• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.4013-4018
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• 2015

Objective: To explore the clinical application of recombinant human endostatin (Endostar) in the treatment of patients with non-small cell lung cancer (NSCLC) in Chinese mainland. Materials and Methods: A total of 75 patients diagnosed as NSCLC were randomly divided into control group (37 cases) and treatment group (38 cases). Control group was treated with postoperative complementary chemotherapy containing two-agent platinum protocol on postoperative d21, 3 weeks as a cycle, for totally 4~6 cycles. On this basis, treatment group was added with Endostar $7.5mg/m^2$ on postoperative d8~9, 3~4 h/time, qd, 14 weeks as a cycle, for totally 4 cycles. The interval between every two cycles was 7 d. The 5-year progression-free survival (PFS), 5-year survival time and complications in both groups were observed. Results: Compared with control group, the average PFS increased evidently in treatment group by 9.8 months (41.6 months vs. 31.8 months), and there was significant difference (P<0.05). And the median PFS was 42.5 months in treatment group, obviously longer than that in control group (33.7 months) by 8.8 months (P<0.05). Additionally, the 5-year overall survival rate (OS), average survival time and median survival time (MST) were 47.4%, 50.1 months and 59.3 months in treatment group, significantly higher than the 29.7%, 42.1 months and 43.5 months in control group (P<0.05). Only 1 patient showed poor healing of surgical wound in treatment group, but no surgery-associated complication was found in control group. Moreover, the postoperative complementary therapy-connected complication rates were 63.2% (24/38) and 59.5% (22/37) in treatment group and control group respectively, but there was no significant difference (P>0.05). Conclusions: The application of Endostar combined with sensitive platinum-contained chemotherapeutic agents in the postoperative complementary chemotherapy can be widely used in clinic because it can significantly prolong the long-term survival time of patients with NSCLC.

• Journal of Periodontal and Implant Science
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• v.27 no.4
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• pp.767-783
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• 1997

Guided tissue regeneration, bone graft procedures, and application of growth factors have been used to regenerate lost periodontal tissues. Recently, enamel matrix derivative has been introduced into periodontal regeneration procedures in expectation of promoting new bone and cementum formation. The purpose' of this study was to evaluate the effect of enamel matrix derivative in 1-wall intrabony defects in beagle dogs. For this purpose, each dog was anesthesized using intravenous anesthesia and mandibular 1st, 3rd premolars were extracted. 2 months later, the 1-wall intrabony defects(mesio-distal width: 4mm, depth: 4mm) were created on the distal side of 2nd premolars and mesial side of 4th premolars. The control group was treated with debridement alone, and experimental group was treated with debridement and enamel matrix derivative application. The healing processes were histologically and histometrically observed after 8 weeks and the results were as follows : 1. The length of junctional epithelium was $0.94{\pm}0.80mm$ in the control group, $0.57{\pm}0.42mm$ in the experimental group, with no statistically significant difference between groups. 2. The connective tissue attachment was $1.36{\pm}0.98mm$ in the control group. $0.38{\pm}0.43mm$ in the experimental group, with statistically significant difference between groups(P<0.05). 3. The new cementum formation was $2.49{\pm}1.06mm$ in the control group, $3.59{\pm}0.74mm$ in the experimental group. with statistically significant difference between groups(P<0.05). 4. The new bone formation was $1.92{\pm}0.97mm$ in the control group, $2.32{\pm}0.59mm$ in the experimental group. with no statistically significant difference between groups. Within the limitation to this study protocol, enamel matrix derivative application in 1-wall intrabony defect enhanced new cementum formation. Although there was no statistically significant difference, enamel matrix derivative also seems to be effective in inhibition of apical migration of junctional epithelium and new bone formation.

• Journal of the Korea Society for Simulation
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• v.16 no.1
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• pp.11-19
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• 2007

Under ubiquitous environment, applications can gather and utilize various sensing information. There are many issues such as energy management, protocol standardization, independency on sensor fields, and security to be resolved for the complete ubiquitous computing. Especially, the independent information access in the sensor field is one of the most important issues to maximize the usability of sensors in various sensor fields. However, existing frameworks are not suitable for the ubiquitous computing environment because of data heterogeneity between data elements in sensor fields. Existing applications are dependent to sensor fields and sensors in the existing ubiquitous computing on environment is dependent to the application in the sensor field. In other word, an application can utilize just information from a specific sensor field. To overcome this restriction, many issues from a hardware or software view must be resolved. In this paper, we provide the design and implementation of the Metadata Registry-based framework (UbiMDR) of the Ubiquitous environment. This framework can provides the semantic interoperability among ubiquitous applications or various sensor fields. In addition, we describe comparison evaluation between conventional Ubiquitous computing framework and UbiMDR framework with data accuracy of interoperability.

• Journal of KIISE:Information Networking
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• v.30 no.4
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• pp.559-571
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• 2003

ENUM(tElephon NUmbering Mapping) is protocol that brings convergence between PSTN Networks and IP Networks using a unique worldwide E.164 telephone number as an identifier between different communication infrastructure. The mechanism provides a bridge between two completely different environments with E.164 number; IP based application services used in PSTN networks, and PSTN based application services used in IP networks. We propose a new way to organize and handle ENUM Tier 2 name servers to improve performance at the name resolution process in ENUM based application service. We build an ENUM based network model when NAPTR(Naming Authority PoinTeR) resource record is registered and managed by area code at the initial registration step. ENUM promises convenience and flexibility to both PSTN and IP users, yet there is no evidence how much patience is required when users decide to use ENUM instead of non-ENUM based applications. We have estimated ENUM response time, and proved how to improve performance up to 3 times when resources are managed by the proposed mechanism. The proposition of this thesis favorably influences users and helps to establish the policy for Tier 2 name server management.

• The KIPS Transactions:PartD
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• v.16D no.1
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• pp.55-64
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• 2009

Various business model and computing environments are currently merged into web services and many web related application products are also develop. Most of IT enterprises in Korea use the Service-oriented architecture (SOA) whenever they develop the web applications. SOA is an approach to loosely coupled, protocol independent, standards-based distributed computing where software resources available on the network are considered as Services. SOA is believed to become the future enterprise technology solution that promises the agility and flexibility the business users have been looking for by leveraging the integration process through composition of the services spanning multiple enterprises. But, There are no specific development methodology to apply into SOA standard model until now. The developer uses the currently existing methodology to develop the application with SOA. The users have some limitations to use it. In this paper, we suggest a Frameworks for applying agile methodology into SOA to address the productivity and quality of small web related project. We design and implement a frameworks architecture for applying the agile method into SOA and describe the process model to implement it. We finally evaluate the frameworks with productivity, flexibility and maintainability.

• Journal of Korea Water Resources Association
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• v.55 no.1
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• pp.43-57
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• 2022

Advances in measurement techniques have reduced measurement costs and enhanced safety resulting in less uncertainty. For example, an acoustic doppler current profiler (ADCP) based suspended sediment concentration (SSC) measurement technique is being accepted as an alternative to the conventional data collection method. In Korean rivers, horizontal ADCPs (H-ADCPs) are mounted on the automatic discharge monitoring stations, where SSC can be measured using the backscatter of ADCPs. However, automatic discharge monitoring stations and sediment monitoring stations do not always coincide which hinders the application of the new techniques that are not feasible to some stations. This work presents and analyzes H-ADCP-SSC models for 9 discharge monitoring stations in Korean rivers. In application of the Gaussian mixture model (GMM) to sediment-related variables (catchment area, particle size distributions of suspended sediment and bed material, water discharge-sediment discharge curves) from 44 sediment monitoring stations, it is revealed that those characteristics can distinguish sediment monitoring stations regionally. Linking the two results, we propose a protocol determining the H-ADCP-SSC model where no H-ADCP-SSC model is available.

• Journal of the Korea Society for Simulation
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• v.18 no.3
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• pp.47-59
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• 2009

Due to the application-specific nature of wireless sensor networks, the sensitivity to such a requirement as data reporting latency may vary depending on the type of applications, thus requiring application-specific algorithm and protocol design paradigms which help us to maximize energy conservation and thus the network lifetime. In this paper, we propose a novel delay-adaptive sensor scheduling scheme for energy-saving data gathering which is based on a two phase clustering (TPC). The ultimate goal is to extend the network lifetime by providing sensors with high adaptability to the application-dependent and time-varying delay requirements. The TPC requests sensors to construct two types of links: direct and relay links. The direct links are used for control and forwarding time critical sensed data. On the other hand, the relay links are used only for data forwarding based on the user delay constraints, thus allowing the sensors to opportunistically use the most energy-saving links and forming a multi-hop path. Simulation results demonstrate that cluster-based delay-adaptive data gathering strategy (CD-DGS) saves a significant amount of energy for dense sensor networks by adapting to the user delay constraints.

• The KIPS Transactions:PartA
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• v.10A no.6
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• pp.691-700
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• 2003

Due to the fast development of wire&wireless internet and computer hardware, more and more internet services are being developed, such as Internet broadcast, VoD (Video On Demand), etc. So QoS (Qualify of Service) is essentially needed to guarantee the quality of these services. Traditional Internet is Best-Effort service in which all packets are transported in FIFO (First In First Out) style. However, FIFO is not suitable to guarantee the quality of some services, so more research in QoS router and QoS protocol are needed. Researched QoS router and protocol are high cost and inefficient because the existing infra is not used. To solve this problem, a new QoS control method, named Network Adaptive QoS, is introduced and applied to client/server-based streaming systems. Based on network bandwidth monitoring mechanism, network adaptive QoS control method can be used in wire&wireless networks to support QoS in real-time streaming system. In order to reduce application cost, the existing streaming service is used in NAQoS. A new module is integrated into the existing server and client. So the router and network line are not changed. By simulation in heavy traffic network conditions, we proved that stream cannot be seamless without network adaptive QoS method.

• The Transactions of the Korea Information Processing Society
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• v.5 no.10
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• pp.2627-2640
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• 1998

In this paper, we analyze the performance of the virtual cell system[1] for the transmission of IP datagrams in mobile computer communications. A virtual cell consistsof a group of physical cells shose base stationsl are implemented b recote bridges and interconnected via high speed datagram packet switched networks. Host mobility is supported at the data link layer using the distributed hierachical location information of mobile hosts. Given mobility and communication ptems among physical cells, the problem of deploying virtual cells is equivalent to the optimization cost for the entire system where interclster communication is more expesive than intracluster communication[2]. Once an iptimal partitionof disjoint clusters is obtained, we deploy the virtual cell system according to the topology of the optimal partition such that each virtual cell correspods to a cluser. To analyze the performance of the virtual cell system, we adopt a BCMP open multipel class queueing network model. In addition to mobility and communication patterns, among physical cells, the topology of the virtual cell system is used to determine service transition probabilities of the queueing network model. With various system parameters, we conduct interesting sensitivity analyses to determine network design tradeoffs. The first application of the proposed model is to determine an adequate network bandwidth for base station networking such that the networks would not become an bottleneck. We also evaluate the network vlilization and system response time due to various types of messages. For instance, when the mobile hosts begin moving fast, the migration rate will be increased. This results of the performance analysis provide a good evidence in demonsratc the sysem effciency under different assumptions of mobility and communication patterns.

• Journal of KIISE:Information Networking
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• v.34 no.6
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• pp.446-457
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• 2007

In wireless sensor network, to provide the proper responses quickly for diverse events, wireless sensor nodes have to cooperate with each other. For successful cooperation, the time synchronization among sensor nodes is an important requirement for application execution. In the wireless sensor network, the message packets including time information are used for the time synchronization. However, the transmission of many message packets will exhaust the battery of wireless sensor nodes. Since wireless sensor nodes works on the limited battery capacity, the excessive transmission of message packets has an negative impact upon their lifetime. In this paper, the Reference Interpolation Protocol (RIP) is proposed to reduce the number of message packets for the time synchronization. The proposed method performs the time interpolation between the reference packet's time and the global time of the base station. The proposed method completes the synchronization operation with only 2 message packets when compared to the previous Reference Broadcast Synchronization (RBS) technique. Due to the simple synchronization procedure, our method greatly reduces the number of synchronization messages and showed the 12.7 times less power consumption than the RBS method. From the decrease in the transmission of message packets, the convergence time among wireless sensor nodes is shortened and the lifetime of wireless sensor nodes is also prolonged as much as the amount of saved battery energy.