• Korean Journal of Psychosomatic Medicine
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• v.28 no.1
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• pp.81-88
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• 2020

Objectives : This study aimed to compare autonomic nervous system (ANS) dysregulation and differential relationships with clinical severities between anxiety disorder, depressive disorder, and trauma·stressor related disorder using heart rate variability (HRV) parameters. Methods : We conducted a retrospective chart review of outpatients from 2017 to 2018 in Stress Clinic of National Center for Mental Health. Total 473 patients were included; 166 anxiety disorder; 184 depressive disorder ; 123 trauma·stressor related disorder. Parameters of 5-min analysis of HRV were compared in three groups. Additionally, we investigated the differential association of each parameters with Clinical Global Impression-Severity Scale (CGI-S) across each group. Results : No significant differences were found in all HRV parameters between the three groups. However, significant group interactions by CGI-S were found in standard deviation of all RR intervals (SDNN) and the square root of the mean squared differences of successive normal-to-normal intervals (RMSSD) (SDNN, p=0.017 ; RMSSD, p=0.034). A negative relationship between CGI-S and SDNN, RMSSD has been found in anxiety disorder and depressive disorder. However, a positive relationship between CGI-S and SDNN, RMSSD has been found in trauma·stressor related disorder. Conclusions : Despite of no significant differences of each HRV parameter, our findings suggested the differential associations of HRV parameters with clinical severity among anxiety disorder, depressive disorder and trauma·stressor related disorder. In trauma·stressor related disorder, the clinical severity and degree of ANS dysregulation may differ, so more aggressive treatment is suggested.

• Journal of Oriental Neuropsychiatry
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• v.14 no.2
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• pp.127-134
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• 2003

This is a case report of a patient with mixed anxiety and depressive disorder treated by Punsimgieum. The symptoms of the patient were anxiety(agitation), numbness(paresthesia), nausea, dyspepsia, insomnia and hopelessness. In this case, we administrated Punsimgieum to a patient suffering from anxiety and depressive disorder symptoms. After administration of Punsimgieum medication clinical symptoms improved Punsimgieum showed desirable effect on anxiety and depressive disorder symptoms.

• Journal of Oriental Neuropsychiatry
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• v.20 no.3
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• pp.297-307
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• 2009

Objectives : Insomnia, depression and anxiety disorder are widespread in elderly patients. Mood disorder and insomnia share complex theoretical and clinical relationships. We investigated if traditional Korean medical treatment and breathing meditation are effective in patient with insomnia, depression and anxiety disorder. Methods : We treated one patient with traditional Korean medical treatment such as accupuncture, herb-medication, moxa and breathing meditation Results : After Treatment, the chief complaint and accompanying symptoms were improved, and the score of BAI, SADS, BDI, PSQI, IQ were decresed. Conclusions : According to this study traditional Korean medical treatment is effective for the cure of insomnia, depression and anxiety disorder and breathing meditation forifies the traditional Korean medical treatment.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.16 no.1
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• pp.124-131
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• 2005

Childhood and adolescent onset-bipolar disorders have higher rate of comorbidity with anxiety disorders as well as attention deficit hyperactivity disorder and conduct disorder. Obsessive compulsive disorder, social phobia, panic disorder, and separational anxiety disorder are common comorbid anxiety disorders with bipolar disorders in child and adolescent. Prospective and reliable data on temporal and causal relationship between the onset of bipolar disorders and the onset of comorbid anxiety disorders are still in debate. The authors report 2 adolescent cases with antidepressant induced-manic episodes with preceding anxiety symptoms. The authors suggest careful prescription of antidepressants for anxiety disorders, even for those who do not have definite past history or family history of bipolar disorders. Further comprehensive and prospective studies are requested for the temporal relationship and pharmacological guideline for comorbid bipolar disorders and anxiety disorder in child and adolescent.

• Journal of Yeungnam Medical Science
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• v.9 no.1
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• pp.156-166
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• 1992

The authors studied anxiety, using Zung's self-rating anxiety scale(SAS), in the subjects of 127 male and 38 female patients with anxiety disorder. The authors investigated 165 patients in Yeungnam university hospital from January, 1987 to June, 1991. In order to analyze the data on anxiety scores Pearson's product moment coefficient correlation method and factor analysis were carried out by SPSS/PC+ program. The results were as follows : There was significant difference in the mean averages of total anxiety scores among patients with anxiety, disorder and male and female college freshmen: patients with anxiety disorder scored $42.40{\pm}7.74$, male students scored $32.91{\pm}5.70$, female students scored $34.48{\pm}6.00$. The anxiety scores relating to the items of body aches & pains, fatigue, anxiousness, panic, and urinary frequency were relatively high in patients with anxiety disorder. The anxiety scores on the items of restlessness, apprehension, dyspnea, sweating, and insomnia were relatively low in patients with anxiety disorder. Twenty-nine anxiety disorder group(17.5%) showed significantly high anxiety scores of 50 or over. The inter-rater reliability of Zung's self-rating anxiety scale was 0.71.

• Anxiety and mood
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• v.9 no.1
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• pp.25-30
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• 2013

Objective : Panic disorder is a chroni, debilitating illness, and has been known to be affected by high anxiety sensitivity and a poor quality of life. We examined if 12 weeks of pharmacotherapy with escitalopram could affect anxiety sensitivity, quality of life, and general disability in patients with panic disorder. Method : We enrolled 27 patients who met the DSM-IV-TR criteria for panic disorder, with or without agoraphobia, and completed 12 weeks of escitalopram treatment. We enrolled 29 normal control subjects who were matched for age and sex compared with the panic patients. All subjects were assessed using the Hamilton Rating Scale for depression (HAM-D), Hamilton Rating Scale for Anxiety (HAM-A), Panic Disorder Severity Scale (PDSS), Anxiety Sensitivity Index-Revised (ASI-R), WHO quality of life assessment (WHO-QOL) and Sheehan Disability Scale (SDS) before and after 12 weeks of treatment. Result : Panic disorder patients had a higher Anxiety sensitivity, a poorer Quality of life, and significant disability than normal control subjects at baseline. After the treatment, Panic disorder patients showed significant improvement in the severity of panic symptoms in terms of the HAM-A p<0.001), HAM-D (p<0.001) in addition, the reached a remission state in terms of the PDSS score. They also showed significant improvement in the ASI-R (p<0.001), WHO-QOL (p<0.001) and SDS (p<0.001), but mean scores of the ASI-R, WHO-QOL and SDS in panic disorder patients were did not reach normal levels. Conclusion : This study suggests that 12 weeks of pharmacotherapy with escitalopram could improve anxiety sensitivity, quality of life, and disability in panic disorder patients, although their anxiety sensitivity, quality of life and disability were not yet normalized after short-term pharmacotherapy. Thus, long-term pharmacotherapy may be necessary for panic disorder patients in order to get an optimal clinical response in terms of anxiety sensitivity, quality of life, and general disability.

• Journal of Digital Policy
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• v.1 no.1
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• pp.1-5
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• 2022

The objective of this study was to examine the effectiveness of newly developed program for the recovery and relapse prevention in patients with anxiety disorder. Twenty-four patients with anxiety disorder received Mindfulness-Based Cognitive Therapy (MBCT) session weekly for a period of overall 8 weeks-program. Changes of depression, anxiety, negative and positive automatic thought were compared before and after the program. Depression and anxiety were improved significantly after the MBCT program(Z=-1.9, p=.06, Z=-2.9, p<.001). Conclusions: MBCT may be effective at reducing negative automatic thought and relieving anxiety and depressive symptoms in patients with anxiety disorder. However, large-sample, randomized controlled trials will be needed for generalization.

• Anxiety and mood
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• v.10 no.1
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• pp.17-23
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• 2014

Objective : Panic disorders are frequently accompanied by major depressive disorder (MDD). There is insufficient information about which clinical factors in panic disorder are associated with comorbid MDD. The aim of this study is to identify clinical factors related with comorbid MDD in patients with panic disorder. Methods : Two experienced psychiatrists diagnosed panic disorder based on DSM-IV criteria. This diagnosis in the 275 subjects was confirmed again by Mini-International Neuropsychiatric Interview (MINI). Lifetime comorbid psychiatric diagnoses were examined by MINI. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Panic Disorder Severity Scale (PDSS) were used to assess the severity of depressive, anxiety and panic symptoms. Results : The result of MINI showed that 95 patients (34%) with panic disorder satisfied the diagnosis of MDD. Multivariate logistic regression model showed that comorbid generalized anxiety disorder (GAD) and the symptom of "fear of losing control or going crazy" were associated with MDD in patients with panic disorder. In female patients, the "chills or hot flushes" symptom was also associated with comorbid MDD. Conclusion : These results showed that coexisting GAD and certain symptoms of panic are associated with comorbid MDD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.1
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• pp.83-91
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• 1997

Objects：This study investigated whether depression, anxiety and perceived parental rearing patterns of the conduct disorder patients are different from those of the normal control group. The correlations were also assessed between perceived parenting style and depression, anxiety, severity of conduct problems and age at onset of conduct disorder in adolescents with conduct disorder. Methods：Thirty hospitalzed patients who met the DSM-Ⅳ criteria of conduct disorder, and 30 normal control subjects completed self-report questionnaires containing the Children’s Depression Inventory(CDI), the State-Trait Anxiety Inventory for Children(STAIC) and the Parental Bonding Instrument(PBI). Results：In the conduct disorder group, the results were as follows：1) The mean scores of CDI and STAIC-T(Trait) were not significantly different from those of the control group, but STAIC-S (State) showed significantly higher scores. 2) Parenting style was perceved to be less caring and more overprotective than in the control subjects. 3) There were negative correlations between maternal care and CDI and between maternal care and severity of conduct problems. 4) There were positive correlations between maternal overprotection and STAIC-T(Trait). 5) There were no correlations between paternal rearing patterns and depression, anxiety, severity of conduct problems, or age at onset of conduct disorder. Conclusion：We failed to identify depression and anxiety as common comorbid disorders in conduct disorder. Parental rearing patterns are thought to be significantly negativistic in conduct disorder group. It is guessed that less caring and more overprotective rearing style of parents, especially of mothers, could have much influence on depression and anxiety, more severe conduct problems and earlier age at onset of conduct disorder in the adolescents with conduct disorder.

• Journal of Preventive Medicine and Public Health
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• v.55 no.2
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• pp.173-181
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• 2022

Objectives: Anxiety disorder is among the most prevalent mental illnesses among adolescents. Early detection and proper treatment are important for preventing sequelae such as suicide and substance use disorder. Studies have suggested that sleep duration is associated with anxiety disorder in adolescents. In the present study, we investigated the association between sleep quality and anxiety in a nationally representative sample of Korean adolescents. Methods: This cross-sectional study was conducted using data from the 2020 Korea Youth Risk Behavior Web-based Survey. The Generalized Anxiety Disorder-7 questionnaire was used to evaluate anxiety. The chi-square test was used to investigate and compare the general characteristics of the study population, and multiple logistic regression analysis was used to analyze the relationship between sleep quality and anxiety. Results: In both sexes, anxiety was highly prevalent in participants with poor sleep quality (adjusted odds ratio [aOR], 1.56; 95% confidence interval [CI], 1.43 to 1.71 in boys; aOR, 1.30; 95% CI, 1.19 to 1.42 in girls). Regardless of sleep duration, participants with poor sleep quality showed a high aOR for anxiety. Conclusions: This study identified a consistent relationship between sleep quality and anxiety in Korean adolescents regardless of sleep duration.