• Clinical and Experimental Vaccine Research
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• v.13 no.2
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• pp.132-145
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• 2024

Purpose: Enterovirus 71, a pathogen that causes hand-foot and mouth disease (HFMD) is currently regarded as an increasing neurotropic virus in Asia and can cause severe complications in pediatric patients with blister-like sores or rashes on the hand, feet, and mouth. Notwithstanding the significant burden of the disease, no authorized vaccine is available. Previously identified attenuated and inactivated vaccines are worthless over time owing to changes in the viral genome. Materials and Methods: A novel vaccine construct using B-cell derived T-cell epitopes from the virulent polyprotein found the induction of possible immune response. In order to boost the immune system, a beta-defensin 1 preproprotein adjuvant with EAAAK linker was added at the N-terminal end of the vaccine sequence. Results: The immunogenicity of the designed, refined, and verified prospective three-dimensional-structure of the multi-epitope vaccine was found to be quite high, exhibiting non-allergenic and antigenic properties. The vaccine candidates bound to toll-like receptor 3 in a molecular docking analysis, and the efficacy of the potential vaccine to generate a strong immune response was assessed through in silico immunological simulation. Conclusion: Computational analysis has shown that the proposed multi-epitope vaccine is possibly safe for use in humans and can elicit an immune response.

• Advances in materials Research
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• v.13 no.4
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• pp.299-319
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• 2024

Due to higher strength-to-weight ratio of composite laminates, they find uses in many weight-sensitive applications like aerospace, automobile and marine structures. From a reliability point of view, accurate prediction of failure of these structures is important. Due to the complexities in the manufacturing processes of composite laminates, there is a variation in the material properties and geometric parameters. Hence stochastic aspects are important while designing the composite laminates. Many existing works of composite laminate failure analysis are based on the deterministic approach but it is important to consider the randomness in the material properties, geometry and loading to predict accurate failure loads. In this paper the statistics of the ultimate failure load of the [0/θ]_s laminated composite plate (LCP) containing the edge crack and voids subjected to the tensile loading are presented in terms of the mean and coefficient of variance (COV). The objective is to better the efficacy of laminate failure by predicting the statistics of the ultimate failure load of LCP with random material, geometric and loading parameters. The stochastic analysis is done by using the extended finite element method (XFEM) combined with the second-order perturbation technique (SOPT). The ultimate failure load of the LCP is obtained by ply-by-ply failure analysis using the ply discount method combined with the Tsai-Wu failure criterion. The aim is to know the effect of the stacking sequence, crack length, crack angle, location of voids and number of voids on the mean and corresponding COV of the ultimate failure load of LCP is investigated. The results of the ultimate failure load obtained by the present method are in good agreement with the existing experimental and numerical results. It is observed that [0/θ]_s LCPs are very sensitive to the randomness in the crack length, applied load, transverse tensile strength of the laminate and modulus of elasticity of the material, so precise control of these parameters is important. The novelty of the present study is, the stochastic implementation in XFEM for the failure prediction of LCPs containing crack and voids.

• Korean Journal of Health Education and Promotion
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• v.18 no.3
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• pp.37-58
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• 2001

This study placed its objectives in suggesting the basic data for setting up an approach to protect the educational environment, by analyzing the relevance between the misconducts of adolescence and the harmful environment around the school, as an object of study, middle school students and high school students all over the country. Thus, this study carried out the questionnaire survey, by the multi-stage of stratified sampling in 2,114 middle school and high school students from June 29, 2000 through July 29, 2000. And the results of analysis were as follows: 1. In case of the ratio of students using harmful environment, the electronic game room had the highest ratio (78.3％); next, the PC room (75.6％), the singing room (71.6％), and the cartoon room (34.3％). 2. In terms of the experiences of using the harmful environment according to the personal characteristics, high school students used it in a higher ratio, compared with middle school students (p〈0.001); the students, whose father graduated from a high school, comparatively used it much more(p〈0.05). Also, when a school is located near to amusement quarters or shopping centers, students used the harmful environment most highly (p〈0.001). And the differences were found to be statistically significant. 3. In case of the perceived susceptibility factors, the harmful environment was found to be used in lower ratio, by the students who answered “very so” to the question item, The more harmful environment facilities are positioned around school, the more student have the opportunities to use them. (p〈0.001). That is, the findings showed that the higher students' degree of perceived susceptibility factors was the less students used harmful environment facilities. The differences were statistically significant. In terms of the ratio of using harmful environment according to perceived seriousness factors, it was founded out that the students, who answered, “If I use any harmful environment facilities, it will be very harmful to myself.”. had the less opportunities of having used them, compared with the students who did not answer so (p〈0.001). This indicated that the higher the degrees perceived seriousness of students, the less they used harmful environment facilities. And the differences were statistically significant. In the side of the ratio of using harmful environment according to the perceived barriers, it was found out that there were any special large differences. That is, perceived barriers had nothing to do with students' using harmful environment. 4. As the result of having analyzed the factors influencing the behaviors of using harmful environment, the factor to explain the behaviors of using harmful environment was found to be the degree of perceived seriousness, among individual perceiving factors; next, the location of a school - one of personal characteristics, the degree of perceived susceptibility and ages, m sequence. 5. Among students' misconduct experiences, drinking was highest (21.6％), next, smoking (11.9％), drug abuse (4.3％), and sexual relations (1.6％), In sequence. Among other problematic behaviors, excessive waste was highest (14.6％); next, disobedience and lie (10.7％), night wandering (7.8％), and bad dressing and making-up (5.5％), in sequence. 6. In terms of the misconducts according to the behaviors of using harmful environment, compared with the students who did not commit any misconducts, harmful environment facilities were used more highly, by each group of students who experienced drinking (p〈0.00l), smoking (p〈0.001), sexual relations (p〈0.05), excessive waste (p〈0.001), disobedience ＆ lie (p〈0.001), and bad dressing ＆ making-up (p〈0.05). And the differences were statistically significant.

• The Journal of Korean Philosophical History
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• no.28
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• pp.87-116
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• 2010

In elementary, environmental education have been doing in various subjects. The features of environmental instruction would be reflected on contents of environmental education and characteristics of each subjects. These contents of environmental education might be contained normative contents, and it is moral subject that treats these normative contents systematically. Then environmental instruction of moral subject in elemental school should be approach and inquire teaching contents related to environment education. In elementary school curriculum of moral subject, teaching contents related to environment are 'preciousness of life' and 'right views of Nature and protection of the environment'. By these contents, moral instruction can approach to life of animal and plants centered on the reason to take them preciously and relation between nature and humans centered on the moral consideration. It is a difference that approaches to the environmental education not by factual understanding but by normative understanding in moral instruction. It must be focused on ethical inquiry for normative approach and reserving identity of moral subject. Necessary conditions for ethical inquiry to the environmental instruction are moral status of things besides humans. For the ethical inquiry to the moral status of nature environments, teachers could be set the logic of instruction based on the developments of environmental ethics. Formal cohesiveness of environmental instruction could be developed in sequence of ethical inquiry on moral status to the life of animal, life of plants, and whole system of nature. For this, teacher could reflect on their instruction focused on some explanations. That is, it is explanation to the animal life based on the individual-extended human oriented ethics for human, plants life based on the individual-non human oriented ethics, whole natural system based on the holistic-non human oriented ethics. When teachers reflect these explanation, they can compose their instruction as 'finding something in common with humans and animals', 'reflection on the attitude to the commons', 'thinking about reasons on the different attitudes to the commons', 'the things that disappear as plants die', 'thinking on values about non organism'. These plan of instruction could be critically reconstruct by other teachers. But environmental consciousness by ethical inquiry should be hold on instruction to the environment reflected on identity of moral subject.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.6
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• pp.1-10
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• 2009

In a network-based approach such as Proxy Mobile IPv6 (PMIPv6), the serving network controls the mobility management on behalf of a Mobile Node (MN), thereby eliminating a MN from any mobility-related signaling. Although PMIPv6 is being standardized by the IETF NetLMM WG, PMIPv6 still suffers from a lengthy handover latency and the on-the-fly packet loss during a handover. Therefore, this paper presents an enhanced fast handover scheme for PMIPv6. The proposed handover scheme uses the Neighbor Discovery message of IPv6 to reduce the handover latency and packet buffering at the Mobile Access Gateway (MAG) to avoid the on-the-fly packet loss during a handover. In addition, it uses an additional packet buffering at the Local Mobility Anchor (LMA) to solve the packet ordering problem. We evaluate the performance of the proposed handover scheme using both analytical model and simulation. The numerical analysis shows that the proposed scheme has a relatively shorter handover latency. Simulation results demonstrate that the proposed scheme could avoid the on-the-fly packet loss and ensure the packet sequence.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4513-4518
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• 2014

The prevalence of BRCA1 gene mutations in breast cancer differs between diverse ethnic groups. Relatively little information is known about patterns of BRCA1 mutations in early-onset breast cancer in women of Uighur or Han descent, the major ethnic populations of the Xinjiang region in China. The aim of this study was to identify BRCA1 mutations in Uighur and Han patients with early-onset (age <35 years), and sporadic breast cancer for genetic predisposition to breast cancer. For detection of BRCA1 mutations, we used a polymerase chain reaction single-stranded conformation polymorphism approach, followed by direct DNA sequencing in 22 Uighur and 13 Han women with early-onset sporadic breast cancer, and 32 women with benign breast diseases. The prevalence of BRCA1 mutations in this population was 22.9% (8/35) among early-onset sporadic breast cancer cases. Of these, 31.8% (7/22) of Uighur patients and 7.69% (1/13) of Han patients were found to have BRCA1 mutations. In 7 Uighur patients with BRCA1 mutations, there were 11 unique sequence alterations in the BRCA1 gene, including 4 clearly disease-associated mutations on exon 11 and 3 variants of uncertain clinical significance on exon 11, meanwhile 4 neutral variants on intron 20 or 2. None of the 11 BRCA1 mutations identified have been previously reported in the Breast Cancer Information Core database. These findings reflect the prevalence of BRCA1 mutations in Uighur women with early-onset and sporadic breast cancer, which will allow for provision of appropriate genetic counseling and treatment for Uighur patients in the Xinjiang region.

• Journal of Korea Water Resources Association
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• v.53 no.7
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• pp.493-505
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• 2020

The rainfall-runoff model has been generally adopted to obtain a consistent runoff sequence with the use of the long-term ground-gauged based precipitation data. The Thiessen polygon is a commonly applied approach for estimating the mean areal rainfall from the ground-gauged precipitation by assigning weight based on the relative areas delineated by a polygon. However, spatial bias is likely to increase due to a sparse network of the rain gauge. This study aims to generate continuous runoff sequences with the mean areal rainfall obtained from radar rainfall estimates through a PRMS rainfall-runoff model. Here, the systematic error of radar rainfall is corrected by applying the G/R Ratio. The results showed that the estimated runoff using the corrected radar rainfall estimates are largely similar and comparable to that of the Thiessen. More importantly, one can expect that the mean areal rainfall obtained from the radar rainfall estimates are more desirable than that of the ground in terms of representing rainfall patterns in space, which in turn leads to significant improvement in the estimation of runoff.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.3
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• pp.180-201
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• 2020

It has been widely known that the effect of diffracted waves at the tip of composite breakwater with finite length causes the change of standing wave height along the length of breakwater, the spatial change of wave pressure on caisson, and the occurrence of meandering damage on the different sliding distance in sequence. It is hard to deal with the spatial change of wave force on trunk of breakwater through the two-dimensional experiment and/or numerical analysis. In this study, two and three-dimensional numerical techniques with olaFlow model are used to approach the spatial change of wave force including the impulsive breaking wave pressure applied to trunk of breakwater, the effect of rear region, and the occurrence of diffracted waves at the tip of caisson located on the high crested rubble mound. In addition, it is thoroughly studied the mean wave height, mean horizontal velocity, and mean turbulent kinetic energy through the numerical analysis. In conclusion, it is confirmed that the larger wave pressure occurs at the front wall of caisson around the still water level than the original design conditions when it generates the shock-crushing wave pressure checked by not two-dimensional analysis, but three-dimensional analysis through the change of wave pressure applied to the caisson along the length of breakwater.

• Journal of Korea Port Economic Association
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• v.24 no.2
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• pp.131-154
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• 2008

The purpose of this paper is to verify the financial validity of dredging the port of Busan with the change of global port logistics circumstances. In order to do so, NPV, IRR, B/C ratio, DPP techniques are adopted. The whole dredging at Northern port area is supposed to be negative at the depth of 16m water. Based upon its financial validity, however, the priority is Shinsundae (option 1) followed by Shinsundae (option 1) and Gamman (option 1), Shinsundae (option 1) and Gamman (option 2), Shinsundae (option 2) and Gamman (option 2), Shinsundae (option 2) and Gamman (option 2) and ShinGamman in sequence. In addition to this, Busan New port is considered to be the positive financial validity at the dredging of 16m water depth. This is because the ultra containerships of over 8,000TEU are trying to call at the port and Hanjin shipping and Hyundai Merchant shipping companies which are now the most significant customers in Northern port are scheduled to divert it.

• Journal of KIISE
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• v.43 no.3
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• pp.370-379
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• 2016

Recently personal media were produced in a variety of ways as a lot of smart devices have been spread and services using these data have been desired. Therefore, research has been actively conducted for the media analysis and recognition technology and we can recognize the meaningful object from the media. The system using the media ontology has the disadvantage that can't classify the media appearing in the video because of the use of a video title, tags, and script information. In this paper, we propose a system to automatically classify video using the objects shown in the media data. To do this, we use a description logic-based reasoning and a rule-based inference for event processing which may vary in order. Description logic-based reasoning system proposed in this paper represents the relation of the objects in the media as activity ontology. We describe how to another rule-based reasoning system defines an event according to the order of the inference activity and order based reasoning system automatically classify the appropriate event to the category. To evaluate the efficiency of the proposed approach, we conducted an experiment using the media data classified as a valid category by the analysis of the Youtube video.