment
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• v.7 no.1
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• pp.5-12
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• 2017

Purpose - In order to achieve the organizational objectives, the behavior of the employees and their collaboration with management should be taken into account. It has been shown that strategic behavior depends on a number of different factors. The aim of this article was determining the relationship between factors related to the strategic behavior. Research design, data, and methodology - Accordingly, a conceptual model was developed and tested in the form of a survey. Participants of the study were the employees working in the social Insurance company of Tehran. Data was collected using a questionnaire conducted among managers and the staff. A correlation model was used for data analysis by employing the SPSS software. Results - The findings showed there was a relationship between employees' engagement and the strategic behavior. Conclusions - Our research has demonstrated the effect of employees' engagement on the strategic-driven behavior, emphasizing the role of employees' engagement in health-care service firms. Although previous service research has focused on the factors that drive employees' performance, it seems that most of this research has been inspired by the idea of the service profit chain, focusing on the effect of employees' satisfaction on performance.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3229-3240
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• 2023

Due to neutron radiation, atomic displacement has a significant effect on material in nuclear reactors. A range of secondary displacement models, including the Kinchin-Pease (K-P), Lindhard, Norgett-Robinson-Torrens (NRT), and athermal recombination-corrected displacement per atom (arc-dpa) have been suggested to calculate the number of displacement per atom (dpa). As neutron elastic interaction is the main cause of displacement damage, the focus of the current study is to calculate the atomic displacement caused by the neutron elastic interaction in order to estimate the exact amount of yield strength in a WWER-1000 reactor pressure vessel. To achieve this purpose, the reactor core is simulated by MCNPX code. In addition, a program is developed to calculate the elastic radiation damage induced by the incident neutron flux (RADIX) based on different models using Fortran programming language. Also, due to non-elastic interaction, the displacement damage is calculated by the HEATR module of the NJOY code. ASME E-693-01 standard, SPECTER, NJOY codes, and other pervious findings have been used to validate RADIX results. The results showed that the RADIX(arc-dpa)/HEATR outputs have appropriate accuracy. The relative error of the calculated dpa resulting from RADIX(arc-dpa)/HEATR is about 8% and 46% less than NJOY code, respectively in the ¼ and ¾ vessel wall.

• Geomechanics and Engineering
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• v.32 no.4
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• pp.445-452
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• 2023

Temperature is one of the important factors affecting the permeability of water in the soil. In the present study, the impact of water temperature on hydraulic conductivity (k) with and without coarse aggregations by considering six types of soils was analyzed. Moreover, the effect of sand and gravel presence in the soil was investigated through the infiltration based on constant and inconstant water head experiments. Results indicated that by increasing the water temperature, adding gravel to sandy soil caused the hydraulic conductivity to raise. It is supposed that the gravel decreased the contact surface between the water and the soil aggregates. It is deduced that due to decreasing kinetic energy, k tends to have lower values. Furthermore, adding the sand to sandy silt-clay soil showed that the sand did not have a marginal effect on the variation of k since the added sand cannot increase the contact surface like gravel. Finally, increasing the main diameter of the soil will increase the effect of the water temperature on hydraulic conductivity.