• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.32-32
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• 2003

Recent, a problem about an animal-experimentation were seriously stated with bright development of human science. Safety of chemical materials is evaluated on the basis of the various toxicity data that used an animal-experimentation. However, an toxicity test used by animal is covered with limit and criticism. A problem of toxicity test by animal can try to approach in ethic a few side and usefulness.(omitted)

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.35-37
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• 2003

Efficacy and safety of drugs are evaluated in the process of drug registration along with the basis of setting test method and acceptance criteria for assuring quality of the drugs. Quality of drugs plays a key role to guarantee the efficacy and safety of drugs approved in the evaluation process at the marketing stage after approval. Most important role of pharmacopoeia is to give the basis of assuring the quality of drugs. (omitted)

• Journal of Plant Biology
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• v.31 no.1
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• pp.51-68
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• 1988

To clarity the species of genus Melandrium (Caryophyllaceae) in Korea, the taxonomic characters were described and interspecific relationships were discussed to the extemal morphology with light and scanning electron microscopy. The position and size of appendages on petal, the shape and venation pattern of leaf, and the external morphology of seed and pollen were approved as the good characters to classify genus Melandrium in Korea. As the result, genus Melandrium in Korea could be arranged as 6 species, 1 variety, 1 forma. M. umbellatum was exclusively distributed in north Korea, and its taxonomic treatment was reserved.

• Communications of the Korean Mathematical Society
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• v.34 no.2
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• pp.465-475
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• 2019

Let X be a Banach space and $X^*$ be its dual. In this paper, we give relationships among some parameters in $X^*$: ${\varepsilon}$-nonsquareness parameter, $J({\varepsilon},X^*)$; ${\varepsilon}$-boundary parameter, $Q({\varepsilon},X^*)$; the modulus of smoothness, ${\rho}_{X^*}({\varepsilon})$; and ${\varepsilon}$-Pythagorean parameter, $E({\varepsilon},X^*)$, and weak orthogonality parameter, ${\omega}(X)$ in X that imply uniform norm structure in X. Some existing results are extended or approved.

• Journal of Integrative Natural Science
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• v.15 no.4
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• pp.187-194
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• 2022

Protein Arginine Methyltransferase 5 (PRMT5), a significant member of the PRMT family, is a promising anticancer target. In this study, novel small compounds that act against the PRMT5 target are found by combining virtual screening with ChEMBL database medicines and Density Functional Theory. The ChEMBL database compounds were screened to retrieve the hit molecules, which further subjected for DFT analysis. Finally we have evaluated that ChEMBL- approved drugs such as Lifitegrast, Abiraterone acetate and Solifenacin may be potential inhibitors for PRMT5.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.9 no.1
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• pp.13-23
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• 1980

sing the physical characteristics of nuclear radiation penerated into the cross section of the measurement of void fraction in saturated vapor & water passing through the is analyzed theoretically and the solutions are achieved by means of computer simulation. These theoretical results are also approved through the experiment with the simulators.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.127-131
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• 2021

Neuroendocrine tumor is one of popular diseases, and somatostatin receptor antagonists have been considered as promising agents for neuroendocrine tumors. Imaging of somatostatin receptor is useful approach on the diagnosis and therapy of neuroendocrine tumors. Thus, several radiolabeled somatostatin derivatives have been developed by scientists, and used for patients with neuroendocrine tumors. In particular, some radiopharmaceuticals for neuroendocrine tumors were approved by FDA. In this highlight review, the development of important radiolabeled somatostatin derivatives is described.

• Journal of Food Hygiene and Safety
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• v.23 no.2
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• pp.91-97
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• 2008

Kimchi is a representative traditional food in Korea and a type of vegetable product that is the unique complex lactic acid fermentation in the world. It can be considered as a unique fermented food generated by various flavors, which are not included in raw materials, that can be generated by mixing and fermenting various spices and seasonings, such as red pepper powder, garlic, ginger, and salted fish, added to Chinese cabbages. Functionalities in Kimchi have been approved through several studies and the probiotic function that is mainly based on lactic acid bacteria including their physical functions in its contents has also verified. Studies on the verification of the safety of Kimchi including its physiological functions have been conducted. In particular, the function of lactic acid bacteria, which is a caused of the fermentation of Kimchi. Although the lactic acid bacteria contributed to the fermentation of Kimchi is generated from raw and sub-materials, the lactic acid bacteria attached on Chinese cabbages has a major role in the process in which the fermentation temperature and dominant bacteria are also related to the process. The salt used in a salt pickling process inhibits the growth of the putrefactive and food poisoning bacteria included in the fermentation process of Kimchi and of other bacteria except for such lactic acid bacteria due to the lactic acid and several antimicrobial substances generated in the fermentation process, such as bacteriocin and hydrogen peroxide. In addition, the carbon dioxide gas caused by heterolactic acid bacteria contributes to the inhibition of aerobic bacteria. Furthermore, special ingredients included in sub-materials, such as garlic, ginger, and red pepper powder, contribute to the inhibition of putrefactive and food poisoning bacteria. The induction of the change in the intestinal bacteria as taking Kimchi have already verified. In conclusion, Kimchi has been approved as a safety food due to the fact that the inhibition of food poisoning bacteria occurs in the fermentation process of Kimchi and the extinction of such bacteria.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.25 no.3
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• pp.123-134
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• 2017

In order to advance into the MRO industry, the Aviation maintenance organization with suitable for the standards for personnel, facilities and operations should be first approved by FAA and EASA. The purpose of study is designed to arrange the standards required for personnel, facility, operation rule for approval of Repair Station maintenance organizations certified by FAA PART 145 of the US Federal Aviation Regulation. Also to consider the following differences through the comparative analysis with domestic AMO certification of the information in the Management, Maintenance Process, and Quality System for approval of maintenance organization authorized, the additional EASA PART 145. As a comparative analysis on maintenance organization certification in the country between FAA and EASA, this study could show us that domestic maintenance organization, certified manual contents are used by applying just many of the FAA system. And we could know that as part of the EASA maintenance organization certification process, airmen personnel were relatively systematically segmented and controlled. For domestic maintenance organization certification, operational as policy implications we would like to present policy implications such as the implication of rating system of Aviation Mechanic License like EASA, the financial support of the training center to resolve the shortage of the FAA or EASA license holders, operational organization as "CAMO" for systematic aviation mechanic certified system should be required, continued construction of hangar or MRO for airworthiness repair under Governmental support, and varied application of DER system from FAA accordingly.

• Clinical and Experimental Pediatrics
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• v.54 no.4
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• pp.146-151
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• 2011

Streptococcus pneumoniae remains a leading cause of invasive infections including bacteremia and meningitis, as well as mucosal infections such as otitis media and pneumonia among children and adults. The 7-valent pneumococcal conjugate vaccine (PCV7) was licensed for use among infants and young children in many countries including Korea. The routine use of PCV7 has resulted in a decreased incidence of invasive pneumococcal disease (IPD) by the vaccine serotypes among the vaccinees and substantial declines in IPD among unvaccinated populations such as older children and adults as well. In addition, there are increasing evidences to suggest that routine immunization with PCV7 is changing the epidemiology of pneumococcal diseases such as serotype distribution of IPD, nasopharyngeal colonization, and antibiotic resistance patterns. In contrast, there is an increase in the number of IPDs caused by nonvaccine serotypes, though it is much smaller than overall declines of vaccine serotype diseases. Several vaccines containing additional serotypes have been developed and tested clinically in order to expand the range of serotypes of Streptococcus pneumoniae. Recently two new pneumococcal protein conjugate vaccines, 10-valent pneumococcal conjugate vaccine (PCV10) and 13-valent pneumococcal conjugate vaccine (PCV13), have been approved for use in several countries including Korea. This report summarizes the recommendations approved by the Committee on Infectious Diseases, the Korean Pediatric Society.